Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects

The biology , function , and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571

Regulation of immune responses by extracellular vesicles

Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260

Bone tissue engineering using 3D printing

Bose, S., Vahabzadeh, S., & Bandyopadhyay, A. K. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.017 · Cited by 1,873

3D bioprinting for engineering complex tissues

Mandrycky, C., Wang, Z., Kim, K., & Kim, D. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,818

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,466

The Smart Drug Delivery System and Its Clinical Potential

Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066

Exosomes: Therapy delivery tools and biomarkers of diseases

Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,053

Growth factor-functionalized titanium implants for enhanced bone regeneration: A review

Che, Z., Sun, Q., Zhao, Z., Wu, Y., Xing, H., Song, K., Chen, A., Wang, B., & Cai, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133153 · Cited by 20

A TMPS-designed personalized mandibular scaffolds with optimized SLA parameters and mechanical properties

Zheng, X., Duan, F., Song, Z., Mo, H., Li, Z., Song, Y., Su, Y., & Wang, X. (2022) · Frontiers in Materials · doi:10.3389/fmats.2022.966031 · Cited by 19

Personalized 3D‐Printed Scaffolds with Multiple Bioactivities for Bioroot Regeneration

Huang, Y., Zhang, Z., Bi, F., Tang, H., Chen, J., Huo, F., Chen, J., Lan, T., Qiao, X., Sima, X., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300625 · Cited by 19

The capacity of exosomes derived from adipose-derived stem cells to enhance wound healing in diabetes

Cai, F., Chen, W., Zhao, R., & Liu, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1063458 · Cited by 19

Therapeutic potential of stem cell-derived exosomes for bone tissue regeneration around prostheses

Wang, B., Lyu, F., Deng, Z., Zheng, Q., Ma, Y., Peng, Y., Guo, S., Lei, G., Lai, Y., & Li, Q. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.007 · Cited by 18

Stem Cell-Derived Extracellular Vesicles for Cancer Therapy and Tissue Engineering Applications

Lee, C., Lee, M., Na, K., & Hwang, H. S. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00376 · Cited by 18

Study of bioactive 3D-printed scaffolds incorporating zinc-based MOF for bone defect repair and anti-inflammatory applications

Han, Y., Jia, X., Yang, Y., Guo, P., Li, C., Zhang, Y., Yin, L., Jia, B., & Wang, H. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101884 · Cited by 20

Photoreceptor-targeted extracellular vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy

Guo, D. S., Sun, Y., Wu, J., Ding, L., Jiang, Y., Xue, Y., Ma, Y., & Sun, F. (2024) · Theranostics · doi:10.7150/thno.99484 · Cited by 18

Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits

Mu, X., Liu, H., Yang, S., Li, Y., Xiang, L., Hu, M., & Wang, X. (2022) · ACS Omega · doi:10.1021/acsomega.2c01176 · Cited by 17

Prospective applications of extracellular vesicle-based therapies in regenerative medicine: implications for the use of dental stem cell-derived extracellular vesicles

Wang, W., Xu, Z., Liu, M., Cai, M., & Liu, X. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1278124 · Cited by 18

Engineered hsa‐miR‐455‐3p‐Abundant Extracellular Vesicles Derived from 3D‐Cultured Adipose Mesenchymal Stem Cells for Tissue‐Engineering Hyaline Cartilage Regeneration

Chen, J., Zhang, E., Wan, Y., Huang, T., Wang, Y., & Jiang, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304194 · Cited by 19

Innovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery

Khobragade, S., Deshmukh, M. P., VYAS, U. B., & Ingle, R. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093937 · Cited by 19

Modulating osteoclasts with nanoparticles: A path for osteoporosis management?

Rouco, H., García‐García, P., Briffault, E., & Díaz‐Rodríguez, P. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1885 · Cited by 16

Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects

Shen, Z., Sun, F., Shan, Y., Lü, Y., Wu, C., Zhang, B., Wu, Q., Yuan, L., Zhu, J., Wang, Q., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100841 · Cited by 17

Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing

Han, D. H., Liu, W., Gong, J., Ma, Y., & Sun, Z. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1568914 · Cited by 15

Exosome-based engineering strategies for the diagnosis and treatment of oral and maxillofacial diseases

Ren, J., Jing, X., Liu, Y., Liu, J., Ning, X., Zong, M., Zhang, R., Cheng, H., Cui, J., Li, B., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02277-4 · Cited by 15

Multidimensional treatment of periprosthetic joint infection using fusion peptide-grafted chitosan coated porous tantalum scaffold

Liu, W., Zhang, K., Sun, Y., Xiao, Z., Hu, H., Xiong, Z., & Hu, Y. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.040 · Cited by 14

Narrative review of gene modification: applications in three-dimensional (3D) bioprinting

Fu, B., Shen, J., Chen, Y., Wu, Y., Zhang, H., Liu, H., & Huang, W. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-2854 · Cited by 14

Study on VEGFA mRNA delivery via GelMA hydrogel-encapsulated extracellular vesicles for enhanced bone regeneration

Li, S., Sheng, Y., You, Y., Wang, Y., Zhang, Y., Tao, J., Wu, C., & Jiang, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102144 · Cited by 17

Preparation of genetically or chemically engineered exosomes and their therapeutic effects in bone regeneration and anti-inflammation

Wang, X., Gong, W., Li, R., Li, L., & Wang, J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1329388 · Cited by 14

Functionalization of Ceramic Scaffolds with Exosomes from Bone Marrow Mesenchymal Stromal Cells for Bone Tissue Engineering

Maevskaia, E. N., Guerrero, J., Ghayor, C., Bhattacharya, I., & Weber, F. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073826 · Cited by 13

Chitosan–exosome synergy: Advanced cell-free scaffold approaches for bone tissue engineering

Suresh, N., Shanmugavadivu, A., & Selvamurugan, N. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140753 · Cited by 15

High resolution intravital photoacoustic microscopy reveals VEGF-induced bone regeneration in mouse tibia

Chen, Q., Wang, Z., Yang, C., Li, B., Ren, X., Liu, C., & Xi, L. (2022) · Bone · doi:10.1016/j.bone.2022.116631 · Cited by 14

The role of exosomes in regulation and application of vascular homeostasis and vascular grafts

Yang, X., Geng, B., Yan, J., Lin, L., Zhao, X., Xiao, H., Hu, H., Ye, L., Lv, W., & Zeng, W. (2023) · Smart Materials in Medicine · doi:10.1016/j.smaim.2023.04.002 · Cited by 13

Reconstructing avascular necrotic femoral head through a bioactive β-TCP system: From design to application

Lu, Y., Chen, X., Lu, X. F., Sun, C., Li, M., Chen, G., Long, Z., Gao, Y., Zhang, H., Huang, M., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.008 · Cited by 12

Non-coding RNA regulates the immune microenvironment in recurrent spontaneous abortion (RSA): new insights into immune mechanisms

Tang, C., & Hu, W. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad157 · Cited by 12

Exosome‐delivered miR ‐410‐3p reverses epithelial‐mesenchymal transition, migration and invasion of trophoblasts in spontaneous abortion

Chen, Z., Li, Z., Zong, Y., Xia, B., Luo, S., Deng, G., & Gao, J. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18097 · Cited by 11

From stem cells to extracellular vesicles: a new horizon in tissue engineering and regenerative medicine

Arbade, G. K., Jose, J. V., Gulbake, A., Kadam, S. S., & Kashte, S. (2024) · Cytotechnology · doi:10.1007/s10616-024-00631-4 · Cited by 15

A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration

Zhu, C., Li, Z., Qiu, X., Zhao, B., Wang, H., Wang, L., Zhuang, M., Liu, J., Han, F., & Li, B. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202500603 · Cited by 12

Monoporous Microsphere as a Dynamically Movable Drug Carrier for Osteoporotic Bone Remodeling

Li, Y., Zha, Y., Hu, W., Chen, J., Liu, S., Zhang, S., & Wang, J. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201242 · Cited by 12

Magnesium dopped Calcium-Fluoride/Icaritin composite multi-layer coating functionalized 3D printed β-TCP scaffold inducessustained bone regeneration in a rabbit model

Xue, P., Chen, H., Xi, H., He, S., Sun, G., Chang, Z., Tan, X., Liu, X., & Du, B. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111156 · Cited by 12

The potential therapeutic value and application prospect of engineered exosomes in human diseases

Liu, G., Wu, J., Chen, G., & Shang, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1051380 · Cited by 12

Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis

Ni, F., Chang, L., Peng, Y., Li, D., Wu, D., Li, K., Zhang, X., Jiang, X., Shao, Z., Chen, Y., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.007 · Cited by 11

Therapeutic Potential of Nano-Sustained-Release Factors for Bone Scaffolds

Jiang, H., Zhang, M., Qu, Y., Xing, B., Wang, B., Liu, Y., & Zhang, P. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16040136 · Cited by 11

Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy

Sun, Y., Chen, S., Qi, X., Sun, Y., Jiang, Z., Chang, J., Ma, Y., Huang, J., You, B., & Sun, F. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03671-w · Cited by 13

Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis

Lu, W., Shi, Y., & Xie, Z. (2022) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00212-4 · Cited by 11

Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair

Chen, J., Xian, G., Xiao, Z., Ge, F., Yuan, S., Li, B., Liang, X., Cai, Z., Zhang, N., Zhang, L., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.10.016 · Cited by 10

Combinational antitumor strategies of exosomes as drug carriers: Mini review

Xiao, G., Xu, Z., & Luo, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1107329 · Cited by 11

Strategies for in situ tissue engineering of vascularized bone regeneration (Review)

He, Y., Liang, L., Luo, C., Zhang, Z., & Huang, J. (2023) · Biomedical Reports · doi:10.3892/br.2023.1625 · Cited by 10

Therapeutic applications of stem cell-derived exosomes in radiation-induced lung injury

Li, Y., & He, Y. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03595-9 · Cited by 10

Advances in Functionalized Nanoparticles for Osteoporosis Treatment

Cai, R., Jiang, Y., Sun, H., Du, F., Zhu, L., Tao, J., Xiao, L., Wang, Z., & Shi, H. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s519945 · Cited by 10

Advanced micro-/nanotechnologies for exosome encapsulation and targeting in regenerative medicine

Golroudbari, H. T., Banikarimi, S. P., Ayati, A., Hadizadeh, A., Zavareh, Z. K., Hajikhani, K., Heirani‐Tabasi, A., Tafti, M. A., Davoodi, S., & Tafti, S. H. A. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-00993-7 · Cited by 10

Extracellular vesicles: A new frontier in the theranostics of cardiovascular diseases

Fu, E., & Li, Z. (2024) · iRadiology · doi:10.1002/ird3.77 · Cited by 9

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Li, G., Wu, J., Cheng, X., Pei, X., Wang, J., & Xie, W. (2024) · Small · doi:10.1002/smll.202408350 · Cited by 10

Exosome-integrated biomaterials: A paradigm in musculoskeletal regeneration

Lv, Z., Xu, J., Cai, X., Wang, Y., Yang, X.-D., Wang, H., Bian, Y., Zhu, Y., Feng, B., & Weng, X. (2025) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.102892 · Cited by 9

Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration

Li, L., Wu, P., Qian, H., Xu, W., Shi, H., & Jiang, J. (2022) · Stem Cells International · doi:10.1155/2022/7695078 · Cited by 9

Harnessing Engineered Extracellular Vesicles from Mesenchymal Stem Cells as Therapeutic Scaffolds for Bone‐Related Diseases

Yu, T., Wang, J., Zhou, Y., Ma, C., Bai, R., Huang, C., Wang, S., Liu, K., & Han, B. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402861 · Cited by 10

Four-Dimensional Perspective on Biomimetic Design and Fabrication of Bone Scaffolds for Comprehensive Bone Regeneration

Xu, H., Li, H., Liu, R., Liu, Y., Tian, F., Gao, X., Wang, Z., Lu, B., Wu, W., Hui, H., et al. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c00889 · Cited by 8

Spheroid-Exosome-Based Bioprinting Technology in Regenerative Medicine

Lee, H.-Y., & Lee, J. W. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15110345 · Cited by 10

BMP2 enhance the osteogenic effect of BMSCs-derived exosomes in skull defect of diabetic rats

He, Y., Wang, Y., Yu, S., Wang, L., Dou, Y., Ma, R., Cao, S., Song, W., & Ma, P. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.113517 · Cited by 8

Application and Mechanism of Adipose Tissue-Derived Microvascular Fragments in Tissue Repair and Regeneration

Gao, Y., Liang, C., Yang, B., Liao, L., & Su, X. (2025) · Biomolecules · doi:10.3390/biom15030422 · Cited by 8

Shear stress-mediated downregulation of miR-423-5p in M2 macrophage exosomes promotes osteogenic differentiation of bone marrow mesenchymal stem cells

Liu, W., Wang, X., Zhang, X., Yang, Y., & Bai, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115298 · Cited by 9

Extracellular vesicles for the treatment of preeclampsia

Yu, Z., Gao, M., Wei, Z., Dan, Y., Qian, Y., & Ruizhe, J. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101860 · Cited by 10

New Insights and Advanced Strategies for In Vitro Construction of Vascularized Tissue Engineering

Liang, J., Zhao, J., Chen, Y., Li, B., Li, Y., Lu, F., & Dong, Z. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0044 · Cited by 8

Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair

Duan, G., Chang, D., Zhang, C., Li, S., Liu, X., Wang, Z., Chen, L., Li, J., Bai, Z., & Weng, J. (2024) · Biosurface and Biotribology · doi:10.1049/bsb2.12081 · Cited by 9

Injectable EC-BMSC hydrogel with prolonged VEGF action for enhanced angiogenesis

Chen, S., Han, B., Zhao, Y., Ren, Y., Ai, S., Jin, M., Song, Y., Qu, X., & Wang, X. (2023) · Polymer Testing · doi:10.1016/j.polymertesting.2023.108109 · Cited by 7

Regulation of endothelial cells on the osteogenic ability of bone marrow mesenchymal stem cells in peri-implantitis

Xia, Y., Geng, N., Ren, J., Liao, C., Wang, M., Chen, S., Chen, H., & Peng, W. J. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102042 · Cited by 7

Scaffold internal network bioprinting for vascularized tissue regeneration

Suo, L., Guo, Y., Mou, S., Jin, Y., Zou, D., Sun, J., & Wang, Z. (2025) · Composites Part B Engineering · doi:10.1016/j.compositesb.2025.112401 · Cited by 6

Exosome-functionalized collagen-coated 3D-printed PCL scaffold for enhanced osteogenic differentiation and bone regeneration: an in vitro and in vivo study

Shemshadsara, F. G., Ai, J., Bayat, M., Ebrahimi‐Barough, S., Shirian, S., Mohamadnia, A., Kouhestani, M., Javdani, M., Karimzadeh, M. H., & Bahrami, N. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00578-w · Cited by 6

Exosomes in Bone Generation and Repair: Focusing on Bone Microenvironmental Crosstalk and Engineering Biomaterial Designs

Lin, Y., Xie, Y., He, Y., Zhang, M., Li, J., & He, J. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s568671 · Cited by 7

Biomaterial-assisted gene therapy for bone repair

Yang, L., Li, W., Yu, Y., Wang, H., & Wang, X. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102886 · Cited by 8

Echinacoside promotes osteogenesis and angiogenesis and inhibits osteoclast formation

Yi, Q., Sun, M., Jiang, G., Liang, P., Chang, Q. H., & Yang, R. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14198 · Cited by 6

Surface-modified electrospun poly-ε-caprolactone incorporating ZnO NPs and QK peptide to repair bone defect via osteogenesis, angiogenesis and antibacterial

Chen, Y., Liu, J., Dai, Z., Hu, H., Liu, Z., & Liu, W. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114388 · Cited by 6

Emerging strategies in bone tissue engineering

Radhakrishnan, A., Sreekumaran, S., Anjali, S., Rajalekshmi, R., & Saravana, R. P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824064-9.00013-7 · Cited by 7

Research trends and hotspot topics of exosomes based on citespace bibliometric analysis

Zhang, Q., Wang, X., Tan, L., Hou, Y., Lei, D., Huang, Y., He, B., & Wang, G. (2022) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2022.100179 · Cited by 6

Systematic review of exosomes derived from various stem cell sources: function and therapeutic potential in disease modulation

Puspita, R., & Jusuf, A. A. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10943-z · Cited by 7

Sympathetic nerve inhibition enhances calvarial bone repair via senescent macrophage-induced osteogenesis and angiogenesis

Zhao, L., Xu, Z., Zhao, P., Pang, Z., You, Y., Wu, C., Zhu, D., Su, M., Zhang, N., Luo, J., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02886-y · Cited by 5

Black phosphorus-based photothermal-responsive hydrogel enhanced osteoporotic bone injury regeneration by alleviating oxidative stress and remodeling bone homeostasis

Zhang, Y., Qi, G., Zhang, L., Chen, Y., Fu, J., Yang, L., Ke, Z., Ma, Y., Zhao, W., Zhao, Y., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04097-8 · Cited by 5

Design of patient-specific mandibular reconstruction plates and a hybrid scaffold

Dogan, S. E., Öztürk, C., & Koç, B. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109380 · Cited by 5

Dual-functional improvement of vascularization and bone formation of complementary PRP-based gel scaffold

Zhang, H., Wang, Z., Wang, Y., Liu, H., Li, M., Chao, B., Liu, S., Jiao, J., & Wu, M. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159512 · Cited by 5

Synergistic potentials of small extracellular vesicles, biomaterials, and 3D bioprinting in periodontal regeneration: a scoping review

Zhang, C., Liu, C., Liaw, A., Ivanovski, S., & Han, P. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.107 · Cited by 5

Engineered Exosomes: Advances in Therapeutic Applications for Otolaryngology–Head and Neck Diseases

Zhu, H., He, J., Yang, S., & Qin, G. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s574708 · Cited by 4

Mesenchymal stem cells and exosomes in bone defects treatment

Greben, A. I., Eremin, P. S., Kostromina, E. Y., Александрович, М. П., & Ринатовна, Г. И. (2024) · Genij Ortopedii · doi:10.18019/1028-4427-2024-30-1-124-133 · Cited by 4

Biomedical applications of extracellular vesicles (EVs): even better with cryogels

Rizqullah, A. H., & Saylan, Y. (2025) · Microchimica Acta · doi:10.1007/s00604-025-07560-9 · Cited by 5

Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head

Mao, R., Bi, W., Yang, M., Qin, L., & Li, W. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05456-1 · Cited by 4

Comprehensive analysis of exosomal circRNA , lncRNA, and mRNA profiles to identify the potential RNAs involved in the pathogenesis of venous malformation

Zhang, L., Shen, Y., Wang, Z., Li, X., Xia, W., Fan, X., Su, L., & Wang, D. (2023) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13416 · Cited by 3

Cell Ratio-Dependent Osteoblast–Endothelial Cell Crosstalk Promoting Osteogenesis–Angiogenesis Coupling via Regulation of Microfluidic Perfusion and Paracrine Signaling

Wang, Y., Chen, S., Fan, W., Zhang, S., & Chen, X. (2025) · Micromachines · doi:10.3390/mi16050539 · Cited by 3

Would Exosome Therapy be Effective for Bone Regeneration? Systematic Review and Meta-Analysis

de Moraes, V. F., Moreira, F. M., Santinoni, C. D. S., Batista, V. E. D. S., & Mori, G. G. (2025) · Calcified Tissue International · doi:10.1007/s00223-025-01438-x · Cited by 4

Acellular fishbone scaffolds loaded with bone marrow mesenchymal stem cell-derived exosomes for bone defect repairing

Zhu, L., Wang, J., Liu, Z., Chen, K., Wu, Z., & Wang, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03961-3 · Cited by 5

The potential of bioengineered exosomes in regenerative medicine: a next generation therapy

Kumari, S., Agnihotri, A., Sharma, A., Dongre, S., Tiwari, A., Soni, N., & Bissa, B. (2026) · Human Cell · doi:10.1007/s13577-026-01400-5 · Cited by 3

Enhanced Osteogenic Differentiation for Bone Tissue Engineering: The Synergistic Effect of Adipose‐Derived Mesenchymal Stem Cell Exosomes and Carboxymethyl Chitosan Hydrogel

Rajabi, R., Mohamadali, M., Sharifi, F., Moradi, Y., Hanjani, G. N., & Irani, S. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70034 · Cited by 3

Treatment with CR500® improves algofunctional scores in patients with knee osteoarthritis: a post-market confirmatory interventional, single arm clinical investigation

Colombini, A., Doró, G., Ragni, E., Forte, L., de Girolamo, L., & Zerbinati, F. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06754-7 · Cited by 3

Exosome MiR‐21‐5p Upregulated by HIF‐1α Induces Adipose Stem Cell Differentiation to Promote Ectopic Bone Formation

Wang, P., Liu, B., Song, C., Jia, J., Wang, Y., Pang, K., Wang, Y., & Chen, C. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301972 · Cited by 3

Advances in natural and synthetic macromolecules with stem cells and extracellular vesicles for orthopedic disease treatment

Wang, S., Jia, Z., Dai, M., Feng, X., Tang, C., Liu, L., & Cao, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131874 · Cited by 3

Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification

Xu, X., Li, J., Lü, Y., Shan, Y., Shen, Z., Sun, F., Zhu, J., Chen, W., & Shi, H. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202300428 · Cited by 3

3D-printed polymeric biomaterials in bone tissue engineering

Xia, T., Zhou, X., Zhou, H., Xiao, J., Xiang, J., Fang, H., Xiong, L., & Ding, F. (2025) · Biomedical Materials · doi:10.1088/1748-605x/ade18d · Cited by 2

Bone Organoids: Bridging Natural Bone with Advanced Organoid Technologies

Mao, K., Wang, Y., Tong, S., Li, B., He, Z., Wang, C., Zhang, C., Wang, X., Cheng, J., Liu, J. F., et al. (2025) · Tissue Engineering Part A · doi:10.1177/19373341251359279 · Cited by 2

Advances in biomimetic nano delivery systems for pulmonary hypertension therapy

Zhao, P., Wang, M., Liu, Z., Zhang, M., Cai, Z., Zhang, B., Shi, Z., Liu, M., & Cheng, Y. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.034 · Cited by 2

Three-dimensional (3D) printing-assisted freeze-casting of processed pyritum-doped β-tricalcium phosphate biomimetic scaffold with angiogenesis and bone regeneration capability

Wei, C., Li, Z., Liang, X., Zhao, Y., Zhu, X., Hua, H., Chen, G., Qin, K., Chen, Z., Shi, C., et al. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400340 · Cited by 2

Advances in 3D-Printed Drug Delivery and Screening Platforms for Bone Disease Therapy

Timofticiuc, I.-A., Grigore, A.-G., Tomescu, E.-T., Vlaicu, T.-M., Dragosloveanu, Ş., Scheau, A.-E., Căruntu, A., Dragosloveanu, C. D. M., Bădărău, I. A., Didilescu, A. C., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111372 · Cited by 2

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

Li, L., Zhang, H., Sun, L., Su, Y., Xu, Y., Huang, J., Wen, J., Zhu, J., Ma, J., & Xu, W. (2026) · Advanced Science · doi:10.1002/advs.74987 · Cited by 3

Working with mineralizing extracellular vesicles. Part V: Use of Mineralizing extracellular vesicles in bone regeneration

Hayann, L., de Melo, M. T., Nogueira, L. F. B., Ciancaglini, P., Bottini, M., & Ramos, A. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99158-2.00013-9 · Cited by 2

Engineering High-Performance Multifunctional Scaffolds from the Acellular Dermal Matrix for Abdominal Wall Defects Repair via a Dopamine Progressive Permeation-Cross-Linking Strategy

Wu, X., Xu, W., Huang, X., Dan, N., Chen, Y., Li, Z., & Wang, Y. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c01847 · Cited by 2

Research on the guidance of bone regeneration by microchannel porous scaffolds loaded with deferoxamine

Xue, Z., Hou, J., Zheng, M., Guo, Y., Yue, X., Chen, Y., & Jing, S. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115066 · Cited by 2

Modern osteoplastic materials

Salekh, K. M., Dymnikov, A. B., Mukhametshin, R. F., & Ivashkevich, S. G. (2023) · RUDN Journal of Medicine · doi:10.22363/2313-0245-2023-27-3-368-378 · Cited by 2

Development and application prospect of stem cell combined with 3D printing technology for oral disease

Jiang, W., LIU, C., CHEN, E., Tang, H., Wu, D., You, Y., HU, Y., CHEN, J., LEE, Y., Xu, Y., et al. (2025) · Biocell · doi:10.32604/biocell.2024.057259 · Cited by 1

Stimuli-responsive materials with programmable shape: programming strategies and applications

Zhou, D., Gao, M., Chen, F., Li, H., Zhen, C., Ju, Z., Lin, G., & Shi, Y. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114101 · Cited by 2

Extracellular Vesicles-Enhanced 3D (Bio)Printing for Bone Regeneration: A Systematic Review

Medojevic, M., Mitić, D., Jaćimović, J., Devillard, R., Jakovljević, A., & Kérourédan, O. (2026) · Tissue Engineering Part B Reviews · doi:10.1177/19373341251363638 · Cited by 1

FTO-engineered extracellular vesicles from bone marrow mesenchymal stem cells ameliorate Staphylococcus aureus-induced osteomyelitis via m6A-dependent suppression of autophagy and pyroptosis

Song, M., Lu, S., Tang, H., Lv, K., Li, X., Shi, J. R., & Xu, Y. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00572-2 · Cited by 1

Native and engineered exosome-based approaches for oral and maxillofacial tissue regeneration: Present and future

Li, Y., Hua, Y., Wang, Y., Qiao, H., Lin, S., Liu, Y., Zhou, M., & Jiang, X. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.114386 · Cited by 2

Gene-activated engineered exosome directs osteoblastic differentiation of progenitor cells and induces vascularized osteogenesis in situ

Lin, T., Zha, Y., Zhang, X., Chen, J., Li, Y., Wang, Z., Zhang, S., Wang, J., & Li, Z. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125939 · Cited by 22

Engineered exosomes for targeted bone regeneration: design, delivery, and functionalization

Emami, A., & Oskouie, I. M. (2026) · Cell and Tissue Banking · doi:10.1007/s10561-026-10213-7 · Cited by 6

Umbilical Mesenchymal Stem Cell-Derived Exosome-Encapsulated Hydrogels Accelerate Bone Repair by Enhancing Angiogenesis

Zhang, Y., Xie, Y., Hao, Z., Zhou, P., Wang, P., Fang, S., Lu, L., Xu, S., & Xia, Y. Q. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c22671 · Cited by 276

Engineering exosomes for bone defect repair

Ma, S., Zhang, Y., Li, S., Li, A., Li, Y., & Pei, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1091360 · Cited by 38

Exosomal Interventions in Bone and Osteochondral Repair: Mechanisms and Outcomes

Mohan, P. S., Majid, N. B. A., Susilo, R. J. K., Kunasekaran, W., Jin, T. L., Ee, L. C., Seng, C. K., & Gopinath, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211172 · Cited by 4