Cited by 382Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismNuclear Receptors and Signaling

An introduction to the free radical hypothesis in Parkinson's disease

Olanow, C. W.·1992·Annals of Neurology

Abstract

Iron-induced oxidant stress has been implicated in the pathogenesis of Parkinson's disease. An increasing body of evidence now indicates that in Parkinson's disease the environment within the substantia nigra is conducive to the formation of cytotoxic free radicals and cell degeneration. Dopamine neurons may be particularly vulnerable because of the oxidative metabolism of dopamine and the potential of neuromelanin to promote the site-specific accumulation and reduction of iron. This hypothesis has attracted considerable attention because it opens the way for employing antioxidant strategies as possible neuroprotective treatment for Parkinson's disease. Although the concept is appealing, free radicals have not yet been proven to play a role in Parkinson's disease, and many important issues remain to be resolved before the oxidative hypothesis can ultimately be confirmed or refuted.

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Crossref · 10.1002/ana.410320703

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Authors
Olanow, C. W.
Affiliations
University of South Florida (US)
Corresponding author
Olanow, C. W.
Venue
Annals of Neurology
Publisher
Wiley
Published
1992
Volume
32
Issue
S1
Pages
S2-S9
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2156259977
Cited by
382
References
68
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 13
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, oxidative stress, iron accumulation, substantia nigra, dopaminergic neurons, neuromelanin, dopamine oxidation, neuroprotection, antioxidants, neurodegeneration
MeSH terms
Animals, Free Radicals, Humans, Iron, Parkinson Disease, Substantia Nigra, Lipid Peroxidation

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