Chiral Drugs. An Overview
Laboratory of Toxicology, Faculty of Pharmacy, University of Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France., Chuong, Pham-Huy, Nguyen, Lien Ai, Department of Pharmacy, Lucile Salter Packard Children's Hospital, Stanford University Medical Center, 725 Welch Road, Palo Alto, CA 94304, USA, He, Hua, Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China·2006·International Journal of Biomedical Science
Cited by (1,000)
Items 301–400 of 1,000
- Reengineering a Reversible Covalent-Bonding Assembly to Optically Detect ee in β-Chiral Primary AlcoholsMatthew B. Minus, Aaron L. Featherston, Sooyun Choi, Sam C. King, Scott J. Miller, Eric V. Anslyn · 2019 · Chem
- A retrospective cross-sectional study to determine chirality status of registered medicines in TanzaniaKissa Watson Mwamwitwa, Raphael M. Kaibere, Adam Mitangu Fimbo · 2020 · Scientific Reports
- Screening Approach for Identifying Cocrystal Types and Resolution Opportunities in Complex Chiral Multicomponent SystemsWei‐Wei Li, Mariëtte de Groen, Herman J. M. Kramer, R. De Gelder, Paul Tinnemans, Hugo Meekes, Joop H. ter Horst · 2020 · Crystal Growth & Design
- An Account of Chiral Metal Surfaces and Their Enantiospecific ChemistryA. Gellman · 2021 · Accounts of Materials Research
- Enantioselective recognition of esomeprazole with a molecularly imprinted sol–gel-based electrochemical sensorLeyla Karadurmuş, M. Emin Çorman, Lokman Uzun · 2022 · Microchimica Acta
- Extended Connectivity Fingerprints as a Chemical Reaction Representation for Enantioselective Organophosphorus-Catalyzed Asymmetric Reaction PredictionRyosuke Asahara, Tomoyuki Miyao · 2022 · ACS Omega
- Chiral plasmonic sensing: From the perspective of light–matter interactionRyeong Myeong Kim, Jeong Hyun Han, Soo Min Lee · 2024 · The Journal of Chemical Physics
- Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explainAndrew G. Leach, Elizabeth A. Pilling, Alfred A. Rabow · 2012 · MedChemComm
- 3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase InhibitorsGaëlle Mariaule, Stéphane De Cesco, Francesco Airaghi, Jerry Kurian, Paolo Schiavini, Sylvain Rocheleau, Igor Huskić, Karine Auclair, Anthony Mittermaier, Nicolas Moitessier · 2015 · Journal of Medicinal Chemistry
- Enhancement of selective separation on molecularly imprinted monolith by molecular crowding agentXian-Hua Wang, Qian Dong, Ling-Ling Ying · 2016 · Analytical and Bioanalytical Chemistry
- Chiral Bambusurils for Enantioselective Recognition of Carboxylate Anion GuestsJan Sokolov, Vladimír Šindelář · 2018 · Chemistry - A European Journal
- Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell DeathPoonam Dangi, Ravi Jain, Rajanikanth Mamidala, Vijeta Sharma, Shalini Agarwal, Chandramohan Bathula, Maringanti Thirumala Chary, Subhabrata Sen, Shailja Singh · 2019 · Scientific Reports
- Giant Tunable Circular Dichroism of Large-Area Extrinsic Chiral Metal Nanocrescent ArraysLiyuan Cao, Jiwei Qi, Qiang Wu et al. · 2019 · Nanoscale Research Letters
- Chip-scale full-Stokes spectropolarimeter in silicon photonic circuitsZhongjin Lin, Tigran Dadalyan, Simon Bélanger-de Villers · 2020 · Photonics Research
- Improvement of the Process Stability of Arylmalonate Decarboxylase by Immobilization for Biocatalytic Profen SynthesisMiriam Aßmann, Carolin Mügge, Sarah Katharina Gaßmeyer · 2017 · Frontiers in Microbiology
- Application of Infrared Multiple Photon Dissociation (IRMPD) Spectroscopy in Chiral AnalysisYingying Shi, Mengying Du, Juan Ren, Kailing Zhang, Yicheng Xu, Xianglei Kong · 2020 · Molecules
- Removal of Enantiomeric Ibuprofen in a Nanofiltration Membrane ProcessCarlyn J. Higgins, Steven J. Duranceau · 2020 · Membranes
- Separating and trapping of chiral nanoparticles with dielectric photonic crystal slabsSaisai Hou, Yingxia Liu, W. X. Zhang · 2021 · Optics Express
- Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic PrecursorsAaron S. Long, Audrey D. Zhang, Caitlin Meyer, Alexander C. Egilman, Joseph S. Ross, Joshua David Wallach · 2021 · JAMA Network Open
- Accumulation of chiral pharmaceuticals (ofloxacin or levofloxacin) onto polyethylene microplastics from aqueous solutionsYanan Chen, Yunkun Qian, Yijun Shi · 2022 · The Science of The Total Environment
- Chiral Resolution ofRS-Baclofen via a Novel Chiral Cocrystal ofR-Baclofen andL-Mandelic AcidSarita Songsermsawad, Phattananawee Nalaoh, Vinich Promarak · 2022 · Crystal Growth & Design
- Implementation of Nuclear Velocity Perturbation and Magnetic Field Perturbation Theory in CP2K and Their Application to Vibrational Circular DichroismEdward Ditler, Tomáš Zimmermann, Chandan Kumar · 2022 · Journal of Chemical Theory and Computation
- Computation-Aided Engineering of Cytochrome P450 for the Production of PravastatinMark A. Ashworth, Elvira Bombino, René M. de Jong, Hein J. Wijma, Dick B. Janssen, Kirsty J. McLean, Andrew W. Munro · 2022 · ACS Catalysis
- Nano‐kirigami enabled chiral nano‐cilia with enhanced circular dichroism at visible wavelengthsXing Liu, Qinghua Liang, Xiaochen Zhang · 2023 · Nanophotonics
- Recent Advances in Metaphotonic BiosensorsDang Du Nguyen, Seho Lee, Inki Kim · 2023 · Biosensors
- Chiral resolution of RS-ofloxacin through a novel diastereomeric cocrystal formation with L-glutamic acid by evaporative crystallization and quantification with capillary electrophoresisRaha Kaviani, Abolghasem Jouyban, Ali Shayanfar · 2024 · Separation and Purification Technology
- Explosive enantiospecific decomposition of aspartic acid on Cu surfacesBharat S. Mhatre, Soham Dutta, Aaron Reinicker, Burcu Karagoz, Andrew J. Gellman · 2016 · Chemical Communications
- Resolution of R‐(−) and S‐(+)‐ enantiomers of clenbuterol in pharmaceutical preparations and black‐market products using liquid chromatography–tandem mass spectrometryBenjamín Velasco‐Bejarano, Jahir Bautista, Ma. Olivia Noguez · 2017 · Drug Testing and Analysis
- Enantioselective optical trapping of chiral nanoparticles by tightly focused vector beamsManman Li, Shaohui Yan, Yanan Zhang, Peng Zhang, Baoli Yao · 2019 · Journal of the Optical Society of America B
- Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipelineKevin R. DeMarco, Pei‐Chi Yang, Vikrant Singh et al. · 2021 · Journal of Molecular and Cellular Cardiology
- Internally and externally induced chiral hybrid metal halide materials for advanced chiroptoelectronic applicationsPuxin Cheng, Yue Wang, Peihan Wang · 2026 · Chemical Society Reviews
- Chiral separation by a terminal chirality triggered P- helical quinoline oligoamide foldamerHiroki Noguchi, Makoto Takafuji, Victor Maurizot · 2016 · Journal of Chromatography A
- Challenges in membrane-based liquid phase separationsZe-Xian Nicholas Low, Huanting Wang · 2021 · Green Chemical Engineering
- Parametric Experimentation to Evaluate Chiral Bars Representative of Granular MotifNima Nejadsadeghi, François Hild A, Anil Kumar Misra · 2022 · International Journal of Mechanical Sciences
- Enantiomer‐Selective Molecular Sensing in the Nonlinear Optical Regime via Upconverting Chiral MetamaterialsKyu‐Tae Lee, Byung‐Hoon Kim, Lakshmi Raju, Sean P. Rodrigues, Doo‐Hyun Ko, Wenshan Cai · 2022 · Advanced Functional Materials
- Green and Strategic Approach for Chiral Resolution by Diastereomeric Salt Formation: The Study of Racemic IbuprofenHung Lin Lee, Ying Lun Hung, Ahmed Amin · 2023 · Industrial & Engineering Chemistry Research
- Optically ActiveT-Butylphenylphosphinothioic Acid: Synthesis, Selected Structural Studies and Applications as a Chiral Solvating AgentJ. Drabowicz, Patrycja Pokora‐Sobczak, D. Krasowska · 2014 · Phosphorus, sulfur, and silicon and the related elements
- New chiral oxo-bridged calix[2]arene[2]triazine for the enantiomeric recognition of α-racemic carboxylic acidsSelahattin Bozkurt, Mustafa Burak Türkmen · 2016 · Tetrahedron Asymmetry
- Synthesis, Molecular Modeling, and Biological Evaluation of Novel Chiral Thiosemicarbazone Derivatives as Potent Anticancer AgentsDemet Taşdemir, Ayşegül Karaküçük‐İyidoğan, Mustafa Ulaşlı, Tuğba Taşkın‐Tok, Emine Elçin Oruç‐Emre, Hasan Bayram · 2014 · Chirality
- Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatmentLuong N. Nguyen, Faisal Ibney Hai, James A. McDonald, Stuart J. Khan, William E. Price, Long Duc Nghiem · 2017 · Water Science & Technology
- Green asymmetric reduction of acetophenone derivatives: Saccharomyces cerevisiae and aqueous natural deep eutectic solventManuela Panić, Doris Delač, Marin Roje · 2018 · Biotechnology Letters
- Racemization of oxazepam and chiral 1,4-benzodiazepines. DFT study of the reaction mechanism in aqueous solutionLucija Hok, Lucija Božičević, Helena Sremec · 2019 · Organic & Biomolecular Chemistry
- Effects of D-arginine on Porphyromonas gingivalis biofilmYuyang Li, Baosheng Li, Weiwei Liu · 2020 · Journal of Oral Science
- On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 proteinKarim M. ElSawy, Chandra Shekhar Verma, David Philip Lane, Leo S. D. Caves · 2013 · Cell Cycle
- Sesquiterpene lactone stereochemistry influences herbivore resistance and plant fitness in the fieldJeffrey R. Ahern, Kenneth D. Whitney · 2013 · Annals of Botany
- Discrimination of Stereoisomers by Their Enantioselective Interactions with Chiral Cholesterol-Containing MembranesHironori Tsuchiya, Maki Mizogami · 2017 · Molecules
- Aqueous Biphasic Systems Using Chiral Ionic Liquids for the Enantioseparation of Mandelic Acid EnantiomersFrancisca A. e Silva, Mariam Kholany, Tânia E. Sintra · 2018 · Solvent Extraction and Ion Exchange
- Enantiospecificity of Cysteine Adsorption on a Ferromagnetic Surface: Is It Kinetically or Thermodynamically Controlled?Y. Lu, Brian P. Bloom, S. Qian, David H. Waldeck · 2021 · The Journal of Physical Chemistry Letters
- Designer phospholipids – structural retrieval, chemo-/bio- synthesis and isotopic labelingOliver Bogojevic, Jens Vinge Nygaard, Lars Wiking, Carl Arevång, Zheng Guo · 2022 · Biotechnology Advances
- Chiral plasmonic Au–Ag core shell nanobipyramid for SERS enantiomeric discrimination of biologically relevant small moleculesHongying Li, Jiale Zhang, Lingling Jiang · 2022 · Analytica Chimica Acta
- Customized optical chirality of vortex structured light through state and degree-of-polarization controlKayn A. Forbes, Dale Green · 2023 · Physical Review A
- Maximum Chirality Empowered by a Bound State in a Continuum in a Plasmonic MetasurfaceHanan Ali, Simone Zanotti, Giovanni Pellegrini · 2024 · ACS Applied Optical Materials
- Bioactive Molecules Profile from Natural CompoundsAdina‐Elena Segneanu, Silvia Maria Velciov, Sorin Olariu, Florentina Adriana Cziple, Daniel Damian, Ioan Grozescu · 2017 · InTech eBooks
- Amino-Acid-Catalyzed Direct Aldol BioconjugationTiauna S. Howard, Ryan D. Cohen, Ogonna Nwajiobi, Zilma Pereira Muneeswaran, Yonnette E. Sim, Neelam Lahankar, Johannes T.‐H. Yeh, Monika Raj · 2018 · Organic Letters
- Synthesis of imprinted styrene-maleic acid functionalized resin for enantio-selective extraction of R-amphetamineMohammed Monier, Ibrahim Youssef, D.A. Abdel-Latif · 2018 · Chemical Engineering Journal
- Whole-body spatially-resolved metabolomics method for profiling the metabolic differences of epimer drug candidates using ambient mass spectrometry imagingZhigang Luo, Dan Liu, Xuechao Pang et al. · 2019 · Talanta
- Chiral effects in low-cost plasmonic arrays of elliptic nanoholesEmilija Petronijevic, Hanan Ali, N. Zaric · 2020 · Optical and Quantum Electronics
- Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and ApplicationsMingshu Cui, Wei Zhang, Luyao Xie, Lu Chen, Lu Xu · 2020 · Molecules
- Exploration of the impact of stereochemistry on the identification of the novel translocator protein PET imaging agent [18F]GE-180Wai-Fung Chau, Andrew Black, Alan Clarke et al. · 2015 · Nuclear Medicine and Biology
- Phototransformation of achiral metasurfaces into handedness-selectable transient chiral mediaAndrew S. Kim, Anjan Goswami, Mohammad Taghinejad · 2024 · Proceedings of the National Academy of Sciences
- Observation of Intricate Chiral Optical Force in a Spin-Curl Light FieldChengxing Lai, Yuzhi Shi, Haiyang Huang et al. · 2024 · Physical Review Letters
- Chirality encoding in resonant metasurfaces governed by lattice symmetriesIvan Sinev, Felix Richter, Ivan Toftul · 2025 · Nature Communications
- Novel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolismQi Huang, Hui Zhang, Li Ping Bai et al. · 2020 · Cell Death and Disease
- Chiral separation and analysis of antifungal drugs by chromatographic and electromigration techniques: Results achieved in 2010–2020Giovanni D’Orazio, Chiara Fanali, Chiara Dal Bosco · 2021 · Reviews in Analytical Chemistry
- Extrinsic Chirality and Circular Dichroism at Visible Frequencies Enabled by Birefringent α-MoO3Nanoscale-Thick Films: Implications for Chiro-Optical ControlEmilija Petronijevic, Sina Abedini Dereshgi, Maria Cristina Larciprete, Marco Centini, Concita Sibilia, Koray Aydın · 2022 · ACS Applied Nano Materials
- Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocksHippolyte Meersseman Arango, Ludivine van den Biggelaar, Patrice Soumillion, Patricia Luis, Tom Leyssens, Francesca Paradisi, Damien P. Debecker · 2023 · Reaction Chemistry & Engineering
- Giant ultrafast dichroism and birefringence with active nonlocal metasurfacesGiulia Crotti, Mert Akturk, Andrea Schirato et al. · 2024 · Light Science & Applications
- Phosphorus-nitrogen compounds: Part 43. Syntheses, spectroscopic characterizations and antimicrobial activities of cis- and trans-N/O dispirocyclotriphosphazenes containing ferrocenyl pendant armsYasemin Tümer, Nuran Asmafiliz, Zeynel Kılıç · 2018 · Journal of Molecular Structure
- On-Surface Synthesis of Chiral π-Conjugate Porphyrin Tapes by Substrate-Regulated Dehydrogenative CouplingFeifei Xiang, Yan Lü, Zhongping Wang et al. · 2019 · The Journal of Physical Chemistry C
- Bioinspired Nitroalkylation for Selective Protein Modification and Peptide StaplingSriram Mahesh, Victor Adebomi, Zilma Pereira Muneeswaran, Monika Raj · 2019 · Angewandte Chemie International Edition
- New Insight Regarding the Relationship Between Enantioselective Toxicity Difference and Enantiomeric Toxicity Interaction from Chiral Ionic LiquidsHuilin Ge, Min Zhou, Daizhu Lv, Mingyue Wang, Cun-Zhu Dong, Yao Wan, Zhenshan Zhang, Suru Wang · 2019 · International Journal of Molecular Sciences
- Zinc oxide/Vancomycin-based Electrochemical Chiral Sensor for the Recognition of Penicillamine EnantiomersRuzniza Mohd Zawawi, Alvin Lim Teik Zheng · 2020 · International Journal of Electrochemical Science
- Rapid and efficient chiral method development for lamivudine and tenofovir disoproxil fumarate fixed dose combination using ultra-high performance supercritical fluid chromatography: A design of experiment approachMoolchand Kurmi, K. S. Jayaraman, Saravanan Natarajan · 2020 · Journal of Chromatography A
- Ni-Catalyzed Asymmetric Alkyl–Alkyl Cross-Coupling: Reaction Mode Development and ApplicationsQiong Yu, Muneer‐ul‐Shafi Bhat, Wei Shu · 2026 · Accounts of Chemical Research
- Advances in Chiral Separations at Nano LevelAl Arsh Basheer, Iqbal Hussain, Marcus Tullius Scotti · 2019 · Current Analytical Chemistry
- Lemon Terpenes Influence Behavior of the African Citrus Triozid Trioza erytreae (Hemiptera: Triozidae)Akua Konadu Antwi‐Agyakwa, Ayuka T. Fombong, Emilie Delétré · 2019 · Journal of Chemical Ecology
- A Proline-Based Tectons and Supramolecular Synthons for Drug Design 2.0: A Case Study of ACEIJoanna Bojarska, Milan Remko, Martin Breza, Izabela D. Madura, Andrzej Fruziñski, Wojciech M. Wolf · 2020 · Pharmaceuticals
- Organic-inorganic double networks as highly permeable separation membranes with a chiral selector for organic solventsMarko Milovanovic, Furkan Tabakoglu, Furkan Saki · 2022 · Journal of Membrane Science
- Experimental Observation of Vector Bound States in the ContinuumHuizhen Zhang, Weixuan Zhang, Shaohu Chen · 2023 · Advanced Optical Materials
- Chiral resolution methods for racemic pharmaceuticals based on cocrystal formationRaha Kaviani, Abolghasem Jouyban, Ali Shayanfar · 2023 · CrystEngComm
- Haloalkane Dehalogenases From Marine OrganismsAntonín Kunka, Jiřı́ Damborský, Zbyněk Prokop · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
- Synergistic enantioseparation systems with either cyclodextrins or cyclofructans and L‐alanine Tert butyl ester lactateAthina G. Nicolaou, Maria C. Mavroudi, Ioannis J. Stavrou · 2018 · Electrophoresis
- Development of environmentally friendly lipase-catalysed kinetic resolution of (R,S)-1-phenylethyl acetate using aqueous natural deep eutectic solventsManuela Panić, Mia Radović, Izabela Maros · 2020 · Process Biochemistry
- A new stability indicating reverse phase high performance liquid chromatography method for the determination of enantiomeric purity of a DPP‐4 inhibitor drug linagliptinAppalacharyulu Salapaka, Kishore Babu Bonige, Raghu Babu Korupolu · 2019 · Electrophoresis
- Interactions between pyrazole derived enantiomers and Chiralcel OJ: Prediction of enantiomer absolute configurations and elution order by molecular dynamics simulationsGuixiang Hu, Meilan Huang, Chengcai Luo · 2016 · Journal of Molecular Graphics and Modelling
- Atropselective Partitioning of Polychlorinated Biphenyls in a HepG2 Cell Culture System: Experimental and Modeling ResultsChunyun Zhang, Susanne Flor, Gabriele Ludewig, Hans‐Joachim Lehmler · 2020 · Environmental Science & Technology
- Single Diastereomers of the Clinical Anticancer ProTide Agents NUC-1031 and NUC-3373 Preferentially Target Cancer Stem CellsIn VitroMagdalena Ślusarczyk, Michaela Serpi, Essam Ahmed Ghazaly · 2021 · Journal of Medicinal Chemistry
- Synthesis of multiple longitudinal polarization vortex structures and its application in sorting chiral nanoparticlesXinyuan Ying, Guanghao Rui, Shuting Zou, Bing Gu, Qiwen Zhan, Yiping Cui · 2021 · Optics Express
- Preparation and evaluation of an ionic liquid embedded C18 and cellulose co-functionalized stationary phase with mixed-mode and chiral separation abilitiesJingqiu Zhou, Yaxin Yang, Meijun Wan · 2021 · Microchemical Journal
- Crystallization Behavior and Crystallographic Properties of dl -Arabinose and dl -Xylose Diastereomer SugarsBradley Tyson, Christopher M. Pask, Neil George, Elena Simone · 2022 · Crystal Growth & Design
- Reconfigurable chirality with achiral excitonic materials in the strong-coupling regimeP. Elli Stamatopoulou, Sotiris Droulias, Guillermo P. Acuna · 2022 · Nanoscale
- Macroscopic quantum electrodynamics theory of resonance energy transfer involving chiral moleculesJ. Franz, Stefan Yoshi Buhmann, Akbar Salam · 2023 · Physical Review A
- Spontaneous Chiral Resolution of a MnIII Spin‐Crossover Complex with High Temperature 80 K HysteresisConor T. Kelly, Ross Jordan, Solveig Felton, Helge Müller‐Bunz, Grace Genevieve Morgan · 2023 · Chemistry - A European Journal
- Chiral Analysis of Pesticides and Emerging Contaminants by Capillary Electrophoresis—Application to Toxicity EvaluationLaura García-Cansino, Marı́a Luisa Marina, Maria Ángeles García · 2024 · Toxics
- Enantioseparation of citalopram analogues with sulfated β‐cyclodextrin by capillary electrophoresisYadi Wang, Shusheng Zhang, Zachary S. Breitbach · 2016 · Electrophoresis
- An indicator displacement assay recognizes enantiomers of chiral carboxylatesSara Sheykhi, Lorenzo Mosca, Johnathon M. Durgala · 2019 · Chemical Communications
- R -VAPOL-phosphoric acid based 1 H and 13 C-NMR for sensing of chiral amines and acidsDurga Prasad, Santosh Mogurampelly, Sachin Rama Chaudhari · 2020 · RSC Advances
- Comparison of polysaccharide‐based and protein‐based chiral liquid chromatography columns for enantioseparation of drugsYandi Fu, Francesc Borrull, Núria Fontanals · 2020 · Chirality
- Enantiomeric separations of chiral pharmaceuticals using chirally modified tetrahexahedral Au nanoparticlesNisha Shukla, D. Yang, Andrew J. Gellman · 2015 · Surface Science
- Human Topoisomerase I mediated cytotoxicity profile of l-valine-quercetin diorganotin(IV) antitumor drug entitiesSabiha Parveen, Sartaj Tabassum, Farukh Arjmand · 2016 · Journal of Organometallic Chemistry