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Consensus guidelines for the detection of immunogenic cell death
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and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine.
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“Immunogenic cell death (ICD) is a functionally peculiar form of RCD that is sufficient to activate an adaptive immune response specific for endogenous (cellular) or exogenous (viral) antigens expressed by dying cells [852, 853].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [853]
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Yang, H., Lundbäck, P., Ottosson, L., Erlandsson-Harris, H., Venereau, E., Bianchi, M. E., Al-Abed, Y., Andersson, U., Tracey, K. J., & Antoine, D. J. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00389 · Cited by 407
Self-citationRetractedRiganti, C., Castella, B., Kopecka, J., Campia, I., Coscia, M., Pescarmona, G., Bosìa, A., Ghigo, D., & Massaia, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060975 · Cited by 50
Self-citationRetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
Self-citationVermes, I., Haanen, C., Steffens-Nakken, H. M., & Reutellingsperger, C. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00072-i · Cited by 5,509
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
The immune contexture in human tumours: impact on clinical outcome
Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981
Self-citationSpatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M. J., Obenauf, A. C., Angell, H. K., Fredriksen, T., Lafontaine, L., Berger, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.003 · Cited by 4,455
Self-citationRelease of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
The Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 1×
“The latter not only mediate direct antineoplastic effects, mostly by secreting interferon γ (IFNγ) and via the granzyme-perforin pathway, but also underlie the establishment of protective immunological memory (Figure 1).(231)”
BackgroundSelf-citationCirculating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Self-citationClassification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Self-citationProtein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
Self-citationImmunogenic cell death and DAMPs in cancer therapy
Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223
Self-citationCalreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
Self-citationApetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · cited 13×
“Huang B, Sikorski R, Kirn DH, Thorne SH. Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1.”
BackgroundMethodInfluentialSelf-citationMartin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Apoptosis: controlled demolition at the cellular level
Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,708
Koopman, G., Reutelingsperger, C. P. M., Kuijten, G., Keehnen, R. M. J., Pals, S. T., & van Oers, M. H. J. (1994) · Blood · doi:10.1182/blood.v84.5.1415.1415 · Cited by 2,687
Mitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
Self-citationMolecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230
Self-citationNatural Innate and Adaptive Immunity to Cancer
Vesely, M. D., Kershaw, M. H., Schreiber, R. D., & Smyth, M. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101324 · Cited by 2,225
Self-citationKoopman, G., Reutelingsperger, C., Kuijten, G., et al. (1994) · Blood · doi:10.1182/blood.v84.5.1415.bloodjournal8451415 · Cited by 2,068
Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898
Self-citationFranchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1703 · Cited by 1,834
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735
Self-citationAutophagy in cell death: an innocent convict?
Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654
Natural adjuvants: Endogenous activators of dendritic cells
Gallucci, S., Lolkema, M. P., & Matzinger, P. (1999) · Nature Medicine · doi:10.1038/15200 · Cited by 1,601
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512
Self-citationTowards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
Galon, J., Mlecnik, B., Bindea, G., Angell, H. K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C. B., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4287 · Cited by 1,389
Self-citationAutophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., et al. (2011) · Science · doi:10.1126/science.1208347 · Cited by 1,377
Self-citationDissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
CD39 and CD73 in immunity and inflammation
Antonioli, L., Pacher, P., Vizi, E. S., & Haskó, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.03.005 · Cited by 1,269
Seong, S., & Matzinger, P. (2004) · Nature reviews. Immunology · doi:10.1038/nri1372 · Cited by 1,224
Immunogenic death of colon cancer cells treated with oxaliplatin
Tesnière, A., Schlemmer, F., Boige, V., Kepp, O., Martins, I., Ghiringhelli, F., Aymeric, L., Michaud, M., Apétoh, L., Barault, L., et al. (2009) · Oncogene · doi:10.1038/onc.2009.356 · Cited by 1,224
Self-citationIntravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210
Danger signals: SOS to the immune system
Gallucci, S., & Matzinger, P. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00191-6 · Cited by 1,204
Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.5.1661 · Cited by 1,166
Self-citationPannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Imamura, H., Nhat, K. P. H., Togawa, H., Saito, K., Iino, R., Kato‐Yamada, Y., Nagai, T., & Noji, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904764106 · Cited by 1,089
Humanized mice for immune system investigation: progress, promise and challenges
Shultz, L. D., Brehm, M. A., García, J. V., & Greiner, D. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3311 · Cited by 1,018
Bracci, L., Schiavoni, G., Sistigu, A., & Belardelli, F. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.67 · Cited by 951
Self-citationEndogenous HMGB1 regulates autophagy
Tang, D., Kang, R., Livesey, K. M., Cheh, C.-W., Farkas, A., Loughran, P., Hoppe, G., Bianchi, M. E., Tracey, K. J., Zeh, H. J., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911078 · Cited by 951
Targeting the unfolded protein response in disease
Hetz, C. A., Chevet, É., & Harding, H. P. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3976 · Cited by 942
High mobility group box 1 protein interacts with multiple Toll-like receptors
Park, J. S., Gamboni-Robertson, F., He, Q., Svetkauskaite, D., Kim, J., Strassheim, D., Sohn, J.-W., Yamada, S., Maruyama, I., Banerjee, A. M., et al. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00401.2005 · Cited by 934
Zitvogel, L., Galluzzi, L., Smyth, M. J., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.014 · Cited by 901
Self-citationCD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin
Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00111-x · Cited by 900
Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death
Panaretakis, T., Kepp, O., Brockmeier, U., Tesniere, A., Bjorklund, A., Chapman, D. C., Durchschlag, M., Joza, N., Pierron, G., van Endert, P., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.1 · Cited by 848
Self-citationChiba, S., Baghdadi, M., Akiba, H., Yoshiyama, H., Kinoshita, I., Dosaka-Akita, H., Fujioka, Y., Ohba, Y., Gorman, J. V., Colgan, J. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2376 · Cited by 838
Cell death modalities: classification and pathophysiological implications
Galluzzi, L., Maiuri, M. C., Vitale, I., Zischka, H., Castedo, M., Zitvogel, L., & Kroemer, G. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402148 · Cited by 832
Self-citationHMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2
Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock · doi:10.1097/01.shk.0000225404.51320.82 · Cited by 832
Self-citationA novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
Garg, A. D., Krysko, D. V., Verfaillie, T., Kaczmarek, A., Ferreira, G. B., Marysael, T., Rubio, N., Firczuk, M., Mathieu, C., Roebroek, A. J. M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.497 · Cited by 800
Self-citationDevelopment and function of human innate immune cells in a humanized mouse model
Rongvaux, A., Willinger, T., Martinek, J., Strowig, T., Gearty, S. V., Teichmann, L. L., Saito, Y., Marches, F., Halene, S., Palucka, A. K., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2858 · Cited by 789
Systems biology of cisplatin resistance: past, present and future
Galluzzi, L., Vitale, I., Michels, J., Brenner, C., Szabadkai, G., Harel-Bellan, A., Castedo, M., & Kroemer, G. (2014) · Cell Death & Disease · doi:10.1038/cddis.2013.428 · Cited by 782
Self-citationChao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776
Shi, Y., Vattem, K. M., Sood, R., An, J., Liang, J., Stramm, L. E., & Wek, R. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7499 · Cited by 776
Mitochondria: master regulators of danger signalling
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733
Self-citationMetabolic targets for cancer therapy
Galluzzi, L., Kepp, O., Heiden, M. G. V., & Kroemer, G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4145 · Cited by 731
Self-citationMa, Y., Adjemian, S., Mattarollo, S. R., Yamazaki, T., Aymeric, L., Yang, H., Catani, J. P. P., Hannani, D., Duret, H., Steegh, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.003 · Cited by 727
Self-citationMutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
Venereau, E., Casalgrandi, M., Schiraldi, M., Antoine, D. J., Cattaneo, A., De Marchis, F., Liu, J., Antonelli, A., Preti, A., Raeli, L., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120189 · Cited by 720
Self-citationGuidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Galluzzi, L., Aaronson, S. A., Abrams, J., Alnemri, E. S., Andrews, D. W., Baehrecke, E. H., Bazan, N. G., Blagosklonny, M. V., Blomgren, K., Borner, C., et al. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.44 · Cited by 713
Self-citationThe secret ally: immunostimulation by anticancer drugs
Galluzzi, L., Senovilla, L., Zitvogel, L., & Kroemer, G. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3626 · Cited by 708
Self-citationHyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Scheibner, K. A., Lutz, M. A., Boodoo, S., Fenton, M. J., Powell, J. D., & Horton, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1272 · Cited by 708
Rainov, N. G. (2000) · Human Gene Therapy · doi:10.1089/104303400750038499 · Cited by 702
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691
Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
Krysko, D. V., Agostinis, P., Krysko, O., Garg, A. D., Bachert, C., Lambrecht, B. N., & Vandenabeele, P. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.01.005 · Cited by 680
Self-citationSchiraldi, M., Raucci, A., Martínez‐Muñoz, L., Livoti, E., Celona, B., Vénéreau, E., Apuzzo, T., Marchis, F. D., Pedotti, M., Bachi, A., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111739 · Cited by 676
The role of defective clearance of apoptotic cells in systemic autoimmunity
Munoz, L. E., Lauber, K., Schiller, M. R., Manfredi, A. A., & i, M. H. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.46 · Cited by 646
Self-citationKazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627
Self-citationThe endoplasmic reticulum stress response in immunity and autoimmunity
Todd, D. J., Lee, A., & Glimcher, L. H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2359 · Cited by 621
Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
Rubartelli, A., & Lotze, M. T. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.08.004 · Cited by 614
Self-citationApétoh, L., Ghiringhelli, F., Tesnière, A., Criollo, A., Ortiz, C., Lidereau, R., Mariette, C., Chaput, N., Mira, J. P., Delaloge, S., et al. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00573.x · Cited by 604
Self-citationHigh‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
Bianchi, M. E., & Manfredi, A. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00574.x · Cited by 600
Self-citationThe Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
Hetz, C. A., Martinon, F., Rodríguez, D. A., & Glimcher, L. H. (2011) · Physiological Reviews · doi:10.1152/physrev.00001.2011 · Cited by 595
HMGB1 is an endogenous immune adjuvant released by necrotic cells
Rovere, P. Q., Capobianco, A., Scaffidi, P., Valentinis, B., Catalanotti, F., Giazzon, M., Dumitriu, I. E., Müller, S., Iannacone, M., Traversari, C., et al. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400205 · Cited by 591
Self-citationCell death assays for drug discovery
Kepp, O., Galluzzi, L., Lipinski, M. M., Yuan, J., & Kroemer, G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3373 · Cited by 587
Self-citationMitochondrial Control of Cellular Life, Stress, and Death
Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 568
Self-citationMolecular mechanisms of ATP secretion during immunogenic cell death
Martins, I., Wang, Y., Michaud, M., Ma, Y., Sukkurwala, A. Q., Shen, S., Kepp, O., Métivier, D., Galluzzi, L., Perfettini, J.-L., et al. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2013.75 · Cited by 563
Self-citationDecoding Cell Death Signals in Inflammation and Immunity
Zitvogel, L., Kepp, O., & Kroemer, G. (2010) · Cell · doi:10.1016/j.cell.2010.02.015 · Cited by 558
Self-citationHyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4
Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., & Gallo, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310859200 · Cited by 545
Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
Clayton, A., Al-Taei, S., Webber, J., Mason, M. D., & Tabi, Z. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003884 · Cited by 540
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F., & Nagata, S. (2014) · Science · doi:10.1126/science.1252809 · Cited by 528
Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation
Garg, A. D., Nowis, D., Gołąb, J., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.003 · Cited by 517
Self-citationCD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
Loi, S., Pommey, S., Haibe‐Kains, B., Beavis, P. A., Darcy, P. K., Smyth, M. J., & Stagg, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222251110 · Cited by 504
Self-citationRAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages
Kokkola, R., Andersson, Å., Mullins, G. E., Östberg, T., Treutiger, C.-J., Arnold, B., Nawroth, P. P., Andersson, J., Harris, R. A., & Harris, H. E. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2005.01534.x · Cited by 496
Liaisons dangereuses: P2X7 and the inflammasome
Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells
Tang, D., Kang, R., Cheh, C.-W., Livesey, K. M., Liang, X., Schapiro, N. E., Benschop, R., Sparvero, L. J., Amoscato, A. A., Tracey, K. J., et al. (2010) · Oncogene · doi:10.1038/onc.2010.261 · Cited by 461
Vega, V. L., Rodríguez-Silva, M., Frey, T., Gehrmann, M., Díaz, J. C., Steinem, C., Multhoff, G., Arispe, N. J., & Maio, A. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.4299 · Cited by 461
Self-citationA dual role for autophagy in a murine model of lung cancer
Rao, S., Tortola, L., Perlot, T., Wirnsberger, G., Novatchkova, M., Nitsch, R., Sykacek, P., Frank, L., Schramek, D., Komnenovic, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms4056 · Cited by 453
Self-citationAutophagy and cellular immune responses
Ma, Y., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.017 · Cited by 447
Self-citationMartins, I., Kepp, O., Schlemmer, F., Adjemian, S., Tailler, M., Shen, S., Michaud, M., Menger, L., Gdoura, A., Tajeddine, N., et al. (2010) · Oncogene · doi:10.1038/onc.2010.500 · Cited by 443
Self-citationAn Immunosurveillance Mechanism Controls Cancer Cell Ploidy
Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., et al. (2012) · Science · doi:10.1126/science.1224922 · Cited by 436
Self-citationGameiro, S. R., Jammeh, M. L., Wattenberg, M. M., Tsang, K. Y., Ferrone, S., & Hodge, J. W. (2013) · Oncotarget · doi:10.18632/oncotarget.1719 · Cited by 424
Self-citationCardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Menger, L., Vacchelli, E., Adjemian, S., Martins, I., Ma, Y., Shen, S., Yamazaki, T., Sukkurwala, A. Q., Michaud, M., Mignot, G., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003807 · Cited by 423
Self-citationLv, L.-H., Wan, Y.-L., Lin, Y., Zhang, W., Yang, M., Li, G.-L., Lin, H.-M., Shang, C.-Z., Chen, Y.-J., & Min, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340588 · Cited by 420
Mitochondrial membrane permeabilization in neuronal injury
Galluzzi, L., Blomgren, K., & Kroemer, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2665 · Cited by 418
Self-citationHuman Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response
Fucikova, J. P., Králíková, P., Fialová, A., Brtnický, T., Rob, L., Bartůňková, J., & Špíšek, R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0950 · Cited by 415
Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity
Aymeric, L., Apétoh, L., Ghiringhelli, F., Tesnière, A., Martins, I., Kroemer, G., Smyth, M. J., & Zitvogel, L. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3566 · Cited by 401
Self-citationExtracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis
Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397
Ahrens, S., Zelenay, S., Sancho, D., Hanč, P., Kjær, S., Feest, C., Fletcher, G., Durkin, C. H., Postigo, A. A., Skehel, M. J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.008 · Cited by 393
Spisek, R., Charalambous, A., Mazumder, A., Vesole, D. H., Jagannath, S., & Dhodapkar, M. V. (2007) · Blood · doi:10.1182/blood-2006-10-054221 · Cited by 388
Self-citationApoptotic cell removal in development and tissue homeostasis
Henson, P. M., & Hume, D. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.005 · Cited by 388
The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.
Samuel, C. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52994-x · Cited by 384
Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
Inoue, H., & Tani, K. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.84 · Cited by 362
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
Curtin, J. F., Liu, N., Candolfi, M., Xiong, W., Assi, H. H., Yagiz, K., Edwards, M. R., Michelsen, K. S., Kroeger, K. M., Liu, C., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000010 · Cited by 362
Self-citationSchiavoni, G., Sistigu, A., Valentini, M., Mattei, F., Sestili, P., Spadaro, F., Sanchez, M., Lorenzi, S., D'Urso, M. T., Belardelli, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2788 · Cited by 362
Self-citationMatzinger, P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03118.x · Cited by 360
Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer
Aniței, M.-G., Zeitoun, G., Mlecnik, B., Marliot, F., Haicheur, N., Mușină, A.-M., Kirilovsky, A., Lagorce, C., Bindea, G., Ferariu, D., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2830 · Cited by 358
Self-citationContribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy
Ma, Y., Aymeric, L., Locher, C., Mattarollo, S. R., Delahaye, N. F., Pereira, P., Boucontet, L., Apétoh, L., Ghiringhelli, F., Casares, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100269 · Cited by 356
Self-citationPivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors
Mattarollo, S. R., Loi, S., Duret, H., Ma, Y., Zitvogel, L., & Smyth, M. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0753 · Cited by 351
Self-citationLi, H., Li, Y., Jiao, J., & Hu, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.153 · Cited by 347
Self-citationThe co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death
Panaretakis, T., Joza, N., Modjtahedi, N., Tesniere, A., Vitale, I., Durchschlag, M., Fimia, G. M., Kepp, O., Piacentini, M., Froehlich, K.-U., et al. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.67 · Cited by 344
Self-citationOncolytic viruses as therapeutic cancer vaccines
Bartlett, D. L., Liu, Z., Sathaiah, M., Ravindranathan, R., Guo, Z., He, Y., & Guo, Z. S. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-103 · Cited by 338
Self-citationATP release and purinergic signaling in NLRP3 inflammasome activation
Gombault, A., Baron, L., & Couillin, I. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00414 · Cited by 326
Radiation Therapy to Convert the Tumor Into an In Situ Vaccine
Formenti, S. C., & Demaria, S. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2012.06.020 · Cited by 323
Self-citationImmunomodulatory effects of cyclophosphamide and implementations for vaccine design
Sistigu, A., Viaud, S., Chaput, N., Bracci, L., Proietti, E., & Zitvogel, L. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0245-0 · Cited by 318
Self-citationClearance of apoptotic and necrotic cells and its immunological consequences
Krysko, D. V., D’Herde, K., & Vandenabeele, P. (2006) · Apoptosis · doi:10.1007/s10495-006-9527-8 · Cited by 316
Self-citationImmunogenic cancer cell death: a key-lock paradigm
Tesnière, A., Apétoh, L., Ghiringhelli, F., Joza, N. A., Panaretakis, T., Kepp, O., Schlemmer, F., Zitvogel, L., & Kroemer, G. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.05.007 · Cited by 315
Self-citationMany faces of DAMPs in cancer therapy
Krysko, O., Aaes, T. L., Bachert, C., Vandenabeele, P., & Krysko, D. V. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.156 · Cited by 309
Self-citationGarg, A. D., Krysko, D. V., Vandenabeele, P., & Agostinis, P. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1184-2 · Cited by 307
Self-citationROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
Garg, A. D., Dudek, A. M., Ferreira, G. B., Verfaillie, T., Vandenabeele, P., Krysko, D. V., Mathieu, C., & Agostinis, P. (2013) · Autophagy · doi:10.4161/auto.25399 · Cited by 305
Self-citationMolecular determinants of immunogenic cell death elicited by anticancer chemotherapy
Kepp, O., Galluzzi, L., Martins, I., Schlemmer, F., Adjemian, S., Michaud, M., Sukkurwala, A. Q., Menger, L., Zitvogel, L., & Kroemer, G. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9273-4 · Cited by 303
Self-citationChemotherapy induces ATP release from tumor cells
Martins, I., Tesnière, A., Kepp, O., Michaud, M., Schlemmer, F., Senovilla, L., Séror, C., Métivier, D., Perfettini, J., Zitvogel, L., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.22.10026 · Cited by 300
Self-citationOncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity
Guo, Z. S., Liu, Z., & Bartlett, D. L. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00074 · Cited by 296
Self-citationFillat, C., Carrió, M., Cascante, A., et al. (2003) · Current Gene Therapy · doi:10.2174/1566523033347426 · Cited by 289
Garg, A. D., & Agostinis, P. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50333j · Cited by 283
Self-citationExtracellular ATP drives systemic inflammation, tissue damage and mortality
Cauwels, A., Rogge, E., Vandendriessche, B., Shiva, S., & Brouckaert, P. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.70 · Cited by 279
ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation
Riteau, N., Baron, L., Villeret, B., Guillou, N., Savigny, F., Ryffel, B., Rassendren, F., Bert, M. L., Gombault, A., & Couillin, I. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.144 · Cited by 275
Korbelik, M., Sun, J., & Cecić, I. (2005) · Cancer Research · doi:10.1158/0008-5472.1018.65.3 · Cited by 273
Self-citationDefective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists
Yamazaki, T., Hannani, D., Poirier-Colame, V., Ladoire, S., Locher, C., Sistigu, A., Prada, N., Adjemian, S., Catani, J. P. P., Freudenberg, M. A., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.72 · Cited by 272
Self-citationVacchelli, E., Senovilla, L., Eggermont, A. M. M., Fridman, W. H., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.23510 · Cited by 270
Self-citationAutophagy regulates selective HMGB1 release in tumor cells that are destined to die
Thorburn, J., Horita, H., Redzic, J., Hansen, K., Frankel, A. E., & Thorburn, A. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.143 · Cited by 268
Self-citationVacchelli, E., Eggermont, A. M. M., Sautès‐Fridman, C., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.24612 · Cited by 260
Self-citationMolecular mechanisms of regulated necrosis
Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G., & Linkermann, A. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.02.006 · Cited by 258
Self-citationSenovilla, L., Vacchelli, E., Galon, J., Adjemian, S., Eggermont, A. M. M., Fridman, W. H., Sautès‐Fridman, C., Ma, Y., Tartour, É., Zitvogel, L., et al. (2012) · OncoImmunology · doi:10.4161/onci.22009 · Cited by 254
Self-citationIn situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival
Ladoire, S., Mignot, G., Dabakuyo‐Yonli, T. S., Arnould, L., Apétoh, L., Rébé, C., Coudert, B. P., Martin, F., Bizollon, M.-H., Vanoli, A., et al. (2011) · The Journal of Pathology · doi:10.1002/path.2866 · Cited by 245
Self-citationTrial watch: FDA-approved Toll-like receptor agonists for cancer therapy
Vacchelli, E., Galluzzi, L., Eggermont, A. M. M., Fridman, W. H., Galon, J., Sautès‐Fridman, C., Tartour, É., Zitvogel, L., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.20931 · Cited by 242
Self-citationCrosstalk between ER stress and immunogenic cell death
Kepp, O., Menger, L., Vacchelli, E., Locher, C., Adjemian, S., Yamazaki, T., Martins, I., Sukkurwala, A. Q., Michaud, M., Senovilla, L., et al. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.001 · Cited by 242
Self-citationMethods for the assessment of mitochondrial membrane permeabilization in apoptosis
Galluzzi, L., Zamzami, N., Rouge, T. D. L. M., Lemaire, C., Brenner, C., & Kroemer, G. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0720-1 · Cited by 234
Self-citationDanger signalling during cancer cell death: origins, plasticity and regulation
Garg, A. D., Martin, S., Gołąb, J., & Agostinis, P. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.48 · Cited by 232
Self-citationLundin, A., & Thore, A. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90723-x · Cited by 223
Suzuki, Y., Mimura, K., Yoshimoto, Y., Watanabe, M., Ohkubo, Y., Izawa, S., Murata, K., Fujii, H., Nakano, T., & Kono, K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0851 · Cited by 223
Self-citationHierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
Tajeddine, N., Galluzzi, L., Kepp, O., Hangen, E., Morselli, E., Senovilla, L., Araujo, N., Pinna, G., Larochette, N., Zamzami, N., et al. (2008) · Oncogene · doi:10.1038/onc.2008.63 · Cited by 217
Self-citationENTPD1/CD39 is a promising therapeutic target in oncology
Bastid, J., Regairaz, A., Alberici, G. F., Bonnefoy, N., Eliaou, J.-F., & Bensussan, A. (2012) · Oncogene · doi:10.1038/onc.2012.269 · Cited by 213
Ko, A., Kanehisa, A., Martins, I., Senovilla, L., Chargari, C., Dugué, D., Mariño, G., Kepp, O., Michaud, M., Perfettini, J., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.124 · Cited by 212
Self-citationMethods for Assessing Autophagy and Autophagic Cell Death
Tasdemir, E., Galluzzi, L., Maiuri, M. C., Criollo, A., Vitale, I., Hangen, E., Modjtahedi, N., & Kroemer, G. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_3 · Cited by 200
Self-citationDying cell clearance and its impact on the outcome of tumor radiotherapy
Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 200
Strange attractors: DAMPs and autophagy link tumor cell death and immunity
Hou, W., Zhang, Q., Yan, Z., Chen, R., Zeh, H. J., Kang, R., Lotze, M. T., & Tang, D. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.493 · Cited by 199
DAMPs activating innate and adaptive immune responses in COPD
Pouwels, S. D., Heijink, I. H., ten Hacken, N. H. T., Vandenabeele, P., Krysko, D. V., Nawijn, M. C., & van Oosterhout, A. J. M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.77 · Cited by 194
Self-citationMétivier, D., Dallaporta, B., Zamzami, N., Larochette, N., Susín, S. A., Marzo, I., & Kroemer, G. (1998) · Immunology Letters · doi:10.1016/s0165-2478(98)00013-3 · Cited by 190
Self-citationVisualization of ATP Release in Pancreatic Acini in Response to Cholinergic Stimulus
Sørensen, C. E., & Novak, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103313200 · Cited by 183
High hydrostatic pressure induces immunogenic cell death in human tumor cells
Fucikova, J. P., Moserova, I. K., Truxová, I., Heřmanová, I., Vančurová, I., Partlová, S., Fialová, A., Sojka, L., Cartron, P., Houška, M., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28766 · Cited by 180
Liikanen, I., Ahtiainen, L., Hirvinen, M., Bramante, S., Cerullo, V., Nokisalmi, P., Hemminki, O., Diaconu, I., Pesonen, S. A., Koski, A., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.51 · Cited by 170
Self-citationObéid, M., Panaretakis, T., Tesnière, A., Joza, N., Tufi, R., Apétoh, L., Ghiringhelli, F., Zitvogel, L., & Kroemer, G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1622 · Cited by 166
Self-citationKomoriya, A., Packard, B. Z., Brown, M. J., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.11.1819 · Cited by 165
Monosodium urate crystals in inflammation and immunity
Shi, Y., Mucsi, A. D., & Ng, G. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00851.x · Cited by 163
Vacchelli, E., Eggermont, A. M. M., Sautès‐Fridman, C., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.25238 · Cited by 160
Self-citationVacchelli, E., Aranda, F., Eggermont, A. M. M., Galon, J., Sautès‐Fridman, C., Cremer, I., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2014) · OncoImmunology · doi:10.4161/onci.27878 · Cited by 160
Self-citationvan Schadewijk, A. M., Wout, E. F. A. V. ’., Stolk, J. N., & Hiemstra, P. S. (2011) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0306-2 · Cited by 158
Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death
England, H., Summersgill, H. R., Edye, M. E., Rothwell, N. J., & Brough, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.557561 · Cited by 151
Self-citationInterleukin-1 Stimulates β-Cell Necrosis and Release of the Immunological Adjuvant HMGB1
Steer, S. A., Scarim, A. L., Chambers, K. T., & Corbett, J. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030017 · Cited by 144
Phosphoregulation of Ire1 RNase splicing activity
Prischi, F., Nowak, P. R., Carrara, M., & Ali, M. M. U. (2014) · Nature Communications · doi:10.1038/ncomms4554 · Cited by 142
Enlightening the impact of immunogenic cell death in photodynamic cancer therapy
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.2 · Cited by 142
Self-citationScreening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set
Sukkurwala, A. Q., Adjemian, S., Senovilla, L., Michaud, M., Spaggiari, S., Vacchelli, E., Baracco, E. E., Galluzzi, L., Zitvogel, L., Kepp, O., et al. (2014) · OncoImmunology · doi:10.4161/onci.28473 · Cited by 141
Self-citationMenger, L., Vacchelli, E., Kepp, O., Eggermont, A. M. M., Tartour, É., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.23082 · Cited by 138
Self-citationChen, H., Wang, P.-H., Chen, S.-S., Wen, C.-C., Chen, Y., Yang, W., & Yang, N. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1258-9 · Cited by 138
Immunogenic cell death in radiation therapy
Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · OncoImmunology · doi:10.4161/onci.26536 · Cited by 138
Self-citationDuran, G. A., Krysko, D. V., Kaczmarek, A., Petrovski, G., Vandenabeele, P., & Fésüs, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040069 · Cited by 137
Self-citationAutophagy-dependent ATP release from dying cells via lysosomal exocytosis
Wang, Y., Martins, I., Ma, Y., Kepp, O., Galluzzi, L., & Kroemer, G. (2013) · Autophagy · doi:10.4161/auto.25873 · Cited by 137
Self-citationChapter 16 Methods for Distinguishing Apoptotic from Necrotic Cells and Measuring Their Clearance
Krysko, D. V., Berghe, T. V., Parthoens, E., D'Herde, K. G. M. A., & Vandenabeele, P. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)01416-x · Cited by 132
Self-citationDong, X. D., Ito, N., Lotze, M. T., DeMarco, R., Popovič, P., Shand, S. H., Watkins, S. C., Winikoff, S. E., Brown, C. K., Bartlett, D. L., et al. (2007) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31804efc76 · Cited by 130
Large G3BP-induced granules trigger eIF2α phosphorylation
Reineke, L. C., Dougherty, J. D., Pierre, P., & Lloyd, R. E. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-05-0385 · Cited by 130
Bugaut, H., Bruchard, M., Berger, H., Dérangère, V., Odoul, L., Euvrard, R., Ladoire, S., Chalmin, F., Végran, F., Rébé, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065181 · Cited by 127
Self-citationThe Role of Brain-derived Neurotrophic Factor (BDNF)-induced XBP1 Splicing during Brain Development
Hayashi, A., Kasahara, T., Iwamoto, K., Ishiwata, M., Kametani, M., Kakiuchi, C., Furuichi, T., & Kato, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704300200 · Cited by 124
Vacchelli, E., Galluzzi, L., Fridman, W. H., Galon, J., Sautès‐Fridman, C., Tartour, É., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.1.2.19026 · Cited by 122
Self-citationMellén, M., de la Rosa, E. J., & Boya, P. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.40 · Cited by 121
Jäger, M., Schoberth, A., Ruf, P., Heß, J., Hennig, M., Schmalfeldt, B., Wimberger, P., Ströhlein, M. A., Theissen, B., Heiss, M. M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2235 · Cited by 120
Immunogenic Cell Death: Can It Be Exploited in PhotoDynamic Therapy for Cancer?
Panzarini, E., Inguscio, V., & Dini, L. (2012) · BioMed Research International · doi:10.1155/2013/482160 · Cited by 120
Self-citationProduction of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape
Ghiringhelli, F., Bruchard, M., Chalmin, F., & Rébé, C. (2012) · BioMed Research International · doi:10.1155/2012/473712 · Cited by 120
Self-citationCancer immunogenicity, danger signals, and DAMPs: What, when, and how?
Garg, A. D., Dudek, A. M., & Agostinis, P. (2013) · BioFactors · doi:10.1002/biof.1125 · Cited by 116
Self-citationTumor immunity times out: TIM-3 and HMGB1
Tang, D., & Lotze, M. T. (2012) · Nature Immunology · doi:10.1038/ni.2396 · Cited by 116
Damage associated molecular pattern molecules
Lotze, M. T., Deisseroth, A., & Rubartelli, A. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.02.006 · Cited by 114
Self-citationA Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States
Tang, D., Billiar, T. R., & Lotze, M. T. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00314 · Cited by 112
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Bindea, G., Mlecnik, B., Angell, H. K., & Galon, J. (2014) · OncoImmunology · doi:10.4161/onci.27456 · Cited by 112
Self-citationEricsson, J. (1969) · Experimental Cell Research · doi:10.1016/0014-4827(69)90462-5 · Cited by 111
Antitumor Immunity Induced after α Irradiation
Gorin, J., Ménager, J., Gouard, S., Maurel, C., Guilloux, Y., Faivre-Chauvet, A., Morgenstern, A., Bruchertseifer, F., Chérel, M., Davodeau, F., et al. (2014) · Neoplasia · doi:10.1016/j.neo.2014.04.002 · Cited by 111
Anticancer activity of cardiac glycosides
Kepp, O., Menger, L., Vacchelli, E., Adjemian, S., Martins, I., Ma, Y., Sukkurwala, A. Q., Michaud, M., Galluzzi, L., Zitvogel, L., et al. (2012) · OncoImmunology · doi:10.4161/onci.21684 · Cited by 109
Self-citation
Research works printed but not linked: 7
- Vogt CI, 1842, Jent
- 10.1038/emboj.2009.1x · DOI
- Dutcher JD, 1963, Antimicrob Agents Chemother (Bethesda), 161, 83
- Olsson L, 1978, Biomedicine, 28, 88
- Fredly H, 2011, Oncol Rep, 25, 1549
- McElroy WD, 1983, J Appl Biochem, 5, 197
- Klionsky DJ, 2009, Methods Enzymol, 452, xxi-xxii
Cited by
Sorted by citations
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Self-citationImmunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Self-citationImmunological effects of conventional chemotherapy and targeted anticancer agents
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.10.012 · Cited by 1,530
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Integrating oncolytic viruses in combination cancer immunotherapy
Bommareddy, P. K., Shettigar, M., & Kaufman, H. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0014-6 · Cited by 704
Metadata
- Authors
- Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buqué, A., Castro, M. G., Cirone, M., Colombo, M. I., Cremer, I., Demaria, S., Dini, L., Eliopoulos, A. G., Faggioni, A., Formenti, S. C., Fučíková, J., Gabriele, L., Gaipl, U. S., Galon, J., Garg, A., Ghiringhelli, F., Giese, N. A., Guo, Z. S., Hemminki, A., Herrmann, M., Hodge, J. W., Holdenrieder, S., Honeychurch, J., Hu, H.-M., Huang, X., Illidge, T. M., Kono, K., Korbelik, M., Krysko, D. V., Loi, S., Lowenstein, P. R., Lugli, E., Ma, Y., Madeo, F., Manfredi, A. A., Martins, I., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, K. L., Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, J.-E., Riganti, C., Rovere-Querini, P., Rubartelli, A., Sistigu, A., Smyth, M. J., Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, A. Q., Tartour, E., Thorburn, A., Thorne, S. H., Vandenabeele, P., Velotti, F., Workenhe, S. T., Yang, H., Zong, W.-X., Zitvogel, L., Kroemer, G., & Galluzzi, L.
- Affiliations
- Inserm (FR)
- Instituto Nazionale Tumori Regina Elena (IT)
- KU Leuven (BE)
- Istituto Pasteur (IT)
- Istituto Superiore di Sanità (IT)
- Université Libre de Bruxelles (BE)
- University of Manchester (GB)
- University of Michigan (US)
- Sapienza University of Rome (IT)
- New York University (US)
- University of Salento (IT)
- University of Crete (GR)
- NYU Langone Health (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Heidelberg (DE)
- University of Pittsburgh (US)
- University of Helsinki (FI)
- National Institutes of Health (US)
- University Hospital Bonn (DE)
- Manchester Academic Health Science Centre (GB)
- National University of Singapore (SG)
- BC Cancer Agency (CA)
- Ghent University (BE)
- Peter MacCallum Cancer Centre (AU)
- University of Milan (IT)
- University of Graz (AT)
- Vita-Salute San Raffaele University (IT)
- Université Paris-Sud (FR)
- Università degli Studi della Tuscia (IT)
- McMaster University (CA)
- TUM Klinikum (DE)
- Comprehensive Cancer Center Vienna (AT)
- Karolinska Institutet (SE)
- University of Turin (IT)
- Ospedale Policlinico San Martino (IT)
- The University of Queensland (AU)
- Jena University Hospital (DE)
- Centre Hospitalier de l’Université de Montréal (CA)
- University of Colorado Anschutz (US)
- University of Hawaii Cancer Center (US)
- Stony Brook University (US)
- Corresponding author
- Galluzzi, Lorenzo
- ORCID
- Kepp, Oliver
- Senovilla, Laura
- Vitale, Ilio
- Vacchelli, Erika
- Adjemian, Sandy
- Agostinis, Patrizia
- Aranda, Fernando
- Barnaba, Vincenzo
- Bloy, Norma
- Bracci, Laura
- Breckpot, Karine
- Brough, David
- Buqué, Aitziber
- Castro, Maria G.
- Cirone, Mara
- Cremer, Isabelle
- Demaria, Sandra
- Eliopoulos, Aristides G.
- Faggioni, Alberto
- Formenti, Silvia C.
- Gabriele, Lucia
- Gaipl, Udo S.
- Galon, Jérôme
- Garg, Abhishek
- Ghiringhelli, François
- Giese, Nathalia A.
- Guo, Zong Sheng
- Hemminki, Akseli
- Hodge, James W.
- Holdenrieder, Stefan
- Honeychurch, Jamie
- Huang, Xing
- Illidge, Tim M.
- Kono, Koji
- Korbelik, Mladen
- Krysko, Dmitri V.
- Loi, Sherene
- Lowenstein, Pedro R.
- Lugli, Enrico
- Ma, Yuting
- Madeo, Frank
- Manfredi, Angelo A.
- Martins, Isabelle
- Mavilio, Domenico
- Menger, Laurie
- Merendino, Nicolò
- Mossman, Karen L.
- Multhoff, Gabriele
- Oehler, Rudolf
- Palombo, Fabio
- Panaretakis, Theocharis
- Pol, Jonathan
- Proietti, Enrico
- Ricci, Jean-Ehrland
- Riganti, Chiara
- Rubartelli, Anna
- Sistigu, Antonella
- Smyth, Mark J.
- Stagg, John
- Thorburn, Andrew
- Thorne, Stephen H.
- Vandenabeele, Peter
- Velotti, Francesca
- Workenhe, Samuel T.
- Yang, Haining
- Zitvogel, Laurence
- Kroemer, Guido
- Galluzzi, Lorenzo
- Venue
- OncoImmunology
- Publisher
- Informa UK Limited
- Published
- 2014-09-02
- Volume
- 3
- Issue
- 9
- Pages
- e955691
- ISSN
- 2162-4011 (ISSN-L)
- 2162-402X
- PMC
- PMC4292729
- OpenAlex
- W2163252162
- Cited by
- 832
- References
- 292
- Citations by year
- 2026: 47 · 2025: 53 · 2024: 44 · 2023: 66 · 2022: 77 · 2021: 95 · 2020: 93 · 2019: 95 · 2018: 63 · 2017: 62 · 2016: 83 · 2015: 48 · 2014: 5
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- OncoImmunology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UnitusOpen (Tuscia University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- AIRUS (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Cancer Research UK (11335, 17737)
- European Commission
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- National Institutes of Health (5r01ns082311-05)
- Labex Immuno-Oncology
- National Cancer Institute (R01CA129536)
- National Institute of Neurological Disorders and Stroke (R01NS074387, R01NS061107, R01NS057711, R01-NS082311)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- immunogenic cell death, calreticulin exposure, extracellular ATP, HMGB1, endoplasmic reticulum stress, autophagy, cancer immunotherapy
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