The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Plasma Phospholipid Long-Chain ω-3 Fatty Acids and Total and Cause-Specific Mortality in Older Adults: A Cohort Study
Open accessAbstract
BACKGROUND: Long-chain ω-3 polyunsaturated fatty acids (ω3-PUFAs), including eicosapentaenoic acid (EPA) (20:5ω-3), docosapentaenoic acid (DPA) (22:5ω-3), and docosahexaenoic acid (DHA) (22:6ω-3), have been shown to reduce cardiovascular risk, but effects on cause-specific and total mortality and potential dose-responses remain controversial. Most observational studies have assessed self-reported dietary intake and most randomized trials have tested effects of adding supplements to dietary intake and evaluated secondary prevention, thus limiting inference for dietary ω3-PUFAs or primary prevention. OBJECTIVE: To investigate associations of plasma phospholipid EPA, DPA, DHA, and total ω3-PUFA levels with total and cause-specific mortality among healthy older adults not receiving supplements. DESIGN: Prospective cohort study. SETTING: 4 U.S. communities. PARTICIPANTS: 2692 U.S. adults aged 74 years (±5 years) without prevalent coronary heart disease (CHD), stroke, or heart failure at baseline. MEASUREMENTS: Phospholipid fatty acid levels and cardiovascular risk factors were measured in 1992. Relationships with total and cause-specific mortality and incident fatal or nonfatal CHD and stroke through 2008 were assessed. RESULTS: During 30 829 person-years, 1625 deaths (including 570 cardiovascular deaths), 359 fatal and 371 nonfatal CHD events, and 130 fatal and 276 nonfatal strokes occurred. After adjustment, higher plasma levels of ω3-PUFA biomarkers were associated with lower total mortality, with extreme-quintile hazard ratios of 0.83 for EPA (95% CI, 0.71 to 0.98; P for trend = 0.005), 0.77 for DPA (CI, 0.66 to 0.90; P for trend = 0.008), 0.80 for DHA (CI, 0.67 to 0.94; P for trend = 0.006), and 0.73 for total ω3-PUFAs (CI, 0.61 to 0.86; P for trend < 0.001). Lower risk was largely attributable to fewer cardiovascular than noncardiovascular deaths. Individuals in the highest quintile of phospholipid ω3-PUFA level lived an average of 2.22 more years (CI, 0.75 to 3.13 years) after age 65 years than did those in the lowest quintile. LIMITATION: Temporal changes in fatty acid levels and misclassification of causes of death may have resulted in underestimated associations, and unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSION: Higher circulating individual and total ω3-PUFA levels are associated with lower total mortality, especially CHD death, in older adults. PRIMARY FUNDING SOURCE: National Institutes of Health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“circulating concentrations of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) inversely correlate with cardiovascular risk. 3,4”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“The potential value of omega-3 fatty acids was supported by epidemiological studies demonstrating aninverserelationship between circulating concentrations of omega-3fattyacidsandcardiovascularrisk. 3,4”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [3]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“than corresponding values from population studies in the USA (0.5 % EPA and 2.9 % DHA) 35 , suggesting higher background consumption of n-3 PUFA in our Norwegian study population.”
From Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction (2021) · cites this paper as [35]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“It is also worth noting that the baseline median levels in our material (2.5 % EPA and 5.6 % DHA) are notably higher than corresponding values from population studies in the USA (0.5 % EPA and 2.9 % DHA) 35 , suggesting higher background consumption of n-3 PUFA in”
From Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction (2021) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“Biomarker levels of these fatty acids are only moderately interrelated (eg, r = 0.43,0.51, and 0.13 for EPA and DHA, EPA and DPA, and DPA and DHA, respectively).41”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [41]
In the citing paper
“Observational evidence supports the recommendation that the intake of fish (at least twice a week) and long chain n-3 fatty acids supplements at low dosage may reduce the risk of CV death and stroke in primary prevention, but have no major effects on plasma lipoprotein metabolism. 183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
In the citing paper
“Not enough data are available to make a recommendation regarding the optimal n-3:n-6 fatty acid ratio.182,183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
In the citing paper
“Observational evidence supports the recommendation that the intake of fish (at least twice a week) and long chain n-3 fatty acids supplements at low dosage may reduce the risk of CV death and stroke in primary prevention, but have no major effects on plasma lipoprotein metabolism.183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bootstrap methods: another look at the jackknife
Efron, B. (1979) · The Annals of Statistics · doi:10.1214/aos/1176344552 · Cited by 17,602
Cox, D. R., & Oakes, D. (2018) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315137438 · Cited by 6,269
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
Breslow, N. E., Cox, D. R., & Oakes, D. (1985) · Biometrics · doi:10.2307/2530888 · Cited by 4,381
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Flexible regression models with cubic splines
Durrleman, S., & Simon, R. M. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080504 · Cited by 2,722
Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60527-3 · Cited by 2,516
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Mozaffarian, D., & Rimm, E. B. (2006) · JAMA · doi:10.1001/jama.296.15.1885 · Cited by 1,966
Self-citationOmega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771
Self-citationRizos, E. C., Ntzani, E. E., Bika, E., Kostapanos, M. S., & Elisaf, M. S. (2012) · JAMA · doi:10.1001/2012.jama.11374 · Cited by 960
Siscovick, D. S. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530170043030 · Cited by 920
Self-citationClarke, R., Shipley, M. J., Lewington, S., Youngman, L. D., Collins, R., Marmot, M. G., & Peto, R. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010013 · Cited by 879
Surveillance and ascertainment of cardiovascular events
Ives, D. G., Fitzpatrick, A. L., Bild, D. E., Psaty, B. M., Kuller, L. H., Crowley, P. M., Cruise, R. G., & Theroux, S. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00093-9 · Cited by 688
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
Imig, J. D., & Hammock, B. D. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2875 · Cited by 616
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.3.242 · Cited by 599
Manson, J. E., Bassuk, S. S., Lee, I.-M. M., Cook, N. R., Albert, M. A., Gordon, D., Zaharris, E., MacFadyen, J. G., Danielson, E., Lin, J., et al. (2011) · Contemporary Clinical Trials · doi:10.1016/j.cct.2011.09.009 · Cited by 559
Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
Rice, T. W. (2011) · JAMA · doi:10.1001/jama.2011.1435 · Cited by 552
Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study
Psaty, B. M., Kuller, L. H., Bild, D. E., Burke, G. L., Kittner, S. J., Mittelmark, M. B., Price, T. R., Rautaharju, P. M., & Robbins, J. B. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00092-8 · Cited by 446
Laboratory methods and quality assurance in the Cardiovascular Health Study
Cushman, M., Cornell, E. S., Howard, P. R., Bovill, E. G., & Tracy, R. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.264 · Cited by 439
Lemaître, R. N., King, I. B., Mozaffarian, D., Kuller, L. H., Tracy, R. P., & Siscovick, D. S. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.319 · Cited by 395
Self-citationCardiac Benefits of Fish Consumption May Depend on the Type of Fish Meal Consumed
Mozaffarian, D., Lemaître, R. N., Kuller, L. H., Burke, G. L., Tracy, R. P., & Siscovick, D. S. (2003) · Circulation · doi:10.1161/01.cir.0000055315.79177.16 · Cited by 391
Self-citation(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368
Self-citationFotuhi, M., Mohassel, P., & Yaffe, K. (2009) · Nature Reviews Neurology · doi:10.1038/ncpneuro1044 · Cited by 344
Omega-3 Fatty Acids in Cardiac Biopsies From Heart Transplantation Patients
Harris, W. S., Sands, S. A., Windsor, S. L., Ali, H. A., Stevens, T. L., Magalski, A., Porter, C., & Borkon, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000142292.10048.b2 · Cited by 329
Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies.
Zheng, J., Huang, T., Yu, Y., Hu, X., Yang, B., & Li, D. (2012) · Public Health Nutrition · doi:10.1017/s1368980011002254 · Cited by 311
Yamagishi, K., Iso, H., Date, C., Fukui, M., Wakai, K., Kikuchi, S., Inaba, Y., Tanabe, N., & Tamakoshi, A. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.018 · Cited by 276
Fish Intake and Risk of Incident Heart Failure
Mozaffarian, D., Bryson, C. L., Lemaître, R. N., Burke, G. L., & Siscovick, D. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.038 · Cited by 275
Self-citationThe relationship between dose of vitamin E and suppression of oxidative stress in humans
Roberts, L. J., Oates, J. A., Linton, M. F., Fazio, S., Meador, B. P., Gross, M., Shyr, Y., & Morrow, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.019 · Cited by 260
ROSNER, B. A., Spiegelman, D. L., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116453 · Cited by 259
Pontes‐Arruda, A., DeMichele, S., Seth, A., & Singer, P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324203 · Cited by 230
Erkkilä, A. T., Lehto, S., Pyörälà, K., & Uusitupa, M. I. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.1.65 · Cited by 201
Virtanen, J. K., Mursu, J., Voutilainen, S., & Tuomainen, T. (2009) · Circulation · doi:10.1161/circulationaha.109.852657 · Cited by 188
Fish Consumption and Stroke Risk in Elderly Individuals: The Cardiovascular Health Study
Mozaffarian, D. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.2.200 · Cited by 183
Self-citationMozaffarian, D., Lemaître, R. N., King, I. B., Song, X., Spiegelman, D. L., Sacks, F. M., Rimm, E. B., & Siscovick, D. S. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-3-201108020-00006 · Cited by 182
Self-citationYuan, J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.9.809 · Cited by 173
Fredman, G., & Serhan, C. N. (2011) · Biochemical Journal · doi:10.1042/bj20110327 · Cited by 162
Mukamal, K. J., Chung, H., Jenny, N. S., Kuller, L. H., Longstreth, W. T., Mittleman, M. A., Burke, G. L., Cushman, M., Psaty, B. M., & Siscovick, D. S. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00561.x · Cited by 158
Self-citationPontes-Arruda, A., Martins, L. F., de Lima, S. M., Isola, A. M., Toledo, D., Rezende, E., Maia, M., Magnan, G. B., & the Investigating Nutritional Therapy with EPA, G. A. A. R. I. S. T. (. S. G. (2011) · Critical Care · doi:10.1186/cc10267 · Cited by 148
Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta‐analysis
Anandan, C., Nurmatov, U. B., & Sheikh, A. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02042.x · Cited by 145
Wu, J. H. Y., Lemaître, R. N., King, I. B., Song, X., Sacks, F. M., Rimm, E. B., Heckbert, S. R., Siscovick, D. S., & Mozaffarian, D. (2012) · Circulation · doi:10.1161/circulationaha.111.062653 · Cited by 143
Self-citationSiscovick, D. S. (1995) · JAMA · doi:10.1001/jama.274.17.1363 · Cited by 140
Self-citationSun, Q., Ma, J., Campos, H., Rexrode, K. M., Albert, C. M., Mozaffarian, D., & Hu, F. B. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.216 · Cited by 132
Self-citationFish Intake, Marine Omega-3 Fatty Acids, and Mortality in a Cohort of Postmenopausal Women
Folsom, A. R. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh307 · Cited by 120
Fish consumption and risk of major chronic disease in men
Virtanen, J. K., Mozaffarian, D., Chiuve, S. E., & Rimm, E. B. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2007.25816 · Cited by 114
Self-citationDietary assessment using a picture-sort approach
Kumanyika, S., Tell, G. S., Shemanski, L. R., Martel, J., & Chinchilli, V. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.4.1123s · Cited by 108
Pottala, J. V., Garg, S. K., Cohen, B. E., Whooley, M. A., & Harris, W. S. (2010) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.896159 · Cited by 95
Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia
Mayurasakorn, K., Williams, J. J., Ten, V. S., & Deckelbaum, R. J. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328342cba5 · Cited by 82
Siscovick (2003) · doi:10.1161/01.cir.0000074779.11379.62 · Cited by 81
Self-citationPicture-Sort Method for Administering a Food Frequency Questionnaire to Older Adults
Kumanyika, S., Tell, G. S., Fried, L. P., Martel, J. K., & Chinchilli, V. M. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00042-9 · Cited by 49
Aarsetoey, H., Pönitz, V., Grundt, H., Staines, H., Harris, W. S., & Nilsen, D. W. T. (2009) · Journal of Nutrition · doi:10.3945/jn.108.096446 · Cited by 45
Lee, S., Shin, M., Kim, J., Ko, Y., Kang, S., Choi, D., Jang, Y., Chung, N., Shim, W., Cho, S.-Y., et al. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0327 · Cited by 43
Corrected score estimation in the proportional hazards model with misclassified discrete covariates
Zucker, D. M., & Spiegelman, D. L. (2008) · Statistics in Medicine · doi:10.1002/sim.3159 · Cited by 38
Long-chain n−3 fatty acids and mortality in elderly patients
Lindberg, M., Saltvedt, I. T., Sletvold, O., & Bjerve, K. S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.3.722 · Cited by 32
Plasma-Saturating intakes of vitamin C confer maximal antioxidant protection to plasma
Johnston, C. S., & Cox, S. K. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719159 · Cited by 31
Mozaffarian, D., Lemaitre, R. N., & Kuller, L. H. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(03)00148-x · Cited by 26
Self-citationTiesset, H., Bernard, H., Bartke, N., Beermann, C., Flachaire, E., Desseyn, J., Gottrand, F., & Husson, M.-O. (2011) · Journal of Nutrition · doi:10.3945/jn.110.134585 · Cited by 24
Inference for the Proportional Hazards Model with Misclassified Discrete‐Valued Covariates
Zucker, D. M., & Spiegelman, D. L. (2004) · Biometrics · doi:10.1111/j.0006-341x.2004.00176.x · Cited by 20
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
fang, X., Singh, P., & Smith, R. G. (2009) · Drugs of the Future · doi:10.1358/dof.2009.34.7.1391872 · Cited by 18
Fish Intake and Risk of Incident Heart Failure
Mozaffarian, D., Bryson, C. L., & Lemaitre, R. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2005.09.025 · Cited by 16
Self-citationSea-cod oil supplementation alters the course of Streptococcus pneumoniae infection in BALB/c mice
Saini, A., Harjai, K., & Chhibber, S. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1099-4 · Cited by 8
Research works printed but not linked: 2
- Breslow NE, 1972, J R Stat Soc Series B Stat Methodol, 34, 216
- Fotuhi M, 2009, Nat Clin Pract Neurol, 5, 140
Cited by
Sorted by citations
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582
Omega-3 polyunsaturated fatty acids and their health benefits
Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390
Metadata
- Authors
- Mozaffarian, D., Lemaitre, R. N., King, I. B., Song, X., Huang, H., Sacks, F. M., Rimm, E. B., Wang, M., & Siscovick, D. S.
- Affiliations
- Brigham and Women's Hospital (US)
- From Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts; University of New Mexico, Albuquerque, New Mexico; and Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington.
- ORCID
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-04-02
- Volume
- 158
- Issue
- 7
- Pages
- 515-525
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- PMC
- PMC3698844
- OpenAlex
- W2015008724
- Cited by
- 283
- References
- 61
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 19 · 2020: 24 · 2019: 20 · 2018: 30 · 2017: 23 · 2016: 29 · 2015: 37 · 2014: 26 · 2013: 19
- FWCI
- 34.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc045133-001, n01hc085079-024, n01hc015103-009, n01hc085084-005, n01hc085085-011, n01hc085083-027, n01hc085080-026, n01hc085086-022, n01hc55222-0-0-0, n01hc075150-004, n01hc035129-010)
- National Institute on Aging (AG 20098, R56AG023629, R01AG020098, AG023629, AG027058, R56AG020098, R01AG023629, R01AG015928, R01AG027058)
- National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85085, N01 HC085086, N01HC-85083, N0-1-HC-85239, N01 HC085079, N01HC85082, N01HC‐75150, N01 HC85086, N01 HC035129, N01HC85080, N01 HC015103, N01 HC55222, HHSN268201200036C, U01HL080295, N01 HC055222, R01HL085710, HL080295, R01HL080295, N01 HC075150, N01 HC045133, N01-HC85079, N01-HC85084)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- plasma phospholipid fatty acids, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, all-cause mortality, cause-specific mortality, cardiovascular mortality, coronary artery disease, stroke, older adults, primary prevention, dietary fatty acids, dietary biomarkers, dose-response relationship
- MeSH terms
- Aged, Cause of Death, Coronary Disease, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Feeding Behavior, Female, Humans, Male, Prospective Studies, Eicosapentaenoic Acid, Biomarkers, Fatty Acids, Omega-3, Diet Records, Risk Assessment, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
