Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease
Open accessAbstract
AIM: Recent studies have suggested that metabolic disorders such as obesity and type 2 diabetes are associated with gut microbiota. The association between atherosclerosis and gut microbiota has also been attracting increased attention. Our aim was to specify a characteristic trend of gut microbiota in coronary artery disease (CAD). METHODS: This study included 39 CAD patients, 30 age- and sex-matched no-CAD controls (Ctrls) with coronary risk factors and 50 healthy volunteers (HVs) without coronary risk factors. Bacterial DNA was extracted from their fecal samples and analyzed by terminal restriction fragment length polymorphism. RESULTS: A characteristic change of gut microbiota was observed in CAD patients, where the order Lactobacillales was increased (CAD, Ctrl vs. HV; 13.6%±12.0%, 6.2%±7.7% vs. 4.1%±5.9%; p＜0.001) and the phylum Bacteroidetes (Bacteroides＋Prevotella) was decreased (CAD, Ctrl vs. HV;35.5%±11.6%, 43.9%±11.2% vs. 47.4%±11.5%; p＜0.001). The CAD group was over-represented in enterotype "others" (III), compared with the Ctrl or HV group (p＜0.001, chi-squared test), although we could not deny the possibility that some drugs affect the gut flora types. CONCLUSIONS: Although this study had some limitations, we demonstrated that the incidence of CAD was linked with an alteration of gut microbiota. A prospective study is desired to clarify a causal relationship between CAD and gut microbiota.
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Gut microbiota has a strong relationship with the progression of cardiovascular diseases, including coronary artery disease.
“Increasing evidence has suggested a strong relationship between gut microbiota and the progression of cardiovascular diseases, and we previously reported such a relationship with coronary artery disease (CAD) for the first time.1,2”
From <i>Bacteroides vulgatus</i> and <i>Bacteroides dorei</i> Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis (2018) · cites this paper as [1]
Individuals classified as enterotype 3, characterized by low levels of Bacteroides, have a higher incidence of symptomatic atherosclerosis.
“Individuals classified as enterotype 3, which is characterized by low levels of Bacteroides, 8 have a higher incidence of symptomatic atherosclerosis.1,9”
From <i>Bacteroides vulgatus</i> and <i>Bacteroides dorei</i> Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis (2018) · cites this paper as [1]
The abundance of Bacteroides is lower in coronary artery disease patients than in non-CAD patients with coronary risk factors or in healthy volunteers.
“our previous study using terminal-restriction fragment length polymorphism analysis confirmed that the abundance of Bacteroides is lower in CAD patients than in non-CAD patients with coronary risk factors or in healthy volunteers.1,2”
From <i>Bacteroides vulgatus</i> and <i>Bacteroides dorei</i> Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis (2018) · cites this paper as [1]
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- Authors
- Emoto, T., Yamashita, T., Sasaki, N., Hirota, Y., Hayashi, T., So, A., Kasahara, K., Yodoi, K., Matsumoto, T., Mizoguchi, T., Ogawa, W., & Hirata, K.-I.
- Affiliations
- Kobe University (JP)
- ORCID
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2016
- Volume
- 23
- Issue
- 8
- Pages
- 908-921
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- PMC
- PMC7399299
- OpenAlex
- W2293306613
- Cited by
- 315
- References
- 24
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 38 · 2023: 32 · 2022: 58 · 2021: 44 · 2020: 33 · 2019: 18 · 2018: 20 · 2017: 11 · 2016: 13
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kobe University Repository Kernel (Kobe University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- gut microbiota, coronary artery disease, Lactobacillales, Bacteroidetes, enterotypes, atherosclerosis, fecal microbiota, obesity, type 2 diabetes, coronary risk factors
- MeSH terms
- Gastrointestinal Microbiome, Aged, Coronary Artery Disease, Diabetes Mellitus, Type 2, DNA, Bacterial, Feces, Female, Humans, Male, Middle Aged, Obesity, Polymorphism, Restriction Fragment Length, Risk Factors, Case-Control Studies, Bacteroidetes
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