Chiral Drugs. An Overview

Laboratory of Toxicology, Faculty of Pharmacy, University of Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France., Chuong, Pham-Huy, Nguyen, Lien Ai, Department of Pharmacy, Lucile Salter Packard Children's Hospital, Stanford University Medical Center, 725 Welch Road, Palo Alto, CA 94304, USA, He, Hua, Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China·2006·International Journal of Biomedical Science

Cited by (1,000)

Items 801–900 of 1,000

  1. Drug Discovery Impasse
    Rathnam Chaguturu, Bhushan Patwardhan · 2016 · Elsevier eBooks
  2. Enantiomeric Determination of Omeprazole and Esomeprazole by a Developed and Validated Chiral HPLC Method and Stability Studies by Microthermal Analysis
    A. F. M. Mustafizur Rahman, Mohammad Rashedul Haque, Md Zakir Sultan · 2018 · Dhaka University Journal of Pharmaceutical Sciences
  3. Enantiopure methoxetamine stereoisomers: chiral resolution, conformational analysis, UV-circular dichroism spectroscopy and electronic circular dichroism
    Kun Won Lee, Ahmed H.E. Hassan, Youngdo Jeong, Seolmin Yoon, Seunghwan Kim, Cheol Jung Lee, Hye Rim Jeon, Suk Woo Chang, Jiyoung Kim, Dae Sik Jang et al. · 2021 · New Journal of Chemistry
  4. Análisis comparativo de los plazos de pago en la industria alimentaria y la distribución comercial
    María Victoria Román González · 1995 · Información Comercial Española, ICE: Revista de economía
  5. Ultrasensitive and Tunable Achiral Metamaterial Substrates as Nanobiosensors for Enantiomer Detection
    Maryam Mirahmadi, Ali Douaki, Vincenzo Caligiuri · 2025 · ACS Applied Materials & Interfaces
  6. Chiral carbon quantum dots as an emerging nanoplatform for catalysis, molecular recognition, and bioimaging
    Damanpreet Singh, Ankush Kumar Tangra, Amanpreet Singh · 2025 · Inorganic Chemistry Communications
  7. Realization of arbitrary linear polarization conversion and wavefront modulation using chiral meta-atoms
    Yijun Fu, Zhengyong Song · 2026 · Optics and Lasers in Engineering
  8. Chiral Ligand-Protected Gold Nanoclusters as Biosensors for Small Chiral Biomolecules: A Computational Study
    Zohreh Fallah, Sami Malola, María Francisca Matus · 2026 · ACS Nano
  9. From Psychoactivity to Antimicrobial Agents: Multifaceted Applications of Synthetic Cathinones and Catha edulis Extracts
    Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Elena Bustamante Munguira, Celia Andrés, Eduardo Pérez‐Lebeña · 2024 · Molecules
  10. Double Salt Formation on Diastereoisomeric Crystallization of Mefloquine with Propionic and Succinic Acid Derivatives: A Structural Study of Chiral Nondiscrimination
    Paulo S. Carvalho, Juan Carlos Tenorio, Luan F. Diniz · 2025 · Crystal Growth & Design
  11. Calculation of Vibrational Circular Dichroism Spectra Employing Nuclear Velocity Perturbation or Magnetic Field Perturbation Theory Using an Atomic-Orbital-Based Linear Response Approach
    Ravi Kumar, Sandra Luber · 2025 · The Journal of Physical Chemistry A
  12. Bovine-Hemoglobin Detection by Single-Particle Plasmon-Coupled Circular Dichroism
    Ojasvi Verma, Subhasis Adhikari, Amrita Chakraborty · 2025 · Nano Letters
  13. Chiral Polythiophenes: Part I: Syntheses of Monomeric Precursors
    D. Krasowska, Rafał Karpowicz, J. Drabowicz · 2021 · Molecules
  14. On the Chirality of Drugs and the Structures of Biomacromolecules
    Ekaterina Belova, E. V. Semenova, V. A. Tverdislov · 2022 · BIOPHYSICS
  15. An enantio- and diastereoselective approach to indoloquinolizidines in continuous flow
    Moreshwar B. Chaudhari, Prachi Gupta, Patricia Llanes · 2022 · Organic & Biomolecular Chemistry
  16. Identification, synthesis, characterization, and a quality control strategy for high-risk chiral impurities in the antifungal drug substance posaconazole
    Bin Hu, Zhiliang Lv, Guiliang Chen · 2022 · Tetrahedron
  17. Diastereomeric salts of ( S , S )-sertraline with l - and d -tartaric acids: an investigation into chiral supramolecular discrimination
    Paulo S. Carvalho, Luan F. Diniz, Alejandro Pedro Ayala · 2023 · CrystEngComm
  18. The Same but Not the Same: The Case of (S)-Naproxen/cis-1-Amino-2-indanol Chiral Resolution via Diastereomeric Salt Formation
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  19. Sub-shot-Noise Circular Dichroism Spectroscopy for the Accelerated Characterization of Molecular Chirality
    Korenobu Matsuzaki, Tahei Tahara · 2024 · ACS Photonics
  20. Reversal of enantioselectivity by tuning the ring size of ProPhenol
    Xu‐Yi Huang, Na Li, Yu‐Hang Miao · 2024 · Organic Chemistry Frontiers
  21. Boric acid modified β-CD polymer as chiral selector for chiral drug separation using gravity mediated capillary electrophoresis
    Yaqin Nan, Xiaoqian Yuan, Xinyu Xu · 2025 · Microchemical Journal
  22. Hydrogen Bonding Interaction Enabled Asymmetric C─H Acylation of Trifluoroethanol by Dual Nickel/Photoredox Catalysis
    Yuanbo Li, Duo‐Duo Hu, Wei‐Ran Ren · 2025 · Angewandte Chemie
  23. Establishment of a Simple and Efficient Screening Protocol for Optical Resolution by Diastereomeric Salt Crystallization: Analyzing Success-Related Factors and Constructing Reliable Procedures from Previous Studies
    Keisuke Suzuki, Tomokazu Ogura, Masaki Hayashi · 2025 · Organic Process Research & Development
  24. Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA
    Dora M. Răsădean, Samuel W. O. Harrison, Isobel R. Owens · 2019 · Molecules
  25. Enantiomeric separation of vilanterol trifenatate by chiral liquid chromatography
    Yajun Guo, Yulei Yang, Jiajuan Peng · 2019 · Chirality
  26. Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs
    Rashid Mehmood, Naghmana Rashid, Shakir Ullah, Maria John Newton Amaldoss, Charles Christopher Sorrell · 2021 · Chemistry
  27. Surface Structure-Sensitive Enantioselectivity: Aspartic Acid Reaction Kinetics on All Surfaces Vicinal to Cu(111)
    Carlos Fernández-Cabán, Andrew J. Gellman · 2021 · The Journal of Physical Chemistry C
  28. Enantioselective synthesis of chiral 3-alkyl-3-nitro-4-chromanones via chiral thiourea-catalysed intramolecular Michael-type cyclization
    Huiqing Chen, Jie Tang, Ting Liu · 2021 · Organic & Biomolecular Chemistry
  29. Design of on-chip polarimetry with Stokes-determined silicon photonic circuits
    Liang Fang, Shuang Zheng, Jian Wang · 2021 · Optics Express
  30. The need to change the approach to the safe use of herbicides by developing chiral and environmentally friendly formulations: a series of enantioselective ( R )- and ( S )-phenylethylammonium chloroacetates
    Marika Turek, Robert Biczak, Barbara Pawłowska · 2022 · Green Chemistry
  31. Expanding the Biological Properties of Alkannins and Shikonins: Their Impact on Adipogenesis and Life Expectancy in Nematodes
    Athanasios S. Arampatzis, O. Tsave, Benjamin Kirchweger · 2022 · Frontiers in Pharmacology
  32. Determination of closantel enantiomers in black goat plasma and their pharmacokinetic characteristics
    Basma Saleh, Lü Li, Xing Chen · 2022 · Journal of Chromatography B
  33. Enantiomer Adsorption in an Applied Magnetic Field: D‐ and L‐Aspartic Acid on Ni(100)
    Michael Radetic, Andrew J. Gellman · 2022 · Israel Journal of Chemistry
  34. Green Asymmetric Reduction of Methylacetophenone
    Aliya R. Chanysheva, Aisilu Sufiyarova, Nikolay Privalov · 2022 · Russian Journal of General Chemistry
  35. StereoPHIP: Stereoselective Parahydrogen‐Induced Polarization
    Mai T. Huynh, Emily Boone Buchanan, Sara Chirayil · 2023 · Angewandte Chemie International Edition
  36. Design and Synthesis of Diphosphine Ligands Based on the Chiral Biindolyl Scaffold and Their Application in Transition-Metal Catalysis
    Fuhao Zhang, Gen‐Qiang Chen, Xumu Zhang · 2024 · Organic Letters
  37. Chirality of 20‐membered unclosed cryptand: Macroring distortion via lariat arm modification
    Janusz Jurczak, Adam A. Sobczuk, Kajetan Dąbrowa, Marcin Lindner, Patryk Niedbała, Paweł Stępniak · 2017 · Chirality
  38. Scalable Synthesis of Both Enantiomers of Vigabatrin, an Antiepileptic Drug
    Gorakhnath R. Jachak, D. Srinivasa Reddy · 2018 · European Journal of Organic Chemistry
  39. Push or Pull for a Better Selectivity? A Study on the Electronic Effects of Substituents of the Pyridine Ring on the Enantiomeric Recognition of Chiral Pyridino-18-Crown-6 Ethers
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  40. On enhanced sensing of chiral molecules in optical cavities
    Philip Scott, Xavier Garcia‐Santiago, Dominik Beutel, Carsten Rockstuhl, Martin Wegener, Ivan Fernandez‐Corbaton · 2020 · Repository KITopen (Karlsruhe Institute of Technology)
  41. Chiral Dualism as a Unifying Principle in Molecular Biophysics
    Ekaterina V. Malyshko, Ekaterina V. Semenova, Olga E. Bagrova, Alina R. Murtazina, V. A. Tverdislov · 2021 · Biophysica
  42. When crown ethers finally click: novel, click-assembled, fluorescent enantiopure pyridino-crown ether-based chemosensors – and an N -2-aryl-1,2,3-triazole containing one
    Balázs Szemenyei, Mira Malmosi, Dávid Pál · 2021 · New Journal of Chemistry
  43. An investigation of chiral diamides as organocatalysts in asymmetric aldol reaction
    Dilek Gul Yilmaz, Feray Aydoğan, Çiğdem Yolaçan · 2022 · Journal of Heterocyclic Chemistry
  44. Estimation of Enantiomeric Impurity in Piperidin‐3‐Amine by Chiral HPLC With Precolumn Derivatization
    Chittabathina Venkata Raghunadha Babu, Nagi Reddy Vuyyuru, K. Padmaja Reddy, Malladi V. S. Suryanarayana, Kaga Mukkanti · 2014 · Chirality
  45. Impact of carbon dioxide solvent separators on the degradation of benzyl-2,3-dihydroxypiperidine-1-carboxylate during preparative supercritical fluid chromatographic purification
    Kathiravan Asokan, Harshavardhan Naidu, Ratalababu Madam et al. · 2017 · Journal of Chromatography A
  46. Optical Resolution of Dimethyl α-Hydroxy-Arylmethylphosphonates via Diastereomer Complex Formation Using Calcium Hydrogen O,O′-Dibenzoyl-(2R,3R)-Tartrate; X-Ray Analysis of the Complexes and Products
    Zita Rádai, Péter Bagi, Mátyás Czugler · 2020 · Symmetry
  47. Nuance in the Narrative of a Brown Poison Frog: Environmental Alkaloids and Specialized Foraging in a Presumed Toxin-Free and Diet-Generalized Species
    Jeffrey L. Coleman, Steven Y. Wang, Paul E. Marek, Colin R. Morrison, Brian E. Sedio, David C. Cannatella · 2025 · Journal of Chemical Ecology
  48. Theoretical study of modified multiple dual-mode elution counter-current chromatography based on chiral separation
    Fuxin Zhang, Xingcui Wang, Xinyi Huang, Jinlong Zhang, Duolong Di, Dong Pei, Jun Hai · 2025 · Journal of Chromatography A
  49. Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs
    Raju Adhikary, Matteo Venturi, Giovanna Salvitti et al. · 2025 · Scientific Reports
  50. A chiral Ni(II) complex immobilized on Carboblack C as a readily available and effective enantioselective voltammetric sensor for recognition of atenolol enantiomers in real samples
    R. A. Zilberg, Yu. B. Teres, Elena O. Bulysheva, P. Yu. Ivanov, Ivan V. Vakulin, Maria V. Panova, Michael G. Medvedev, Mikhail Khrizanforov, Victor I. Maleev, Vladimir A. Larionov · 2025 · Electrochimica Acta
  51. Asymmetric construction of non-activated C-SCF3 stereocenter via copper-catalyzed hydroallylation of SCF3-alkenes
    Wei-Cheng Zhao, Yan He, Chenhui Jiang, Peng Liu, Qian Gao, Duo‐Duo Hu, Xi‐Sheng Wang · 2025 · Chinese Chemical Letters
  52. Enantioselective comparative analysis of the anticonvulsant potency of fenfluramine and norfenfluramine in mice
    Yara Sheeni, Natalia Erenburg, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer · 2025 · Epilepsia
  53. Strong coupling of chiral light with chiral matter: a macroscopic study
    Sergey A. Dyakov, Ilia A. Smagin, Natalia S. Salakhova · 2025 · Optica
  54. Rapid Vibrational Circular Dichroism Spectroscopy via Synchronized Photoelastic Modulator-Quantum Cascade Laser Integration
    Viviana Arrunategui Norvick, Michael Le, Eric Modesitt · 2025 · ACS Measurement Science Au
  55. Chiral Self-Assembly of Zinc and Magnesium Porphyrins with Enantiopure Cyclohexanohemicucurbiturils in Solution and in Solid State
    Marko Šakarašvili, Khai‐Nghi Truong, Lukáš Ustrnul et al. · 2025 · Inorganic Chemistry
  56. Chirality Transfer and Induction Across Multiscales Using Chiral Plasmonic Structures and Macroscopic Deformation
    Yousang Won, Jeongwoo Lee, Yoon Ho Lee · 2025 · Accounts of Chemical Research
  57. Revealing Electric‐Magnetic Asymmetry of Transverse Spin Angular Momentum using Polarization‐Selected Chiral Lateral Forces
    Lv Feng, Ruohu Zhang, Z. H. Li · 2025 · Laser & Photonics Review
  58. Induced chirality in metal porphyrin-based biomimetic catalysts promotes ORR activity by enabling spin-polarization effects
    Anujit Balo, Utkarsh Utkarsh, Mive Yasmin, Koyel Banerjee-Ghosh · 2026 · Journal of Materials Chemistry A
  59. Chiral Transformation of a Nanostructured Silver Film by Illumination with Circularly Polarized Light
    Daler R. Dadadzhanov, Nikita S. Petrov, Igor A. Gladskikh et al. · 2026 · ACS Nano
  60. Lessons in Stereochemistry: Resolution, Synthesis, and Characterization of Chiral Compounds
    Kevin A. Scott, Alexander Marciniak, William G. Benson · 2020 · Journal of Chemical Education
  61. Multigram‐scale HPLC enantioseparation as a rescue pathway for circumventing racemization problem during enantioselective synthesis of ethyl 3,4‐dihydro‐2H‐1,4‐benzoxazine‐2‐carboxylate
    Hong-Ngoc Pham, Axelle Arrault, Nicolas Vanthuyne, Samir Acherar · 2021 · Chirality
  62. Sensitive Chirality Measurements with Electrical Readout Utilizing the CISS Effect
    Shira Yochelis, Yossi Paltiel · 2022 · Israel Journal of Chemistry
  63. Prospects of Application of D-amino Acid Transaminase from Aminobacterium colombiense for (R)-selective Amination of α‑Keto Acids
    Sofia A. Shilova, Tatiana V. Rakitina, Vladimir O. Popov · 2023 · Moscow University Chemistry Bulletin
  64. STM/TERS observation of ( M )-type diphenyl[7]thiaheterohelicene on Ag(111)
    Sho Kimura, Takuma Hattori, Changqing Ye · 2024 · Physical Chemistry Chemical Physics
  65. Enantioselective ecotoxicity of promethazine in two freshwater organisms: daphnia (Daphnia magna) and zebrafish ( Danio rerio )
    Maria Miguel Coelho, Ondina Ribeiro, Ana Rita Carvalho · 2025 · Environmental Toxicology and Chemistry
  66. Stereochemical Control of Cocrystal and Hybrid Salt–Cocrystal Formation in the Baclofen–Mandelic Acid System
    Sarita Songsermsawad, Kajjana Boonpalit, Oleksii Shemchuk · 2025 · Crystal Growth & Design
  67. Rapid Access to Chiral 3-Oxabicyclo[3.1.1]heptanes by Iridium-Catalyzed Asymmetric Hydrogenation and Sequential Cyclization
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  68. Enantioselective assembly of amphipathic chiral polymer and racemic chiral small molecules during preparation of micro-scale polymer vesicles
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  69. The Effects of the Wild African Potato (Hypoxis hemerocallidea) Supplementation on Streptozotocin-Induced Diabetic Wistar Rats Reproductive Function
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  70. Practical Synthesis of Two Different Pseudoenantiomeric Organocatalysts with cis‐Cyclohexanediamine Structure from a Common Chiral Source
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  71. Asymmetric Ir-catalyzed hydrogenation of 1,5-benzodiazepinones using mixtures of ligands
    Sergey Evgen'evich Lyubimov, Dmitry V. Ozolin, Vadim A. Davankov · 2017 · Russian Chemical Bulletin
  72. The chiral nature of the enhanced interrogation programme
    Myles Balfe · 2018 · Aggression and Violent Behavior
  73. Vibrational spectra and conformations for chiral opiates in changing solvents
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  74. Dual Decomposition Pathways for L-Aspartic acid on Ni(100)
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  75. Fourier Transform Infrared Spectroscopy and Vibrational Circular Dichroism Assisted Elucidation of the Solution-State Supramolecular Speciation in Racemic and Enantiopure Ketoprofen
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  76. Chirality of proteinoid nanoparticles made of lysine and phenylalanine
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  77. Identification of the three Isomers of Monochlorophenol: Application of Briggs-Rauscher Oscillation
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  78. Vibrational dynamics of ethosuximide polymorphs. Infrared absorption and inelastic neutron scattering spectroscopy and model calculations
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  79. Enantiomeric Separation of (R)-5-(1-Hydroxyethyl)-2-(pyridine- 2-yl)-[1, 3, 4]-thiadiazole, an Intermediate of Nafithromycin on Immobilized Amylose Based Stationary Phase
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  80. Plasmonic characteristics of the structure with double graphene layers immersed in chiral media and applications in detection of chirality
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  81. Enantiomeric Resolution of Pidotimod and Its Isomers in Pidotimod Oral Solutions Using Chiral RP-HPLC with Quadrupole Dalton Analyzer Detection
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  82. Nickel-catalyzed N-arylation of optically pure amino acid esters with activated (hetero)aryl electrophiles
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  83. Theoretical and computational study of the effects of the complex chirality parameter in chiral-coated planar waveguides
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  85. Valbenazine isomers and enantiomer determination by chiral normal phase liquid chromatography
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  86. RETRACTED: Novel fabrication of Cu(II)-incorporated chiral d-penicillamine-chitosan nanocomposites enantio-selectively inhibit the induced amyloid β aggregation for Alzheimer's disease therapy
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  87. Synthesis of New Chiral β-Carbonyl Selenides with Antioxidant and Anticancer Activity Evaluation—Part I
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  88. Using the nature of the achiral solvent to orient chiral resolution
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  89. Atomic-scale origin of the enantiospecific decomposition of tartaric acid on chiral copper surfaces
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  93. A Chiral COFs Membrane for Enantioselective Amino Acid Separation
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  94. Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2‐a : 2,3‐c : 3,2‐h : 2′′′,3′′′‐j]Phenazine Ligand for Biomedical Applications
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  97. Super-enantiospecific Autocatalytic Decomposition of Tartaric Acid and Aspartic Acid on Cu Surfaces
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  98. 1,3,5,8-Tetrasubstituted 1,3,4-Benzotriazepin-2-one Scaffolds for β-Turn Mimicry without Stereogenic Carbon Centers: Synthesis and Conformational Analysis
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  99. Complete Genome Sequence of Sphingorhabdus sp. YGSMI21, Exhibiting High Enantioselective Epoxide Hydrolase Activity
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  100. Practical synthesis of four different pseudoenantiomeric organocatalysts with both cis- and trans-substituted 1,2-cis-cyclohexanediamine structures from a common intermediate
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