The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects
Open accessAbstract
In our current work, we designed specifically engineered exosomes based on the requirements of vascularized bone repair in segmental bone defects. This work simultaneously illuminates the potential of functional exosomes in acellular tissue engineering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Zha et al. extracted ATDC5 (chondrogenic progenitor cell line)-derived exosomes to load the vascular endothelial growth factor (VEGF) gene, which can effectively restore segmental bone defects by increasing osteogenesis and angiogenesis [86].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Regulation of immune responses by extracellular vesicles
Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260
Bone tissue engineering using 3D printing
Bose, S., Vahabzadeh, S., & Bandyopadhyay, A. K. (2013) · Materials Today · doi:10.1016/j.mattod.2013.11.017 · Cited by 1,873
3D bioprinting for engineering complex tissues
Mandrycky, C., Wang, Z., Kim, K., & Kim, D. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,818
Extracellular Vesicles: Unique Intercellular Delivery Vehicles
Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,466
The Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066
Exosomes: Therapy delivery tools and biomarkers of diseases
Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,053
Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 743
Oh, S. H., Park, I. K., Kim, J., & Lee, J. H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.024 · Cited by 720
Bonadio, J. F., Smiley, E. C., Patil, P. V., & Goldstein, S. A. (1999) · Nature Medicine · doi:10.1038/10473 · Cited by 650
Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551
Size Matters: Defining Critical in Bone Defect Size!
Schemitsch, E. H. (2017) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000000978 · Cited by 503
Vascularized 3D printed scaffolds for promoting bone regeneration
Yan, Y., Chen, H., Zhang, H., Guo, C., Yang, K., Chen, K., Cheng, R., Qian, N., Sandler, N., Zhang, Y. S., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.033 · Cited by 475
Chen, P., Zheng, L., Wang, Y., Tao, M., Xie, Z., Xia, C., Gu, C., Chen, J., Qiu, P., Mei, S., et al. (2019) · Theranostics · doi:10.7150/thno.31017 · Cited by 475
Martino, M. M., Tortelli, F., Mochizuki, M., Traub, S., Ben-David, D., Kuhn, G. A., Müller, R., Livne, E., Eming, S. A., & Hubbell, J. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002614 · Cited by 459
Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy
Gao, X., Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., & Yin, H. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0195 · Cited by 426
Prospects for Stem Cell-Based Therapy
Daley, G. Q., & Scadden, D. T. (2008) · Cell · doi:10.1016/j.cell.2008.02.009 · Cited by 305
Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration
Xia, Y., Sun, J., Zhao, L., Zhang, F., Liang, X., Guo, Y., Weir, M. D., Reynolds, M. A., Gu, N., & Xu, H. H. K. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.040 · Cited by 302
3D Bioprinting in Skeletal Muscle Tissue Engineering
Ostrovidov, S., Salehi, S., Costantini, M., Suthiwanich, K., Ebrahimi, M., Sadeghian, R. B., Fujie, T., Shi, X., Cannata, S. M., Gargioli, C., et al. (2019) · Small · doi:10.1002/smll.201805530 · Cited by 296
Bone tissue engineering with premineralized silk scaffolds
Kim, H. J., Kim, U., Kim, H. S., Li, C., Wada, M., Leisk, G. G., & Kaplan, D. L. (2008) · Bone · doi:10.1016/j.bone.2008.02.007 · Cited by 294
Cheng, G., Yin, C., Tu, H., Jiang, S., Wang, Q., Zhou, X. M., Xing, X., Xie, C., Shi, X., Du, Y., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b06032 · Cited by 258
Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds
Wang, J., Yang, M., Zhu, Y., Wang, L., Tomsia, A. P., & Mao, C. (2014) · Advanced Materials · doi:10.1002/adma.201400154 · Cited by 242
Wang, L., Yang, G., Zhao, D., Wang, J., Bai, Y., Peng, Q., Wang, H., Fang, R., Chen, G., Wang, Z., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0997-z · Cited by 232
Non-genetic engineering of cells for drug delivery and cell-based therapy
Wang, Q., Cheng, H., Peng, H., Zhou, H., Li, P. Y., & Langer, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.003 · Cited by 225
Wen, S., Dooner, M. S., Cheng, Y., Papa, E. F., Tatto, M. D., Pereira, M. G., Deng, Y., Goldberg, L. R., Aliotta, J. M., Chatterjee, D., et al. (2016) · Leukemia · doi:10.1038/leu.2016.107 · Cited by 219
ATDC5: An excellent in vitro model cell line for skeletal development
Yao, Y., & Wang, Y. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24467 · Cited by 207
Vrijsen, K. R., Maring, J. A., Chamuleau, S. A. J., Verhage, V., Mol, E. A., Deddens, J. C., Metz, C. H. G., Lodder, K., van Eeuwijk, E. C. M., van Dommelen, S. M., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600308 · Cited by 203
Designer Exosomes for Active Targeted Chemo‐Photothermal Synergistic Tumor Therapy
Wang, J., Dong, Y., Li, Y., Li, W., Cheng, K., Qian, Y., Xu, G., Zhang, X., Hu, L., Chen, P., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707360 · Cited by 187
3D Bioprinting Using a Templated Porous Bioink
Armstrong, J. P. K., Burke, M., Carter, B. M., Davis, S. A., & Perriman, A. W. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600022 · Cited by 183
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
Zuo, B., Han, Q., Lu, Z. F., Chen, L., Sun, B., Yang, R., Zhang, Y., Liu, Z., Gao, X., You, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15569-2 · Cited by 172
Gelinsky, M., Welzel, P. B., Simon, P., Bernhardt, A., & König, U. (2007) · Chemical Engineering Journal · doi:10.1016/j.cej.2007.09.029 · Cited by 153
Wei, M., Gao, X., Liu, L., Li, Z., Wan, Z., Dong, Y., Chen, X., Niu, Y. Z., Zhang, J., & Yang, G. (2020) · ACS Nano · doi:10.1021/acsnano.0c01860 · Cited by 149
Ruan, J., Wang, X., Zhang, Y., Wang, Z., Xie, Q., Zhang, D., Huang, Y., Zhou, H., Bi, X., Xiao, C., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201504141 · Cited by 145
The skeletal vascular system – Breathing life into bone tissue
Stegen, S., & Carmeliet, G. (2017) · Bone · doi:10.1016/j.bone.2017.08.022 · Cited by 130
Huang, Y., Ji, Y., Kang, Z., Li, F., Ge, S., Yang, D., Ruan, J., & Fan, X. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125098 · Cited by 116
3D Molecularly Functionalized Cell‐Free Biomimetic Scaffolds for Osteochondral Regeneration
Li, L., Li, J., Guo, J., Zhang, H., Zhang, X., Yin, C., Wang, L., Zhu, Y., & Yao, Q. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201807356 · Cited by 111
Exosome-mimetics as an engineered gene-activated matrix induces in-situ vascularized osteogenesis
Zha, Y., Lin, T., Li, Y., Zhang, X., Wang, Z., Li, Z., Ye, Y., Wang, B., Zhang, S., & Wang, J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119985 · Cited by 94
Dang, M., Koh, A. J., Jin, X., McCauley, L. K., & Ma, P. X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.049 · Cited by 92
Sun, X., Jung, J., Arvola, O., Santoso, M. R., Giffard, R. G., Yang, P. C.-M., & Stary, C. M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00394 · Cited by 90
Dual growth factor delivery using biocompatible core–shell microcapsules for angiogenesis
Choi, D. H., Subbiah, R., Kim, I. H., Han, D. K., & Park, K. (2013) · Small · doi:10.1002/smll.201300427 · Cited by 60
Local delivery of small and large biomolecules in craniomaxillofacial bone
Ji, W., Wang, H., van den Beucken, J. J. J. P., Yang, F., Walboomers, X. F., Leeuwenburgh, S. C. G., & Jansen, J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.03.003 · Cited by 56
Adult Stem Cells in Vascular Remodeling
Wang, D., Li, L. K., Dai, T., Wang, A., & Li, S. (2017) · Theranostics · doi:10.7150/thno.19577 · Cited by 43
Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing
Lopez, C. D., Bekisz, J. M., Corciulo, C., Mediero, A., Coelho, P. G., Witek, L., Flores, R. L., & Cronstein, B. N. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.010 · Cited by 35
Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles
Frampton, A. E., & Giovannetti, E. (2019) · Gut · doi:10.1136/gutjnl-2019-319896 · Cited by 5
Flagged first, then by citations
Cited by
Sorted by citations
Al-Shalawi, F. D., Ariff, A. H. M., Jung, D. W., Ariffin, M. K. A. M., Looi, C. S. K., Brabazon, D., & Al-Osaimi, M. O. (2023) · Polymers · doi:10.3390/polym15122601 · Cited by 250
Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes
Lei, F., Li, M., Lin, T., Zhou, H., Wang, F., & Su, X. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.12.035 · Cited by 213
Ding, J., Zhang, Y., Cai, X., Zhang, Y., Yan, S., Wang, J., Zhang, S., Yin, T., Yang, C., & Yang, J. (2021) · Theranostics · doi:10.7150/thno.58731 · Cited by 172
Cell-free exosome-laden scaffolds for tissue repair
Huang, J., Xiong, J., Yang, L., Zhang, J., Sun, S., & Liang, Y. (2021) · Nanoscale · doi:10.1039/d1nr01314a · Cited by 152
Ling, Z., Chen, Z., Deng, J. G., Wang, Y., Yuan, B., Yang, X., Lin, H., Cao, J., Zhu, X., & Zhang, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130302 · Cited by 141
Metadata
- Authors
- Zha, Y., Li, Y., Lin, T., Chen, J., Zhang, S., & Wang, J.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Zhang, Shengmin
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 1
- Pages
- 397-409
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7681080
- OpenAlex
- W3095185855
- Cited by
- 232
- References
- 47
- Citations by year
- 2026: 25 · 2025: 55 · 2024: 55 · 2023: 48 · 2022: 39 · 2021: 10
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (2017YFC1103900, 31670968, 91939111, SZSM201812055, 31800805, 81601610)
- Sanming Project of Medicine in Shenzhen (SZSM201812055)
- National Key Research and Development Program of China (2018YFC1105700, 2017YFC1103900)
- Fundamental Research Funds for the Central Universities (2019kfyRCPY103)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- exosomes, progenitor cells, vascular endothelial growth factor, osteogenic induction, vascular remodeling, segmental bone defect, gene delivery
- MeSH terms
- Animals, Bone and Bones, Bone Regeneration, Cell Adhesion, Cell Line, Male, Materials Testing, Osteogenesis, Plasmids, Polyesters, Radius, Stem Cells, Tissue Engineering, Vascular Endothelial Growth Factor A, Cell Proliferation, Mice, Rats, Tissue Scaffolds, X-Ray Microtomography, Exosomes, Vascular Remodeling, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review