Auditory cortex shapes sound responses in the inferior colliculus
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Abstract
The extensive feedback from the auditory cortex (AC) to the inferior colliculus (IC) supports critical aspects of auditory behavior but has not been extensively characterized. Previous studies demonstrated that activity in IC is altered by focal electrical stimulation and pharmacological inactivation of AC, but these methods lack the ability to selectively manipulate projection neurons. We measured the effects of selective optogenetic modulation of cortico-collicular feedback projections on IC sound responses in mice. Activation of feedback increased spontaneous activity and decreased stimulus selectivity in IC, whereas suppression had no effect. To further understand how microcircuits in AC may control collicular activity, we optogenetically modulated the activity of different cortical neuronal subtypes, specifically parvalbumin-positive (PV) and somatostatin-positive (SST) inhibitory interneurons. We found that modulating the activity of either type of interneuron did not affect IC sound-evoked activity. Combined, our results identify that activation of excitatory projections, but not inhibition-driven changes in cortical activity, affects collicular sound responses.
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The inferior colliculus, receiving limited cortical input primarily from the auditory cortex, was spared from plaque attenuation in ExN-Bace1cKO;AD mice.
“the inferior colliculus, receiving limited cortical input (Extended Data Fig. 8c) primarily from the auditory cortex19, was spared from plaque attenuation in ExN-Bace1cKO;AD mice.”
From Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice (2024) · cites this paper as [19]
The Introduction (page unavailable) states that the auditory cortex sends feedback to the inferior colliculus and that the colliculus receives inputs from auditory-cortex neurons. It does not establish that auditory cortex is the primary source of the colliculus’s cortical input. Citation 19 is attached to that anatomical clause, not to the separate plaque-attenuation finding. (LLM, conf=0.78)
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“8c) primarily from the auditory cortex 19 , was spared from plaque attenuation in ExN-Bace1 cKO ;AD mice.”
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- Authors
- Blackwell, J. M., Lesicko, A. M., Rao, W., De Biasi, M., & Geffen, M. N.
- Affiliations
- Stony Brook University (US)
- University of Pennsylvania (US)
- Department of Psychiatry, University of Pennsylvania, Philadelphia, United States
- Corresponding author
- Geffen, Maria N
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2020-01-31
- Volume
- 9
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC7062464
- OpenAlex
- W3003862701
- Cited by
- 68
- References
- 82
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 18 · 2023: 15 · 2022: 10 · 2021: 9 · 2020: 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Deafness and Other Communication Disorders (R03DC013660, NIH R01DC014779, NIH R01DC015527)
- Human Frontier Science Program (Young Investigator Award)
- Pennsylvania Lions Club Hearing Research Fellowship
- Klingenstein Award in Neurosciences
- National Institute of Mental Health (1F32MH120890)
- National Institutes of Health (R01NS113241)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- auditory cortex, inferior colliculus, optogenetic manipulation, parvalbumin interneurons, somatostatin interneurons, inhibitory interneurons, spontaneous activity, stimulus selectivity, sound-evoked responses, projection neurons
- MeSH terms
- Acoustic Stimulation, Animals, Auditory Cortex, Female, Inferior Colliculi, Interneurons, Male, Mice, Inbred C57BL, Mice, Feedback, Sensory, Optogenetics
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