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Cited by 238Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

Autophagy Regulates Ageing in C. elegans

Open access
Hars, Eszter S., Qi, Haiyan, Jin, Shengkan V., Cai, Li, Hu, Chengcheng, Liu, Leroy F.·2007·Autophagy
DOI 10.4161/auto.3636
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Abstract

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

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  • Activation of macroautophagy is a common feature of all the long-lived mutant worms, including the models for dietary restriction.

    “Activation of macroautophagy is a common feature of all the long-lived mutant worms, including the models for dietary restriction (Hansen et al., 2008; Hars et al., 2007; Melendez et al., 2003; Tóth et al., 2008).”

    From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Hars et al., 2007

    The paper’s Abstract reports that knocking down autophagy genes shortened the lifespan of long-lived daf-2 mutant worms, supporting a role for autophagy in their longevity. It does not show that macroautophagy is activated in all long-lived mutant worms or address dietary-restriction models; searches for dietary restriction and autophagy activation found no such result. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The lifespan extension observed in worms mutant for the equivalent of the insulin-signaling pathway, such as daf-2, is drastically reduced when macroautophagy genes are knocked down.

    “The lifespan extension observed in worms mutant for the equivalent of the insulin-signaling pathway, such as daf-2, is drastically reduced when macroautophagy genes are knocked down (Hars et al., 2007; Melendez et al., 2003).”

    From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Hars et al., 2007

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Research works printed but not linked: 20

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Authors
Hars, E. S., Qi, H., Jin, S. V., Cai, L., Hu, C., & Liu, L. F.
Affiliations
  • University of Medicine and Dentistry of New Jersey (US)
  • Rutgers, The State University of New Jersey (US)
  • Harvard University (US)
ORCID
Venue
Autophagy
Publisher
Informa UK Limited
Published
2007-03-27
Volume
3
Issue
2
Pages
93-95
ISSN
  • 1554-8627 (ISSN-L)
  • 1554-8635
DOI
10.4161/auto.3636
OpenAlex
W2060830629
Cited by
238
References
0
Citations by year
2026: 7 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 9 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 16
FWCI
6.30
Type
journal article
Language
en
Open access
Locations
  • Autophagy (publishedVersion)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders
  • U.S. Department of Defense
  • National Institutes of Health
  • National Institute on Aging (AG19890, R01AG019890)
  • National Cancer Institute (R01CA102463, R01CA039662, CA 39662, CA 102463)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
aging, lifespan, Caenorhabditis elegans, Beclin-1, daf-2 mutant, RNAi knockdown
MeSH terms
Aging, Animals, Autophagy, Longevity, Proportional Hazards Models, Survival Analysis, Caenorhabditis elegans, Caenorhabditis elegans Proteins, RNA Interference

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