The DOI matches its Crossref record; 292 of the 292 references it cites were found in a registry or an index.
Consensus guidelines for the detection of immunogenic cell death
Open accessAbstract
and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Immunogenic cell death (ICD) is a functionally peculiar form of RCD that is sufficient to activate an adaptive immune response specific for endogenous (cellular) or exogenous (viral) antigens expressed by dying cells [852, 853].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [853]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Yang, H., Lundbäck, P., Ottosson, L., Erlandsson-Harris, H., Venereau, E., Bianchi, M. E., Al-Abed, Y., Andersson, U., Tracey, K. J., & Antoine, D. J. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00389 · Cited by 407
Self-citationRetractedRiganti, C., Castella, B., Kopecka, J., Campia, I., Coscia, M., Pescarmona, G., Bosìa, A., Ghigo, D., & Massaia, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060975 · Cited by 50
Self-citationRetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
Self-citationVermes, I., Haanen, C., Steffens-Nakken, H. M., & Reutellingsperger, C. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00072-i · Cited by 5,509
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
Research works printed but not linked: 7
- Vogt CI, 1842, Jent
- 10.1038/emboj.2009.1x · DOI
- Dutcher JD, 1963, Antimicrob Agents Chemother (Bethesda), 161, 83
- Olsson L, 1978, Biomedicine, 28, 88
- Fredly H, 2011, Oncol Rep, 25, 1549
- McElroy WD, 1983, J Appl Biochem, 5, 197
- Klionsky DJ, 2009, Methods Enzymol, 452, xxi-xxii
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationImmunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Self-citationImmunological effects of conventional chemotherapy and targeted anticancer agents
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.10.012 · Cited by 1,530
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Integrating oncolytic viruses in combination cancer immunotherapy
Bommareddy, P. K., Shettigar, M., & Kaufman, H. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0014-6 · Cited by 704
Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer
Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378
Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Caspases Connect Cell-Death Signaling to Organismal Homeostasis
Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.020 · Cited by 350
Self-citationMetal-based anticancer agents as immunogenic cell death inducers: the past, present, and future
Sen, S., Won, M., Levine, M. S., Noh, Y., Sedgwick, A. C., Kim, J. S., Sessler, J. L., & Arambula, J. F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00417d · Cited by 297
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death
Pozzi, C., Cuomo, A., Spadoni, I., Magni, E., Silvola, A., Conte, A., Sigismund, S., Ravenda, P. S., Bonaldi, T., Zampino, M. G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4078 · Cited by 292
Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
Izzo, V., Bravo-San Pedro, J. M., Sica, V., Kroemer, G., & Galluzzi, L. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.04.006 · Cited by 205
Self-citationRegulated cell death and adaptive stress responses
Galluzzi, L., Bravo-San Pedro, J. M., Kepp, O., & Kroemer, G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2209-y · Cited by 177
Self-citationDNA Damage Response and Autophagy: A Meaningful Partnership
Eliopoulos, A. G., Havaki, S., & Gorgoulis, V. G. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00204 · Cited by 169
Self-citationThe P2X7 Receptor-Interleukin-1 Liaison
Giuliani, A. L., Sarti, A. C., Falzoni, S., & Di Virgilio, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00123 · Cited by 166
Prognostic and predictive value of DAMPs and DAMP-associated processes in cancer
Fucikova, J., Moserova, I., Urbanova, L., Bezu, L., Kepp, O., Cremer, I., Salek, C., Strnad, P., Kroemer, G., Galluzzi, L., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00402 · Cited by 159
Self-citationFucikova, J., Truxova, I., Hensler, M., Becht, E., Kasikova, L., Moserova, I., Vosahlikova, S., Klouckova, J., Church, S. E., Cremer, I., et al. (2016) · Blood · doi:10.1182/blood-2016-08-731737 · Cited by 135
Self-citationZhai, J., Gu, X., Liu, Y., Hu, Y., Jiang, Y., & Zhang, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152934 · Cited by 131
Type I interferons and dendritic cells in cancer immunotherapy
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.06.001 · Cited by 124
Self-citationGarg, A. D., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., et al. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.15 · Cited by 120
Self-citationType I interferons and endoplasmic reticulum stress in health and disease
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.10.004 · Cited by 83
Garg, A. D., Elsen, S., Krysko, D. V., Vandenabeele, P., de Witte, P., & Agostinis, P. (2015) · Oncotarget · doi:10.18632/oncotarget.4754 · Cited by 87
Self-citationNigro, A., Ricciardi, L., Salvato, I., Sabbatino, F., Vitale, M., Crescenzi, M. A., Montico, B., Triggiani, M., Pepe, S., Stellato, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03135 · Cited by 70
Petrazzuolo, A., Perez-Lanzon, M., Martins, I., Liu, P., Kepp, O., Minard-Colin, V., Maiuri, M. C., & Kroemer, G. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03997-x · Cited by 36
Self-citation
Metadata
- Authors
- Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buqué, A., Castro, M. G., Cirone, M., Colombo, M. I., Cremer, I., Demaria, S., Dini, L., Eliopoulos, A. G., Faggioni, A., Formenti, S. C., Fučíková, J., Gabriele, L., Gaipl, U. S., Galon, J., Garg, A., Ghiringhelli, F., Giese, N. A., Guo, Z. S., Hemminki, A., Herrmann, M., Hodge, J. W., Holdenrieder, S., Honeychurch, J., Hu, H.-M., Huang, X., Illidge, T. M., Kono, K., Korbelik, M., Krysko, D. V., Loi, S., Lowenstein, P. R., Lugli, E., Ma, Y., Madeo, F., Manfredi, A. A., Martins, I., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, K. L., Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, J.-E., Riganti, C., Rovere-Querini, P., Rubartelli, A., Sistigu, A., Smyth, M. J., Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, A. Q., Tartour, E., Thorburn, A., Thorne, S. H., Vandenabeele, P., Velotti, F., Workenhe, S. T., Yang, H., Zong, W.-X., Zitvogel, L., Kroemer, G., & Galluzzi, L.
- Affiliations
- Inserm (FR)
- Instituto Nazionale Tumori Regina Elena (IT)
- KU Leuven (BE)
- Istituto Pasteur (IT)
- Istituto Superiore di Sanità (IT)
- Université Libre de Bruxelles (BE)
- University of Manchester (GB)
- University of Michigan (US)
- Sapienza University of Rome (IT)
- New York University (US)
- University of Salento (IT)
- University of Crete (GR)
- NYU Langone Health (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Heidelberg (DE)
- University of Pittsburgh (US)
- University of Helsinki (FI)
- National Institutes of Health (US)
- University Hospital Bonn (DE)
- Manchester Academic Health Science Centre (GB)
- National University of Singapore (SG)
- BC Cancer Agency (CA)
- Ghent University (BE)
- Peter MacCallum Cancer Centre (AU)
- University of Milan (IT)
- University of Graz (AT)
- Vita-Salute San Raffaele University (IT)
- Université Paris-Sud (FR)
- Università degli Studi della Tuscia (IT)
- McMaster University (CA)
- TUM Klinikum (DE)
- Comprehensive Cancer Center Vienna (AT)
- Karolinska Institutet (SE)
- University of Turin (IT)
- Ospedale Policlinico San Martino (IT)
- The University of Queensland (AU)
- Jena University Hospital (DE)
- Centre Hospitalier de l’Université de Montréal (CA)
- University of Colorado Anschutz (US)
- University of Hawaii Cancer Center (US)
- Stony Brook University (US)
- Corresponding author
- Galluzzi, Lorenzo
- ORCID
- Kepp, Oliver
- Senovilla, Laura
- Vitale, Ilio
- Vacchelli, Erika
- Adjemian, Sandy
- Agostinis, Patrizia
- Aranda, Fernando
- Barnaba, Vincenzo
- Bloy, Norma
- Bracci, Laura
- Breckpot, Karine
- Brough, David
- Buqué, Aitziber
- Castro, Maria G.
- Cirone, Mara
- Cremer, Isabelle
- Demaria, Sandra
- Eliopoulos, Aristides G.
- Faggioni, Alberto
- Formenti, Silvia C.
- Gabriele, Lucia
- Gaipl, Udo S.
- Galon, Jérôme
- Garg, Abhishek
- Ghiringhelli, François
- Giese, Nathalia A.
- Guo, Zong Sheng
- Hemminki, Akseli
- Hodge, James W.
- Holdenrieder, Stefan
- Honeychurch, Jamie
- Huang, Xing
- Illidge, Tim M.
- Kono, Koji
- Korbelik, Mladen
- Krysko, Dmitri V.
- Loi, Sherene
- Lowenstein, Pedro R.
- Lugli, Enrico
- Ma, Yuting
- Madeo, Frank
- Manfredi, Angelo A.
- Martins, Isabelle
- Mavilio, Domenico
- Menger, Laurie
- Merendino, Nicolò
- Mossman, Karen L.
- Multhoff, Gabriele
- Oehler, Rudolf
- Palombo, Fabio
- Panaretakis, Theocharis
- Pol, Jonathan
- Proietti, Enrico
- Ricci, Jean-Ehrland
- Riganti, Chiara
- Rubartelli, Anna
- Sistigu, Antonella
- Smyth, Mark J.
- Stagg, John
- Thorburn, Andrew
- Thorne, Stephen H.
- Vandenabeele, Peter
- Velotti, Francesca
- Workenhe, Samuel T.
- Yang, Haining
- Zitvogel, Laurence
- Kroemer, Guido
- Galluzzi, Lorenzo
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2014-09-02
- Volume
- 3
- Issue
- 9
- Pages
- e955691
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC4292729
- OpenAlex
- W2163252162
- Cited by
- 832
- References
- 292
- Citations by year
- 2026: 47 · 2025: 53 · 2024: 44 · 2023: 66 · 2022: 77 · 2021: 95 · 2020: 93 · 2019: 95 · 2018: 63 · 2017: 62 · 2016: 83 · 2015: 48 · 2014: 5
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- OncoImmunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UnitusOpen (Tuscia University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- AIRUS (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Cancer Research UK (11335, 17737)
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- National Institutes of Health (5r01ns082311-05)
- Labex Immuno-Oncology
- National Cancer Institute (R01CA129536)
- National Institute of Neurological Disorders and Stroke (R01NS074387, R01NS061107, R01NS057711, R01-NS082311)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- immunogenic cell death, calreticulin exposure, extracellular ATP, HMGB1, endoplasmic reticulum stress, autophagy, cancer immunotherapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
