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Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content
Open accessAbstract
Study objectives Melatonin is an important neurohormone, which mediates circadian rhythms and the sleep cycle. As such, it is a popular and readily available supplement for the treatment and prevention of sleep-related disorders including insomnia and jet lag. This study quantified melatonin in 30 commercial supplements, comprising different brands and forms and screened supplements for the presence of serotonin.Methods A total of 31 supplements were analyzed by ultraperformance liquid chromatography with electrochemical detection for quantification of melatonin and serotonin. Presence of serotonin was confirmed through analysis by ultraperformance liquid chromatography with mass spectrometry detection.Results Melatonin content was found to range from -83% to +478% of the labelled content. Additionally, lot-to-lot variable within a particular product varied by as much as 465%. This variability did not appear to be correlated with manufacturer or product type. Furthermore, serotonin (5-hydroxytryptamine), a related indoleamine and controlled substance used in the treatment of several neurological disorders, was identified in eight of the supplements at levels of 1 to 75 μg.Conclusions Melatonin content did not meet label within a 10% margin of the label claim in more than 71% of supplements and an additional 26% were found to contain serotonin. It is important that clinicians and patients have confidence in the quality of supplements used in the treatment of sleep disorders. To address this, manufacturers require increased controls to ensure melatonin supplements meet both their label claim, and also are free from contaminants, such as serotonin.Commentary A commentary on this article appears in this issue on page 163.
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“The melatonin content of the 31 over-the-counter melatonin products was found to be −83% to +478% of that listed on the label. [257]”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [257]
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Boyer, E. W., & Shannon, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041867 · Cited by 1,821
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Vohra, S., Klassen, T. P., & Baker, G. (2006) · BMJ · doi:10.1136/bmj.38731.532766.f6 · Cited by 454
Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders
Auld, F., Maschauer, E. L., Morrison, I., Skene, D. J., & Riha, R. L. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.005 · Cited by 402
Murch, S. J., KrishnaRaj, S., & Saxena, P. K. (2000) · Plant Cell Reports · doi:10.1007/s002990000206 · Cited by 364
Tan, D. X., Hardeland, R., Back, K., Manchester, L. C., Alatorre-Jiménez, M. A., & Reiter, R. J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12336 · Cited by 282
Wasdell, M. B., Jan, J. E., Bomben, M. M., Fréeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., & Weiss, M. D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00528.x · Cited by 261
Serotonin: A never-ending story
Olivier, B. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.031 · Cited by 253
Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review
Kaye, A. D. (2015) · Pain Physician · doi:10.36076/ppj.2015/18/395 · Cited by 247
A double-blind trial of melatonin as a treatment for jet lag in international cabin crew
Petrie, K. J., Dawson, A. G., Thompson, L., & Brook, R. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90007-z · Cited by 212
Flagged first, then by citations
Research works printed but not linked: 1
- Ipsos-Reid Public Affairs. Natural Health Product Tracking Survey - 2010 Final Report. Ottawa, ON, Canada: Health Canada; 2011:1–73.
Cited by
Sorted by citations
Devlin, J. W., Skrobik, Y. K., Gélinas, C., Needham, D. M., Slooter, A. J. C., Pandharipande, P. P., Watson, P. L., Weinhouse, G. L., Nunnally, M., Rochwerg, B. N., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003299 · Cited by 4,280
Gringras, P., Nir, T., Breddy, J., Frydman-Marom, A., & Findling, R. L. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.09.414 · Cited by 306
Sutton, E. L. (2021) · Annals of Internal Medicine · doi:10.7326/aitc202103160 · Cited by 298
Williams Buckley, A., Hirtz, D., Oskoui, M., Armstrong, M. J., Batra, A., Bridgemohan, C., Coury, D., Dawson, G., Donley, D., Findling, R. L., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009033 · Cited by 228
Meléndez-Fernández, O. H., Liu, J. A., & Nelson, R. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043392 · Cited by 227
Maras, A., Schroder, C. M., Malow, B. A., Findling, R. L., Breddy, J., Nir, T., Shahmoon, S., Zisapel, N., & Gringras, P. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0020 · Cited by 176
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176
Safety of higher doses of melatonin in adults: A systematic review and meta-analysis
Menczel Schrire, Z., Phillips, C. L., Chapman, J. L., Duffy, S. L., Wong, G., D’Rozario, A. L., Comas, M., Raisin, I., Saini, B., Gordon, C. J., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12782 · Cited by 133
Pharmacological Management of Insomnia
Madari, S., Golebiowski, R., Mansukhani, M. P., & Kolla, B. P. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01010-z · Cited by 146
Bioreactor-based advances in plant tissue and cell culture: challenges and prospects
Valdiani, A., Hansen, O. K., Nielsen, U. B., Johannsen, V. K., Shariat, M., Georgiev, M. I., Omidvar, V., Ebrahimi, M., Dinanai, E. T., & Abiri, R. (2018) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2018.1489778 · Cited by 118
Contaminants: a dark side of food supplements?
Costa, J. G., Vidović, B. B., Saraiva, N., Costa, M. D. C., Favero, G. D., Marko, D., Oliveira, N., & Fernandes, A. S. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1636045 · Cited by 108
Trends in Use of Melatonin Supplements Among US Adults, 1999-2018
Li, J., Somers, V. K., Xu, H., Lopez-Jimenez, F., & Covassin, N. (2022) · JAMA · doi:10.1001/jama.2021.23652 · Cited by 97
Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities
Duffy, J. F., Abbott, S. M., Burgess, H. J., Crowley, S. J., Emens, J. S., Epstein, L. J., Gamble, K. L., Hasler, B. P., Kristo, D. A., Malkani, R. G., et al. (2021) · SLEEP · doi:10.1093/sleep/zsaa281 · Cited by 100
Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder
Lalanne, S., Fougerou-Leurent, C., Anderson, G. M., Schroder, C. M., Nir, T., Chokron, S., Delorme, R., Claustrat, B., Bellissant, E., Kermarrec, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031490 · Cited by 90
Palagini, L., Manni, R., Aguglia, E., Amore, M., Brugnoli, R., Bioulac, S., Bourgin, P., Micoulaud‐Franchi, J., Girardi, P., Grassi, L. G., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.688890 · Cited by 96
Pediatric Melatonin Ingestions — United States, 2012–2021
Lelak, K. A., Vohra, V., Neuman, M. I., Toce, M. S., & Sethuraman, U. (2022) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7122a1 · Cited by 73
Tuft, C., Matar, E., Schrire, Z. M., Grunstein, R. R., Yee, B. J., & Hoyos, C. M. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s361519 · Cited by 72
Quantity of Melatonin and CBD in Melatonin Gummies Sold in the US
Cohen, P. A., Avula, B., Wang, Y.-H., Katragunta, K., & Khan, I. (2023) · JAMA · doi:10.1001/jama.2023.2296 · Cited by 72
Palagini, L., Manni, R., Aguglia, E., Amore, M., Brugnoli, R., Girardi, P., Grassi, L. G., Mencacci, C., Plazzi, G., Minervino, A., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00558 · Cited by 72
Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition
Benvenga, S., Feldt‐Rasmussen, U., Bonofiglio, D., & Asamoah, E. (2019) · Nutrients · doi:10.3390/nu11092214 · Cited by 69
Poor Quality Control of Over-the-Counter Melatonin: What They Say Is Often Not What You Get
Grigg-Damberger, M. M., & Ianakieva, D. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6434 · Cited by 62
Chronic Administration of Melatonin: Physiological and Clinical Considerations
Givler, D., Givler, A., Luther, P. M., Wenger, D. M., Ahmadzadeh, S., Shekoohi, S., Edinoff, A. N., Dorius, B. K., Baptiste, C. J., Cornett, E. M., et al. (2023) · Neurology International · doi:10.3390/neurolint15010031 · Cited by 59
Melatonin: From Neurobiology to Treatment
Biggio, G., Biggio, F., Talani, G., Mostallino, M. C., Aguglia, A., Aguglia, E., & Palagini, L. (2021) · Brain Sciences · doi:10.3390/brainsci11091121 · Cited by 56
Updated consensus guidelines on the management of Phelan–McDermid syndrome
Srivastava, S., Şahin, M., Buxbaum, J. D., Berry‐Kravis, E., Soorya, L. V., Thurm, A. E., Bernstein, J. A., Asante‐Otoo, A., Bennett, W. E., Betancur, C., et al. (2023) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63312 · Cited by 52
Revolutionizing Sleep Health: The Emergence and Impact of Personalized Sleep Medicine
Garbarino, S., & Bragazzi, N. L. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14060598 · Cited by 49
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Zhou, E. S., Gardiner, P. M., & Bertisch, S. M. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.04.005 · Cited by 49
For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases
Diallo, A. B., Coiffard, B., Léone, M., Mezouar, S., & Mège, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01457 · Cited by 47
Skrzelowski, M., Brookhaus, A., Shea, L. A., & Berlau, D. J. (2021) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-26.1.4 · Cited by 46
Use of dietary supplements by children and adolescents
Barretto, J. R., Gouveia, M. A. D. C., & Alves, C. (2023) · Jornal de Pediatria · doi:10.1016/j.jped.2023.09.008 · Cited by 42
Mantle, D., Smits, M. G., Boss, M., Miedema, I., & van Geijlswijk, I. M. (2020) · Sleep Medicine X · doi:10.1016/j.sleepx.2020.100022 · Cited by 47
Edemann-Callesen, H., Andersen, H. K., Ussing, A., Virring, A., Jennum, P., Debes, N. M., Laursen, T., Baandrup, L., Gade, C., Nielsen, J. D., et al. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.102048 · Cited by 41
Kotagal, S., Malow, B. A., Spruyt, K., Wang, G., Almeida, C. E. B., Tavera-Saldaña, L. M., Blunden, S. L., Narang, I., Ipsiroglu, O., Bruni, O., et al. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.04.008 · Cited by 36
Relia, S., & Ekambaram, V. (2018) · Medical Sciences · doi:10.3390/medsci6040095 · Cited by 33
Kumar, N., & Goyal, R. N. (2020) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2020.114458 · Cited by 33
Boafo, A., Greenham, S. L., Sullivan, M., Bazaid, K., Suntharalingam, S., Silbernagel, L., Magner, K., & Robillard, R. (2020) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-020-00316-8 · Cited by 32
Bruni, O., Breda, M., Nobili, L., Fietze, I., Capdevila, Ó. S., & Gronfier, C. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-024-05556-w · Cited by 33
What do we really know about the safety and efficacy of melatonin for sleep disorders?
Kennaway, D. J. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.2000714 · Cited by 33
Melatonin Use in Pediatrics: A Clinical Review on Indications, Multisystem Effects, and Toxicity
Shenoy, P., Etcheverry, A., Ia, J., Witmans, M., & Tablizo, M. A. (2024) · Children · doi:10.3390/children11030323 · Cited by 30
Ribeiro, D. S. M., Castro, R. C., Soares, J. X., & Santos, J. L. M. (2020) · Microchemical Journal · doi:10.1016/j.microc.2020.104728 · Cited by 30
Melatonin’s Benefits and Risks as a Therapy for Sleep Disturbances in the Elderly: Current Insights
Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s380465 · Cited by 35
Lauritzen, E. S., Kampmann, U., Pedersen, M. G. B., Christensen, L., Jessen, N., Møller, N., & Støy, J. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12809 · Cited by 29
Bologna, C., Madonna, P., & Pone, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245857 · Cited by 28
Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols
Conti, F., MCCUE, J., Dituro, P., Galpin, A. J., & Wood, T. R. (2024) · Nutrients · doi:10.3390/nu16152430 · Cited by 33
Danilovich, M. E., Alberto, M. R., & Tomás, M. S. J. (2021) · Journal of Applied Microbiology · doi:10.1111/jam.15012 · Cited by 29
Medications Used for Pediatric Insomnia.
Ekambaram, V., & Owens, J. (2021) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.09.001 · Cited by 19
Sleep and Circadian Disturbances in Children With Neurodevelopmental Disorders
Tamir, S., Dye, T. J., & Witt, R. M. (2023) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2023.101090 · Cited by 29
Notifications and Health Consequences of Unauthorized Pharmaceuticals in Food Supplements
Amidžić, M., Fuentes, J. B., Banović, J., & Torović, L. D. (2023) · Pharmacy · doi:10.3390/pharmacy11050154 · Cited by 28
Melatonin Supplementation in Undetermined Pediatric Deaths
Bishop-Freeman, S. C., Young, K. A., Labay, L. M., Beuhler, M. C., & Hudson, J. S. (2022) · Journal of Analytical Toxicology · doi:10.1093/jat/bkac033 · Cited by 25
Ghareghani, M., Zibara, K., & Rivest, S. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219334120 · Cited by 27
Drugs Used in Circadian Sleep-Wake Rhythm Disturbances
Burgess, H. J., & Emens, J. S. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2018.02.006 · Cited by 25
2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults - Brazilian Sleep Association
Drager, L. F., Assis, M., Bacelar, A. F. R., Poyares, D. L. R., Conway, S. G., Pires, G. N., de Azevedo, A. P., Carissimi, A., Eckeli, A. L., Pentagna, Á., et al. (2023) · Sleep Science · doi:10.1055/s-0043-1776281 · Cited by 25
Bueno, A. P. R., Savi, F. M., Alves, I. A., & Bandeira, V. A. C. (2021) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x-anp-2020-0379 · Cited by 27
Shin, J.-W. (2023) · encephalitis · doi:10.47936/encephalitis.2022.00094 · Cited by 23
Owens, J. A., Simakajornboon, N., Kotagal, S., & Gringras, P. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.02.002 · Cited by 21
Melatonin Use in the ICU: A Systematic Review and Meta-Analysis
Tang, B. H. Y., Manalo, J., Chowdhury, S. R., Aldrich, J., Weinhouse, G. L., Cordoza, M. L., Louzon, P., Balas, M. C., Stollings, J. L., McNett, M., et al. (2025) · Critical Care Medicine · doi:10.1097/ccm.0000000000006767 · Cited by 21
Fraud in nutritional supplements for athletes: a narrative review
Martínez-Sanz, J. M., Ripoll, M. S., Braza, J. M. P., Martínez-Segura, A., Sánchez-Oliver, A. J., Ordóñez, F. M., & Cortell-Tormo, J. M. (2021) · Nutrición Hospitalaria · doi:10.20960/nh.03413 · Cited by 24
Sleep and chronotype in adults with persistent tic disorders
Ricketts, E. J., Montalbano, G. E., Burgess, H. J., McMakin, D. L., Coles, M. E., Piacentini, J. C., & Colwell, C. S. (2022) · Journal of Clinical Psychology · doi:10.1002/jclp.23323 · Cited by 21
Zisapel, N. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2053520 · Cited by 19
Adolescent sleep myths: Identifying false beliefs that impact adolescent sleep and well-being
Robbins, R., Beebe, D. W., Byars, K. C., Grandner, M. A., Hale, L., Tapia, I. E., Wolfson, A. R., & Owens, J. A. (2022) · Sleep Health · doi:10.1016/j.sleh.2022.08.001 · Cited by 20
Melatonin Treatment for Pediatric Patients with Insomnia: Is There a Place for It?
Rolling, J., Rabot, J., & Schroder, C. M. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s340944 · Cited by 23
Melatonin May Increase Anticancer Potential of Pleiotropic Drugs
Bojková, B., Kubatka, P., Qaradakhi, T., Zulli, A., & Kajo, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123910 · Cited by 21
Management of Sleep Disturbances Associated with Smith-Magenis Syndrome
Kaplan, K., Elsea, S. H., & Potocki, L. (2020) · CNS Drugs · doi:10.1007/s40263-020-00733-5 · Cited by 18
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Bell, A., Hewins, B., Bishop, C., Fortin, A. H., Wang, J., Creamer, J. L., Collen, J. F., & Werner, J. K. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5020016 · Cited by 19
Boccanegra, B., Verhaart, I. E. C., Cappellari, O., Vroom, E., & Luca, A. D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104917 · Cited by 18
Zakki, S. A., Muhammad, J. S., Li, J., Sun, L., Li, M.-L., Feng, Q., Li, Y., Cui, Z., & Inadera, H. (2019) · Metallomics · doi:10.1039/c9mt00238c · Cited by 17
Sleep problems during and after paediatric brain tumours.
Litsenburg, R. V. V., Kamara, D., Irestorm, E., Partanen, M., de Vries, R., Crabtree, V. M., & Daniel, L. C. (2023) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(22)00380-7 · Cited by 13
New pharmacologic agents for insomnia and hypersomnia
Earl, D. C., & Tyle, K. M. V. (2020) · Current opinion in pulmonary medicine · doi:10.1097/mcp.0000000000000722 · Cited by 14
Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals
Okeke, E. S., Ogugofor, M. O., Nkwoemeka, N. E., Nweze, E. J., & Okoye, C. O. (2021) · Microbes and Infection · doi:10.1016/j.micinf.2021.104886 · Cited by 16
Smithburger, P. L., & Patel, M. K. (2019) · Journal of Pharmacy Practice · doi:10.1177/0897190019840120 · Cited by 16
Ortiz, L. E., Morse, A. M., Krahn, L. E., Lavender, M., Horsnell, M., Cronin, D., Schneider, B., & Gudeman, J. (2025) · CNS Drugs · doi:10.1007/s40263-024-01142-8 · Cited by 15
Miglis, M. G., & Barwick, F. H. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.05.002 · Cited by 16
Thomas, S. J., Sakhuja, S., Colantonio, L. D., Li, M., Muntner, P., Reynolds, K., & Bowling, C. B. (2022) · SLEEP · doi:10.1093/sleep/zsac063 · Cited by 13
Melatonin use in children and adolescents: A scoping review of caregiver perspectives
Lee, S. K. M., Smith, L. D., Tan, E. C. K., Cairns, R. F., Grunstein, R. R., & Cheung, J. M. Y. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101808 · Cited by 14
Update and Progress in Pediatric Sleep Disorders
DelRosso, L. M., Mogavero, M. P., Ferri, R., Bruni, O., & Chen, M. L. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.08.030 · Cited by 16
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Gentile, C. P., Rosenthal, S. L., Blume, H. K., Rastogi, R. G., McVige, J. W., Bicknese, A. R., Ladak, A., Zaveri, H., Greene, K. A., & Barlow, K. M. (2024) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14795 · Cited by 13
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Salahub, C. M., Wu, P. E., Burry, L. D., Soong, C., Sheehan, K., MacMillan, T. E., & Lapointe‐Shaw, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010256 · Cited by 12
Wu, L., Isah, M. B., Zhang, S., Dang, M., & Zhang, X. (2023) · Analytical Methods · doi:10.1039/d3ay01182h · Cited by 13
Petti, T. A., Gupta, M., Fradkin, Y., & Gupta, N. (2023) · BJPsych Open · doi:10.1192/bjo.2023.589 · Cited by 14
Paiva, R., Correia, M., Delerue-Matos, C. M., & Amaral, J. S. (2024) · Foods · doi:10.3390/foods13060908 · Cited by 15
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Papillon‐Ferland, L., & Mallet, L. (2019) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v72i4.2920 · Cited by 13
Goldman, R. D., Bongiorno, P. B., Olcese, J., Witt‐Enderby, P. A., & Shatkin, J. P. (2021) · Pediatric Annals · doi:10.3928/19382359-20210823-01 · Cited by 13
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Metadata
- Authors
- Erland, L. A. E., & Saxena, P. K.
- Affiliations
- University of Guelph (CA)
- Corresponding author
- Saxena, Praveen K.
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2017-02-15
- Volume
- 13
- Issue
- 2
- Pages
- 275-281
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC5263083
- OpenAlex
- W2587113438
- Cited by
- 273
- References
- 27
- Citations by year
- 2026: 29 · 2025: 39 · 2024: 37 · 2023: 48 · 2022: 35 · 2021: 28 · 2020: 26 · 2019: 17 · 2018: 10 · 2017: 4
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada (46741)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pharmaceutical Quality and Counterfeiting
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Keywords
- serotonin, supplement quality, lot-to-lot variation, insomnia, sleep disorders, supplement regulation
- MeSH terms
- Biological Products, Chromatography, Liquid, Melatonin, Serotonin, Mass Spectrometry, Dietary Supplements, Electrochemical Techniques
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