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Mucoadhesive drug delivery systems
Open accessAbstract
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).
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Lee, S. H., Bajracharya, R., Min, J. Y., Han, J.-W., Park, B. J., & Han, H.-K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12010068 · Cited by 318
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Mendes, A. C., Sevilla Moreno, J., Hanif, M., E.L. Douglas, T., Chen, M., & Chronakis, I. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082266 · Cited by 55
Samprasit, W., Opanasopit, P., & Chamsai, B. (2021) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2021.1873370 · Cited by 50
Ch, S., Padaga, S. G., Ghosh, B., Roy, S., & Biswas, S. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120822 · Cited by 40
RetractedSustained release T3 therapy: animal models and translational applications
Idrees, T., Price, J. D., Piccariello, T., & Bianco, A. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00544 · Cited by 30
Rampedi, P. N., Ogunrombi, M. O., & Adeleke, O. A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060712 · Cited by 15
Lajarin-Reinares, M., Naveira-Souto, I., Mallandrich, M., Suñer-Carbó, J., Llagostera Casas, M., Calvo, M. A., & Fernandez-Campos, F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051436 · Cited by 2
Metadata
- Authors
- Donnelly, R., Shaikh, R., Raj Singh, T., Garland, M., & Woolfson, A.
- Venue
- Journal of Pharmacy And Bioallied Sciences
- Publisher
- Medknow
- Published
- 2011
- Volume
- 3
- Issue
- 1
- Pages
- 89
- ISSN
- 0975-7406 (ISSN-L)
- OpenAlex
- W2020935675
- Cited by
- 740
- References
- 0
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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