The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
Open accessAbstract
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
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“The receptors to these peptides are expressed locally in the gut enteric neurons and vagal afferents, as well as in the central nervous system (CNS), including the brainstem and hypothalamus (De Silva and Bloom, 2012;Richards et al., 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as De Silva and Bloom, 2012
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“This basal secretion of GLP-1 and PYY is thought to play an important role in the control of food intake, body weight, and metabolism since obese individuals are generally characterized by decreased serum levels of both GLP-1 and PYY (De Silva and Bloom, 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as De Silva and Bloom, 2012
Experimental — accuracy not yet measuredIn the citing paper
“GLP-1 and PYY signal the brain via the vagus nerve, impacting appetite and feeding [89].”
From Unraveling the Connections: Eating Issues, Microbiome, and Gastrointestinal Symptoms in Autism Spectrum Disorder (2025) · cites this paper as [89]
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Citations
Cites
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Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Short-chain fatty acids in control of body weight and insulin sensitivity
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Metadata
- Authors
- Silva, A. D., & Bloom, S. R.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Bloom, Stephen R.
- ORCID
- Bloom, Stephen R.
- Venue
- Gut and Liver
- Published
- 2012-01-30
- Volume
- 6
- Issue
- 1
- Pages
- 10-20
- ISSN
- 1976-2283 (ISSN-L)
- 2005-1212
- PMC
- PMC3286726
- OpenAlex
- W2004923528
- Cited by
- 373
- References
- 85
- Citations by year
- 2026: 29 · 2025: 46 · 2024: 22 · 2023: 19 · 2022: 31 · 2021: 23 · 2020: 36 · 2019: 36 · 2018: 32 · 2017: 23 · 2016: 20 · 2015: 16 · 2014: 18 · 2013: 15 · 2012: 7
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut and Liver (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- gastrointestinal hormones, appetite regulation, peptide YY, glucagon-like peptide-1, obesity, gastric bypass, food intake regulation, therapeutic target
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