The Role of Advanced Glycation End Products in Diabetic Vascular Complications
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In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.
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Endogenous AGEs are produced and slowly accumulated within the body during normal aging and under oxidative stress, inflammatory, and hyperglycemic conditions often observed in diabetes and other metabolic syndromes.
“Endogenous AGEs represent adducts that are produced and slowly accumulated within the body during the normal aging process and under the oxidative stress, inflammatory, and hyperglycemic (high blood sugar) conditions often observed in diabetes and other metabolic syndromes1,4,12,13.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [12]
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Diabetes, insulin resistance, and asthma: a review of potential links
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Therapeutic Potential of Polyphenols in the Management of Diabetic Neuropathy
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Cerebral Microvascular Senescence and Inflammation in Diabetes
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Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?
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Unraveling the Link between Ιnsulin Resistance and Bronchial Asthma
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Glucose Lowering Effect of Basil Leaves in Diabetic Rats
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Vascular Inflammation Risk Factors in Retinal Disease
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Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats
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- Authors
- Rhee, S. Y., & Kim, Y. S.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Kim, Young Seol
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2018
- Volume
- 42
- Issue
- 3
- Pages
- 188
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC6015964
- OpenAlex
- W2806671364
- Cited by
- 274
- References
- 52
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 20 · 2023: 25 · 2022: 44 · 2021: 58 · 2020: 46 · 2019: 24 · 2018: 3
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Health and Welfare (HI10C2020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- advanced glycation end products, diabetic vascular complications, chronic hyperglycemia, AGE receptor, AGE formation, glycemic control, diabetes complications
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