The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Plasma Phospholipid Long-Chain ω-3 Fatty Acids and Total and Cause-Specific Mortality in Older Adults: A Cohort Study
Open accessAbstract
BACKGROUND: Long-chain ω-3 polyunsaturated fatty acids (ω3-PUFAs), including eicosapentaenoic acid (EPA) (20:5ω-3), docosapentaenoic acid (DPA) (22:5ω-3), and docosahexaenoic acid (DHA) (22:6ω-3), have been shown to reduce cardiovascular risk, but effects on cause-specific and total mortality and potential dose-responses remain controversial. Most observational studies have assessed self-reported dietary intake and most randomized trials have tested effects of adding supplements to dietary intake and evaluated secondary prevention, thus limiting inference for dietary ω3-PUFAs or primary prevention. OBJECTIVE: To investigate associations of plasma phospholipid EPA, DPA, DHA, and total ω3-PUFA levels with total and cause-specific mortality among healthy older adults not receiving supplements. DESIGN: Prospective cohort study. SETTING: 4 U.S. communities. PARTICIPANTS: 2692 U.S. adults aged 74 years (±5 years) without prevalent coronary heart disease (CHD), stroke, or heart failure at baseline. MEASUREMENTS: Phospholipid fatty acid levels and cardiovascular risk factors were measured in 1992. Relationships with total and cause-specific mortality and incident fatal or nonfatal CHD and stroke through 2008 were assessed. RESULTS: During 30 829 person-years, 1625 deaths (including 570 cardiovascular deaths), 359 fatal and 371 nonfatal CHD events, and 130 fatal and 276 nonfatal strokes occurred. After adjustment, higher plasma levels of ω3-PUFA biomarkers were associated with lower total mortality, with extreme-quintile hazard ratios of 0.83 for EPA (95% CI, 0.71 to 0.98; P for trend = 0.005), 0.77 for DPA (CI, 0.66 to 0.90; P for trend = 0.008), 0.80 for DHA (CI, 0.67 to 0.94; P for trend = 0.006), and 0.73 for total ω3-PUFAs (CI, 0.61 to 0.86; P for trend < 0.001). Lower risk was largely attributable to fewer cardiovascular than noncardiovascular deaths. Individuals in the highest quintile of phospholipid ω3-PUFA level lived an average of 2.22 more years (CI, 0.75 to 3.13 years) after age 65 years than did those in the lowest quintile. LIMITATION: Temporal changes in fatty acid levels and misclassification of causes of death may have resulted in underestimated associations, and unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSION: Higher circulating individual and total ω3-PUFA levels are associated with lower total mortality, especially CHD death, in older adults. PRIMARY FUNDING SOURCE: National Institutes of Health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“circulating concentrations of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) inversely correlate with cardiovascular risk. 3,4”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“The potential value of omega-3 fatty acids was supported by epidemiological studies demonstrating aninverserelationship between circulating concentrations of omega-3fattyacidsandcardiovascularrisk. 3,4”
From Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk (2020) · cites this paper as [3]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“than corresponding values from population studies in the USA (0.5 % EPA and 2.9 % DHA) 35 , suggesting higher background consumption of n-3 PUFA in our Norwegian study population.”
From Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction (2021) · cites this paper as [35]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“It is also worth noting that the baseline median levels in our material (2.5 % EPA and 5.6 % DHA) are notably higher than corresponding values from population studies in the USA (0.5 % EPA and 2.9 % DHA) 35 , suggesting higher background consumption of n-3 PUFA in”
From Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction (2021) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“Biomarker levels of these fatty acids are only moderately interrelated (eg, r = 0.43,0.51, and 0.13 for EPA and DHA, EPA and DPA, and DPA and DHA, respectively).41”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [41]
In the citing paper
“Observational evidence supports the recommendation that the intake of fish (at least twice a week) and long chain n-3 fatty acids supplements at low dosage may reduce the risk of CV death and stroke in primary prevention, but have no major effects on plasma lipoprotein metabolism. 183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
In the citing paper
“Not enough data are available to make a recommendation regarding the optimal n-3:n-6 fatty acid ratio.182,183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
In the citing paper
“Observational evidence supports the recommendation that the intake of fish (at least twice a week) and long chain n-3 fatty acids supplements at low dosage may reduce the risk of CV death and stroke in primary prevention, but have no major effects on plasma lipoprotein metabolism.183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [183]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bootstrap methods: another look at the jackknife
Efron, B. (1979) · The Annals of Statistics · doi:10.1214/aos/1176344552 · Cited by 17,602
Cox, D. R., & Oakes, D. (2018) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315137438 · Cited by 6,269
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
Breslow, N. E., Cox, D. R., & Oakes, D. (1985) · Biometrics · doi:10.2307/2530888 · Cited by 4,381
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Flexible regression models with cubic splines
Durrleman, S., & Simon, R. M. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080504 · Cited by 2,722
Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60527-3 · Cited by 2,516
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Mozaffarian, D., & Rimm, E. B. (2006) · JAMA · doi:10.1001/jama.296.15.1885 · Cited by 1,966
Self-citation
Research works printed but not linked: 2
- Breslow NE, 1972, J R Stat Soc Series B Stat Methodol, 34, 216
- Fotuhi M, 2009, Nat Clin Pract Neurol, 5, 140
Cited by
Sorted by citations
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582
Omega-3 polyunsaturated fatty acids and their health benefits
Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390
Nicholls, S. J., Lincoff, A. M., Garcia, M., Bash, D., Ballantyne, C. M., Barter, P. J., Davidson, M. H., Kastelein, J. J. P., Koenig, W., McGuire, D. K., et al. (2020) · JAMA · doi:10.1001/jama.2020.22258 · Cited by 1,028
Self-citationStark, K. D., Van Elswyk, M. E., Higgins, M. R., Weatherford, C. A., & Salem, N. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.05.001 · Cited by 519
Association of Specific Dietary Fats With Total and Cause-Specific Mortality
Wang, D. D., Li, Y., Chiuve, S. E., Stampfer, M. J., Manson, J. E., Rimm, E. B., Willett, W. C., & Hu, F. B. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.2417 · Cited by 439
Self-citationDel Gobbo, L. C., Imamura, F., Aslibekyan, S., Marklund, M., Virtanen, J. K., Wennberg, M., Yakoob, M. Y., Chiuve, S. E., dela Cruz, L., Frazier-Wood, A. C., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.2925 · Cited by 404
Self-citationSokoła-Wysoczańska, E., Wysoczański, T., Wagner, J., Czyż, K., Bodkowski, R., Lochyński, S., & Patkowska-Sokoła, B. (2018) · Nutrients · doi:10.3390/nu10101561 · Cited by 376
Saini, R. K., Prasad, P., Sreedhar, R. V., Akhilender Naidu, K., Shang, X., & Keum, Y.-S. (2021) · Antioxidants · doi:10.3390/antiox10101627 · Cited by 337
Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction
Kalstad, A. A., Myhre, P. L., Laake, K., Tveit, S. H., Schmidt, E. B., Smith, P., Nilsen, D. W. T., Tveit, A., Fagerland, M. W., Solheim, S., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.052209 · Cited by 311
Targeting inflammation in metabolic syndrome
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
Harris, W. S., Tintle, N. L., Imamura, F., Qian, F., Korat, A. V. A., Marklund, M., Djoussé, L., Bassett, J. K., Carmichael, P.-H., Chen, Y.-Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22370-2 · Cited by 244
Self-citationDietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances
Wang, D. D., & Hu, F. B. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064614 · Cited by 228
Disorders of lipid metabolism. Clinical Guidelines 2023
Владиславович, Е. М., Kukharchuk, V. V., Сергиенко, И. В., Alieva, A. S., Antsiferov, M. B., Ansheles, A. A., Arabidze, G. G., Dm, A., Arutyunov, G. P., Ахмеджанов, Н. М., et al. (2023) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2023-5471 · Cited by 270
Health benefits of plant-derived α-linolenic acid
Rajaram, S. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071514 · Cited by 211
Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality
Wu, J. H. Y., Lemaître, R. N., King, I. B., Song, X., Psaty, B. M., Siscovick, D. S., & Mozaffarian, D. (2014) · Circulation · doi:10.1161/circulationaha.114.011590 · Cited by 202
Self-citationThe role of omega-3 in the prevention and treatment of sarcopenia
Dupont, J., Dedeyne, L., Dalle, S., Koppo, K., & Gielen, E. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01146-1 · Cited by 219
Doaei, S., Gholami, S., Rastgoo, S., Gholamalizadeh, M., Bourbour, F., Bagheri, S. E., Samipoor, F., Akbari, M. E., Shadnoush, M., Ghorat, F., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02795-5 · Cited by 197
Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement
Mensah, G. A., Arnold, N., Prabhu, S. D., Ridker, P. M., & Welty, F. K. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.08.047 · Cited by 231
Kuda, O., Březinová, M., Rombaldová, M., Slavı́ková, B., Pošta, M., Beier, P., Janovská, P., Veleba, J., Kopecký, J., Kudová, E., et al. (2016) · Diabetes · doi:10.2337/db16-0385 · Cited by 192
The Effect of n-3 Fatty Acids on Glucose Homeostasis and Insulin Sensitivity
Flachs, P., Rossmeisl, M., & Kopecký, J. (2014) · Physiological Research · doi:10.33549/physiolres.932715 · Cited by 190
Otto, M. C. D. O., Wu, J. H. Y., Baylín, A., Vaidya, D. M., Rich, S. S., Tsai, M. Y., Jacobs, D. R., & Mozaffarian, D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000506 · Cited by 179
Self-citationNestel, P., Clifton, P., Colquhoun, D., Noakes, M., Mori, T. A., Sullivan, D., & Thomas, B. (2015) · Heart, Lung and Circulation · doi:10.1016/j.hlc.2015.03.020 · Cited by 160
The Omega-6:Omega-3 ratio: A critical appraisal and possible successor
Harris, W. S. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.03.003 · Cited by 153
Genomics in Personalized Nutrition: Can You “Eat for Your Genes”?
Mullins, V. A., Bresette, W., Johnstone, L. M., Hallmark, B., & Chilton, F. H. (2020) · Nutrients · doi:10.3390/nu12103118 · Cited by 163
Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., & Welty, F. K. (2016) · The FASEB Journal · doi:10.1096/fj.201500155r · Cited by 143
Harris, W. S., Tintle, N., Etherton, M. R., & Vasan, R. S. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.02.010 · Cited by 149
Tessier, A., & Chevalier, S. (2018) · Nutrients · doi:10.3390/nu10081099 · Cited by 139
Dietary sources, current intakes, and nutritional role of omega‐3 docosapentaenoic acid
Byelashov, O. A., Sinclair, A. J., & Kaur, G. (2015) · Lipid Technology · doi:10.1002/lite.201500013 · Cited by 128
Jiang, H., Wang, L., Wang, D., Yan, N., Li, C., Wu, M., Wang, F., Mi, B., Chen, F., Jia, W., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.06.034 · Cited by 120
Kousoulaki, K., Østbye, T.-K. K., Krasnov, A., Torgersen, J. S., Mørkøre, T., & Sweetman, J. W. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.14 · Cited by 114
Bioactive metabolites of docosahexaenoic acid
Kuda, O. (2017) · Biochimie · doi:10.1016/j.biochi.2017.01.002 · Cited by 112
Maki, K. C., Palacios, O. M., Bell, M., & Toth, P. P. (2017) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.07.010 · Cited by 107
Afshordel, S., Hagl, S., Werner, D., Röhner, N., Kögel, D., Bazan, N. G., & Eckert, G. P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.008 · Cited by 115
The balance between food and dietary supplements in the general population
Lentjes, M. A. H. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002525 · Cited by 106
Inflammation and cardiovascular disease: are marine phospholipids the answer?
Lordan, R., Redfern, S., Τσούπρας, Α., & Zabetakis, I. (2020) · Food & Function · doi:10.1039/c9fo01742a · Cited by 104
Impact of Functional Foods on Prevention of Cardiovascular Disease and Diabetes
Sikand, G., Kris‐Etherton, P. M., & Boulos, N. M. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0593-9 · Cited by 109
Omega-3 fatty acids and adipose tissue biology
Kuda, O., Rossmeisl, M., & Kopecký, J. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.004 · Cited by 103
Omega-3 Fatty Acid Blood Levels
Superko, H. R., Superko, S. M., Nasir, K., Agatston, A. A., & Garrett, B. C. (2013) · Circulation · doi:10.1161/circulationaha.113.002731 · Cited by 100
Fenton, J. I., Hord, N. G., Ghosh, S., & Gurzell, E. A. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.011 · Cited by 99
Harris, W. S., Varvel, S. A., Pottala, J. V., Warnick, G. R., & McConnell, J. P. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.05.001 · Cited by 98
Wolfram, G., Bechthold, A., Boeing, H., Ellinger, S., Hauner, H., Kroke, A., Leschik-Bonnet, E., Linseisen, J., Lorkowski, S., Schulze, M., et al. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000437243 · Cited by 94
Rossmeisl, M., Medříková, D., van Schothorst, E. M., Pavlišová, J., Kuda, O., Hensler, M., Bardová, K., Flachs, P., Staňková, B., Vecka, M., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.010 · Cited by 94
Matthan, N. R., Ooi, E. M. M., Horn, L. V., Neuhouser, M. L., Woodman, R. J., & Lichtenstein, A. H. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000764 · Cited by 91
Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health: A Comprehensive Review
Elagizi, A., Lavie, C. J., Marshall, K., DiNicolantonio, J. J., O’Keefe, J. H., & Milani, R. V. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.03.006 · Cited by 92
Davidson, M. H. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000019 · Cited by 88
Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis
Kelly, O. J., Gilman, J. C., Kim, Y. J., & Ilich, J. Z. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.04.012 · Cited by 89
Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review
Rizzo, G., Baroni, L., & Lombardo, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031683 · Cited by 95
Virtanen, J. K., Siscovick, D. S., Lemaître, R. N., Longstreth, W. T., Jr., Spiegelman, D. L., Rimm, E. B., King, I. B., & Mozaffarian, D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000305 · Cited by 84
Self-citationZhu, Y., Li, M., Rahman, M. L., Hinkle, S. N., Wu, J., Weir, N. L., Lin, Y., Yang, H., Tsai, M. Y., Ferrara, A., et al. (2019) · PLOS Medicine · doi:10.1371/journal.pmed.1002910 · Cited by 79
Harris, W. S., Luo, J., Pottala, J. V., Espeland, M. A., Margolis, K. L., Manson, J. E., Wang, L., Brasky, T. M., & Robinson, J. G. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.12.013 · Cited by 75
Fontes, J. D., Rahman, F., Lacey, S., Larson, M. G., Vasan, R. S., Benjamin, E. J., Harris, W. S., & Robins, S. J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.03.043 · Cited by 74
Cancer Related Anemia: An Integrated Multitarget Approach and Lifestyle Interventions
Natalucci, V., Virgili, E., Calcagnoli, F., Valli, G., Agostini, D., Zeppa, S. D., Barbieri, E., & Emili, R. (2021) · Nutrients · doi:10.3390/nu13020482 · Cited by 71
The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment
Billman, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.011 · Cited by 69
Laidlaw, M., Cockerline, C. A., & Rowe, W. J. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-99 · Cited by 70
Darwesh, A. M., Bassiouni, W., Sosnowski, D. K., & Seubert, J. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107703 · Cited by 66
Liu, Q. K. (2021) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.05.007 · Cited by 65
Uncommon Fatty Acids and Cardiometabolic Health
Li, K., Sinclair, A. J., Zhao, F., & Li, D. (2018) · Nutrients · doi:10.3390/nu10101559 · Cited by 62
Rolland, Y., Barreto, P. D. S., Maltais, M. L., Guyonnet, S., Cantet, C., Andrieu, S., & Vellas, B. J. (2019) · Nutrients · doi:10.3390/nu11081931 · Cited by 62
Houston, M. C. (2018) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944717743920 · Cited by 62
Borges, M. C., Schmidt, A. F., Jefferis, B. J. M. H., Wannamethee, S. G., Lawlor, D. A., Mika Kivimaki, B., Meena Kumari, B., Gaunt, T. R., Ben‐Shlomo, Y., Tillin, T., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.013131 · Cited by 60
Fatty acids linked to cardiovascular mortality are associated with risk factors
Ebbesson, S. O. E., Voruganti, V. S., Higgins, P. B., Fabsitz, R. R., Ebbesson, L. O. E., Laston, S., Harris, W. S., Kennish, J. M., Umans, B. D., Wang, H., et al. (2015) · International Journal of Circumpolar Health · doi:10.3402/ijch.v74.28055 · Cited by 59
Zhuang, P., Wang, W., Wang, J., Zhang, Y., & Jiao, J. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.02.019 · Cited by 60
Otto, M. C. D. O., Lemaître, R. N., Song, X., King, I. B., Siscovick, D. S., & Mozaffarian, D. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy117 · Cited by 62
Self-citationDietary and Pharmacological Fatty Acids and Cardiovascular Health
Wu, H., Xu, L., & Ballantyne, C. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz174 · Cited by 59
Allaire, J., Harris, W. S., Vors, C., Charest, A., Marin, J., Jackson, K. H., Tchernof, A., Couture, P., & Lamarche, B. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.008 · Cited by 63
Iacoviello, L., Bonaccio, M., Cairella, G., Catani, M. V., Costanzo, S., D’Elia, L., Giacco, R., Rendina, D., Sabino, P., Savini, I., et al. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.12.010 · Cited by 60
Using High-Dose Omega-3 Fatty Acid Supplements to Lower Triglyceride Levels in 10- to 19-Year-Olds
de Ferranti, S. D., Milliren, C. E., Denhoff, E. R., Steltz, S. K., Selamet Tierney, E. S., Feldman, H. A., & Osganian, S. K. (2014) · Clinical Pediatrics · doi:10.1177/0009922814528032 · Cited by 58
Mitochondria orchestrate macrophage effector functions in atherosclerosis
Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 60
Patterson, A. C., Chalil, A., Henao, J. J. A., Streit, I. T., & Stark, K. D. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.09.016 · Cited by 60
de la Torre, R., Corella, D., Castañer, O., Martínez‐González, M. Á., Salas‐Salvadó, J., Vila, J., Estruch, R., Sorlí, J. V., Arós, F., Fiol, M., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.145813 · Cited by 57
Rice, H. B., Bernasconi, A. A., Maki, K. C., Harris, W. S., von Schacky, C., & Calder, P. C. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.01.003 · Cited by 57
Simple Wet Rendering Method for Extraction of Prime Quality Oil from Skipjack Tuna Eyeballs
Pudtikajorn, K., & Benjakul, S. (2020) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202000077 · Cited by 55
Chen, G., Yang, J., Eggersdorfer, M. L., Zhang, W., & Qin, L. (2016) · Scientific Reports · doi:10.1038/srep28165 · Cited by 53
Nahab, F. B., Pearson, K. E., Frankel, M., Ard, J. D., Safford, M. M., Kleindorfer, D., Howard, V. J., & Judd, S. E. (2016) · Public Health Nutrition · doi:10.1017/s136898001600152x · Cited by 55
Leng, S., Picchi, M. A., Tesfaigzi, Y., Wu, G., Gauderman, W. J., Xu, F., Gilliland, F. D., & Belinsky, S. A. (2017) · International Journal of COPD · doi:10.2147/copd.s142237 · Cited by 54
Intake of Long-Chain -3 Fatty Acids From Diet and Supplements in Relation to Mortality
Bell, G. A., Kantor, E. D., Lampe, J. W., Kristal, A. R., Heckbert, S. R., & White, E. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt326 · Cited by 52
Pitfalls in the use of randomised controlled trials for fish oil studies with cardiac patients
James, M. J., Sullivan, T., Metcalf, R. G., & Cleland, L. G. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001408 · Cited by 51
Wong, M. W. K., Braidy, N., Pickford, R., Vafaee, F., Crawford, J. D., Muenchhoff, J., Schofield, P. W., Attia, J., Brodaty, H., Sachdev, P. S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214141 · Cited by 50
Alfaddagh, A., Elajami, T. K., Saleh, M. A., Mohebali, D., Bistrian, B. R., & Welty, F. K. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.04.213 · Cited by 53
Chen, G., Arthur, R., Qin, L.-Q., Chen, L., Mei, Z., Zheng, Y., Li, Y., Wang, T., Rohan, T. E., & Qi, Q. (2021) · Diabetes Care · doi:10.2337/dc20-2328 · Cited by 49
Darwesh, A. M., Sosnowski, D. K., Lee, T. Y., Keshavarz-Bahaghighat, H., & Seubert, J. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.04.037 · Cited by 51
Wu, J. H. Y., & Mozaffarian, D. (2014) · Heart · doi:10.1136/heartjnl-2013-305257 · Cited by 47
Self-citationSmith, C. E., Follis, J. L., Nettleton, J. A., Foy, M., Wu, J. H. Y., Ma, Y., Tanaka, T., Manichakul, A. W., Wu, H., Chu, A. Y., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400734 · Cited by 46
Self-citationSeafood and health: What you need to know?
Liu, C., & Ralston, N. V. C. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.04.001 · Cited by 53
Skulas‐Ray, A. C., Flock, M. R., Richter, C. K., Harris, W. S., West, S., & Kris‐Etherton, P. M. (2015) · Nutrients · doi:10.3390/nu7085291 · Cited by 45
Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity
Rychter, A. M., Ratajczak, A. E., Zawada, A. E., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2020) · Nutrients · doi:10.3390/nu12030814 · Cited by 46
Sekikawa, A., Miyamoto, Y., Miura, K., Nishimura, K., Willcox, B. J., Masaki, K. H., Rodriguez, B., Tracy, R. P., Okamura, T., & Kuller, L. H. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv143 · Cited by 44
Nutritional factors in the prevention and management of coronary artery disease and heart failure
Das, U. N. (2014) · Nutrition · doi:10.1016/j.nut.2014.08.011 · Cited by 44
Marklund, M., Leander, K., Vikström, M., Laguzzi, F., Gigante, B., Sjögren, P., Cederholm, T., Fairé, U. D., Hellénius, M.-L., & Risérus, U. (2015) · Circulation · doi:10.1161/circulationaha.115.015607 · Cited by 46
Sanders, T. A. B. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003789 · Cited by 42
Kukharchuk, V. V., Владиславович, Е. М., Викторович, С. И., Arabidze, G. G., Балахонова, Т. В., Gurevich, V. S., Zelveyan, P. A., Murataliev, T. M., Myrzakhmetova, G., Александровна, С. О., et al. (2020) · Eurasian heart journal · doi:10.38109/2225-1685-2020-2-6-29 · Cited by 49
Eide, I. A., Jenssen, T. G., Hartmann, A., Diep, L. M., Dahle, D. O., Reisæter, A. V., Bjerve, K. S., Christensen, J. H., Schmidt, E. B., & Svensson, M. H. S. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11931214 · Cited by 42
Nutritional Needs of the Older Adult
Bernstein, M. (2017) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2017.06.008 · Cited by 46
Yang, T., Yi, J., He, Y., Zhang, J., Li, X., Ke, S., Xia, L., & Liu, L. (2022) · Nutrients · doi:10.3390/nu14173608 · Cited by 42
Veleba, J., Kopecký, J., Janovská, P., Kuda, O., Horakova, O., Malínská, H., Kazdová, L., Oliyarnyk, O., Škop, V., Trnovská, J., et al. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0047-9 · Cited by 42
Potential of Omega 3 Supplementation for Coronavirus Disease 2019 (COVID-19): A Scoping Review
Fadiyah, N. N., Megawati, G., & Luftimas, D. E. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s357460 · Cited by 40
Metadata
- Authors
- Mozaffarian, D., Lemaitre, R. N., King, I. B., Song, X., Huang, H., Sacks, F. M., Rimm, E. B., Wang, M., & Siscovick, D. S.
- Affiliations
- Brigham and Women's Hospital (US)
- From Brigham and Women's Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts; University of New Mexico, Albuquerque, New Mexico; and Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington.
- ORCID
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-04-02
- Volume
- 158
- Issue
- 7
- Pages
- 515-525
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- PMC
- PMC3698844
- OpenAlex
- W2015008724
- Cited by
- 283
- References
- 61
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 19 · 2020: 24 · 2019: 20 · 2018: 30 · 2017: 23 · 2016: 29 · 2015: 37 · 2014: 26 · 2013: 19
- FWCI
- 34.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc045133-001, n01hc085079-024, n01hc015103-009, n01hc085084-005, n01hc085085-011, n01hc085083-027, n01hc085080-026, n01hc085086-022, n01hc55222-0-0-0, n01hc075150-004, n01hc035129-010)
- National Institute on Aging (AG 20098, R56AG023629, R01AG020098, AG023629, AG027058, R56AG020098, R01AG023629, R01AG015928, R01AG027058)
- National Heart, Lung, and Blood Institute (N01-HC-85081, N01HC85085, N01 HC085086, N01HC-85083, N0-1-HC-85239, N01 HC085079, N01HC85082, N01HC‐75150, N01 HC85086, N01 HC035129, N01HC85080, N01 HC015103, N01 HC55222, HHSN268201200036C, U01HL080295, N01 HC055222, R01HL085710, HL080295, R01HL080295, N01 HC075150, N01 HC045133, N01-HC85079, N01-HC85084)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- plasma phospholipid fatty acids, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, all-cause mortality, cause-specific mortality, cardiovascular mortality, coronary artery disease, stroke, older adults, primary prevention, dietary fatty acids, dietary biomarkers, dose-response relationship
- MeSH terms
- Aged, Cause of Death, Coronary Disease, Docosahexaenoic Acids, Fatty Acids, Unsaturated, Feeding Behavior, Female, Humans, Male, Prospective Studies, Eicosapentaenoic Acid, Biomarkers, Fatty Acids, Omega-3, Diet Records, Risk Assessment, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
