The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
Open accessAbstract
An important role for bioenergetic dysfunction is increasingly emerging to potentially explain the paradox of clinical and biochemical organ failure in sepsis yet minimal cell death, maintained tissue oxygenation and recovery in survivors. Associations are well-recognized between the degree of mitochondrial dysfunction and outcomes. While this does not confirm cause-and-effect, it does nevertheless suggest a new route for therapeutic intervention focused on either mitochondrial protection or acceleration of the recovery process through stimulation of mitochondrial biogenesis (new protein turnover). This is particularly pertinent in light of the multiple trial failures related to immunomodulatory therapies. This overview will provide insights into mitochondrial biology, the relevance to sepsis, and therapeutic opportunities that possibly emerge.
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Cites
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Cited by
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Sepsis: a roadmap for future research
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The immune system’s role in sepsis progression, resolution, and long-term outcome
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The Pathogenesis of Sepsis and Potential Therapeutic Targets
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Metadata
- Authors
- Singer, M.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-11
- Volume
- 5
- Issue
- 1
- Pages
- 66-72
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W2057585285
- Cited by
- 617
- References
- 11
- FWCI
- 16.43
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
