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Health-Related Quality of Life Across the Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
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OBJECTIVE: Although clinical studies have documented that specific anxiety disorders are associated with impaired psychosocial functioning, little is known regarding their comparative effects on health-related quality of life within a general population. The current analysis compares health-related quality of life in a US community-dwelling sample of adults with DSM-IV social anxiety disorder, generalized anxiety disorders (GAD), panic disorder, and specific phobia. METHOD: A face-to-face survey of a US nationally representative sample of over 43,000 adults aged 18 years and older residing in households and group quarters was conducted. Prevalence of DSM-IV anxiety disorders and relative associations with health-related quality of life indicators were examined. The survey was conducted from 2001 to 2002. RESULTS: Roughly 9.8% of respondents met diagnostic criteria for at least 1 of 4 twelve-month DSM-IV anxiety disorders which, relative to the non-anxiety-disordered general population, were each associated with lower personal income, increased rates of 12-month physical conditions, and greater numbers of Axis I and Axis II DSM-IV psychiatric conditions. After adjusting for sociodemographic and clinical correlates, including other anxiety disorders, GAD was associated with significant decrements in the SF-12 mental component summary score. In similar models, GAD and, to a lesser extent, panic disorder were significantly associated with impairment in social functioning, role emotional, and mental health SF subscales. CONCLUSIONS: GAD, followed by panic disorder, appears to exact significant and independent tolls on health-related quality of life. Results underscore the importance of prompt and accurate clinical identification and improving access to effective interventions for these disorders.
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“Anxiety disorders are associated with high socioeconomic costs and often a chronic, debilitating course for the affected person [5–7].”
From Results of a randomized controlled superiority trial of the effect of modified collaborative assessment vs. standard assessment on patients’ readiness for psychotherapy (CO-ASSM-RCT) (2024) · cites this paper as [5]
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“Patients with anxiety disorders have a higher prevalence of hypertension and other cardiovascular conditions, gastrointestinal disease, arthritis, thyroid disease, respiratory disease, migraine headaches, and allergic conditions compared to those without anxiety disorders [16,52].”
From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]
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“Medical conditions frequently reported in patients with anxiety and related disorders include cardiovascular disease, gastrointestinal disease, arthritis, respiratory disease, thyroid disease, migraine, and allergic conditions [16,52].”
From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]
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“Medical conditions are reported in over 60% of patients with anxiety and related disorders including cardiovascular diseases, gastrointestinal diseases, arthritis, respiratory diseases such as asthma, thyroid disease, migraine headaches, back pain, and allergic conditions [16,52,1430-1432].”
From Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders (2014) · cites this paper as [16]
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“Comorbidities are particularly common among patients with GAD, panic disorder, and PTSD [16,140,515, 517,1390,1433].”
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“Anxiety and related disorders often present together with other psychiatric or medical conditions [3,16,43, 1382,1383].”
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Self-citation
Metadata
- Authors
- Comer, J. S., Blanco, C., Hasin, D. S., Liu, S.-M., Grant, B. F., Turner, J. B., & Olfson, M.
- Affiliations
- New York State Psychiatric Institute (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Corresponding author
- Olfson, Mark
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2010-08-24
- Volume
- 72
- Issue
- 01
- Pages
- 43-50
- ISSN
- 0160-6689 (ISSN-L)
- PMC
- PMC3000882
- OpenAlex
- W2011237439
- Cited by
- 214
- References
- 77
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 21 · 2020: 10 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 12 · 2015: 13 · 2014: 18 · 2013: 15 · 2012: 3
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Foundation for Suicide Prevention
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- National Institutes of Health (Z99‐AA999999)
- Agency for Healthcare Research and Quality (U18HS016097)
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000449, AA-014223, K05AA014223)
- National Institute of Mental Health (T32MH016434, MH076051, R01MH076051)
- National Institute on Drug Abuse (R01DA020783, DA019606, DA020783, DA023200, R01DA019606, K02DA023200)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- health-related quality of life, anxiety disorders, generalized anxiety disorder, panic disorder, social anxiety disorder, specific phobia, social functioning, mental health, physical health, psychiatric comorbidity, income, community-dwelling adults
- MeSH terms
- Adolescent, Adult, Alcoholism, Anxiety Disorders, Data Collection, Female, Health Status, Health Surveys, Humans, Male, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, United States, Prevalence, Diagnostic and Statistical Manual of Mental Disorders
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