Cited by 203Sleep and Work-Related FatigueSleep and Wakefulness ResearchNeural and Behavioral Psychology Studies

Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone

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Choo, Wei-Chieh, Lee, Wei-Wei, Venkatraman, Vinod, Sheu, Fwu-Shan, Chee, Michael W.L.·2005·NeuroImage

Abstract

Working memory is an important mental capacity that is compromised following sleep deprivation (SD). To understand how working memory load interacts with state to influence brain activation in load-sensitive regions, and the extent to which SD-related changes are common across different loads, we used fMRI to study twelve healthy subjects following 24 h of SD using a verbal n-back task with three load levels. Performance decline was observed by way of reduced accuracy and slower response times following SD. The left prefrontal region and thalamus showed load dependent activity modulation that interacted with state. The right parietal and anterior medial frontal regions showed load dependent changes in activity as well as an effect of state. The anterior cingulate and occipital regions showed activation that displayed state effects that were independent of working memory load. These findings represent a step toward identifying how different brain regions exhibit varying vulnerability to the deleterious effects of SD on working memory.

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Crossref · 10.1016/j.neuroimage.2004.11.029

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  • Various brain regions are differentially activated following sleep deprivation depending upon the complexity of the working memory task.

    “Additional work has suggested that various brain regions are differentially activated following sleep deprivation depending upon the complexity of the working memory task (Choo et al. 2005).”

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Authors
Choo, W.-C., Lee, W.-W., Venkatraman, V., Sheu, F.-S., & Chee, M. W. L.
Affiliations
  • SingHealth (SG)
  • National University of Singapore (SG)
Corresponding author
Chee, Michael W.L.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-04
Volume
25
Issue
2
Pages
579-587
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2089696953
Cited by
203
References
30
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 15 · 2012: 15
FWCI
13.01
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
  • SSRN Electronic Journal (submittedVersion)
Funders
  • National Medical Research Council
  • Biomedical Research Council
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
sleep deprivation, working memory load, prefrontal cortex, thalamus, parietal cortex, anterior cingulate cortex, occipital cortex, brain activation, state effects
MeSH terms
Adult, Cerebral Cortex, Female, Humans, Male, Memory, Sleep Deprivation

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