The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables
Open accessAbstract
Edible plant-derived exosome-like nanoparticles (EPDELNs) are novel naturally occurring plant ultrastructures that are structurally similar to exosomes. Many EPDELNs have anti-inflammatory properties. MicroRNAs (miRNAs) play a critical role in mediating physiological and pathological processes in animals and plants. Although miRNAs can be selectively encapsulated in extracellular vesicles, little is known about their expression and function in EPDELNs. In this study, we isolated nanovesicles from 11 edible fruits and vegetables and subjected the corresponding EPDELN small RNA libraries to Illumina sequencing. We identified a total of 418 miRNAs—32 to 127 per species—from the 11 EPDELN samples. Target prediction and functional analyses revealed that highly expressed miRNAs were closely associated with the inflammatory response and cancer-related pathways. The 418 miRNAs could be divided into three classes according to their EPDELN distributions: 26 “frequent” miRNAs (FMs), 39 “moderately present” miRNAs (MPMs), and 353 “rare” miRNAs (RMs). FMs were represented by fewer miRNA species than RMs but had a significantly higher cumulative expression level. Taken together, our in vitro results indicate that miRNAs in EPDELNs have the potential to regulate human mRNA.
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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery
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“The most important and well-studied of these exosomal cargo loads is miRNAs, which are short non-coding RNAs of an average size of about 22 nucleotides (nt), capable of regulating gene expression by specifically binding and inhibiting translation function or cleaving of target mRNAs [20].”
BackgroundPlant-Derived Nanovesicles: Further Exploration of Biomedical Function and Application Potential
Li, A., Li, D., Gu, Y., Liu, R., Tang, X., Zhao, Y., Qi, F., Wei, J., & Liu, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.022 · Cited by 137
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110
Self-citationFarley, J. T., Eldahshoury, M. K., & de Marcos Lousa, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.883841 · Cited by 23
Metadata
- Authors
- Xiao, J., Feng, S., Wang, X., Long, K., Luo, Y., Wang, Y., Ma, J., Tang, Q., Jin, L., Li, X., & Li, M.
- Venue
- PeerJ
- Publisher
- PeerJ
- Published
- 2018-07-31
- Volume
- 6
- Pages
- e5186
- ISSN
- 2167-8359 (ISSN-L)
- OpenAlex
- W2885833309
- Cited by
- 325
- References
- 61
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- gold
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