Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort
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STUDY OBJECTIVES: To investigate the relationship between sleep duration and insomnia severity and the risk of all-cause death and cardiovascular disease (CVD) events. DESIGN: Prospective cohort study. SETTING: Community-based. PARTICIPANTS: A total of 3,430 adults aged 35 years or older. INTERVENTION: None. MEASUREMENTS AND RESULTS: During a median 15.9 year (interquartile range, 13.1 to 16.9) follow-up period, 420 cases developed cardiovascular disease and 901 cases died. A U-shape association between sleep duration and all-cause death was found: the age and gender-adjusted relative risks (95% confidence interval [CI]) of all-cause death (with 7 h of daily sleep being considered for the reference group) for individuals reporting < or = 5 h, 6 h, 8 h, and > or = 9 h were 1.15 (0.91-1.45), 1.02 (0.85-1.25), 1.05 (0.88-1.27), and 1.43 (1.16-1.75); P for trend, 0.019. However, the relationship between sleep duration and risk of CVD were linear. The multivariate-adjusted relative risk (95% CI) for all-cause death (using individuals without insomnia) were 1.02 (0.86-1.20) for occasional insomnia, 1.15 (0.92-1.42) for frequent insomnia, and 1.70 (1.16-2.49) for nearly everyday insomnia (P for trend, 0.028). The multivariate adjusted relative risk (95% CI) was 2.53 (1.71-3.76) for all-cause death and 2.07 (1.11-3.85) for CVD rate in participants sleeping > or = 9 h and for those with frequent insomnia. CONCLUSIONS: Sleep duration and insomnia severity were associated with all-cause death and CVD events among ethnic Chinese in Taiwan. Our data indicate that an optimal sleep duration (7-8 h) predicted fewer deaths.
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In a US study of over 3,400 men and women aged 35 or older, those who complained of insomnia every day had a significant increase in cardiovascular disease events compared to those without any insomnia complaint (RR 1.78, 95% CI 1.03-3.08).
“A study in the US of over 3,400 men and women 35 years of age or older reported a significant increase of cardiovascular disease events in those who complained of insomnia every day compared to those without any insomnia complaint (RR: 1.78, 95%CI 1.03–3.08) [214].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [214]
A few studies examined cardiovascular disease mortality in relation to self-reported sleep duration, but none found a significant association in fully adjusted models.
“A few studies have examined cardiovascular disease mortality in relation to self-reported sleep duration, but none found a significant association in fully adjusted models [212–214].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [214]
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- Authors
- Chien, K.-L., Chen, P.-C., Hsu, H.-C., Su, T.-C., Sung, F.-C., Chen, M.-F., & Lee, Y.-T.
- Affiliations
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- China Medical University (TW)
- China Medical University Hospital (TW)
- Corresponding author
- Lee, Yuan-Teh
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 33
- Issue
- 2
- Pages
- 177-184
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC2817905
- OpenAlex
- W2190946050
- Cited by
- 350
- References
- 46
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 23 · 2023: 24 · 2022: 31 · 2021: 16 · 2020: 21 · 2019: 17 · 2018: 27 · 2017: 20 · 2016: 27 · 2015: 25 · 2014: 28 · 2013: 35 · 2012: 18
- FWCI
- 30.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- National Taiwan University Hospital
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- sleep duration, insomnia, all-cause mortality, cardiovascular disease, cardiovascular events, U-shaped relationship, ethnic Chinese, optimal sleep duration, long sleep
- MeSH terms
- Adult, Aged, Cardiovascular Diseases, Cause of Death, Female, Habits, Health Surveys, Humans, Disorders of Excessive Somnolence, Sleep Initiation and Maintenance Disorders, Life Style, Male, Middle Aged, Prospective Studies, Risk, Sleep, Sleep Deprivation, Statistics as Topic, Taiwan, Cohort Studies, Health Behavior, Multivariate Analysis
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