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Cited by 92Mindfulness and Compassion InterventionsTreatment of Major DepressionPsychotherapy Techniques and Applications

A Breathing-Based Meditation Intervention for Patients With Major Depressive Disorder Following Inadequate Response to Antidepressants: A Randomized Pilot Study

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Sharma, Anup, Barrett, Marna S., Cucchiara, Andrew J., Gooneratne, Nalaka S., Thase, Michael E.·2017·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.16m10819PMC PMC5272872
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Abstract

OBJECTIVE: To evaluate feasibility, efficacy, and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment. METHODS: Patients with MDD (defined by DSM-IV-TR) who were depressed despite ≥ 8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8 weeks. The primary efficacy end point was change in 17-item Hamilton Depression Rating Scale (HDRS-17) total score from baseline to 2 months. The key secondary efficacy end points were change in Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) total scores. Analyses of the intent-to-treat (ITT) and completer sample were performed. The study was conducted at the University of Pennsylvania between October 2014 and December 2015. RESULTS: In the ITT sample (n = 25), the SKY arm (n = 13) showed a greater improvement in HDRS-17 total score compared to waitlist control (n = 12) (-9.77 vs 0.50, P = .0032). SKY also showed greater reduction in BDI total score versus waitlist control (-17.23 vs -1.75, P = .0101). Mean changes in BAI total score from baseline were significantly greater for SKY than waitlist (ITT mean difference: -5.19; 95% CI, -0.93 to -9.34; P = .0097; completer mean difference: -6.23; 95% CI, -1.39 to -11.07; P = .0005). No adverse events were reported. CONCLUSIONS: Results of this randomized, waitlist-controlled pilot study suggest the feasibility and promise of an adjunctive SKY-based intervention for patients with MDD who have not responded to antidepressants. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02616549.

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  • Meditation displays some adjunctive therapeutic effects on patients with severe major depressive disorder who are less effectively treated with antidepressant medication therapy.

    “Meanwhile, meditation displays some adjunctive therapeutic effects on patients with severe major depressive disorder who are less effectively treated with antidepressant medication therapy.40”

    From Biological mechanism study of meditation and its application in mental disorders (2020) · cites this paper as [40]

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Research works printed but not linked: 3

  1. [12]Janakiramaiah N Gangadhar BN Naga Venkatesha Murthy PJ Therapeutic efficacy of sudarshan kriya yoga (SKY) in dysthymic disorder Nimhans Journal 1998 16 1 21 28
  2. [17]American Psychiatric Association Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision Washington, DC American Psychiatric Association 2000
  3. [24]Venables WN Ripley BD Modern Applied Statistics with S 4 New York Springer 2002 111 111

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Authors
Sharma, A., Barrett, M. S., Cucchiara, A. J., Gooneratne, N. S., & Thase, M. E.
Affiliations
University of Pennsylvania (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2016-11-22
Volume
78
Issue
01
Pages
e59-e63
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.16m10819
PMC
PMC5272872
OpenAlex
W2555207778
Cited by
92
References
18
Citations by year
2026: 5 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 13 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 5
FWCI
11.60
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000003)
  • National Institute of Mental Health (R01MH041884)
  • National Center for Research Resources (M01RR000056)
  • National Center for Advancing Translational Sciences
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
Sudarshan Kriya Yoga, major depressive disorder, antidepressant-resistant depression, adjunctive psychotherapy, yoga, depression severity, anxiety, feasibility, tolerability
MeSH terms
Adolescent, Adult, Aged, Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Feasibility Studies, Female, Humans, Male, Middle Aged, Pilot Projects, Psychiatric Status Rating Scales, Respiration, Yoga, Case-Control Studies, Treatment Outcome, Meditation, Young Adult, Depressive Disorder, Treatment-Resistant

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