The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Neural Correlates of Working Memory Performance in Primary Insomnia
Open accessAbstract
STUDY OBJECTIVES: To examine neural correlates of working memory performance in patients with primary insomnia (PIs) compared with well-matched good sleepers (GSs). DESIGN: Twenty-five PIs and 25 GSs underwent functional MRI while performing an N-back working memory task. SETTING: VA hospital sleep laboratory and University-based functional imaging center. PATIENTS OR PARTICIPANTS: 25 PIs, 25 GSs. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Although PIs did not differ from GSs in cognitive performance, PIs showed the expected differences from GSs in both self-reported and objective sleep measures. PIs, relative to GSs, showed reduced activation of task-related working memory regions. This manifested both as an overall reduction in activation of task-related regions and specifically as reduced modulation of right dorsolateral prefrontal cortex with increasing task difficulty. Similarly, PIs showed reduced modulation (i.e., reduced deactivation) of default mode regions with increasing task difficulty, relative to GSs. However, PIs showed intact performance. CONCLUSIONS: These data establish a profile of abnormal neural function in primary insomnia, reflected both in reduced engagement of task-appropriate brain regions and an inability to modulate task-irrelevant (i.e., default mode) brain areas during working memory performance. These data have implications for better understanding the neuropathophysiology of the well established, yet little understood, discrepancy between ubiquitous subjective cognitive complaints in primary insomnia and the rarely found objective deficits during testing.
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Citations
Cites
N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies.
Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005) · Human Brain Mapping · doi:10.1002/hbm.20131 · Cited by 3,560
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252
Functional Neuroimaging Evidence for Hyperarousal in Insomnia
Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2126 · Cited by 752 · cited 2×
“The omnibus MANOVA for sleep continuity variables was also not significant [F(5,44) = 1.”
MethodMedical and socio-professional impact of insomnia
Léger, D., Guilleminault, C., Bader, G., Lévy, E., & Paillard, M. (2002) · Sleep · doi:10.1093/sleep/25.6.621 · Cited by 468 · cited 1×
“Race, n (%) White 17 (68) 20 (80) American Indian or Alaskan Native 0 (0) 0 (0) Asian 4 (16) 0 (0) Native Hawaiian or Pacific Islander 1 (4) 0 (0) Black or African American 2 (8) 4 (16) Mixed race 1 (4) 1 (4)”
BackgroundChien, K.-L., Chen, P.-C., Hsu, H.-C., Su, T.-C., Sung, F.-C., Chen, M.-F., & Lee, Y.-T. (2010) · SLEEP · doi:10.1093/sleep/33.2.177 · Cited by 350 · cited 1×
“Sleep Diaries The omnibus MANOVA was significant [F(9,40) = 24.”
MethodInsomnia as predictor versus outcome of PTSD and depression among Iraq combat veterans
Wright, K. M., Britt, T. W., Bliese, P. D., Adler, A. B., Picchioni, D., & Moore, D. (2011) · Journal of Clinical Psychology · doi:10.1002/jclp.20845 · Cited by 264 · cited 1×
“Self-Report Measures The omnibus MANOVA was significant [F(10,39) = 67.”
MethodChoo, W.-C., Lee, W.-W., Venkatraman, V., Sheu, F.-S., & Chee, M. W. L. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.029 · Cited by 203
Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI
Huang, Z., Liang, P., Jia, X., Zhan, S., Li, N., Ding, Y., Lu, J., Wang, Y., & Li, K. (2012) · European Journal of Radiology · doi:10.1016/j.ejrad.2011.03.029 · Cited by 194
Fernandez-Mendoza, J., Vgontzas, A. N., Bixler, E. O., Singareddy, R., Shaffer, M. L., Calhoun, S. L., Karataraki, M., Vela-Bueno, A., & Liao, D. (2012) · SLEEP · doi:10.5665/sleep.1832 · Cited by 115
Cited by
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746
Brain mechanisms of insomnia: new perspectives on causes and consequences
Van Someren, E. J. W. (2021) · Physiological Reviews · doi:10.1152/physrev.00046.2019 · Cited by 543
Olaithe, M., Bucks, R. S., Hillman, D. R., & Eastwood, P. R. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2017.03.005 · Cited by 350
Hyperarousal in insomnia disorder: Current evidence and potential mechanisms
Dressle, R. J., & Riemann, D. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13928 · Cited by 218
Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies
Schiel, J. E., Holub, F., Petri, R., Leerssen, J., Tamm, S., Tahmasian, M., Riemann, D., & Spiegelhalder, K. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-01173-0 · Cited by 86
Metadata
- Authors
- Drummond, S. P. A., Walker, M., Almklov, E., Campos, M., Anderson, D. E., & Straus, L. D.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-01
- Volume
- 36
- Issue
- 9
- Pages
- 1307-1316
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2052555230
- Cited by
- 191
- References
- 10
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- green
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