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Cited by 320

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Roles of Matrix Metalloproteinases in Tumor Metastasis and Angiogenesis

Open access
Yoon, Sang-Oh, Park, Soo-Jin, Yun, Chang-Hyun, Chung, An-Sik·2003·BMB Reports
DOI 10.5483/bmbrep.2003.36.1.128
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Abstract

Matrix metalloproteinases (MMPs), zinc dependent proteolytic enzymes, cleave extracellular matrix (ECM: collagen, laminin, firbronectin, etc) as well as non-matrix substrates (growth factors, cell surface receptors, etc). The deregulation of MMPs is involved in many diseases, such as tumor metastasis, rheumatoid arthritis, and periodontal disease. Metastasis is the major cause of death among cancer patients. In this review, we will focus on the roles of MMPs in tumor metastasis. The process of metastasis involves a cascade of linked, sequential steps that involve multiple host-tumor interactions. Specifically, MMPs are involved in many steps of tumor metastasis. These include tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Therefore, without MMPs, the tumor cell cannot perform successful metastasis. The activities of MMPs are tightly regulated at the gene transcription levels, zymogen activation by proteolysis, and inhibition of active forms by endogenous inhibitors, tissue inhibitor of metalloproteinase (TIMP), and RECK. The detailed regulations of MMPs are described in this review.

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Metadata

Authors
Yoon, S.-O., Park, S.-J., Yun, C.-H., & Chung, A.-S.
Venue
BMB Reports
Publisher
Korean Society for Biochemistry and Molecular Biology - BMB Reports
Published
2003-01-31
Volume
36
Issue
1
Pages
128-137
ISSN
1976-6696 (ISSN-L)
DOI
10.5483/bmbrep.2003.36.1.128
OpenAlex
W2107398206
Cited by
320
References
73
FWCI
5.43
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Roles of Matrix Metalloproteinases in Tumor Metastasis and Angiogenesis. https://app.cochat.ai/papers/10.5483/bmbrep.2003.36.1.128
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Yoon, S.-O., Park, S.-J., Yun, C.-H., & Chung, A.-S. (2003). Roles of Matrix Metalloproteinases in Tumor Metastasis and Angiogenesis. BMB Reports. https://doi.org/10.5483/bmbrep.2003.36.1.128

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.