The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
The regulation of inflammation by interferons and their STATs
Open accessAbstract
Interferons (IFN) are subdivided into type I IFN (IFN-I, here synonymous with IFN-α/β), type II (IFN-γ) and type III IFN (IFN-III/IFN-λ) that reprogram nuclear gene expression through STATs 1 and 2 by forming STAT1 dimers (mainly IFN-γ) or the ISGF3 complex, a STAT1-STAT2-IRF9 heterotrimer (IFN-I and IFN-III). Dominant IFN activities in the immune system are to protect cells from viral replication and to activate macrophages for enhanced effector function. However, the impact of IFN and their STATs on the immune system stretches far beyond these activities and includes the control of inflammation. The goal of this review is to give an overview of the different facets of the inflammatory process that show regulatory input by IFN/STAT.
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Cites
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Cited by
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Loh, C.-Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00048 · Cited by 348
Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis
Fensterl, V., & Sen, G. C. (2015) · Journal of Virology · doi:10.1128/jvi.02744-14 · Cited by 339
Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.003 · Cited by 317
The Role of Interferons in Inflammation and Inflammasome Activation
Kopitar-Jerala, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00873 · Cited by 260
Metadata
- Authors
- Rauch, I., Müller, M., & Decker, T.
- Venue
- JAK-STAT
- Publisher
- Informa UK Limited
- Published
- 2013-01
- Volume
- 2
- Issue
- 1
- Pages
- e23820-e23820
- ISSN
- 2162-3988 (ISSN-L)
- 2162-3996
- OpenAlex
- W1986107968
- Cited by
- 281
- References
- 137
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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