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Predictors of Atherosclerosis
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Increased hepatic LDLR expression is strongly associated with a decreased risk of developing cardiovascular disease in humans.
“which is strongly associated with a decreased risk of developing cardiovascular disease in humans”
From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [5]
The Plasma Lipoproteins section says that elevated plasma LDL is a risk factor for coronary artery disease and recommends reducing LDL cholesterol in certain high-risk subjects. It does not address hepatic LDL receptor (LDLR) expression or an association between increased expression and reduced cardiovascular disease risk in humans (searched: hepatic LDL receptor expression; LDL receptor liver expression). (LLM, conf=0.76)
Experimental — accuracy not yet measuredIncreased hepatic LDLR expression results in improved clearance of plasma LDL-C through receptor-mediated endocytosis.
“Increased hepatic LDLR expression results in improved clearance of plasma LDL-C through receptor-mediated endocytosis”
From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [5]
The Plasma Lipoproteins section discusses LDL-C as a clinical measure and LDL levels as a coronary risk factor, but does not address hepatic LDLR expression or LDL clearance. Searches for LDL receptor, receptor-mediated endocytosis, and clearance found no passage establishing the claimed mechanism. (LLM, conf=0.76)
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Sacks, F. M., Alaupovic, P., Moye, L. A., Cole, T. G., Sussex, B., Stampfer, M. J., Pfeffer, M. A., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.102.16.1886 · Cited by 490
Marcovina, S. M., Koschinsky, M. L., Albers, J. J., & Skarlatos, S. (2003) · Clinical Chemistry · doi:10.1373/clinchem.2003.023689 · Cited by 288
Karpe, F., Boquist, S., Tang, R., Bond, G. M., de Faire, U., & Hamsten, A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32331-2 · Cited by 174
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Plasma myeloperoxidase is related to the severity of coronary artery disease
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Different Distribution of Pentraxin 3 and C-Reactive Protein in Coronary Atherosclerotic Plaques
Matsuura, Y., Hatakeyama, K., Imamura, T., Tsuruda, T., Shibata, Y., Kodama, T., Kitamura, K., & Asada, Y. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12526 · Cited by 31
Metadata
- Authors
- Homma, Y.
- Affiliations
- Health Evaluation and Promotion Center, Tokai University Hospital
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2004
- Volume
- 11
- Issue
- 5
- Pages
- 265-270
- ISSN
- 1340-3478
- 1880-3873
- Cited by
- 52
- References
- 4
- Language
- en
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