Chiral Drugs. An Overview

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1. Low Temperature Dynamic Chromatography for the Separation of the Interconverting Conformational Enantiomers of the Benzodiazepines Clonazolam, Flubromazolam, Diclazepam and Flurazepam
   Roberta Franzini, Alessia Rosetti, Claudio Villani · 2021 · Symmetry
2. Local versus bulk circular dichroism enhancement by achiral all‐dielectric nanoresonators
   Krzysztof M. Czajkowski, Tomasz J. Antosiewicz · 2022 · Nanophotonics
3. Development, Robustness by Design Expert and Validation of a Method for Enantiomeric Impurity Content Determination in Pretomanid Drug Substance and Pharmaceutical Dosage Form
   Surapuraju Pavan Kumar Raju, Raveendra Reddy Juturu · 2022 · Journal of Chromatographic Science
4. Multicomponent Chiral Quantification with Ultraviolet Circular Dichroism Spectroscopy: Ternary and Quaternary Phase Diagrams of Levetiracetam
   Maxime D. Charpentier, Raghunath Venkatramanan, Céline Rougeot, Tom Leyssens, Karen Johnston, Joop H. ter Horst · 2022 · Molecular Pharmaceutics
5. Chiral Inversion of Pharmaceutical Drugs - Mini Review
   Hassan Youssef Aboul-Enein, Valliappan Kannappan, Selvakumar Kanthiah · 2023 · Combinatorial Chemistry & High Throughput Screening
6. Chiral Co3Y Propeller-Shaped Chemosensory Platforms Based on19F-NMR
   Gabrielle Audsley, Harry Carpenter, Nsikak Bassey Essien et al. · 2023 · Inorganic Chemistry
7. Optical Chirality of Gold Chiral Helicoid Nanoparticles in the Strong Coupling Region
   Haowei Cheng, Kun Liang, Xuyan Deng · 2023 · Photonics
8. Molecular Origins of Chiral Amplification on an Achiral Surface: 2D Monolayers of Aspartic Acid on Cu(111)
   L. Cramer, Amanda M. Larson, Avery S. Daniels, E. Sykes, A. Gellman · 2023 · ACS Nano
9. A Chiral Emissive Conjugated Corral for High‐Affinity and Highly Enantioselective Recognition in Water
   Rong Fu, Qingyu Zhao, Han Han et al. · 2023 · Angewandte Chemie
10. Unraveling the Link between Solvent-Mediated Proton Transfer and the Salt Formation of Saccharin and Sulfamethazine
    Luís Padrela, Jacek Żegliński, Kevin Michael Ryan · 2018 · Crystal Growth & Design
11. Large Enantiospecificity of Step–kink Metal Surfaces: Contributions from the Backbone and Side Chain of α-Amino Acids
    Chao Chen, Sha Yang, Guirong Su, Qingmin Ji, Miguel Fuentes‐Cabrera, Shuang Li, Wei Liu · 2019 · The Journal of Physical Chemistry C
12. Theoretical study of anisotropy-induced extrinsic chirality and chiral discrimination of surface plasmon polaritons
    Qiang Zhang, Junqing Li, Rui Zhao, Xingguang Liu, Gebeyehu Dirbeba · 2020 · Physical Review A
13. β-cyclodextrin improve the tolerant of freshwater algal Spiny Scenedesmus to chiral drugs venlafaxine and its metabolite
    Wei Wang, Wenwen Gong, Shuangxi Zhou · 2020 · Journal of Hazardous Materials
14. Optimisation, scope and advantages of the synthesis of chiral phenylethanols using whole seeds ofBauhinia variegataL. (Fabaceae) as a new and stereoselective bio-reducer of carbonyl compounds
    Gabriela I. Demmel, Daniela L. Bordón, Ana María Vázquez · 2020 · Biocatalysis and Biotransformation
15. Chiral Templating of Polycarbonate Membranes by Pinene Using the Modified Atomic Layer Deposition Approach
    Libuše Brožová, Raúl Zazpe, Miroslav Otmar, Jan Přikryl, Roman Bulánek, Jan Žitka, Sabina Krejčíková, Pavel Izák, Jan M. Macák · 2020 · Langmuir
16. Eine enantioselektive elektronische Nase: Ein Array nanoporöser homochiraler MOF‐Filme zur stereospezifischen Erkennung chiraler Geruchsmoleküle
    Salih Okur, Peng Qin, Abhinav Chandresh, Chun Li, Zejun Zhang, Ulrich Lemmer, Lars Heinke · 2020 · Angewandte Chemie
17. Enhanced circular dichroism of sparse nanoobjects by localized superchiral optical field
    Guanghao Rui, Xinyuan Ying, Shuting Zou · 2021 · Journal of Optics
18. Local controllability of hot electron and thermal effects enabled by chiral plasmonic nanostructures
    Bowen Kang, Tingting Zhang, Lei Yan · 2022 · Nanophotonics
19. Optimal operation of batch enantiomer crystallization: From ternary diagrams to predictive control
    Caio Felippe Curitiba Marcellos, Helen Durand, Joseph Sang‐Il Kwon · 2017 · AIChE Journal
20. Enantioselective Separation of Racemic Tryptophan with Sonochemically Prepared Egg Albumin Microspheres
    Amruta Mutalikdesai, Amani Zoabi, Vijay Bhooshan Kumar · 2018 · ChemistrySelect
21. CuI‐Catalysed Enantioselective Alkyl 1,4‐Additions to (E)‐Nitroalkenes and Cyclic Enones with Phosphino‐Oxazoline Ligands
    Minkyeong Shin, Min-Ji Gu, Sung Soo Lim · 2018 · European Journal of Organic Chemistry
22. X-shaped chiral plasmonic nanostructured metasurfaces: A numerical study
    Khai Quang Le · 2019 · Optics Communications
23. Design, Synthesis and Pharmacological Evaluation of N ‐Benzyl Linoleamide Analogues from Tropaeolum tuberosum as NF‐κB Inhibitors and Nrf2 Activators
    Luis Apaza Ticona, Víctor Tena Pérez, Andreea Mădălina Șerban, Javier Sánchez Sánchez-Corral, Ángel Rumbero Sánchez · 2020 · ChemistrySelect
24. Expanding proteomics into the analysis of chiral drugs
    Sui, Jianjun, Zhang, Jianhua, Ching, Chi Bun, Chen, Wei Ning · 2009 · Molecular BioSystems
25. Navigating the future of ROA: Can it surprise us?
    Carin R. Lightner, Agnieszka Kaczor, Christian Johannessen · 2024 · Vibrational Spectroscopy
26. Engineering the Signal Resolution of a Paper-Based Cell-Free Glutamine Biosensor with Genetic Engineering, Metabolic Engineering, and Process Optimization
    Tyler J. Free, Joseph P. Talley, Chad D. Hyer · 2024 · Sensors
27. Enhancing the Screening Efficiency of Chiral Cocrystals for the Separation of Praziquantel through the Use of Coformer Derivatives
    Peerapon Rapeenun, Sarita Songsermsawad, Kajjana Boonpalit · 2025 · Crystal Growth & Design
28. Near-Field Terahertz Nanoscopy Spatially Resolves Chiral Drug–Cell Interactions: Toward Precision Intracellular Pharmacology
    Xitian Hu, Yadi Wang, Yue Wang · 2025 · Analytical Chemistry
29. Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers
    Jörg Duschmalé, Adrian Schäublin, Erik Daa Funder et al. · 2022 · Molecular Therapy — Nucleic Acids
30. Development of indolealkylamine derivatives as potential multi-target agents for COVID-19 treatment
    Jyoti Chauhan, Erika Cecon, Nedjma Labani, Florence Gbahou, Fernando Real, Morgane Bomsel, Kshatresh Dutta Dubey, Ranajit Das, Julie Dam, Ralf Jockers et al. · 2023 · European Journal of Medicinal Chemistry
31. Determination of Enantiomer in Tofacitinib Citrate Using Reversed-Phase Chiral High-Performance Liquid Chromatography
    Xue Lian Wang, Bo Jin, Zhijun Wang, Kaijing Guo, Tingting Zhang, Chen Ma · 2024 · Separations
32. Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED
    Lygia S. de Moraes, Jessica E. Burch, David A. Delgadillo et al. · 2024 · Organic Letters
33. A Chiral Hexa-amino Cyclotriphosphazene for Enantioselective Recognition of Small Organic Compounds
    Cavya Jose, Naniyil Sradha, Ramamoorthy Boomishankar · 2024 · Inorganic Chemistry
34. Plasmon-Enhanced Optical Chiral Molecule Detection Using Gold Nanoparticle Dimer Sensors
    Hao Xie, Dongdong Yan, Yi Liu, Xiaoyu Wang, Minghuai Yu, Weixiang Ye · 2024 · The Journal of Physical Chemistry C
35. Exploring the Crystal Landscape of Mandelamide and Chiral Resolution via Cocrystallization
    Shan Huang, Deirbhile Fitzgerald, Samuel A. Koledoye · 2024 · Crystal Growth & Design
36. SURMOFs: Liquid-Phase Epitaxy of Metal-Organic Frameworks on Surfaces
    Lars Heinke, Hartmut Gliemann, Pierre Tremouilhac · 2016 · Wiley-VCH eBooks
37. Fano-Induced Circular Dichroism in Three-Dimensional Plasmonic Chiral Metamolecules
    Khai Quang Le · 2017 · Journal of Electronic Materials
38. A New Approach to Chiral Enrichment by Exposure of Racemates of Amino Acids to Sonochemically‐Prepared BSA Microspheres
    Vijay Bhooshan Kumar, Yael Steinberg, Ze’ev Porat · 2017 · ChemistrySelect
39. Externe Umkehr eines Chiralitätstransfers im Photoschalter
    Christoph Jurissek, Fabian Berger, Fabian Eisenreich · 2018 · Angewandte Chemie
40. Innovation and Validation of an Assessment Method Using Molecular Models Following Stereochemistry Instruction in an Organic Chemistry Course
    Aisha A. Alsfouk · 2022 · Journal of Chemical Education
41. A Scent of Peppermint—A Microwave Spectroscopy Analysis on the Composition of Peppermint Oil
    Anna Krin, María Mar Quesada‐Moreno, Cristóbal Pérez · 2022 · Symmetry
42. Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β‐Lactams
    Eavan C. McLoughlin, John E. O’Brien, Cristina Trujillo · 2022 · ChemistryOpen
43. Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers
    Ana Sofia Almeida, Bárbara Silva, João Pedro Silva · 2023 · Molecules
44. Vibrational circular dichroism spectra of natural products by means of the nuclear velocity perturbation theory
    Edward Ditler, Chandan Kumar, Sandra Luber · 2023 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
45. Synthesis and Anti-Inflammatory Evaluation of a Library of Chiral Derivatives of Xanthones Conjugated with Proteinogenic Amino Acids
    Sara F. Vieira, Joana Araújo, Virgínia M. F. Gonçalves · 2023 · International Journal of Molecular Sciences
46. Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics
    Xiaozheng Wei, Sitan Diarra, Antoine Douchez · 2023 · Journal of Medicinal Chemistry
47. RNA nucleosides as chiral sensing agents in NMR spectroscopy
    Nanjundappa Lokesh, S. L. Sachin, Lagumaddepalli V. Narendra · 2015 · Organic & Biomolecular Chemistry
48. Towards EMIC rational design: setting the molecular simulation toolbox for enantiopure molecularly imprinted catalysts
    Tessa Jalink, Tom Farrand, Carmelo Herdes · 2016 · Chemistry Central Journal
49. Multiple homonuclear band‐selective decoupling NMR : Fast and unambiguous determination of diastereomeric excess
    Kavitha Rachineni, Veera Mohana Rao Kakita, Ramakrishna V. Hosur · 2017 · Magnetic Resonance in Chemistry
50. Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers
    Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda · 2018 · Pharmacology
51. Femtosecond Laser Mass Spectrometry and High Harmonic Spectroscopy of Xylene Isomers
    Abdullah Alharbi, Andrey E. Boguslavskiy, Dane R. Austin et al. · 2018 · Scientific Reports
52. Enantioselective synthesis of functionalized αα-aminophosphonic acid derivatives
    Aitor Maestro, Xabier del Corte, Edorta Martínez de Marigorta · 2019 · Phosphorus, sulfur, and silicon and the related elements
53. Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC Method
    Gowramma Byran, Ramachandran Senthil Kumar, Kalirajan Rajagopal · 2019 · Current Drug Research Reviews
54. Asymmetric Synthesis and Absolute Configuration Determination of an Enantioenriched Alcohol: A Discovery-Based Undergraduate Laboratory Experiment
    Ryan P. King, Alexander J. Wagner, Alexander Burtea · 2020 · Journal of Chemical Education
55. Plasmonically Enhanced Enantioselective Nanocolorimetry
    Po‐Wen Tang, Chao-Yi Tai · 2020 · ACS Sensors
56. Predicting Drug-Drug Interactions from Heterogeneous Data: An Embedding Approach
    Devendra Singh Dhami, Siwen Yan, Gautam Kunapuli · 2021 · Lecture notes in computer science
57. Enantiospecific Desorption Triggered by Circularly Polarized Light
    Farinaz Mortaheb, Katrin E. Oberhofer, Johann Riemensberger · 2019 · Angewandte Chemie
58. Construction of Micropore Membranes for Efficient Separation of Chiral Pesticides Based on Layer-by-Layer Technology
    Bizhu Lv, Ruying Zhong, Yue Wang, Guang Li, Siyun Zhang, Lei Yang, Meng Cai, Jin Zhang, Zhiyan Lu, Haibing Li et al. · 2022 · ACS Agricultural Science & Technology
59. Development and Validation of a Normal Phase Chiral HPLC Method for Analysis of Afoxolaner Using a Chiralpak®AD-3 Column
    Jinyou Zhuang, Satish Kumar, Abu M. Rustum · 2016 · Journal of Chromatographic Science
60. Enantiospecific adsorption of propranolol enantiomers on naturally chiral copper surface: A molecular dynamics simulation investigation
    Tahereh Sedghamiz, Maryam Bahrami, Mohammad Hadi Ghatee · 2017 · Chemical Physics
61. Diffusion of chiral molecules and propagation of structural chirality in anisotropic liquids
    Mireille Quémener, Tigran Galstian, Thomas Marmin, Victoria Laroche, Yves L. Dory · 2017 · Physical review. E
62. Dual 2-Hydroxypropyl-β-Cyclodextrin and 5,10,15,20-Tetrakis (4-Hydroxyphenyl) Porphyrin System as a Novel Chiral-Achiral Selector Complex for Enantioseparation of Aminoalkanol Derivatives with Anticancer Activity in Capillary Electrophoresis
    Błażej Grodner, Mariola Napiórkowska · 2021 · Molecules
63. Toxicology of Chiral Drugs
    Guang Zhong Yang, Hai‐Zhi Bu · 2011 · Wiley eBooks
64. Impact of the Polymorphic Form of Drugs/ NCE s on Preformulation and Formulation Development
    MHD. Bashir Alsirawan, Anant R. Paradkar · 2019 · Methods and principles in medicinal chemistry
65. Temperature Cycling Induced Deracemization of p-Synephrine in the Presence of Degradation
    Po Sang Lo, Madiha Nisar, Richard Lakerveld · 2024 · ACS Omega
66. Exploring the Impact of Chirality of Synthetic Cannabinoids and Cathinones: A Systematic Review on Enantioresolution Methods and Enantioselectivity Studies
    Ana Sofia Almeida, Rita M. G. Santos, Paula Guedes de Pinho · 2025 · International Journal of Molecular Sciences
67. Chiral Metasurfaces with Multidimensional Tunability for Optical Chiral States
    Dayang Lin, Abbas Ghaffari, Qing Gu · 2025 · Advanced Optical Materials
68. Cardamonin as a potential anticancer agent: Preclinical insights and clinical implications
    Nassrin A. Badroon, Abdulsamad Alsalahi, Musheer Abdulwahid Abdo Aljaberi · 2025 · World Journal of Clinical Oncology
69. Nanophotonic Strategies for Chiral Biosensing: Nanoparticles, Metasurfaces, Magneto‐Optical, and Quantum Approaches
    Jorge Ricardo Mejía-Salazar · 2025 · Advanced Photonics Research
70. Near-Field Topology-Optimized Superchiral Metasurfaces for Enhanced Chiral Sensing
    Zhongjun Jiang, Soyaib Sohag, You Jie Zhou · 2026 · Nano Letters
71. Stereoselective, sex-dependent 5-HT2A receptor modulation of cortical plasticity by MDMA in mice
    Maya Gaines-Smith, Justin M. Silverman, Michael Fiorillo, Jason Younkin, K. Moore, Jessica L. Maltman, Mario de la Fuente Revenga, Jennifer T. Wolstenholme, Richard A. Glennon, Maƚgorzata Dukat et al. · 2026 · Neuropsychopharmacology
72. Stereoselective Inhibition of High- and Low-Affinity Organic Cation Transporters
    Lukas Gebauer, Ole Jensen, Muhammad Rafehi · 2023 · Molecular Pharmaceutics
73. Thiolated Chiral Naphthalene Diimide Derivatives as Effective Selectors of the β‐Blocker Atenolol Enantiomers
    Agata Kowalczyk, Michał Duszczyk, Sławomir Sęk · 2024 · Advanced Functional Materials
74. Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism
    Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião · 2025 · Critical Reviews in Analytical Chemistry
75. Crystallization Resolution of a Racemic Compound (R,S)-Sulpiride Promoted by Chiral Ionic Liquids: Insight into the Effect on Selective Nucleation
    Yuxu Tao, Yue Xu, Yini Wang et al. · 2025 · Crystal Growth & Design
76. Identification of human hepatic UDP-glucuronosyltransferases involved in the glucuronidation of temazepam
    Keti Bardhi, Shelby Coates, Mengqi Zhao · 2025 · Drug Metabolism and Disposition
77. Natural Products with Potent Antimycobacterial Activity (2000–2024): A Review
    Biniam Paulos, Daniel Bisrat, Mariamawit Yonathan Yeshak, Kaleab Asres · 2025 · Molecules
78. Modified Gaussian models applied to the description and deconvolution of peaks in chiral liquid chromatography
    Mireia Pérez‐Baeza, Laura Escuder‐Gilabert, María José Medina-Hernández · 2020 · Journal of Chromatography A
79. Chiral Recognition of Dansyl Derivatives with an Amino Acid-Based Molecular Micelle: A Molecular Dynamics Investigation
    Mauro A. Garcia, Nathan Black, Eugene J. Billiot · 2021 · Open Journal of Physical Chemistry
80. Estimating the concentration of chiral media with bright squeezed light
    Alexandre Belsley, Jonathan C. F. Matthews · 2022 · Applied Physics Letters
81. Theoretical Study on the Alkylimino-Substituted Sulfonamides with Potential Biological Activity
    Jakub Brzeski, Aleksandra Ciesielska, Mariusz Makowski · 2023 · The Journal of Physical Chemistry B
82. Comparative study for chiral separation of Atracurium besylate isomers: Eco-friendly HPLC using Lux Cellulose-3 chiral column, and TLC-Densitomerty approaches
    Marina A. Nessiem, Safa'a Mohamed Riad, Ahmed S. Fayed · 2023 · Sustainable Chemistry and Pharmacy
83. Chiral recognition without π−π-interactions: Highly efficient chiral strong cation exchangers lacking an aromatic unit in the molecular structure
    Magdaléna Labíková, Jiří Svoboda, Jiří Tůma, Wolfgang F. Lindner, Michal Kohout · 2024 · Journal of Chromatography A
84. Exploring Naproxen Cocrystals Through Solid‐State Vibrational Circular Dichroism
    Adam Sklenář, Anne Zehnacker, Jakub Kaminský · 2025 · Chirality
85. The Development and Validation of a Chiral High Performance Liquid Chromatography Method for the Identification and Quantification of (R)-Enantiomer in 10-Hydroxycamptothecin
    Arala Venkateshwarlu, A. V. R. RAO, Khagga Mukkanti · 2013 · Journal of the Brazilian Chemical Society
86. Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization
    Claudia Sanfilippo, Alessandra Forni, Angela Patti · 2016 · RSC Advances
87. Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs
    Wusan Wang, Hui Ji, Tingting Li · 2016 · Acta Pharmaceutica
88. Enantioselective rhodium-catalyzed hydroacylation to access the four stereoisomers of anti-rodent difenacoum
    Maïwenn Jacolot, Sylvie Moebs‐Sanchez, Florence Popowycz · 2017 · Tetrahedron Letters
89. Multiphase bioreactors in the pharmaceutical industry
    Rodrigo Melgarejo-Torres, Samuel Bernardo Pérez-Vega, Víctor M. Rivera · 2019 · Advances in chemical engineering
90. The effect of stereoisomerism on the 4D-QSAR study of some dipeptidyl boron derivatives
    Sevinç Çatalkaya, Nazmiye Sabancı, Sevtap Çağlar Yavuz · 2019 · Computational Biology and Chemistry
91. Development and Optimization of Stereoselective Liquid Chromatographic Method for Chiral Separation of (±)-cetirizine and Enantiopurity Assessment of R-levocetirizine
    Valliappan Kannappan, Selvakumar Kanthiah · 2020 · Journal of Analytical Chemistry
92. Effect of Chirality on the Compression of 2-(2-Oxo-1-pyrrolidinyl)butyramide: A Tale of Two Crystals
    Suse S. Bebiano, Joop H. ter Horst, Iain D. H. Oswald · 2020 · Crystal Growth & Design
93. The impact of chirality on the analysis of alkaloids in plant
    Ngoc‐Van Thi Nguyen, Kim-Ngan Huynh Nguyen, Kien Trung Nguyen, Kyeong Ho Kim, Hassan Youssef Aboul-Enein · 2021 · Pharmacia
94. Channels with Helical Modulation Display Stereospecific Sensitivity for Chiral Superstructures
    Renáta Rusková, Dušan Račko · 2021 · Polymers
95. Enantioseparation of amino acid and mandelic acid enantiomers using Josiphos‐metal complexes as chiral extractants
    Hou Wang, Yanning Yang, Shuping Qin · 2023 · Chirality
96. Enhancing temperature cycle-induced deracemization via combined cooling and antisolvent crystallization: A proof of concept study
    Emese Pálovics, Dorottya Fruzsina Bánhegyi, Hajnalka Pataki, Botond Szilágyi · 2023 · Arabian Journal of Chemistry
97. Synthesis, crystal structure, and biological activity of menthol-based chiral quaternary phosphonium salts (CQPSs)
    Daria M. Arkhipova, Aida Ildusovna Samigullina, Mikhail Evgenievich Minyaev · 2023 · Structural Chemistry
98. Employing quasidegenerate optical modes for chiral sensing
    S. F. Almousa, T. Weiss, Egor A. Muljarov · 2024 · Physical review. B./Physical review. B
99. Stereospecific quantitation of 6-prenylnaringenin in commercially available H. lupulus-containing natural health products and dietary supplements.
    Stephanie E. Martinez, Neal M. Davies · 2015 · PubMed
100. Diastereoselective Hydrolysis of Branched Malonate Diesters by Porcine Liver Esterase: Synthesis of 5‐Benzyl‐Substituted Cα‐Methyl‐β‐proline and Catalytic Evaluation
     Hari Kiran Kotapati, Jamarii D. Robinson, Daniel R. Lawrence · 2017 · European Journal of Organic Chemistry