Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Aβ-induced cognitive disorder rats
Open accessAbstract
Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was examined, and effects of curcumin on spatial learning and memory abilities and hippocampal axonal growth were investigated in amyloid β-protein (Aβ)1-40-induced AD rats. Results showed that the expression of NgR in the AD group significantly increased and the number of axonal protein-positive fibers significantly reduced. The spatial learning and memory abilities of AD rats were significantly improved in the curcumin group. Furthermore, hippocampal expressions of NgR mRNA and protein decreased, and the expression of axonal protein significantly increased. There was a negative correlation between the expression of NgR and axonal growth. Together, these results suggested that curcumin could improve the spatial learning and memory abilities of AD rats. The mechanism might be related with its lowering of hippocampal NgR expression and promoting axonal regeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Treatment with 300 mg/kg curcumin reversed spatial learning and memory impairment accompanied by hippocampal regeneration in the Aβ1-40 Alzheimer's disease model.
“The protective effect of curcumin on a Aβ1–40 AD model was documented by Wang et al. [132] and Yin et al. [133], where treatment with 300 mg/kg curcumin reversed spatial learning and memory impairment accompanied by hippocampal regeneration.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [133]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Chomczyński, P. (1993) · PubMed · Cited by 2,788 · see citing works
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., & Glabe, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48529-8 · Cited by 1,014 · see citing works
Motterlini, R., Foresti, R., Bassi, R., & Green, C. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00294-x · Cited by 846 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
Fournier, A. E., Takizawa, B. T., & Strittmatter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01416.2003 · Cited by 644 · see citing works
A Potential Role of the Curry Spice Curcumin in Alzheimers Disease
Ringman, J. M., Frautschy, S. A., Cole, G. M., Masterman, D. L., & Cummings, J. L. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585882 · Cited by 519 · see citing works
Thiyagarajan, M., & Sharma, S. S. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.06.042 · Cited by 418 · see citing works
The Nogo-66 receptor: focusing myelin inhibition of axon regeneration
McGee, A. W., & Strittmatter, S. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00062-6 · Cited by 298 · see citing works
Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?
Perry, E. K., & Howes, M. R. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00202.x · Cited by 160 · see citing works
Giri, R. K., Rajagopal, V., & Kalra, V. K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02800.x · Cited by 143 · see citing works
Progressive brain dysfunction following intracerebroventricular infusion of beta1–42-amyloid peptide
Nakamura, S., Murayama, N., Noshita, T., Annoura, H., & Ohno, T. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02704-4 · Cited by 140 · see citing works
Park, J. H., Gimbel, D. A., GrandPré, T., Lee, J.-K., Kim, J., Li, W., Lee, D. H. S., & Strittmatter, S. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3291-05.2006 · Cited by 134 · see citing works
Challenges associated with curcumin therapy in Alzheimer disease
Belkacemi, A., Doggui, S., Dao, L. H., & Ramassamy, C. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002055 · Cited by 129 · see citing works
COLE, G. M., MORIHARA, T., LIM, G. P., YANG, F., BEGUM, A., & FRAUTSCHY, S. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.005 · Cited by 129 · see citing works
Zhang, X., Hongmei, Z., Lu, S. Q., & Li, Y. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70629-6 · Cited by 116 · see citing works
Park, J. H., Widi, G. A., Gimbel, D. A., Harel, N. Y., Lee, D. H. S., & Strittmatter, S. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4504-06.2006 · Cited by 107 · see citing works
Nogo-A Expression in the Human Hippocampus in Normal Aging and in Alzheimer Disease
Gil, V., Nicolás, O., Mingorance, A., Ureña, J. M., Tang, B. L., Hirata, T., Sáez‐Valero, J., Ferrer, I., Soriano, E., & del Rı́o, J. A. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000222894.59293.98 · Cited by 72 · see citing works
Inhibitory effect of curcumin on the Al(III)-induced Aβ42 aggregation and neurotoxicity in vitro
Jiang, T., Zhi, X., Zhang, Y., Pan, L., & Zhou, P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.04.015 · Cited by 61 · see citing works
Protective Effects of Curcumin on Amyloid-β-Induced Neuronal Oxidative Damage
Huang, H., Chang, P., Dai, X., & Jiang, Z.-F. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0754-9 · Cited by 53 · see citing works
Zhu, H., Guo, H.-F., Hou, H.-L., Liu, Y., Sheng, S.-L., & Zhou, J.-N. (2007) · Human Pathology · doi:10.1016/j.humpath.2006.09.010 · Cited by 27 · see citing works
Wang, J., Zhang, Y. J., & Du, S. (2012) · PubMed · Cited by 20 · see citing works
Luo, H. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.692 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Paxinos G and Watson C (1998). The Rat Brain in Stereotaxic Coodinate. 4th edn. Academic Press, New York.
Cited by
Sorted by citations
Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
The impact of curcumin and its modified formulations on Alzheimer's disease
Farkhondeh, T., Samarghandian, S., Pourbagher‐Shahri, A. M., & Sedaghat, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28411 · Cited by 109 · see citing works
Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery
Ege, D. (2021) · Materials · doi:10.3390/ma14123332 · Cited by 91 · see citing works
Curcumin alleviates cisplatin-induced learning and memory impairments
Öz, M. C., Atalık, K. E. N., Yerlikaya, F. H., & Demir, E. A. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.05.001 · Cited by 69 · see citing works
Potential hippocampal genes and pathways involved in Alzheimer’s disease: a bioinformatic analysis
Zhang, L., Guo, X. Q., Chu, J. F., Zhang, X., Yan, Z., & Li, Y. Z. (2015) · Genetics and Molecular Research · doi:10.4238/2015.june.29.15 · Cited by 54 · see citing works
Amoah, S. K. S., Dalla Vecchia, M. T., Pedrini, B., Carnhelutti, G. L., Gonçalves, A. E., dos Santos, D. A., Biavatti, M. W., & de Souza, M. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.018 · Cited by 40 · see citing works
Turmeric improves post-prandial working memory in pre-diabetes independent of insulin.
Lee, M., Wahlqvist, M. L., Chou, Y., Fang, W., Lee, J., Kuan, J.-C., Liu, H., Lu, T.-M., Xiu, L., Hsu, C., et al. (2014) · PubMed · doi:10.6133/apjcn.2014.23.4.24 · Cited by 37 · see citing works
Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults
Santos-Parker, J. R., Lubieniecki, K. L., Rossman, M. J., Ark, H. J. V., Bassett, C. J., Strahler, T. R., Chonchol, M., Justice, J., & Seals, D. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170029 · Cited by 31 · see citing works
Huang, H., Chang, P., Lu, S., Zheng, B.-W., & Jiang, Z.-F. (2015) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1006331 · Cited by 30 · see citing works
Lagoa, R., Logesh, R., Violante, C., Babiaka, S. B., Marques‐da‐Silva, D., Kapoor, B., Reis, F., & Atanasov, A. G. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108568 · Cited by 24 · see citing works
Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis
Yu, L.-R., Li, N., Li, B., Ye, K., Guo, J.-Y., Shan, J., Cao, L.-W., Song, M., Wang, Y., Lee, T.-S., et al. (2025) · The journal of prevention of Alzheimer's disease · doi:10.1016/j.tjpad.2025.100248 · Cited by 21 · see citing works
Fan, L., & Zhang, Z. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-02946-7 · Cited by 12 · see citing works
Zholos, A. V., Moroz, O. F., & Storozhuk, M. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467211666181012150847 · Cited by 12 · see citing works
Gimblet, C. J., Kruse, N. T., Geasland, K. M., Michelson, J., Sun, M., Eyck, P. T., Linkenmeyer, C., Mandukhail, S. R., Rossman, M. J., Sambharia, M., et al. (2024) · Antioxidants · doi:10.3390/antiox13080983 · Cited by 8 · see citing works
Curcumin induces structural change and reduces the growth of amyloid-β fibrils: a QCM-D study
Wang, C.-G., Xu, L., Cheng, F., Wang, H.-Q., & Jia, L. (2015) · RSC Advances · doi:10.1039/c5ra02314a · Cited by 7 · see citing works
Kumaree, K. K., Brimson, J. M., Verma, K., Chuchawankul, S., Tencomnao, T., & Prasansuklab, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-93462-y · Cited by 6 · see citing works
Shabbir, A., Rehman, K., Akbar, M., & Akash, M. S. H. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220607161328 · Cited by 6 · see citing works
Zhang, Y. (2018) · International Journal of Polymer Science · doi:10.1155/2018/3041417 · Cited by 6 · see citing works
Potential Neuroprotective Effects of Curcumin against Dementia
Brondino, N., Fusar‐Poli, L., Panisi, C., & Politi, P. (2017) · doi:10.1002/9781119155195.ch22 · Cited by 4 · see citing works
Design of data mining algorithm based on rough entropy for us stock market abnormality
Wang, G., & Miao, J. (2020) · Journal of Intelligent & Fuzzy Systems · doi:10.3233/jifs-189006 · Cited by 3 · see citing works
Dorman, G. S., Flores, I., Gutiérrez, C., Castaño, R. F., Aldecoa, M., & Kim, L. M. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210809121230 · Cited by 2 · see citing works
Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature
Dhingra, A. K., & Chopra, B. (2022) · The Natural Products Journal · doi:10.2174/2210315512666220627153553 · Cited by 1 · see citing works
Paliwal, A., Nigam, A. K., Gour, J. K., Singh, D., Pandey, P., & Singh, M. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00018-9 · Cited by 1 · see citing works
Zhang, S., Zhou, Y., Zhang, K.-J., Luan, J., & Qi, S.-M. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.10.024
Friel, H., & Frautschy, S. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812259-4.00006-0
Gofir, A., Rochmah, M. A., Wibowo, S., Hakimi, M., & Mustofa, M. (2021) · Indonesian Journal of Pharmacology and Therapy · doi:10.22146/ijpther.1765
- Authors
- Yin, H. L., Wang, Y. L., Li, J. F., Han, B., Zhang, X. X., Wang, Y. T., & Geng, S.
- Venue
- Genetics and Molecular Research
- Publisher
- Genetics and Molecular Research
- Published
- 2014
- Volume
- 13
- Issue
- 1
- Pages
- 2039-2047
- ISSN
- 1676-5680 (ISSN-L)
- OpenAlex
- W2102966243
- Cited by
- 27
- References
- 24
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics and Molecular Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chongqing Medical University
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- curcumin, Nogo receptor, axon regeneration, Alzheimer's disease, amyloid-beta, hippocampus, spatial learning and memory, axon growth inhibition, cognitive impairment
- MeSH terms
- Nogo Receptor 1, Alzheimer Disease, Animals, Axons, Curcumin, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Male, Myelin Proteins, Receptors, Cell Surface, RNA, Messenger, Amyloid beta-Peptides, Maze Learning, Rats, GPI-Linked Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
