Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics: FAT BROWNING AND THEIR POTENTIAL AS THERAPEUTICS

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410 · see citing works

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works

Energy balance and obesity

Hill, J. O., Wyatt, H. R., & Peters, J. C. (2012) · Circulation · doi:10.1161/circulationaha.111.087213 · Cited by 1,317 · see citing works

Obesity and the role of adipose tissue in inflammation and metabolism

Greenberg, A. S., & Obin, M. S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.461s · Cited by 1,271 · see citing works

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180 · see citing works

Adiponectin as an anti-inflammatory factor

Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 883 · see citing works

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 845 · see citing works

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 749 · see citing works

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

Sidossis, L. S., & Kajimura, S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78362 · Cited by 689 · see citing works

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J. W., Joris Hoeks, J., Brans, B. T., van der Lans, A. A. J. J., Schaart, G., van den Driessche, J. J., Jörgensen, J. A., Boekschoten, M. V., Hesselink, M. K. C., Havekes, B., et al. (2015) · Nature Medicine · doi:10.1038/nm.3891 · Cited by 587 · see citing works

The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

Giralt, M., & Villarroya, F. (2013) · Endocrinology · doi:10.1210/en.2013-1403 · Cited by 556 · see citing works

The Browning of White Adipose Tissue: Some Burning Issues

Nedergaard, J., & Cannon, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.005 · Cited by 500 · see citing works

White Adipose Tissue as Endocrine Organ and Its Role in Obesity

Frigolet, M. E., Torres, N., & Tovar, A. R. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2008.09.005 · Cited by 457 · see citing works

Adiponectin and inflammation: Consensus and controversy

Fantuzzi, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.018 · Cited by 402 · see citing works

Effects of obesity, diabetes and exercise on <i>Fndc5</i> gene expression and irisin release in human skeletal muscle and adipose tissue: <i>in vivo</i> and <i>in vitro</i> studies

Kurdiova, T., Balaz, M., Vician, M., Maderova, D., Vlcek, M., Valkovic, L., Srbecky, M., Imrich, R., Kyselovicova, O., Belan, V., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264655 · Cited by 401 · cited 2× · see citing works

Brown fat as a therapy for obesity and diabetes

Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes &amp; Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376 · see citing works

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

Planavila, A., Redondo‐Angulo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L., Sitges, M., Giralt, M., van Bilsen, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3019 · Cited by 371 · see citing works

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

Stanford, K. I., Middelbeek, R. J. W., & Goodyear, L. J. (2015) · Diabetes · doi:10.2337/db15-0227 · Cited by 342 · see citing works

The occurrence of brown adipose tissue in outdoor workers

Huttunen, P., Hirvonen, J., & Kinnula, V. L. (1981) · European Journal of Applied Physiology · doi:10.1007/bf00422121 · Cited by 335 · see citing works

The varying faces of IL-6: from cardiac protection to cardiac failure

Fontes, J. A., Rose, N., & Čiháková, D. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.024 · Cited by 334 · see citing works

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations

Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331 · see citing works

Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide

Gao, Y., Lü, C., Su, L., Sharma, A. M., & Lee, R. M. K. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707228 · Cited by 323 · see citing works

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

Gunawardana, S. C., & Piston, D. W. (2012) · Diabetes · doi:10.2337/db11-0510 · Cited by 290 · see citing works

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

Chen, Y., Siegel, F., Kipschull, S., Haas, B., Fröhlich, H., Meister, G., & Pfeifer, A. (2013) · Nature Communications · doi:10.1038/ncomms2742 · Cited by 285 · see citing works

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

Rodrı́guez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 281 · see citing works

Clinical review: Adiponectin biology and its role in inflammation and critical illness

Robinson, K., Prins, J. B., & Venkatesh, B. (2011) · Critical Care · doi:10.1186/cc10021 · Cited by 238 · see citing works

Human Brown Adipose Tissue: What We Have Learned So Far

Betz, M. J., & Enerbäck, S. (2015) · Diabetes · doi:10.2337/db15-0146 · Cited by 223 · see citing works

Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes

Lo, K. A., & Sun, L. (2013) · Bioscience Reports · doi:10.1042/bsr20130046 · Cited by 212 · see citing works

Oral Treatment with γ-Aminobutyric Acid Improves Glucose Tolerance and Insulin Sensitivity by Inhibiting Inflammation in High Fat Diet-Fed Mice

Tian, J., Dang, H. N., Yong, J., Chui, W.-S., Dizon, M. P., Yaw, C. K. Y., & Kaufman, D. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025338 · Cited by 198 · see citing works

Musclin is an activity-stimulated myokine that enhances physical endurance

Subbotina, E., Sierra, A., Zhu, Z., Gao, Z., Koganti, S. R. K., Reyes, S., Stepniak, E., Walsh, S. A., Acevedo, M. R., Perez-Terzic, C. M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514250112 · Cited by 198 · see citing works

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

Gutierrez, D. A., Puglisi, M. J., & Hasty, A. H. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0006-9 · Cited by 194 · see citing works

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Fu, T., Seok, S., Choi, S.-E., Huang, Z., Suino-Powell, K., Xu, H., Kemper, B., & Kemper, J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00596-14 · Cited by 187 · see citing works

Musclin, a novel skeletal muscle-derived secretory factor

Nishizawa, H., Matsuda, M., Yamada, Y., Kawai, K., Suzuki, E., Makishima, M., Kitamura, T., & Shimomura, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400066200 · Cited by 182 · see citing works

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S., Li, Y. C., Zhang, L., & Wu, Y. (2013) · Scientific Reports · doi:10.1038/srep02767 · Cited by 179 · see citing works

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

Moisan, A., Lee, Y., Zhang, J. D., Hudak, C. S. S., Meyer, C. A., Prummer, M., Zoffmann, S., Truong, H., Ebeling, M., Kiialainen, A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3075 · Cited by 177 · see citing works

Brown Fat in Humans: Turning up the Heat on Obesity

Seale, P., & Lazar, M. A. (2009) · Diabetes · doi:10.2337/db09-0622 · Cited by 176 · see citing works

Role of Perivascular Adipose Tissue–Derived Methyl Palmitate in Vascular Tone Regulation and Pathogenesis of Hypertension

Lee, Y., Chang, H., Chiang, C., Liu, C., Yeh, J., Chen, M., Chen, P., Kuo, J., & Lee, T. J.-F. (2011) · Circulation · doi:10.1161/circulationaha.111.027375 · Cited by 168 · see citing works

FGF21-based pharmacotherapy – potential utility for metabolic disorders

Gimeno, R. E., & Moller, D. E. (2014) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2014.03.001 · Cited by 163 · see citing works

BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

Jung, T. W., Hwang, H.-J., Hong, H. C., Yoo, H. J., Baik, S. H., & Choi, K. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3663-z · Cited by 145 · see citing works

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y.-X., Liu, N., Rudnicki, M. A., & Kuang, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003626 · Cited by 144 · see citing works

Dual Modulation of Vascular Function by Perivascular Adipose Tissue and Its Potential Correlation with Adiposity/Lipoatrophy-Related Vascular Dysfunction

Gao, Y.-J. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039634 · Cited by 129 · see citing works

Browning of white fat: does irisin play a role in humans?

Elsen, M., Raschke, S., & Eckel, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0189 · Cited by 127 · see citing works

Role of Exercise in the Activation of Brown Adipose Tissue

Sánchez‐Delgado, G., Martínez‐Téllez, B., Olza, J., Aguilera, C. M., Gil, Á., & Ruiz, J. R. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437173 · Cited by 114 · see citing works

Is adipose tissue metabolically different at different sites?

Gil, Á., Olza, J., Gil‐Campos, M., Gómez‐Llorente, C., & Aguilera, C. M. (2011) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2011.604326 · Cited by 114 · see citing works

Brown vs white adipocytes: The PPARγ coregulator story

Koppen, A., & Kalkhoven, E. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.035 · Cited by 108 · see citing works

β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes

Shi, C.-X., Zhao, M.-X., Shu, X.-D., Xiong, X.-Q., Wang, J.-J., Gao, X.-Y., Chen, Q., Li, Y.-H., Kang, Y.-M., & Zhu, G.-Q. (2016) · Scientific Reports · doi:10.1038/srep21924 · Cited by 108 · see citing works

Differential effects of statins on endogenous H2S formation in perivascular adipose tissue

Wójcicka, G., Jamróz-Wiśniewska, A., Atanassova, P. K., Chaldakov, G. N., Chylińska-Kula, B., & Bełtowski, J. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.10.011 · Cited by 95 · see citing works

Paradoxical Roles of Perivascular Adipose Tissue in Atherosclerosis and Hypertension

Chang, L., Milton, H., Eitzman, D. T., & Chen, Y. E. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-1393 · Cited by 86 · see citing works

A Novel Role for Adiponectin in the Regulation of Inflammation

Ouchi, N., & Walsh, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.165068 · Cited by 85 · see citing works

GABA _B receptor activation inhibits exocytosis in rat pancreatic β‐cells by G‐protein‐dependent activation of calcineurin

Braun, M., Wendt, A., Buschard, K., Salehi, A., Sewing, S., Gromada, J., & Rorsman, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066563 · Cited by 80 · see citing works

Circulating adiponectin levels and risk of type 2 diabetes in the Japanese

Yamamoto, S., Matsushita, Y., Nakagawa, T., Hayashi, T., Noda, M., & Mizoue, T. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.27 · Cited by 76 · see citing works

Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy

Thoonen, R., Ernande, L., Cheng, J., Nagasaka, Y., Yao, V., Miranda-Bezerra, A., Chen, C., Chao, W., Panagia, M., Sosnovik, D. E., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.05.002 · Cited by 75 · see citing works

Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease

Lastra, G., & Manrique, C. M. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0010 · Cited by 70 · see citing works

Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease

Houben, A. J. H. M., Eringa, E. C., Jonk, A. M., Serné, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0214-0 · Cited by 62 · see citing works

Vascular Actions of Adipokines

Xu, A., Wang, Y., Lam, K. S. L., & Vanhoutte, P. M. (2010) · Advances in pharmacology · doi:10.1016/b978-0-12-385061-4.00008-8 · Cited by 57 · see citing works

Mitochondrial Uncoupling and the Regulation of Glucose Homeostasis

Giralt, M., & Villarroya, F. (2016) · Current Diabetes Reviews · doi:10.2174/1573399812666160217122707 · Cited by 54 · see citing works

Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders

Román, S., Agil, A., Perán, M., Alvaro-Galue, E., Ruiz‐Ojeda, F. J., Fernández‐Vázquez, G., & Marchal, J. A. (2014) · Translational research · doi:10.1016/j.trsl.2014.11.002 · Cited by 52 · see citing works

MicroRNAs involved in the browning process of adipocytes

Arias, N., Aguirre, L., Fernández‐Quintela, A., González, M. A., Lasa, A., Miranda, J., Macarulla, M. T., & Portillo, M. P. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0459-z · Cited by 51 · see citing works

Brown Adipose Tissue: Research Milestones of a Potential Player in Human Energy Balance and Obesity

Zafrir, B. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1348264 · Cited by 49 · see citing works

A New Role for Browning as a Redox and Stress Adaptive Mechanism?

Jeanson, Y., Carrière, A., & Casteilla, L. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00158 · Cited by 47 · see citing works

White and brown adipose stem cells: From signaling to clinical implications

Algire, C., Medříková, D., & Herzig, S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.10.001 · Cited by 47 · see citing works

Musclin Inhibits Insulin Activation of Akt/Protein Kinase B in Rat Skeletal Muscle

Liu, Y., Huo, X., Pang, X., Zh, Z., Meng, X., & Gl, L. (2008) · Journal of International Medical Research · doi:10.1177/147323000803600314 · Cited by 47 · see citing works

Breaking BAT: can browning create a better white?

Warner, A., & Mittag, J. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0408 · Cited by 43 · see citing works

Adipose Tissue Depots and Their Cross‐Sectional Associations With Circulating Biomarkers of Metabolic Regulation

Lee, J., Britton, K. A., Pedley, A., Massaro, J. M., Speliotes, E. K., Murabito, J. M., Hoffmann, U., Ingram, C., Keaney, J. F., Vasan, R. S., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002936 · Cited by 43 · see citing works

Effect of GABA on oxidative stress in the skeletal muscles and plasma free amino acids in mice fed high‐fat diet

Xie, Z., Xia, S., Qiao, Y., Shi, Y., & Le, G. (2014) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12254 · Cited by 37 · see citing works

Bioengineering Beige Adipose Tissue Therapeutics

Tharp, K. M., & Stahl, A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00164 · Cited by 37 · see citing works

MicroRNA Functions in Brite/Brown Fat — Novel Perspectives towards Anti-Obesity Strategies

Karbiener, M., & Scheideler, M. (2014) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2014.09.005 · Cited by 37 · see citing works

The Beneficial Effects of Brown Fat Transplantation: Further Evidence of an Endocrine Role of Brown Adipose Tissue

Villarroya, F., & Giralt, M. (2015) · Endocrinology · doi:10.1210/en.2015-1423 · Cited by 36 · see citing works

Brown adipose tissue: endocrine determinants of function and therapeutic manipulation as a novel treatment strategy for obesity

Reddy, N. L., Tan, B. K., Barber, T. M., & Randeva, H. S. (2014) · BMC Obesity · doi:10.1186/s40608-014-0013-5 · Cited by 36 · see citing works

Regulation of UCP1 in the Browning of Epididymal Adipose Tissue byβ3-Adrenergic Agonist: A Role for MicroRNAs

Zheng, Z., Liu, X., Zhao, Q., Zhang, L., Li, C., & Xue, Y. (2014) · International Journal of Endocrinology · doi:10.1155/2014/530636 · Cited by 34 · see citing works

Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by Activation of Phosphatidylinositol 3-Kinase

Wei, K., Liu, L., Xie, F., Hao, X., Luo, J., & Min, S. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.10101 · Cited by 30 · see citing works

Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor

Zheng, L., Zhang, Y., Han, J., Sun, Z., Zhou, S., Zhao, W.-T., & Wang, L. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.01.006 · Cited by 30 · see citing works

Determination of UCP1 expression in subcutaneous and perirenal adipose tissues of patients with hypertension

Li, X., Liu, J., Wang, G., Yu, J., Sheng, Y., Wang, C., Lv, Y., Lv, S., Qi, H., Di, W., et al. (2015) · Endocrine · doi:10.1007/s12020-015-0572-3 · Cited by 29 · see citing works

Role of Adipose Tissue in Metabolic System Disorders

Rezaee, F. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s13-008 · Cited by 26 · see citing works

Fifty Shades of Brown

Kiefer, F. W., Cohen, P., & Plutzky, J. (2012) · Circulation · doi:10.1161/circulationaha.112.123521 · Cited by 20 · see citing works

Positive Regulation by GABABR1 Subunit of Leptin Expression through Gene Transactivation in Adipocytes

Nakamura, Y., Hinoi, E., Takarada, T., Takahata, Y., Yamamoto, T. M., Fujita, H., Takada, S., Hashizume, S., & Yoneda, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020167 · Cited by 18 · see citing works

Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice

Gao, M., Zhang, C., Ma, Y., & Liu, D. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9746-4 · Cited by 9 · see citing works

PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response

Abu Shelbayeh, O., Arroum, T., Morris, S., & Busch, K. B. (2023) · Antioxidants · doi:10.3390/antiox12051075 · Cited by 552 · see citing works

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works

Muscle as a paracrine and endocrine organ

Giudice, J., & Taylor, J. M. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.05.005 · Cited by 331 · see citing works

Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 204 · see citing works

Browning of white adipose tissue: lessons from experimental models

Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0051 · Cited by 200 · see citing works

Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review

Montanari, T., Pošćić, N., & Colitti, M. (2017) · Obesity Reviews · doi:10.1111/obr.12520 · Cited by 189 · see citing works

Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis

Okla, M., Kim, J.-Y., Koehler, K., & Chung, S. (2017) · Advances in Nutrition · doi:10.3945/an.116.014332 · Cited by 187 · see citing works

Impact of Skeletal Muscle Mass on Metabolic Health

Kim, G., & Kim, J. H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.35.1.1 · Cited by 171 · see citing works

Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db/db mice

Zhuang, P., Li, H., Jia, W. P., Shou, Q., Zhu, Y., Mao, L., Wang, W., Wu, F. L., Chen, X., Wan, X., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01126-6 · Cited by 168 · see citing works

Myokines mediate the cross talk between skeletal muscle and other organs

Chen, W., Wang, L., You, W., & Shan, T. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30033 · Cited by 162 · see citing works

Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications

Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103607 · Cited by 156 · see citing works

Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury

Wang, H., Zhao, Y., Zhang, S.-Y., Dubielecka, P., Du, J., Yano, N., Chin, Y., Zhuang, S., Qin, G., & Zhao, T. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25857 · Cited by 136 · see citing works

Dietary polyphenols and their roles in fat browning

Silvester, A. J., Aseer, K. R., & Yun, J. W. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.028 · Cited by 131 · see citing works

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Harms, M., Li, Q., Lee, S., Zhang, C., Kull, B., Hallén, S., Thorell, A., Alexandersson, I., Hagberg, C. E., Peng, X., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.026 · Cited by 131 · see citing works

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182937 · Cited by 136 · see citing works

PGC-1α affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis

Kong, S., Cai, B., & Nie, Q. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01878-2 · Cited by 125 · see citing works

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

Ortega, M. A., Fraile‐Μartinez, O., Naya, I., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., Asúnsolo, Á., & de la Torre, B. (2020) · Nutrients · doi:10.3390/nu12092749 · Cited by 117 · see citing works

Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression

Huang, Q., Wu, M., Wu, X., Zhang, Y., & Xia, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188761 · Cited by 118 · see citing works

Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans

Thyagarajan, B., & Foster, M. T. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0016 · Cited by 106 · see citing works

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Liu, X., Zhang, Z., Song, Y., Xie, H., & Dong, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1065263 · Cited by 102 · see citing works

Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway

Xiong, W., Xiong, Z., Song, A., Lei, C., Ye, C., & Zhang, C. (2021) · Theranostics · doi:10.7150/thno.56082 · Cited by 89 · see citing works

Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice

von Essen, G., Lindsund, E., Cannon, B., & Nedergaard, J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00097.2017 · Cited by 86 · see citing works

Modulation of the renin–angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

Frantz, E. D. C., Prodel, E., Bráz, I. D., Giori, I. G., Bargut, T. C. L., Magliano, D. C., & da Nóbrega, A. C. L. (2018) · Clinical Science · doi:10.1042/cs20180276 · Cited by 75 · see citing works

Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation

Choi, H., Kim, C.-S., & Yu, R. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.2.102 · Cited by 74 · see citing works

The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

Wang, Q., Sun, J., Liu, M., Zhou, Y., Zhang, L., & Li, Y. (2021) · Biomolecules · doi:10.3390/biom11121757 · Cited by 70 · see citing works

Anti-Obesity Medications and Investigational Agents: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022

Bays, H. E., Fitch, A., Christensen, S., Burridge, K., & Tondt, J. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2022.100018 · Cited by 68 · see citing works

The key role of a glucagon-like peptide-1 receptor agonist in body fat redistribution

Zhao, L., Zhu, C., Lu, M., Chen, C., Nie, X., Abudukerimu, B., Zhang, K., Ning, Z., Chen, Y., Cheng, J., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0374 · Cited by 67 · see citing works

Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control

Youssef, M. E., Yahya, G., Popoviciu, M. S., Cavalu, S. D., Abdel-Dayem, M. A., & Saber, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076039 · Cited by 71 · see citing works

Deciphering the Anti-obesity Benefits of Resveratrol: The “Gut Microbiota-Adipose Tissue” Axis

Zhou, L., Xiao, X., Zhang, Q., Zheng, J., & Deng, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00413 · Cited by 66 · see citing works

Cyanidin-3-glucoside attenuates high-fat and high-fructose diet-induced obesity by promoting the thermogenic capacity of brown adipose tissue

You, Y., Han, X., Guo, J., Guo, Y., Yin, M., Liu, G., Huang, W., & Zhan, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.025 · Cited by 65 · see citing works

Role of Perivascular Adipose Tissue in Health and Disease

Fernández‐Alfonso, M. S., Somoza, B., Tsvetkov, D., Kuczmanski, A., Dashwood, M. R., & Gil‐Ortega, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170004 · Cited by 69 · see citing works

Role of Human Brown Fat in Obesity, Metabolism and Cardiovascular Disease: Strategies to Turn Up the Heat

Ruiz, J. R., Martínez‐Téllez, B., Sánchez‐Delgado, G., Osuna‐Prieto, F. J., Rensen, P. C. N., & Boon, M. R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.002 · Cited by 64 · see citing works

A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice

Jia, Y., Wu, C., Kim, Y. S., Yang, S. O., Kim, Y., Kim, J., Jeong, M.-Y., Lee, J. H., Kim, B., Lee, S., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01231-6 · Cited by 62 · see citing works

Nutrition and physical activity: An Obesity Medicine Association (OMA) Clinical Practice Statement 2022

Alexander, L., Christensen, S. M., Richardson, L., Ingersoll, A. B., Burridge, K., Golden, A., Karjoo, S., Cortez, D., Shelver, M., & Bays, H. E. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2021.100005 · Cited by 61 · see citing works

Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4

Zhao, Y., Wang, H., Zhang, S.-Y., Du, J., Zhuang, S., & Zhao, T. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166182 · Cited by 58 · see citing works

Uncovering the Role of p38 Family Members in Adipose Tissue Physiology

Leiva, M., Matesanz, N., Pulgarín-Alfaro, M., Nikolić, I., & Sabio, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572089 · Cited by 58 · see citing works

Developmental programming of offspring adipose tissue biology and obesity risk

Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57 · see citing works

Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

Zhao, Y., Wang, J., Yano, N., Zhang, L. X., Wang, H., Zhang, S.-Y., Qin, G., Dubielecka, P., Zhuang, S., Liu, P., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27037 · Cited by 57 · see citing works

PPAR-α agonists are still on the rise: an update on clinical and experimental findings

Ferri, N., Corsini, A., Sirtori, C. R., & Ruscica, M. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1312339 · Cited by 56 · see citing works

Sarcopenia in patients with non‐alcoholic fatty liver disease: is it a clinically significant entity?

Fré, C. H. D., Fré, M. A. D., Kwanten, W. J., Op de Beeck, B., Gaal, L. F. V., & Francque, S. (2018) · Obesity Reviews · doi:10.1111/obr.12776 · Cited by 53 · see citing works

Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet

Zhang, F., Ai, W., Hu, X., Meng, Y., Yuan, C., Su, H., Wang, L., Zhu, X., Gao, P., Shu, G., et al. (2018) · Food & Function · doi:10.1039/c7fo01817g · Cited by 52 · see citing works

Trigonelline induces browning in 3T3‐L1 white adipocytes

Choi, M., Mukherjee, S., & Yun, J. W. (2020) · Phytotherapy Research · doi:10.1002/ptr.6892 · Cited by 52 · see citing works

Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis

Rao, Y., Yu, H., Gao, L., Lu, Y., Zhao, X. D., Liu, H., Gu, L., Ye, J., & Huang, Z. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13855 · Cited by 51 · see citing works

Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

Yamakawa, D., Katoh, D., Kasahara, K., Shiromizu, T., Matsuyama, M., Matsuda, C., Maeno, Y., Watanabe, M., Nishimura, Y., & Inagaki, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108817 · Cited by 48 · see citing works

Fighting obesity: Non-pharmacological interventions

Higuera-Hernández, M. F., Reyes-Cuapio, E., Gutiérrez-Mendoza, M., Rocha, N., Veras, A. B., Budde, H., Jesse, J., Zaldívar-Rae, J., Blanco‐Centurion, C., Machado, S. E. D. C., et al. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.04.005 · Cited by 48 · see citing works

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression

Brun, J., Berthou, F., Trajkovski, M., Maechler, P., Foti, M., & Bonnet, N. (2017) · Diabetes · doi:10.2337/db17-0116 · Cited by 47 · see citing works

Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway <i>in vivo</i> and <i>in vitro</i>

Zhu, E., Yang, Y., Zhang, J., Li, Y., Li, C., Chen, L., & Sun, B. (2016) · Oncotarget · doi:10.18632/oncotarget.13189 · Cited by 42 · see citing works

The Protective Effects of Sulforaphane on High-Fat Diet-Induced Obesity in Mice Through Browning of White Fat

Liu, Y., Fu, X., Chen, Z., Luo, T., Zhu, C., Ji, Y., & Bian, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665894 · Cited by 41 · see citing works

Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice

Zhu, R., Wei, J., Liu, H., Liu, C., Wang, L., Chen, B., Li, L., Jia, Q., Tian, Y., Li, R., et al. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108335 · Cited by 41 · see citing works

Effects of Regular Taekwondo Intervention on Oxidative Stress Biomarkers and Myokines in Overweight and Obese Adolescents

Roh, H., Cho, S.-Y., & So, W.-Y. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072505 · Cited by 41 · see citing works

Grape Seed Proanthocyanidins Improve White Adipose Tissue Expansion during Diet-Induced Obesity Development in Rats

Pascual‐Serrano, A., Bladé, C., Suárez, M., & Arola‐Arnal, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092632 · Cited by 36 · see citing works

Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice

Wang, Z., Feeley, B. T., Kim, H. T., & Liu, X. (2018) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000000335 · Cited by 34 · see citing works

Effect of high-intensity interval training and high-intensity resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity

Haghighi, A. H., hajinia, M., Askari, R., Abbasian, S., & Goldfied, G. (2022) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2021-0712 · Cited by 34 · see citing works

Novel GLP-1 Analog Supaglutide Reduces HFD-Induced Obesity Associated with Increased Ucp-1 in White Adipose Tissue in Mice

Wan, Y., Bao, X., Huang, J., Zhang, X., Liu, W., Cui, Q., Jiang, D., Wang, Z., Liu, R., & Wang, Q. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00294 · Cited by 33 · see citing works

Adipose tissue inflammation linked to obesity: A review of current understanding, therapies and relevance of phyto-therapeutics

Aruwa, C. E., & Sabiu, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23114 · Cited by 34 · see citing works

Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice

Laiglesia, L. M., Escoté, X., Sáinź, N., Félix‐Soriano, E., Santamaría, E., Collantes, M., Fernández‐Galilea, M., Colón-Mesa, I., Martínez‐Fernández, L., Quesada‐López, T., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101749 · Cited by 31 · see citing works

Anti‐contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high‐fat diet: role of aerobic exercise training

Araújo, H. N., Victorio, J. A., da Silva, C. P. V., Sponton, A. C. D. S., Vettorazzi, J. F., de Moraes, C., Davel, A. P., Zanesco, A., & Delbin, M. A. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12882 · Cited by 31 · see citing works

Browning of Human Subcutaneous Adipose Tissue after Its Transplantation in Nude Mice

Qiu, L., Zhang, Z., Zheng, H., Xiong, S., Su, Y., Ma, X., & Yi, C. (2018) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000004603 · Cited by 31 · see citing works

Liraglutide demonstrates a therapeutic effect on mitochondrial dysfunction in human SGBS adipocytes in vitro

Vaittinen, M., Ilha, M., Herbers, E., Wagner, A., Virtanen, K. A., Pietiläinen, K. H., Pirinen, E., & Pihlajamäki, J. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110635 · Cited by 30 · see citing works

Cardiovascular disease treatment using traditional Chinese medicine：Mitochondria as the Achilles' heel

Gao, J., & Hou, T. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114999 · Cited by 31 · see citing works

Muscle endocrinology and its relation with nutrition

Romagnoli, C., Pampaloni, B., & Brandi, M. L. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01188-5 · Cited by 30 · see citing works

Bifidobacterium longum DS0956 and Lactobacillus rhamnosus DS0508 culture-supernatant ameliorate obesity by inducing thermogenesis in obese-mice

Hossain, M. M., Park, D., Rahman, M. S., Ki, S. J., Lee, Y. R., Imran, K. M., Yoon, D., Heo, J.-Y., Lee, T.-J., & Kim, Y. S. (2020) · Beneficial Microbes · doi:10.3920/bm2019.0179 · Cited by 29 · see citing works

Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress

Yue, R., Lv, M., Lan, M., Zheng, Z., Tan, X., Zhao, X., Zhang, Y., Pu, J., Xu, L., & Hu, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-11343-0 · Cited by 29 · see citing works

Glucagon‐like peptide‐1 receptor agonist regulates fat browning by altering the gut microbiota and ceramide metabolism

Lin, K., Dong, C., Zhao, B., Zhou, B., & Li, Y. (2023) · MedComm · doi:10.1002/mco2.416 · Cited by 26 · see citing works

Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localizationPreprint

Kim, J., Bilder, D. H., & Neufeld, T. P. (2018) · Genes & Development · doi:10.1101/gad.305870.117 · Cited by 26 · see citing works

Lactobacillus plantarum dy‐1 fermented barley extraction activates white adipocyte browning in high‐fat diet‐induced obese rats

Gu, Y., Xiao, X., Pan, R., Zhang, J., Zhao, Y., Dong, Y., & Cui, H. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13680 · Cited by 25 · see citing works

The Arcuate Nucleus of the Hypothalamus and Metabolic Regulation: An Emerging Role for Renin–Angiotensin Pathways

Mehay, D., Silberman, Y., & Arnold, A. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137050 · Cited by 25 · see citing works

Dietary curcumin supplementation promotes browning and energy expenditure in postnatal overfed rats

Zhu, X., Du, S., Yan, Q., Min, C., Zhou, N., Zhou, W., & Li, X. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00625-5 · Cited by 25 · see citing works

Impact of estrogens on resting energy expenditure: A systematic review

Weidlinger, S., Winterberger, K., Pape, J., Weidlinger, M., Janka, H., von Wolff, M., & Stute, P. (2023) · Obesity Reviews · doi:10.1111/obr.13605 · Cited by 25 · see citing works

The Role of FNDC5/Irisin in Cardiovascular Disease

Grzeszczuk, M., Dzięgiel, P., & Nowińska, K. (2024) · Cells · doi:10.3390/cells13030277 · Cited by 25 · see citing works

Secreted protein acidic and rich in cysteine (SPARC) regulates thermogenesis in white and brown adipocytes

Mukherjee, S., Choi, M. J., Kim, S. W., & Yun, J. W. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110757 · Cited by 24 · see citing works

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging

Chen, Y., Ding, J., Zhao, Y., Ju, S., Mao, H. Z., & Peng, X. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211006049 · Cited by 24 · see citing works

The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease

Atorrasagasti, C., Onorato, A. M., & Mazzolini, G. D. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00913-5 · Cited by 24 · see citing works

Huang-Qi San ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes

Hao, M., Guan, Z., Gao, Y. T., Xing, J., Zhou, X., Wang, C., Xu, J., & Li, W. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153292 · Cited by 24 · see citing works

Gut microbiota mediates the anti-obesity effect of intermittent fasting by inhibiting intestinal lipid absorption

Yang, H., Li, C., Che, M., Li, Y., Feng, R., & Sun, C. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109318 · Cited by 23 · see citing works

The improvement effect of ellagic acid and urolithins on metabolic diseases: Pharmacology and mechanism

Wang, Y.-H., Peng, W.-Y., Li, C., Wu, Y., Sheng, J., Zi, C., & Wu, X. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420058 · Cited by 23 · see citing works

Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro

Li, T., Du, ‬., Wang, H., & Mao, X. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108372 · Cited by 23 · see citing works

Reactive Oxygen Species, Glucose Metabolism, and Lipid Metabolism

Yang, Y., Wu, Y., Sun, X., & Zhang, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_9 · Cited by 25 · see citing works

Cytochrome P450 2E1 (CYP2E1) positively regulates lipid catabolism and induces browning in 3T3-L1 white adipocytes

Dang, T. T. H., & Yun, J. W. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119648 · Cited by 23 · see citing works

Dietary Supplementation of Lauric Acid Alleviates the Irregular Estrous Cycle and the Impaired Metabolism and Thermogenesis in Female Mice Fed with High-Fat Diet (HFD)

Zhang, F., Song, M., Chen, L., Yang, X., Li, F., Yang, Q., Duan, C., Ling, M., Lai, X., Zhu, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05235 · Cited by 23 · see citing works

Irisin Improves Myocardial Performance and Attenuates Insulin Resistance in Spontaneous Mutation (Leprdb) Mice

Wang, J., Zhao, Y., Zhang, L. X., Dubielecka, P., Zhuang, S., Qin, G., Chin, Y., Zhang, S.-Y., & Zhao, T. C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00769 · Cited by 19 · see citing works

The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders

Passos, G. R., Ghezzi, A. C., Antunes, E., de Oliveira, M. G., & Mónica, F. Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.626155 · Cited by 22 · see citing works

Fat Grafting Can Induce Browning of White Adipose Tissue

Hoppela, E., Grönroos, T. J., Saarikko, A. M., Tervala, T. V., Kauhanen, S., Nuutila, P., Kivinen, K., & Hartiala, P. (2018) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000001804 · Cited by 21 · see citing works

Withaferin A Promotes White Adipose Browning and Prevents Obesity Through Sympathetic Nerve–Activated Prdm16-FATP1 Axis

Guo, B., Liu, J., Wang, B., Zhang, C., Su, Z., Zhao, M., Qin, L., Zhang, W., & Zheng, R. (2021) · Diabetes · doi:10.2337/db21-0470 · Cited by 22 · see citing works

“Ferrocrinology”—Iron Is an Important Factor Involved in Gluco- and Lipocrinology

Szklarz, M., Gontarz-Nowak, K., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Nutrients · doi:10.3390/nu14214693 · Cited by 20 · see citing works

Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring

Li, T., Gong, H., Yuan, Q., Du, ‬., Ren, F., & Mao, X. (2020) · The FASEB Journal · doi:10.1096/fj.201901867rrr · Cited by 20 · see citing works

Lower circulating irisin levels in type 2 diabetes mellitus patients with chronic complications: A meta-analysis

Hou, Q., Song, R., Zhao, X., Yang, C., & Feng, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21859 · Cited by 20 · see citing works

Hormonal and nutritional signalling in the control of brown and beige adipose tissue activation and recruitment

Giralt, M., Cairó, M., & Villarroya, F. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.08.005 · Cited by 19 · see citing works

Mixed conjugated linoleic acid sex‐dependently reverses high‐fat diet‐induced insulin resistance via the gut‐adipose axis

Li, H., Zhuang, P., Zhang, Y., Shou, Q., Lu, Y., Wang, G., Qiu, J., Wang, J., He, L., Chen, J., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002161rr · Cited by 19 · see citing works

Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects

Zhang, H., Butoyi, C., Yuan, G., & Jia, J. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110781 · Cited by 18 · see citing works

Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective

Méndez-Gutiérrez, A., Osuna‐Prieto, F. J., Aguilera, C. M., Ruiz, J. R., & Sánchez‐Delgado, G. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01319-7 · Cited by 18 · see citing works

Brown Algae Ecklonia cava Extract Modulates Adipogenesis and Browning in 3T3-L1 Preadipocytes through HO-1/Nrf2 Signaling

Suryaningtyas, I. T., Lee, D.-S., & Je, J. (2024) · Marine Drugs · doi:10.3390/md22080330 · Cited by 17 · see citing works

RNA sequencing and immunofluorescence of the myotendinous junction of mature horses and humans

Jakobsen, J. R., Schjerling, P., Svensson, R. B., Buhl, R., Carstensen, H., Koch, M., Krogsgaard, M. R., Kjær, M., & Mackey, A. L. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00218.2021 · Cited by 17 · see citing works

Browning is activated in the subcutaneous white adipose tissue of mice metabolically challenged with a high-fructose diet submitted to high-intensity interval training

Motta, V. F., Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.008 · Cited by 17 · see citing works

Loss of ADAMTS15 Promotes Browning in 3T3-L1 White Adipocytes via Activation of β3-adrenergic Receptor

Choi, M. J., Mukherjee, S., & Yun, J. W. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-021-0036-y · Cited by 16 · see citing works

C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes

Guo, Q., Hu, H., Liu, X., Yang, D., Yin, Y., Zhang, B., He, H., Oh, Y., Wu, Q., Liu, C., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00478.2018 · Cited by 16 · see citing works

Sestrin2 ablation attenuates the exercise‐induced browning of white adipose tissue in C57BL/6J mice

Wang, L., Liu, X., Liu, S., Niu, Y., & Fu, L. (2022) · Acta Physiologica · doi:10.1111/apha.13785 · Cited by 16 · see citing works

Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin

Kim, D. Y., Choi, M. J., Ko, T. K., Lee, N. H., Kim, O., & Cheon, H. G. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013834 · Cited by 15 · see citing works

β-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity

Dobritzsch, D., Meijer, J., Meinsma, R., Maurer, D., Monavari, A. A., Gummesson, A., Reims, A., Asin-Cayuela, J., Kuklina, N., Benoist, J., et al. (2022) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2022.01.102 · Cited by 15 · see citing works

Protective Effects of Coumestrol on Metabolic Dysfunction and Its Estrogen Receptor-Mediated Action in Ovariectomized Mice

Park, S.-G., Sim, K., Heo, W., & Kim, J.-H. (2023) · Nutrients · doi:10.3390/nu15040954 · Cited by 18 · see citing works

The Browning of White Adipocytes: A New Therapeutic Target for Obesity and Its Related Metabolic Disorders

Feng-yin, G. (2013) · Medical Recapitulate

Metabolic regulation of brown adipose : a possible new therapeutic approach for metabolic diseases

Xiao, Z.-H. (2014) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2014.10.001

Browning of white adipose tissue: lessons from experimental models

Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0051 · Cited by 200 · see citing works

Current Progress in Adipose Tissue Biology: Implications in Obesity and Its Comorbidities

Meiliana, A., Dewi, N. M., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i2.1171 · Cited by 3 · see citing works

Brown and beige fat: From molecules to physiology

Chondronikola, M., & Sidossis, L. S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.05.014 · Cited by 36 · see citing works