Cited by 30Mollusks and Parasites StudiesWound Healing and TreatmentsSilk-based biomaterials and applications

Snail mucus as an innovative ingredient used in the cosmetology and medical industry

Open access
Student Scientific Association of Biologists - Biocosmetology Section, Faculty of Environmental Biology, University of Life Sciences in Lublin, Wargala, Eliza, Zalewska, Agnieszka, Student Scientific Association of Biologists - Biocosmetology Section, Faculty of Environmental Biology, University of Life Sciences in Lublin, Sławska, Martyna, Student Scientific Association of Biologists - Biocosmetology Section, Faculty of Environmental Biology, University of Life Sciences in Lublin, Kot, Izabela, Sub-department of Entomology, Department of Plant Protection, Faculty of Horticulture and Landscape Architecture, University of Life Sciences in Lublin·2023·Aesthetic Cosmetology and Medicine

Abstract

Snail slime is obtained from Helix aspersa Müller and H. aspersa var. maxima. Two types of mucus are obtained: lymosine and cryptosine, the one used in medicine and cosmetology. The work aimed to present the method of obtaining snail slime, to analyze its qualitative and quantitative composition and properties based on literature data. This raw material, in addition to antibacterial, antifungal, antimicrobial, antiviral and anticancer properties, also has antioxidant, regenerative, stimulating, moisturizing, nourishing, cleansing, anti-wrinkle and sunscreen properties. This gives the opportunity to widely use mucus in the cosmetic and medical industries.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.52336/acm.2023.001

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • SSF has well-documented wound healing effectiveness and anti-inflammatory actions.

    “Beyond cosmetics, SSF’s well-documented wound healing effectiveness and anti-inflammatory actions extend its use to medical-grade products like wound dressings, ointments, and therapeutic gels [5].”

    From Hidden benefits of snail mucus: A natural skincare marvel (2024) · cites this paper as [5]

    The SNAIL MUCUS IN MEDICINE and SUMMARY sections say snail mucus aids wound healing and is used in wound-healing agents. SNAIL MUCUS IN COSMETOLOGY reports anti-inflammatory effects, but the paper does not establish that these effects are well documented specifically for snail secretion filtrate (SSF). It also does not identify wound dressings, ointments, and therapeutic gels as medical-grade SSF products; the medicine section says its medical use remains under study. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • SSF's wound healing and anti-inflammatory actions extend its use to medical-grade products like wound dressings, ointments, and therapeutic gels.

    “Beyond cosmetics, SSF’s well-documented wound healing effectiveness and anti-inflammatory actions extend its use to medical-grade products like wound dressings, ointments, and therapeutic gels [5].”

    From Hidden benefits of snail mucus: A natural skincare marvel (2024) · cites this paper as [5]

    The ‘Snail Mucus in Medicine’ section says snail mucus is used in wound-healing agents and surgical adhesives, while ‘Snail Mucus in Cosmetology’ reports anti-inflammatory effects. The paper does not establish use in medical-grade wound dressings or ointments; its reference list mentions a wound-healing gel, but the medicine section cautions that medical uses remain under study. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Advances in sustainable and ethical agricultural methods help promote SSF's dual appeal, improving its economic viability.

    “Advances in sustainable and ethical agricultural methods help promote SSF’s dual appeal, improving its economic viability [5].”

    From Hidden benefits of snail mucus: A natural skincare marvel (2024) · cites this paper as [5]

    The SNAIL MUCUS EXTRACTION section describes a modern method as harmless to snails and says it permits repeated extraction. The Abstract describes uses in both cosmetics and medicine. Neither passage says these methods improve the economic viability of snail secretion filtrate (SSF), so that part of the claim is unsupported. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Snail mucus is among ingredients obtained without causing suffering or harm to snails using the non-lethal Muller method or electrical stimulation at low voltage, so there are no ethical concerns with industrial manufacture using these methods.

    “Despite what has just been said concerning the classification, snail mucus is among the ingredients obtained without causing suffering or harm to snails using the non-lethal Muller method (acid stimulation) or electrical stimulation at low voltage; therefore, there are no ethical concerns with the industrial manufacture of snail mucus using these methods [17,24,28].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [28]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured
  • Cosmetic products containing snail mucus are being developed to decrease stretch marks, acne, and pigment spots; soothe and moisturize the skin; eliminate signs of photoaging and reduce damage caused by free radicals; fight age-related skin changes; and recover gray hair color.

    “Cosmetic products in different forms containing snail mucus (ampoules, creams, serums, etc.) are being developed that are designed to decrease stretch marks, acne, and pigment spots; to soothe and moisturize the skin; to eliminate signs of photoaging and reduce damage caused by free radicals; to fight age-related skin changes; to recover gray hair color; etc.”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [28]

    The “Snail Mucus in Cosmetology” section (page not available) describes snail-mucus products and supports the claimed uses for acne, stretch marks, soothing, moisturizing, photoaging, free-radical damage, and skin ageing. The review also says the mucus reduces skin discoloration, which broadly supports the pigment-spots claim. Our copy does not support the claim that these products recover gray hair color. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 41

  1. Zając K. Sekretne życie ślimaków. Wszechświat. 2016;117(4-6):137-140.
  2. Dankowiakowska W, Domagalska B. Ślimaki lądowe jako źródło su- rowców o potencjalnym wykorzystaniu w kosmetologii i dermatologii. Pol J Cosmetol. 2018;21:114-120.
  3. Trapella C, Rizzo R, Gallo S, et al. Helix Complex snail mucus exhibits pro- -survival, proliferative and pro-migration effects on mammalian fibro- blasts. Sci Rep. 2018;8(1):1-10. https://doi.org/10.1038/s41598-018-35816-3 · DOI · Paper page
  4. Mazzulla S, Anile D, De Sio S, et al. In vivo evaluations of emulsion o/w for a new topical anti-aging formulation: Short-term and long-term effica- cy. J Cosmet Dermatol Sci Appl. 2018;8(03):110-125. https://doi.org/10.4236/jcdsa.2018.83013 · DOI · Paper page
  5. Gunia-Krzyżak A, Sowa A, Piska K, et al. Zaskakujące i niezwykłe skład- niki współczesnych kosmetyków. Farmacja Polska. 2021;77(5):287-296. https://doi.org/10.32383/farmpol/138771 · DOI
  6. Vassilev NG, Simova SD, Dangalov M, et al. An 1H NMR-and MS-based study of metabolites profiling of garden snail Helix aspersa mucus. Me- tabolites. 2020;10(9):1-15. https://doi.org/10.3390/metabo10090360 · DOI · Paper page
  7. Rosanto YB, Hasan CY, Rahardjo SA. The Potential of Snail (Achatina Fulica) Mucus Gel as a Phythopharmaca to Accelerate the Inflammation Process during Wound Healing. World J Dent. 2022;13(3):224-227.
  8. Cilia G, Fratini F. Antimicrobial properties of terrestrial snail and slug mucus. J Complement. Integr Med. 2018;15(3):1-10. https://doi.org/10.1515/jcim-2017-0168 · DOI
  9. Smith AM, Robinson TM, Salt MD, et al. Robust cross-links in mol- luscan adhesive gels: testing for contributions from hydrophobic and electrostatic interactions. Comp Biochem Physiol B Biochem Mol Biol. 2019;152(2):110-117. https://doi.org/10.1016/j.cbpb.2008.10.004 · DOI
  10. Gugliandolo E, Cordaro M, Fusco R, et al. Protective effect of snail se- cretion filtrate against ethanol-induced gastric ulcer in mice. Sci Rep. 2021;11(1):1-12. https://doi.org/10.1038/s41598-021-83170-8 · DOI · Paper page
  11. Greistorfer S, Klepal W, Cyran N, et al. Snail mucus -glandular origin and composition in Helix pomatia. Zoology. 2017;122:126-138. https://doi.org/10.1016/j.zool.2017.05.001 · DOI
  12. Wojnarowicz J, Wilk A, Duchnik E, Marchlewicz M. The effect of snail se- cretion filtrate on photoaged skin. J Face Aesthet. 2021;4(2):113-127.
  13. Waluga-Kozłowska E, Jasik K, Wcisło-Dziadecka D, Zimmermann, et al. Snail mucus-a natural origin substance with potential use in medicine. Acta Pol Pharm. 2021;78(6):793-800. https://doi.org/10.32383/appdr/145377 · DOI
  14. Dolashki A, Nissimova A, Daskalova E, et al. Structure and antibacterial activity of isolated peptides from the mucus of garden snail Cornuasper- sum Bulg Chem Commun C. 2018;50:195-200.
  15. Mumuni MA, Kenechukwu FC, Ofokansi KC, et al. Insulin-loaded Mu- coadhesive Nanoparticles Based on Mucin-Chitosan Complexes for Oral Delivery and Diabetes Treatment. Carbohydr Polym. 2020;229:115506. https://doi.org/10.1016/j.carbpol.2019.115506 · DOI
  16. Kaliniak-Dziura A, Skałecki P, Florek M, et al. Surowce zwierzęce wyko- rzystywane w kosmetyce. In: Chwil M, Denisow B, eds. Wybrane aspek- ty biokosmetologii. Lublin: Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie; 2021:152-177. https://doi.org/10.24326/mon.2021.15 · DOI
  17. Kusy J, Masłowska A, Januś E. Ślimak w kuchni i w salonie urody. In: Ba- bicz M, Kropiwiec-Domańska K, eds. Wybrane zagadnienia z zakresu produkcji surowców, żywności i kosmetyków; Lublin: Wydawnictwo Uni- wersytetu Przyrodniczego w Lublinie; 2021:88-95. https://doi.org/10.24326/mon.2021.9 · DOI
  18. Stępniowska A. Biosurfaktanty w kosmetykach. In: Chwil M, Denisow B, eds. Wybrane aspekty biokosmetologii. Lublin: Wydawnictwo Uniwersy- tetu Przyrodniczego w Lublinie; 2021:142-149. https://doi.org/10.24326/mon.2021.15 · DOI
  19. Nguyen JK, Masub N, Jagdeo J. Bioactive ingredients in Korean cosme- ceuticals: Trends and research evidence. J Cosmet Dermatol. 2020;19(7): 1555-1569. https://doi.org/10.1111/jocd.13344 · DOI
  20. Murgia MS, Meuli M, MannuC, Casu C. New Enzymatic Gel as Adjuvant Treatment for Wound Healing Processes in Oral Surgery, a Mini-Review and a Case Report. Sch J Med Case Rep. 2021;1:55-60. https://doi.org/10.36347/sjmcr.2021.v09i01.015 · DOI
  21. Liu L, Sood A, Steinweg S. Snails and skin care -an uncovered combina- tion. JAMA dermatology. 2017;153(7):650-650. https://doi.org/10.1001/jamadermatol.2017.1383 · DOI
  22. Truchuelo MT, Vitale M. A cosmetic treatment based on the secretion of Cryptomphalus aspersa 40% improves the clinical results after the use of nonablative fractional laser in skin aging. J Cosmet Dermatol. 2020;19(3):622-628. https://doi.org/10.1111/jocd.13052 · DOI
  23. Arora G. Insights into Cosmeceuticals. CSDM. 2021;1(32):1-8. https://doi.org/10.25259/CSDM_34_2021 · DOI
  24. Cristiano L, Guagni M. Zooceuticals and Cosmetic Ingredients Derived from Animals. Cosmetics. 2022;9(1):1-14. https://doi.org/10.3390/cosmetics9010013 · DOI · Paper page
  25. Liudmyla K, Olena C, Nadiia S. Chemical properties of Helix aspersa mu- cus as a component of cosmetics and pharmaceutical products. Mate- rials Today: Proceedings. 2022;62(15):7650-7653. https://doi.org/10.1016/j.matpr.2022.02.217 · DOI · Paper page
  26. Laneri S, Lorenzo RD, Sacchi A, Dini I. Dosage of bioactive molecules in the nutricosmeceutical Helix aspersa muller mucus and formula- tion of new cosmetic cream with moisturizing effect. Nat Prod Commun. 2019;14(8). https://doi.org/10.1177%2F1934578X19868606 · DOI · Paper page
  27. Tsakanova G, Ayvazyan V, Arakelova E, et al. Helix pomatia albumen gland water soluble protein extract as powerful antiaging agent. Exp Ge- rontol. 2021;146:111244. https://doi.org/10.1016/j.exger.2021.111244 · DOI
  28. Bortolotti D, Trapella C, Bernardi T, Rizzo R. Antimicrobial properties of mucus from the brown garden snail Helix aspersa. Br J Biomed Sci. 2016;73(1):49-50. https://doi.org/10.1080/09674845.2016.1155377 · DOI
  29. Angulo DEL, do Amaral Sobral PJ. Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpo- se. Int J Biol Macromol. 2016;92:645-653. https://doi.org/10.1016/j.ijbiomac.2016.07.029 · DOI
  30. Gentili V, Bortolotti D, Benedusi M, et al. Helix Complex snail mucus as a potential technology against O 3 induced skin damage. PLoS ONE. 2020;15:e0229613. https://doi.org/10.1371/journal.pone.0229613 · DOI · Paper page
  31. Lim VZ, Yong AA, Tan WPM, et al. Efficacy and safety of a new cosme- ceutical regimen based on the combination of snail secretion filtrate and snail egg extract to improve signs of skin aging. J Clin Aesthet Der- matol. 2020;13(3):31-36.
  32. Mencucci R, Strazzabosco G, Cristofori V, et al. GlicoPro, Novel Standar- dized and Sterile Snail Mucus Extract for Multi-Modulative Ocular For- mulations: New Perspective in Dry Eye Disease Management. Pharma- ceutics. 2021;13(12):2139. https://doi.org/10.3390/pharmaceutics13122139 · DOI · Paper page
  33. Adikwu MU, Alozie BU. Application of snail mucin dispersed in deta- rium gum gel in wound healing. Sci Res Essay. 2007;2(6):195-198. https://doi.org/10.5897/SRE.9000205 · DOI
  34. EL-Zawawy NA, Mona MM. Evaluation and comparison of antimicro- bial efficacy of snail mucus of Egyptian Eremina desertorum and He- lix aspersa with novel approach of their anti-inflammatory and wound healing potencies. PREPRINT (Version 1) available at Research Square. 2021:1-21. https://doi.org/10.21203/rs.3.rs-899280/v1 · DOI
  35. Tsoutsos D, Kakagia D, Tamparopoulos K. The efficacy of Helix asper- sa Müller extract in the healing of partial thickness burns: a novel tre- atment for open burn management protocols. J Dermatolog Treat. 2009;20(4):219-222. https://doi.org/10.1080/09546630802582037 · DOI
  36. Iglesias-de la Cruz MC, Sanz-Rodríguez F, Zamarrón A, et al. A secretion of the mollusc Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro. Int J Cosmet Sci. 2012;34(2):183-189. https://doi.org/10.1111/j.1468-2494.2011.00699.x · DOI
  37. Kantawong F, Thaweenan P, Mungkala S, et al. Mucus of Achatina fuli- ca stimulates mineralization and inflammatory response in dental pulp cells. Turk J Biol. 2016;40(2):353-359. https://doi.org/10.3906/biy-1505-29 · DOI
  38. Harti AS, Sulisetyawati SD, Murharyati A, et al. The effectiveness of snail slime and chitosan in wound healing. Int J Pharma Med Biol Sci. 2016;5(1):76-80. https://doi.org/10.18178/ijpmbs.5.1.76-80 · DOI
  39. Noothuan N, Apitanyasai K, Panha S, Tassanakajon A. Snail mucus from the mantle and foot of two land snails, Lissachatinafulica and Hemiplec- tadistincta, exhibits different protein profile and biological activity. BMC Res Notes. 2021;14(1):1-7. https://doi.org/10.1186/s13104-021-05557-0 · DOI · Paper page
  40. Ellijimi C, Hammouda MB, Othman H, et al. Helix aspersa maxima mu- cus exhibits antimelanogenic and antitumoral effects against melano- ma cells. Biomed Pharmacother. 2018;101:871-880. https://doi.org/10.1016/j.biopha.2018.03.020 · DOI · Paper page
  41. Ekin İ, Şeşen R. Molluscs: Their Usage as Nutrition, Medicine, Aphrodi- siac, Cosmetic, Jewelry, Cowry, Pearl, Accessory and So on from the Hi- story to Today. Middle East J Sci. 2018;4(1):45-51. https://doi.org/10.23884/mejs.2018.4.1.06 otrzymano / received: 21.09.2022 | poprawiono / corrected: 08.10.2022 | zaakceptowano / accepted: 16.10.2022 Aesthetic Cosmetology and Medicine 2 / 2023 / vol. 12 · DOI

Cited by

Sorted by citations

Authors
Student Scientific Association of Biologists - Biocosmetology Section, F. O. E. B., Wargala, E., Zalewska, A., Student Scientific Association of Biologists - Biocosmetology Section, F. O. E. B., Sławska, M., Student Scientific Association of Biologists - Biocosmetology Section, F. O. E. B., Kot, I., & Sub-department of Entomology, D. O. P. P.
Affiliations
University of Life Sciences in Lublin (PL)
Venue
Aesthetic Cosmetology and Medicine
Published
2023-04
Volume
12
Issue
2
Pages
45-49
ISSN
2719-3241 (ISSN-L)
OpenAlex
W4368341469
Cited by
30
References
1
Citations by year
2026: 8 · 2025: 11 · 2024: 10 · 2023: 1
FWCI
5.45
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Aesthetic Cosmetology and Medicine (publishedVersion, cc-by)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
snail mucus, Helix aspersa, cosmetic ingredients, antibacterial properties, antifungal activity, antioxidant activity, regenerative properties

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review