Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in C. elegans
Open accessAbstract
Dietary restriction extends life span in diverse species including Caenorhabditis elegans. However, the downstream cellular targets regulated by dietary restriction are largely unknown. Autophagy, an evolutionary conserved lysosomal degradation pathway, is induced under starvation conditions and regulates life span in insulin signaling C. elegans mutants. We now report that two essential autophagy genes (bec-1 and Ce-atg7) are required for the longevity phenotype of the C. elegans dietary restriction mutant (eat-2(ad1113) animals. Thus, we propose that autophagy mediates the effect, not only of insulin signaling, but also of dietary restriction on the regulation of C. elegans life span. Since autophagy and longevity control are highly conserved from C. elegans to mammals, a similar role for autophagy in dietary restriction-mediated life span extension may also exist in mammals.
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The role of macroautophagy in lifespan extension mediated by caloric restriction has been genetically confirmed in C. elegans.
“the role of macroautophagy in lifespan extension mediated by caloric restriction has also been genetically confirmed in C. elegans (Jia and Levine, 2007)”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Jia and Levine, 2007
The effect of SAHA/vorinostat treatment on autophagy is context dependent.
“however, SAHA/vorinostat treatment has also been reported to suppress”
From Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016) · cites this paper as [1723]
The Abstract and the section on autophagy and dietary-restriction-mediated life-span extension discuss C. elegans, dietary restriction, and autophagy, but not SAHA/vorinostat treatment. Searches for SAHA/vorinostat and its alternative name found no passage addressing whether its effect on autophagy depends on context. Page numbers are unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredCalorie restriction is a strong inducer of autophagy and increases the lifespan in C. elegans.
“Furthermore, calorie restriction is a strong inducer of autophagy and increases the lifespan in C. elegans (230).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [230]
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- Authors
- Jia, K., & Levine, B.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2007-11-26
- Volume
- 3
- Issue
- 6
- Pages
- 597-599
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2078903854
- Cited by
- 341
- References
- 18
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 21 · 2020: 7 · 2019: 18 · 2018: 22 · 2017: 12 · 2016: 23 · 2015: 21 · 2014: 21 · 2013: 19 · 2012: 20
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- U.S. Public Health Service (R01 85254)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- dietary restriction, lifespan extension, longevity, Caenorhabditis elegans, EAT-2, ATG7, insulin signaling, starvation, lysosomal degradation
- MeSH terms
- Animals, Autophagy, Food Deprivation, Longevity, Plasmids, Caenorhabditis elegans, Genes, Helminth, Caenorhabditis elegans Proteins, Caloric Restriction, Vesicular Transport Proteins, RNA Interference
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