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Mitochondria removal by autophagy
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Other mechanisms causing defective bioenergetics include accumulation of mutations and deletions in mtDNA, oxidation of mitochondrial proteins, destabilization of respiratory chain supercomplexes, changes in lipid composition of mitochondrial membranes, alterations in mitochondrial dynamics, and defective quality control by mitophagy.
“Other mechanisms causing defective bioenergetics include accumulation of mutations and deletions in mtDNA, oxidation of mitochondrial proteins, destabilization of the macromolecular organization of respiratory chain (super)complexes, changes in the lipid composition of mitochondrial membranes, alterations in mitochondrial dynamics resulting from imbalance of fission and fusion events, and def”
From The Hallmarks of Aging (2013) · cites this paper as Wang and Klionsky, 2011
The Introduction (page not provided) says ROS can damage mitochondrial proteins, DNA and lipids, and identifies mitophagy as a mitochondrial quality-control process. It does not identify mtDNA mutations or deletions, respiratory-chain supercomplex destabilization, altered membrane-lipid composition, or a fission–fusion imbalance as causes of defective bioenergetics. Its discussion of mitophagy also does not directly establish that defective mitophagy causes defective bioenergetics. (LLM, conf=0.86)
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Metadata
- Authors
- Wang, K., & Klionsky, D. J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2011-03
- Volume
- 7
- Issue
- 3
- Pages
- 297-300
- ISSN
- 1554-8627
- 1554-8635
- Cited by
- 380
- References
- 9
- Language
- en
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