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Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
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α-Synuclein oligomers induce cellular stress responses, including aberrant autophagy-lysosome pathways, dysregulation of lipid metabolism, and a reduction in membrane trafficking.
“α-Synuclein oligomers are known to induce cellular stress responses, including aberrant autophagy-lysosome pathways [161,162], dysregulation of lipid metabolism [163,164], and a reduction in membrane trafficking [4].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [161]
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Metadata
- Authors
- Poehler, A.-M., Xiang, W., Spitzer, P., May, V. E. L., Meixner, H., Rockenstein, E., Chutna, O., Outeiro, T. F., Winkler, J., Masliah, E., & Klucken, J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2014-10-30
- Volume
- 10
- Issue
- 12
- Pages
- 2171-2192
- ISSN
- 1554-8627
- 1554-8635
- Cited by
- 212
- References
- 10
- Language
- en
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