Recent data on obesity research: β-aminoisobutyric acid
Open accessAbstract
The world-wide epidemic of obesity is now affecting up to a third of the adult population. Research attempting to contribute to management of this health scourge has been recently refocused on the essential role of physical activity. Muscle activity induces a dramatic increase in transcription of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). This protein is a regulator of mitochondrial biogenesis and function. Very recently, in 2014 it was revealed that the mediator of this metabolic process is a low molecular myokine, the beta- aminoisobutyric acid (BAIBA). This compound with a simple molecular structure has a key metabolic role: it converts the cells of white adipose tissue into brown fat. The brown adipocytes contain a protein thermogenin. This substance turns off the energy stores, among others the adenosine triphosphate (ATP), thereby accelerating the breakdown of lipids into heat, water and CO2. We may be at the threshold of new and effective management of obesity. The world eagerly expects to see how the BAIBA will compare with other recently reported agents to fight the overweight (Fig. 2, Ref. 6).
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BAIBA has an important therapeutic role against obesity, mainly by stimulating fatty acid oxidation, reducing lipogenesis in white adipose tissue, and attenuating inflammation and insulin resistance.
“BAIBA also has an important therapeutic role against obesity (Ginter and Simko, 2014), mainly by stimulating the oxidation of fatty acids, reducing the process of lipogenesis in WAT, and attenuating inflammation and insulin resistance (Jung et al., 2018).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Ginter and Simko, 2014
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“BAIBA also has an important therapeutic role against obesity (Ginter and Simko, 2014), mainly by stimulating the oxidation of fatty acids, reducing the process of lipogenesis in WAT, and attenuating inflammation and insulin resistance (Jung et al., 2018).”
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- Authors
- Ginter, E., & Simko, V.
- Affiliations
- Slovak Medical University (SK)
- Corresponding author
- Ginter, E.
- Venue
- Bratislava Medical Journal
- Published
- 2014
- Volume
- 115
- Issue
- 08
- Pages
- 492-493
- ISSN
- 0006-9248 (ISSN-L)
- 1336-0345
- OpenAlex
- W1996573028
- Cited by
- 19
- References
- 4
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bratislavské lekárske listy/Bratislava medical journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, beta-aminoisobutyric acid, myokines, PGC-1α, mitochondrial biogenesis, brown adipose tissue, thermogenesis, white adipose tissue browning, physical activity, obesity treatment
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Aminoisobutyric Acids, Humans, Obesity, Transcription Factors, Adipocytes
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