Prothrombin Kringle-2: a potential inflammatory pathogen in the parkinsonian dopaminergic system

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works

Parkinson's disease

Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,412 · see citing works

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works

Toll-like receptors in innate immunity

Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328 · see citing works

Neuroinflammation in Parkinson’s disease: A target for neuroprotection?

Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works

Microglia as a source and target of cytokines

Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645 · see citing works

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

Olson, J. K., & Miller, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3916 · Cited by 1,215 · see citing works

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works

Redox Regulation of Cellular Signalling

Kamata, H., & Hirata, H. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00037-0 · Cited by 1,150 · see citing works

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,056 · see citing works

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986 · see citing works

Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Wang, Q., Liu, Y., & Zhou, J. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0042-0 · Cited by 884 · see citing works

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

Kagan, J. C., & Medzhitov, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.047 · Cited by 847 · see citing works

Microglial activation and dopamine terminal loss in early Parkinson's disease

Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., & Torizuka, T. (2005) · Annals of Neurology · doi:10.1002/ana.20338 · Cited by 846 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Does neuroinflammation fan the flame in neurodegenerative diseases?

Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751 · see citing works

Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia

Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Winklhofer, K. F., & Haass, C. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.013 · Cited by 688 · see citing works

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

Exner, N., Lutz, A. K., Haass, C., & Winklhofer, K. F. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.170 · Cited by 652 · see citing works

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Wu, D., Teismann, P., Tieu, K., Vila, M., Jackson-Lewis, V. R., Ischiropoulos, H., & Przedborski, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937239100 · Cited by 634 · see citing works

Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke

Caso, J. R., Pradillo, J. M., Hurtado, O., Lorenzo, P. L., Moro, M. Á., & Lizasoaín, I. (2007) · Circulation · doi:10.1161/circulationaha.106.603431 · Cited by 606 · see citing works

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

Chen, D., Endres, R. L., Erickson, C. A., Weis, K. F., McGregor, M. W., Kawaoka, Y., & Payne, L. G. (2000) · Nature Medicine · doi:10.1038/80538 · Cited by 547 · see citing works

Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease

Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schüffer, W., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110455 · Cited by 543 · see citing works

Neurotoxin-based models of Parkinson's disease

Bové, J., & Perier, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.057 · Cited by 508 · see citing works

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

Molteni, M., Gemma, S., & Rossetti, C. (2016) · Mediators of Inflammation · doi:10.1155/2016/6978936 · Cited by 456 · see citing works

Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439 · see citing works

Neuroinflammation of the nigrostriatal pathway during progressive 6‐OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging

Cicchetti, F., Brownell, A., Williams, K. S., Chen, Y. I., Livni, E., & Ole Isacson, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01938.x · Cited by 406 · see citing works

Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease

Mosley, R. L., Benner, E. J., Kadiu, I., Thomas, M., Boska, M. D., Hasan, K. M., Laurie, C. D., & Gendelman, H. E. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.006 · Cited by 388 · see citing works

Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction

Sanchez-Mejia, R., Ona, V., Li, M.-W., & Friedlander, R. (2001) · Neurosurgery · doi:10.1097/00006123-200106000-00051 · Cited by 373 · see citing works

Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Liu, B., & Hong, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06181.2003 · Cited by 338 · see citing works

Prothrombin mRNA is expressed by cells of the nervous system

Dihanich, M., Kaser, M. R., Reinhard, E., Cunningham, D. D., & Monard, D. (1991) · Neuron · doi:10.1016/0896-6273(91)90060-d · Cited by 338 · see citing works

Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants

Cui, K., Luo, X., Xu, K., & Murthy, M. R. V. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.023 · Cited by 334 · see citing works

Minocycline markedly protects the neonatal brain against hypoxic‐ischemic injury

Arvin, K. L., Han, B., Du, Y.-S., Lin, S.-Z., Paul, S. M., & Holtzman, D. (2002) · Annals of Neurology · doi:10.1002/ana.10242 · Cited by 323 · see citing works

Oxidative and Inflammatory Pathways in Parkinson’s Disease

Miller, R. L., James-Kracke, M., Sun, G. Y., & Sun, A. Y. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9656-2 · Cited by 306 · see citing works

Microglial Reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Induced Parkinson's Disease Mice Model

Członkowska, A., Kohutnicka, M., Kurkowska‐Jastrzębska, I., & Członkowski, A. (1996) · Neurodegeneration · doi:10.1006/neur.1996.0020 · Cited by 279 · see citing works

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

Jin, J.-J., Kim, H.-D., Maxwell, J. A., Li, L., & Fukuchi, K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-23 · Cited by 272 · see citing works

Mechanism of 6‐hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6‐hydroxydopamine‐induced degeneration of dopaminergic neurons

Rodríguez‐Pallares, J., Parga, J. A., Muñoz, A., Rey, P., Guerra, M. J., & Labandeira-García, J. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04699.x · Cited by 232 · see citing works

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

Ros-Bernal, F., Hunot, S., Herrero, M. T., Parnadeau, S., Corvol, J.-C., Lu, L., Alvarez-Fischer, D., Carrillo-de Sauvage, M. A., Saurini, F., Coussieu, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017820108 · Cited by 231 · see citing works

Microglial activation mediates neurodegeneration related to oligodendroglial α‐synucleinopathy: Implications for multiple system atrophy

Stefanova, N., Reindl, M., Neumann, M., Kahle, P. J., Poewe, W. H., & Wenning, G. K. (2007) · Movement Disorders · doi:10.1002/mds.21671 · Cited by 217 · see citing works

Treatment of Parkinson's disease: levodopa as the first choice

Katzenschlager, R., & Lees, A. J. (2002) · Journal of Neurology · doi:10.1007/s00415-002-1204-4 · Cited by 209 · see citing works

TLR4 Contributes to Disease-Inducing Mechanisms Resulting in Central Nervous System Autoimmune Disease

Kerfoot, S. M., Long, E. M., Hickey, M. J., Andonegui, G., Lapointe, B. M., Zanardo, R. C. O., Bonder, C. S., James, W. G., Robbins, S. M., & Kubes, P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.7070 · Cited by 208 · see citing works

[13] Prothrombin

Mann, K. G. (1976) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(76)45016-4 · Cited by 200 · see citing works

Long term motor complications of levodopa: clinical features, mechanisms, and management strategies

Thanvi, B. R., & Lo, T. C. N. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2003.013912 · Cited by 194 · see citing works

Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction

Mejia, R. O. S., Ona, V. O., Li, M., et al. (2001) · Neurosurgery · doi:10.1227/00006123-200106000-00051 · Cited by 171 · see citing works

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169 · see citing works

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

Noelker, C., Morel, L., Lescot, T., Osterloh, A., Alvarez-Fischer, D., Breloer, M., Henze, C., Depboylu, C., Skrzydelski, D., Michel, P. P., et al. (2013) · Scientific Reports · doi:10.1038/srep01393 · Cited by 164 · see citing works

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases

Sokolova, E., & Reiser, G. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-03-0131 · Cited by 153 · see citing works

Absence of TLR4 Reduces Neurovascular Unit and Secondary Inflammatory Process after Traumatic Brain Injury in Mice

Ahmad, A., Crupi, R., Campolo, M., Genovese, T., Esposito, E., & Cuzzocrea, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057208 · Cited by 133 · see citing works

Toll-Like Receptors in Alzheimer’s Disease: A Therapeutic Perspective

Gambuzza, M., Sofo, V., Salmeri, F., Soraci, L., Marino, S., & Bramanti, P. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140806124850 · Cited by 131 · see citing works

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

Noble, W., Garwood, C., Stephenson, J., Kinsey, A. M., Hanger, D., & Anderton, B. (2009) · The FASEB Journal · doi:10.1096/fj.08-113795 · Cited by 123 · see citing works

Agrin and microvascular damage in Alzheimer's disease.

Berzin, T., Zipser, B., Rafii, M., Kuo-Leblanc, V., Yancopouloš, G., Glass, D., Fallon, J., & Stopa, E. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00121-4 · Cited by 116 · see citing works

Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders?

Gomes‐Leal, W. (2012) · Brain and Behavior · doi:10.1002/brb3.51 · Cited by 115 · see citing works

Inhibition of thrombin‐induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo

Choi, S. H., Lee, D. Y., Chung, E. S., Hong, Y. B., Kim, S. U., & Jin, B. K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03503.x · Cited by 111 · see citing works

Upregulation of Protease-Activated Receptor-1 in Astrocytes in Parkinson Disease: Astrocyte-Mediated Neuroprotection Through Increased Levels of Glutathione Peroxidase

Ishida, Y., Nagai, A., Kobayashi, S., & Kim, S. U. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000195941.48033.eb · Cited by 109 · see citing works

AAV transduction of dopamine neurons with constitutively active rheb protects from neurodegeneration and mediates axon regrowth

Kim, S. R., Kareva, T., Yarygina, O., Kholodilov, N., & Burke, R. E. (2012) · Molecular Therapy · doi:10.1038/mt.2011.213 · Cited by 107 · see citing works

Prothrombin Kringle-2 Domain Has a Growth Inhibitory Activity against Basic Fibroblast Growth Factor-stimulated Capillary Endothelial Cells

Lee, T.-H., Rhim, T., & Kim, S. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28805 · Cited by 95 · see citing works

Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson’s Disease

Nam, J. H., Leem, E., Jeon, M.-T., Jeong, K. H., Park, J.-W., Jung, U. J., Kholodilov, N., Burke, R. E., Jin, B. K., & Kim, S. R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8729-2 · Cited by 76 · see citing works

Expression of factor X in both the rat brain and cells of the central nervous system

Shikamoto, Y., & Morita, T. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01657-9 · Cited by 68 · see citing works

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease

Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65 · see citing works

Microglial Cells Are Involved in the Susceptibility of NADPH Oxidase Knockout Mice to 6-Hydroxy-Dopamine-Induced Neurodegeneration

Hernandes, M. S., Santos, G. D. R., Café-Mendes, C. C., Lima, L. S., Scavone, C., Munhoz, C. D., & Britto, L. R. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075532 · Cited by 54 · see citing works

Human Prothrombin Fragment 1 and 2 Inhibit bFGF-Induced BCE Cell Growth

Rhim, T. Y., Park, C.-S., Kim, E., & Kim, S. S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9682 · Cited by 44 · see citing works

Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation

Kim, S. R., Chung, E. S., Bok, E., Baik, H. H., Chung, Y. C., Won, S. Y., Joe, E., Kim, T. H., Kim, S. S., Jin, M. Y., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22318 · Cited by 43 · see citing works

Myricitrin Ameliorates 6-Hydroxydopamine-Induced Dopaminergic Neuronal Loss in the Substantia Nigra of Mouse Brain

Kim, H. D., Jeong, K. H., Jung, U. J., & Kim, S. R. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3581 · Cited by 41 · see citing works

Prothrombin Kringle-2 Activates Cultured Rat Brain Microglia

Ryu, J., Min, K., Rhim, T. Y., Kim, T. H., Pyo, H., Jin, B.-K., Kim, S.-U., Jou, I., Kim, S. S., & Joe, E.-H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5805 · Cited by 36 · see citing works

Blood Coagulation Factor Xa Interacts with a Linear Sequence of the Kringle 2 Domain of Prothrombin

Taneda, H., Andoh, K., Nishioka, J., Takeya, H., & Suzuki, K. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124565 · Cited by 36 · see citing works

Prothrombin kringle-2-induced oxidative stress contributes to the death of cortical neurons in vivo and in vitro: Role of microglial NADPH oxidase

Won, S.-Y., Choi, S., & Jin, B. K. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.07.005 · Cited by 23 · see citing works

Recombinant human prothrombin kringle-2 induces bovine capillary endothelial cell cycle arrest at G0–G1 phase through inhibition of cyclin D1/CDK4 complex: Modulation of reactive oxygen species generation and up-regulation of cyclin-dependent kinase inhibitors

Kim, T. H., Oh, S. V., & Kim, S. S. (2006) · Angiogenesis · doi:10.1007/s10456-005-9020-y · Cited by 16 · see citing works

Inhibition of thrombin activity by prothrombin activation fragment 1.2

Dasgupta, S. K., & Thiagarajan, P. (2007) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-007-0018-8 · Cited by 12 · see citing works

Recombinant human prothrombin kringle-2 inhibits B16F10 melanoma metastasis through inhibition of neovascularization and reduction of matrix metalloproteinase expression

Kim, T. H., Ahn, S., Kim, J., Kim, I., Yang, M. Z., Lee, J. E., & Kim, S. S. (2006) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9048-4 · Cited by 6 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 173 · see citing works

Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids

Kim, T. Y., Leem, E., Lee, J. M., & Kim, S. R. (2020) · Antioxidants · doi:10.3390/antiox9070583 · Cited by 128 · see citing works

Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms

Haddadi, R., Shahidi, Z., & Brooshghalan, S. E. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153320 · Cited by 55 · see citing works

Pathophysiological Role of Microglial Activation Induced by Blood-Borne Proteins in Alzheimer’s Disease

Kim, S., Sharma, C., Jung, U. J., & Kim, S. R. (2023) · Biomedicines · doi:10.3390/biomedicines11051383 · Cited by 40 · see citing works

Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss

Zhou, Y., Wang, G., Li, D., Wang, Y., Wu, Q., Shi, J., & Zhang, F. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1194-5 · Cited by 17 · see citing works

Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

Kim, S., Moon, G. J., Oh, Y., Park, J., Shin, W.-H., Jeong, J. Y., Choi, K. S., Jin, B. K., Kholodilov, N. G., Burke, R. E., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.261 · Cited by 17 · see citing works

Control of hippocampal prothrombin kringle‐2 (pKr‐2) expression reduces neurotoxic symptoms in five familial Alzheimer's disease mice

Kim, S., Moon, G. J., Kim, H. J., Kim, D., Kim, J., Nam, Y., Sharma, C., Leem, E., Lee, S., Kim, K., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15681 · Cited by 14 · see citing works

Effects of Silibinin Against Prothrombin Kringle-2-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System In Vivo

Leem, E., Oh, Y., Shin, W.-H., Jin, B. K., Jeong, J. Y., Shin, M., Kim, D. W., Jang, J., Kim, H., Ha, C. M., et al. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4266 · Cited by 10 · see citing works

pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain

Kim, S., Sharma, C., Shin, M., Kim, H., Kim, J., & Kim, S. R. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100593 · Cited by 5 · see citing works

Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis

Kim, S. R., & Lee, J. M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335813 · Cited by 4 · see citing works

Naringin as a beneficial natural product against degeneration of the nigrostriatal dopaminergic projection in the adult brain

Kim, S. R. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.213694 · Cited by 4 · see citing works

Application of flavonoids for the protection of nigral dopaminergic neurons from oxidative stress

Kim, S. R. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.301010 · Cited by 3 · see citing works

Therapeutic targeting of blood-derived protein infiltration to modulate neuroinflammation in cerebellar ataxia

Park, S. M., Kim, S. S., Cho, E., Lee, G. B., Lee, J. H., Kim, D. W., Kim, J.-E., Kim, J.-E., Choi, G. E., Lee, H.-W., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03811-5 · Cited by 1 · see citing works

Neuroprotective Effects of Minocycline

Kapoor, S. N. (2017) · The Neurologist · doi:10.1097/nrl.0000000000000160

Linking Thrombin to α-Synuclein truncation reveals a molecular bridge between neuroinflammation and Parkinson diseasePreprint

de Laureto, P. P., Trolese, P., Fongaro, B., Scapin, V., Sosic, A., Scano, M., Sandonà, D., & Acquasaliente, L. (2025) · Research Square · doi:10.21203/rs.3.rs-8050047/v1

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Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65 · see citing works

Prothrombin kringle-2 as a potential neuro-inflammatory factor in parkinsonian dopaminergic system

Kim, S., Lee, J. M., Leem, E., & Kim, S. R. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.08.3604

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Kim, S. R., Chung, E. S., Bok, E., Baik, H. H., Chung, Y. C., Won, S. Y., Joe, E., Kim, T. H., Kim, S. S., Jin, M. Y., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22318 · Cited by 43 · see citing works

Inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo

Nam, J. H., Leem, E., Jeon, M., Kim, Y., Jung, U. J., Choi, M.-S., Maeng, S., Jin, B. K., & Kim, S. R. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000122 · Cited by 14 · see citing works

Effects of Silibinin Against Prothrombin Kringle-2-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System In Vivo

Leem, E., Oh, Y., Shin, W.-H., Jin, B. K., Jeong, J. Y., Shin, M., Kim, D. W., Jang, J., Kim, H., Ha, C. M., et al. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4266 · Cited by 10 · see citing works