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Cited by 68Ovarian function and disordersPhysical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Resistance exercise impacts lean muscle mass in women with polycystic ovary syndrome

KOGURE, GISLAINE SATYKO, MIRANDA-FURTADO, CRISTIANA LIBARDI, SILVA, RAFAEL COSTA, MELO, ANDERSON SANCHES, FERRIANI, RUI ALBERTO, DE SÁ, MARCOS FELIPE SILVA, REIS, ROSANA MARIA DOS·2016·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000000822
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Abstract

PURPOSE: This study investigated the effects of progressive resistance training (PRT) on lean muscle mass (LMM) in women with or without polycystic ovary syndrome (PCOS) and its effects on metabolic factors and concentrations of related steroid hormones. DESIGN: This was a nonrandomized, therapeutic, open, single-arm study. PARTICIPANTS: All in all, 45 sedentary women with PCOS and 52 without (non-PCOS), 18-37 yr of age, with body mass indexes (BMI) of 18-39.9 kg·m(-2) of all races and social status, performed PRT three times a week for 4 months. Before and after PRT, the concentrations of hormones and metabolic factors and waist circumference were measured. LMM and total body fat percentage were determined using dual-energy x-ray absorptiometry. Clinical characteristics, LMM, and fasting glucose were adjusted for confounding covariables and compared using general linear mixed models. Each patient's menstrual history was taken before study enrollment and after PRT. RESULTS: PRT resulted in reduced plasma testosterone and fasting glucose levels. After PRT, the androstenedione concentration increased and the sex hormone-binding globulin concentration decreased in women with PCOS. The waist circumference was reduced (P < 0.01) and the muscle mass index, lean mass (LM)/height2, increased in women with PCOS (P = 0.04). Women with PCOS showed increased muscle mass indexes of appendicular LM/height2 (P = 0.03) and LM/height2 (P < 0.01) compared with the baseline. Total LM and trunk LM were elevated in women with PCOS (P = 0.01) at the baseline and after PRT. CONCLUSION: To our knowledge, this is the first report to show that resistance exercise alone can improve hyperandrogenism, reproductive function, and body composition by decreasing visceral fat and increasing LMM, but it has no metabolic impact on women with PCOS.

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  • Three studies reported that there was no statistically significant difference in fasting glucose post-intervention between the two groups.

    “The majority of studies did not report whether there were between-group statistical significance, and three studies [35,43,44] reported that there was no statistically significant difference in fasting glucose post-intervention between the two groups (Table 4).”

    From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [44]

  • Only one study reported a p-value for the between-group difference in fasting insulin following the interventions (p = 0.58).

    “Only one of these studies reported a p-value for the between-group difference following the interventions (p = 0.58) [44] (Table 4).”

    From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [44]

  • Only one study reported a non-statistically significant difference in waist circumference between groups following progressive resistance training.

    “The majority of studies did not compare between-group differences after the interventions, with only one study reporting a non-statistically significant difference in WC between groups following progressive resistance training [44].”

    From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [44]

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Authors
KOGURE, G. S., MIRANDA-FURTADO, C. L., SILVA, R. C., MELO, A. S., FERRIANI, R. A., DE SÁ, M. F. S., & REIS, R. M. D.
Affiliations
Universidade de São Paulo (BR)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-04
Volume
48
Issue
4
Pages
589-598
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/mss.0000000000000822
OpenAlex
W2327904698
Cited by
68
References
49
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 5
FWCI
7.23
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, resistance training, lean muscle mass, hyperandrogenism, testosterone, sex hormone-binding globulin, androstenedione, waist circumference, body composition, visceral fat, fasting blood glucose, menstrual function, sedentary women
MeSH terms
Adolescent, Adult, Androstenedione, Blood Glucose, Exercise Therapy, Female, Humans, Polycystic Ovary Syndrome, Sex Hormone-Binding Globulin, Testosterone, Absorptiometry, Photon, Muscle, Skeletal, Intra-Abdominal Fat, Adiposity, Resistance Training, Waist Circumference, Young Adult

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