The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Open accessAbstract
BACKGROUND: In animal models, variations in early maternal care are associated with differences in hypothalamic-pituitary-adrenal(HPA) stress response in the offspring, mediated via changes in the epigenetic regulation of glucocorticoid receptor (GR) gene (Nr3c1) expression. OBJECTIVE: To study this in humans, relationships between prenatal exposure to maternal mood and the methylation status of a CpG-rich region in the promoter and exon 1F of the human GR gene (NR3C1) in newborns and HPA stress reactivity at age three months were examined. RESULTS: Prenatal exposure to increased third trimester maternal depressed/anxious mood was associated with increased methylation of NR3C1 at a predicted NGFI-A binding site. Increased NR3C1 methylation at this site was also associated with increased salivary cortisol stress responses at 3 months, controlling for prenatal SRI exposure, postnatal age and pre and postnatal maternal mood. METHODS: The methylation status of a CpG-rich region of the NR3C1 gene, including exon 1F, in genomic DNA from cord blood mononuclear cells was quantified by bisulfite pyrosequencing in infants of depressed mothers treated with a serotonin reuptake inhibitor antidepressant (SRI) (n = 33), infants of depressed nontreated mothers (n = 13) and infants of non depressed/non treated mothers (n = 36). To study the functional implications of the newborn methylation status of NR3C1 in newborns, HPA function was assessed at three months using salivary cortisol obtained before and following a non noxious stressor and at a late afternoon basal time. CONCLUSIONS: Methylation status of the human NR3C1 gene in newborns is sensitive to prenatal maternal mood and may offer a potential epigenetic process that links antenatal maternal mood and altered HPA stress reactivity during infancy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“With respect to the promoter and exon 1F of the human GR gene Nr3c1, Oberlander et al. (406) showed specific epigenetic effects (gene hypermethylation) and elevated cortisol stress reactivity in the offspring due to maternal depression even during late pregnancy.”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [406]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“only the heightened methylation of a CpG island colocalizing with the NGFI-A binding site in newborns predicted infant HPA reactivity in form of an elevated cortisol release during a stress challenge at three months of age”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Oberlander et al., 2008
The cited source says what the claim attributes to it.
In the citing paper
“For example, increased methylation was found in newborns exposed to prenatal stress [57] and the cord blood of mothers with third trimester depression/anxiety [58].”
The cited source says what the claim attributes to it.
In the citing paper
“indicating that maternal mood and offspring HPA axis reactivity may be linked through epigenetic processes and sensitive to fetal developmental stage”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [141]
The cited source says what the claim attributes to it.
In the citing paper
“methylation levels were associated with salivary cortisol stress responses in the newborns at 3 months”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [141]
The cited source says what the claim attributes to it.
In the citing paper
“third trimester maternal depression/anxiety associated with higher methylation of NR3C1 at a predicted NGF1-A binding site 141”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [141]
In the citing paper
“Similar associations between early adversity and GR NR3C1 methylation have recently been demonstrated in humans who likely experienced severe stress or trauma. These samples have included brain tissue of deceased human adults who had committed suicide following a history of child abuse (McGowan et al., 2009), cord blood of infants with depressed mothers (Oberlander et al., 2008), white blood cells”
From Associations Between Early Life Stress and Gene Methylation in Children (2015) · cites this paper as Oberlander et al., 2008
In the citing paper
“adversity-related increases in methylation in this region are associated with decreased gene expression in human postmortem brain tissue (McGowan et al., 2009) and increased physiological stress responding in infants (Oberlander et al., 2008).”
From Associations Between Early Life Stress and Gene Methylation in Children (2015) · cites this paper as Oberlander et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression Scale
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.6.782 · Cited by 14,183
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
MatInspector and beyond: promoter analysis based on transcription factor binding sites
Cartharius, K., Frech, K., Grote, K., Klocke, B., Haltmeier, M., Klingenhoff, A., Frisch, M., Bayerlein, M., & Werner, T. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti473 · Cited by 2,003
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Van den Bergh, B. R. H., Mulder, E. J. H., Mennes, M., & Glover, V. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.007 · Cited by 1,104
Flagged first, then by citations
Research works printed but not linked: 4
- [31]31. Oberlander TF, Weinberg J, Mayes L, Riggs W, Rurak D, Papsdorf M, Misri S, Grunau R. Hypothalamic-pituitary-adrenal (HPA) axis function in 3 month old infants with pre- natal serotonin reuptake inhibitor (SRI) antidepressant exposure. Abstract. XVIth Biennial International Conference on Infant Studies. Vancouver, BC 2008.
- [33]33. Prechtl HF, O'Brien MJ. Behavioural states of the full-term newborn: the emergence of a concept. In: Stratton P, editor. Psychobiology of the Human Newborn. New York, NY: John Wiley and Sons Ltd 1982; 53-73.
- [40]40. Abidin RR. Parenting Stress Index. Charlottesville, VA: Pediatric Psychology Press; 1990.
- [43]43. Kim J, Riggs KW, Misri S, Kent N, Oberlander TF, Grunau RE, Fitzgerald C, Rurak DW. Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast- feeding. Br J Clin Pharmacol 2006; 61:155-63.
Cited by
Sorted by citations
Items 401–500 of 1,000
Epigenetics, maternal prenatal psychosocial stress, and infant mental health
DeSocio, J. E. (2018) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2018.09.001 · Cited by 72
Robinson, L. R., Bitsko, R. H., O’Masta, B., Holbrook, J. R., Ko, J. Y., Barry, C. M., Maher, B. S., Cerles, A. A., Saadeh, K., MacMillan, L., et al. (2022) · Prevention Science · doi:10.1007/s11121-022-01383-3 · Cited by 78
Perinatal depression and infant and toddler neurodevelopment: A systematic review and meta-analysis
Fan, X., Ni, W., Tu, Y., Zang, T., Bai, J., Peng, G., & Liu, Y. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105579 · Cited by 70
Epigenetics and developmental plasticity across species
Champagne, F. A. (2012) · Developmental Psychobiology · doi:10.1002/dev.21036 · Cited by 69
Genetics and Peer Relations: A Review
Brendgen, M. R. (2012) · Journal of Research on Adolescence · doi:10.1111/j.1532-7795.2012.00798.x · Cited by 70
Juruena, M. F., Baes, C. V. W., Menezes, I. C., & Graeff, F. G. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150105125500 · Cited by 69
Prenatal maternal psychopathology and stress and offspring HPA axis function at 6 years
Molenaar, N. M., Tiemeier, H. W., van Rossum, E. F. C., Hillegers, M. H. J., Bockting, C., Hoogendijk, W. J. G., van den Akker, E. L., den Berg, M. P. L., & Marroun, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.003 · Cited by 68
Ramo-Fernández, L., Boeck, C., Koenig, A. M., Schury, K., Binder, E. B., Gündel, H., Fegert, J. M., Karabatsiakis, A., & Kolassa, I.-T. (2019) · Scientific Reports · doi:10.1038/s41598-018-36689-2 · Cited by 67
Riyahi, S., Sánchez-Delgado, M., Calafell, F., Monk, D., & Señar, J. C. (2015) · Epigenetics · doi:10.1080/15592294.2015.1046027 · Cited by 67
Can we observe epigenetic effects on human brain function?
Nikolova, Y. S., & Hariri, A. R. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.003 · Cited by 73
Early determinants of mental health
Räikkönen, K., Pesonen, A., Roseboom, T. J., & Eriksson, J. G. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.03.001 · Cited by 67
Dopamine D4 Receptor Gene Associated with Fairness Preference in Ultimatum Game
Zhong, S., Israel, S., Shalev, I., Xue, H., Ebstein, R. P., & Chew, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013765 · Cited by 70
Soubry, A., Murphy, S. K., Huang, Z., Murtha, A. P., Schildkraut, J. M., Jirtle, R. L., Wang, F., Kurtzberg, J., Demark‐Wahnefried, W., Forman, M., et al. (2011) · Clinical Epigenetics · doi:10.1186/1868-7083-3-2 · Cited by 67
Humphreys, K. L., Moore, S. R., Davis, E., MacIsaac, J. L., Lin, D. T. S., Kobor, M. S., & Gotlib, I. H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0582-7 · Cited by 70
Sinclair, D., Webster, M. J., Wong, J., & Weickert, C. S. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.28 · Cited by 66
Khalyfa, A., Carreras, A., Hakim, F., Cunningham, J. M., Wang, Y., & Gozal, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.12 · Cited by 67
Cárdenas, A., Houseman, E. A., Baccarelli, A., Quamruzzaman, Q., Rahman, M., Mostofa, G., Wright, R. O., Christiani, D. C., & Kile, M. L. (2015) · Epigenetics · doi:10.1080/15592294.2015.1105424 · Cited by 66
Pickles, A. R., Sharp, H. M., Hellier, J. M., & Hill, J. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0886-6 · Cited by 66
NR3C1 hypermethylation in depressed and bullied adolescents
Efstathopoulos, P., Andersson, F., Melas, P. A., Yang, L. L., Villaescusa, J. C., Rüegg, J., Ekström, T. J., Forsell, Y., Galanti, M. R., & Lavebratt, C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0169-8 · Cited by 74
Provençal, N., Suderman, M. J., Caramaschi, D., Wang, D., Hallett, M. T., Vitaro, F., Tremblay, R. E., & Szyf, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071691 · Cited by 66
Mapping the developmental pathways of child conduct problems through the neurobiology of empathy
Moul, C., Hawes, D. J., & Dadds, M. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.016 · Cited by 72
Integrating and synthesizing adversity and resilience knowledge and action: The ICARE model.
Hays-Grudo, J., Morris, A. S., Beasley, L. O., Ciciolla, L. M., Shreffler, K. M., & Croff, J. M. (2021) · American Psychologist · doi:10.1037/amp0000766 · Cited by 65
Epigenetics as the mediator of fetal programming of adult onset disease: what is the evidence?
Saffery, R., & Novakovic, B. (2014) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12431 · Cited by 67
Wiley, J. W., Higgins, G. A., & Athey, B. D. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12706 · Cited by 66
Gemmel, M., Bögi, E., Ragan, C. M., Hazlett, M. F., Dubovický, M., van den Hove, D., Oberlander, T. F., Charlier, T. D., & Pawluski, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.023 · Cited by 68
Self-citationEdelman, S., Shalev, I., Uzefovsky, F., Israel, S., Knafo, A., Kremer, I., Mankuta, D., Kaitz, M., & Ebstein, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048597 · Cited by 64
Monteleone, M. C., Adrover, E., Pallarés, M. E., Antonelli, M. C., Frasch, A. C., & Brocco, M. A. (2014) · Epigenetics · doi:10.4161/epi.25925 · Cited by 64
Kentner, A. C., Cryan, J. F., & Brummelte, S. (2019) · Developmental Psychobiology · doi:10.1002/dev.21775 · Cited by 64
Bakusic, J., Vrieze, E., Ghosh, M., Bekaert, B., Claes, S. J., & Godderis, L. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100272 · Cited by 64
Uddin, M., Sipahi, L., Li, J., & Koenen, K. C. (2013) · Depression and Anxiety · doi:10.1002/da.22167 · Cited by 66
Early environments, glucocorticoid receptors, and behavioral epigenetics.
Champagne, F. A. (2013) · Behavioral Neuroscience · doi:10.1037/a0034186 · Cited by 65
Environmental enrichment as an intervention for adverse health outcomes of prenatal stress
McCreary, J. K., & Metz, G. A. S. (2016) · Current Zoology · doi:10.1093/eep/dvw013 · Cited by 64
Epigenetics/Programming in the HPA Axis
Buschdorf, J. P., & Meaney, M. J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140027 · Cited by 64
Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation
Sammallahti, S., Hidalgo, A. P. C., Tuominen, S., Malmberg, A., Mulder, R. H., Brunst, K. J., Alemany, S., McBride, N., Yousefi, P., Heiss, J. A., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00976-0 · Cited by 63
Doan, S. N. (2021) · Developmental Psychobiology · doi:10.1002/dev.22107 · Cited by 68
Inheritance of paternal lifestyles and exposures through sperm DNA methylation
Greeson, K. W., Crow, K. M. S., Edenfield, R. C., & Easley, C. A. (2023) · Nature Reviews Urology · doi:10.1038/s41585-022-00708-9 · Cited by 64
Conradt, E. D., Fei, M., LaGasse, L. L., Tronick, E. Z., Guerin, D. J., Gorman, D., Marsit, C. J., & Lester, B. M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00130 · Cited by 63
Kumsta, R. (2019) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/papt.12227 · Cited by 66
Efficacy of progressive muscle relaxation on pregnancy outcome among anxious indian primi mothers
Singaravelu, R., & SanjeevaReddy, N. (2019) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/ijnmr.ijnmr_207_18 · Cited by 63
Güiza, F., Vanhorebeek, I., Verstraete, S., Verlinden, I., Derese, I., Ingels, C., Dulfer, K., Verbruggen, S. C. A. T., Guerra, G. G., Joosten, K., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30046-1 · Cited by 62
Placental CRH as a Signal of Pregnancy Adversity and Impact on Fetal Neurodevelopment
Kassotaki, I., Valsamakis, G., Mastorakos, G. P., & Grammatopoulos, D. K. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.714214 · Cited by 67
Henderson, A. J., & Warner, J. O. (2012) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2012.01.006 · Cited by 63
Blaze, J., & Roth, T. L. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.04.004 · Cited by 64
DNA methylation, the early-life social environment and behavioral disorders
Szyf, M. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9079-2 · Cited by 63
Castillo, P., Ibanez-Carrasco, F., Guajardo, A., Llanos, M. N., & Ronco, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044139 · Cited by 64
Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
Zovkic, I. B., Meadows, J. P., Kaas, G. A., & Sweatt, J. D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00060 · Cited by 66
Champagne, F. A., & Rahia Mashoodh, A. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01622.x · Cited by 62
St‐Hilaire, A., Steiger, H., Liu, A., Laplante, D. P., Thaler, L., Magill, T., & King, S. (2015) · International Journal of Eating Disorders · doi:10.1002/eat.22391 · Cited by 62
Huizink, A. C., & de Rooij, S. R. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000354 · Cited by 68
Early life trauma, depression and the glucocorticoid receptor gene—An epigenetic perspective
Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H. (2015) · Psychological Medicine · doi:10.1017/s0033291715001555 · Cited by 61
Paquette, A. G., Lester, B. M., Lesseur, C., Armstrong, D. A., Guerin, D. J., Appleton, A. A., & Marsit, C. J. (2015) · Epigenomics · doi:10.2217/epi.15.28 · Cited by 63
Incorporating epigenetic mechanisms to advance fetal programming theories
Conradt, E., Adkins, D. E., Crowell, S. E., Raby, K. L., Diamond, L. M., & Ellis, B. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000469 · Cited by 60
Glucocorticoid receptor gene methylation and HPA-axis regulation in adolescents. The TRAILS study
van der Knaap, L. J., Oldehinkel, A. J., Verhulst, F. C., van Oort, F. V. A., & Riese, H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.012 · Cited by 60
Spry, E., Moreno-Betancur, M., Becker, D., Romaniuk, H., Carlin, J. B., Molyneaux, E., Howard, L. M., Ryan, J., Letcher, P., McIntosh, J., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291719000709 · Cited by 60
Tyrka, A. R., Parade, S. H., Eslinger, N. M., Marsit, C. J., Lesseur, C., Armstrong, D. A., Philip, N. S., Josefson, B., & Seifer, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000176 · Cited by 60
Barker, E. D., Cecil, C. A. M., Walton, E., Houtepen, L. C., O’Connor, T. G., Danese, A., Jaffee, S. R., Jensen, S. K. G., Pariante, C. M., McArdle, W. L., et al. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000330 · Cited by 65
Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome
Zhu, J.-Q., Zhu, L., Liang, X., Xing, F., Schatten, H., & Sun, Q. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap089 · Cited by 62
Epigenetic alterations associated with war trauma and childhood maltreatment
Ramo‐Fernández, L., Schneider, A., Wilker, S., & Kolassa, I. (2015) · Behavioral Sciences & the Law · doi:10.1002/bsl.2200 · Cited by 59
Alvarez, H. A. O., Appleton, A. A., Fuller, C. H., Belcourt, A., & Kubzansky, L. D. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0191-2 · Cited by 66
Aging and stress: past hypotheses, present approaches and perspectives.
Garrido, P. (2011) · Europe PMC (PubMed Central) · Cited by 61
Barker, E. D. (2012) · Psychological Medicine · doi:10.1017/s0033291712002450 · Cited by 59
Lee, R. S. (2018) · Alcohol research · doi:10.35946/arcr.v39.2.05 · Cited by 59
Ritter, H. D., Antonova, L., & Mueller, C. R. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0423-t · Cited by 59
Sobolewski, M., Varma, G., Adams, B., Anderson, D. W., Schneider, J. S., & Cory‐Slechta, D. A. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy046 · Cited by 60
The biological basis and clinical significance of hormonal imprinting, an epigenetic process
Csaba, G. (2011) · Clinical Epigenetics · doi:10.1007/s13148-011-0024-8 · Cited by 58
Ancestry Dependent DNA Methylation and Influence of Maternal Nutrition
Mozhui, K., Smith, A. K., & Tylavsky, F. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118466 · Cited by 61
The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres
Blaze, J., Asok, A., & Roth, T. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00079 · Cited by 61
Kim, D. J., Kubzansky, L. D., Baccarelli, A., Sparrow, D., Spiro, A., Tarantini, L., Cantone, L., Vokonas, P., & Schwartz, J. D. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-009790 · Cited by 61
Stonawski, V., Frey, S., Golub, Y., Rohleder, N., Kriebel, J., Goecke, T. W., Fasching, P. A., Beckmann, M. W., Kornhuber, J., Kratz, O., et al. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000056 · Cited by 62
Psychotherapy and Genetic Neuroscience: An Emerging Dialog
Jiménez, J. P., Botto, A., Herrera, L., Leighton, C., Rossi, J. L., Quevedo, Y., Silva, J. R., Martínez, F. I., Assar, R., Salazar, L. A., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00257 · Cited by 62
Doi, S. K., Fujiwara, T., & Isumi, A. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000334 · Cited by 58
Zhou, A., & Ryan, J. (2023) · Genes · doi:10.3390/genes14081639 · Cited by 57
“stress [57] and the cord blood of mothers with third trimester depression/anxiety [58].”
BackgroundWolf, C., & Linden, D. E. J. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00752.x · Cited by 59
The Epigenetic Lorax: Gene–Environment Interactions in Human Health
Latham, K. E., Sapienza, C., & Engel, N. (2012) · Epigenomics · doi:10.2217/epi.12.31 · Cited by 63
Colle, R., Deflesselle, É., Martin, S., David, D. J. P., Hardy, P., ŢĂRANU, A. M., Falissard, B., Verstuyft, C., & Corruble, E. (2015) · Pharmacogenomics · doi:10.2217/pgs.15.56 · Cited by 60
Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort
Brunst, K. J., Tignor, N. L., Just, A. C., Liu, Z., Lin, X., Hacker, M. R., Enlow, M. B., Wright, R. O., Wang, P., Baccarelli, A., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1497387 · Cited by 57
Shields, A. E., Wise, L. A., Ruiz-Narváez, E., Seddighzadeh, B., Byun, H., Cozier, Y. C., Rosenberg, L. A., Palmer, J. R., & Baccarelli, A. (2016) · Epigenomics · doi:10.2217/epi-2016-0074 · Cited by 60
Belsky, J., & Shalev, I. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000900 · Cited by 58
Viuff, A. F., Sharp, G. C., Rai, D., Henriksen, T. B., Pedersen, L. H., Kyng, K. J., Staunstrup, N. H., Hidalgo, A. P. C., Neumann, A., Felix, J. F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0286-4 · Cited by 58
Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms
Parets, S. E., Bedient, C. E., Menon, R., & Smith, A. K. (2014) · Biology · doi:10.3390/biology3030498 · Cited by 57
Marić, N. P., & Adžić, M. (2013) · PubMed · Cited by 56
Hoang, M., Kim, J. J., Kim, Y., Tong, E. L., Benjamin, T., Liu, Y., Shi, S., Lee, C.-R., Hong, C., Wang, C., et al. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.05.021 · Cited by 55
Psychosocial Stress and Adversity: Effects from the Perinatal Period to Adulthood
Barrero‐Castillero, A., Morton, S. U., Nelson, C. A., & Smith, V. C. (2019) · NeoReviews · doi:10.1542/neo.20-12-e686 · Cited by 60
How do established developmental risk-factors for schizophrenia change the way the brain develops?
Eyles, D. W. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01273-2 · Cited by 58
The interplay of biology and the environment broadly defined.
Diamond, A. D. (2009) · Developmental Psychology · doi:10.1037/a0014601 · Cited by 58
Zaidan, H., & Gaisler‐Salomon, I. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.013 · Cited by 55
Kantake, M., Yoshitake, H., Ishikawa, H., Araki, Y., & Shimizu, T. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005318 · Cited by 55
Epigenetic perpetuation of the impact of early life stress on behavior
Janusek, L. W., Tell, D., & Mathews, H. L. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.004 · Cited by 54
Schury, K., & Kolassa, I. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06617.x · Cited by 53
Women's posttraumatic stress symptoms and autism spectrum disorder in their children
Roberts, A. L., Koenen, K. C., Lyall, K., Ascherio, A., & Weisskopf, M. G. (2014) · Research in Autism · doi:10.1016/j.rasd.2014.02.004 · Cited by 59
Brietzke, E. M., Mansur, R. B., Soczynska, J. K., Powell, A. M., & McIntyre, R. S. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.004 · Cited by 56
Barua, S., Kuizon, S., Brown, W. T., & Junaid, M. A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00168 · Cited by 53
What drives phenotypic divergence among coral clonemates of Acropora palmata ?
Devlin-Durante, M. K., Baums, I. B., Williams, D. E., Vohsen, S. A., & Kemp, D. W. (2019) · Molecular Ecology · doi:10.1111/mec.15140 · Cited by 53
Rogers, A., Youssef, G. J., Teague, S. J., Sunderland, M., Bas, G. A. L., Macdonald, J. A., Mattick, R. P., ALLSOP, S. J., Elliott, E. J., Olsson, C. A., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.06.020 · Cited by 52
de Rooij, S. R., Costello, P. M., Veenendaal, M. V. E., Lillycrop, K. A., Gluckman, P. D., Hanson, M. A., Painter, R. C., & Roseboom, T. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.010 · Cited by 52
Neuroimmune endocrine effects of antidepressants
Carvalho, L. A. (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16409 · Cited by 52
Steiger, H., & Thaler, L. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.041 · Cited by 52
Prenatal programming of postnatal plasticity revisited—And extended
Hartman, S., & Belsky, J. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000548 · Cited by 60
DNA methylation correlates of PTSD: Recent findings and technical challenges
Morrison, F. G., Miller, M. W., Logue, M. W., Assef, M., & Wolf, E. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.011 · Cited by 56
Manning, K. Y., Long, X., Watts, D., Tomfohr-Madsen, L., Giesbrecht, G. F., & Lebel, C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.05.011 · Cited by 51
Metadata
- Authors
- Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M.
- Affiliations
- University of British Columbia (CA)
- Child and Family Research Institute (CA)
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2008-03-24
- Volume
- 3
- Issue
- 2
- Pages
- 97-106
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2106670153
- Semantic Scholar
- ec7f4fffee56f7acb1607720d117b531525b0713
- Cited by
- 1,432
- References
- 45
- Citations by year
- 2026: 30 · 2025: 42 · 2024: 50 · 2023: 53 · 2022: 56 · 2021: 82 · 2020: 104 · 2019: 65 · 2018: 91 · 2017: 95 · 2016: 117 · 2015: 123 · 2014: 124 · 2013: 100 · 2012: 122
- FWCI
- 58.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epigenetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation (12-FY01-30)
- Canadian Institutes of Health Research (54490, 57837, MOP54490)
- National Institute on Alcohol Abuse and Alcoholism (R01AA007789)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- maternal depression, prenatal exposure, glucocorticoid receptor gene, NR3C1, DNA methylation, hypothalamic-pituitary-adrenal axis, cortisol stress response, serotonin reuptake inhibitors, umbilical cord blood, epigenetic regulation, maternal mood, infant development
- MeSH terms
- Adult, Base Sequence, Depression, Exons, Female, Fetal Blood, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Leukocytes, Mononuclear, Molecular Sequence Data, Mothers, Pituitary-Adrenal System, Pregnancy, Pregnancy Complications, Promoter Regions, Genetic, Receptors, Glucocorticoid, Selective Serotonin Reuptake Inhibitors, Antidepressive Agents, Second-Generation, CpG Islands, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
