Cited by 373Regulation of Appetite and ObesityPharmacology and Obesity TreatmentDiabetes Treatment and Management

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

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Silva, Akila De, Bloom, Stephen R.·2012·Gut and Liver

Abstract

The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.

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Research works printed but not linked: 7

  1. Rossi, 1998, Endocrinology, 139, 4428, 10.1210/en.139.10.4428 · DOI · Paper page
  2. Abbott, 2001, Endocrinology, 142, 3457, 10.1210/en.142.8.3457 · DOI
  3. Lluis, 1989, Rev Esp Fisiol, 45, 377
  4. Kanatani, 2000, Endocrinology, 141, 1011, 10.1210/en.141.3.1011 · DOI
  5. Kieffer, 1995, Endocrinology, 136, 3585, 10.1210/en.136.8.3585 · DOI · Paper page
  6. Willms, 1996, J Clin Endocrinol Metab, 81, 327, 10.1210/jc.81.1.327 · DOI · Paper page
  7. Larsen, 1997, Endocrinology, 138, 4445, 10.1210/en.138.10.4445 · DOI

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Metadata

Authors
Silva, A. D., & Bloom, S. R.
Affiliations
Imperial College London (GB)
Corresponding author
Bloom, Stephen R.
Venue
Gut and Liver
Published
2012-01-30
Volume
6
Issue
1
Pages
10-20
ISSN
  • 1976-2283 (ISSN-L)
  • 2005-1212
OpenAlex
W2004923528
Cited by
373
References
85
Citations by year
2026: 29 · 2025: 46 · 2024: 22 · 2023: 19 · 2022: 31 · 2021: 23 · 2020: 36 · 2019: 36 · 2018: 32 · 2017: 23 · 2016: 20 · 2015: 16 · 2014: 18 · 2013: 15 · 2012: 7
FWCI
7.99
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Gut and Liver (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
gastrointestinal hormones, appetite regulation, peptide YY, glucagon-like peptide-1, obesity, gastric bypass, food intake regulation, therapeutic target

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