Hardingham, Giles E.

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 1,686

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 1,644

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 531

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience

Redox biology and oxidative stressNeuroscience and Neuropharmacology Research

Cited by 498

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

Bilican, B., Serio, A., Barmada, S. J., Nishimura, A. L., Sullivan, G. J., Carrasco, M., Phatnani, H. P., Puddifoot, C. A., Story, D., Fletcher, J., et al. (2012) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchPluripotent Stem Cells Research

Cited by 328

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 304

Influence of GluN2 subunit identity on NMDA receptor function

Wyllie, D. J. A., Livesey, M. R., & Hardingham, G. E. (2013) · Neuropharmacology

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 260

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Jiwaji, Z., Tiwari, S. S., Avilés-Reyes, R. X., Hooley, M., Hampton, D., Torvell, M., Johnson, D. A., McQueen, J., Baxter, P., Sabari-Sankar, K., et al. (2022) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 223

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Bell, K. F. S., Al-Mubarak, B., Martel, M.-A., McKay, S., Wheelan, N., Hasel, P., Márkus, N. M., Baxter, P., Deighton, R. F., Serio, A., et al. (2015) · Nature Communications

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 191

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., et al. (2019) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 179

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Molina-Gonzalez, I., Holloway, R. K., Jiwaji, Z., Dando, O., Kent, S. A., Emelianova, K., Lloyd, A. F., Forbes, L. H., Mahmood, A., Skripuletz, T., et al. (2023) · Nature Communications

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 176

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Baxter, P. S., Bell, K. F. S., Hasel, P., Kaindl, A. M., Fricker, M., Thomson, D., Cregan, S. P., Gillingwater, T. H., & Hardingham, G. E. (2015) · Nature Communications

Redox biology and oxidative stressGenomics, phytochemicals, and oxidative stress

Cited by 139

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

Bell, K. F., Al-Mubarak, B., Fowler, J. H., Baxter, P. S., Gupta, K., Tsujita, T., Chowdhry, S., Patani, R., Chandran, S., Horsburgh, K., et al. (2011) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressCardiac Ischemia and Reperfusion

Cited by 133

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

Baxter, P. S., Dando, O., Emelianova, K., He, X., McKay, S., Hardingham, G. E., & Qiu, J. (2021) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 122

SynGAP isoforms exert opposing effects on synaptic strength

McMahon, A. C., Barnett, M. W., O'Leary, T. S., Stoney, P. N., Collins, M. O., Papadia, S., Choudhary, J. S., Komiyama, N. H., Grant, S. G. N., Hardingham, G. E., et al. (2012) · Nature Communications

Neuroscience and Neuropharmacology ResearchRNA Research and Splicing

Cited by 91

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

Asiminas, A., Jackson, A. D., Louros, S. R., Till, S. M., Spano, T., Dando, O., Bear, M. F., Chattarji, S., Hardingham, G. E., Osterweil, E. K., et al. (2019) · Science Translational Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 78

The influence of synaptic activity on neuronal health

Bell, K. F., & Hardingham, G. E. (2011) · Current Opinion in Neurobiology

Neuroscience and Neuropharmacology ResearchCell death mechanisms and regulation

Cited by 77

CNS Peroxiredoxins and Their Regulation in Health and Disease

Bell, K. F. S., & Hardingham, G. E. (2011) · Antioxidants & Redox Signaling

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 71

Phosphoinositide 3-Kinases Upregulate System x c − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

Lewerenz, J., Baxter, P., Kassubek, R., Albrecht, P., Van Liefferinge, J., Westhoff, M.-A., Halatsch, M.-E., Karpel-Massler, G., Meakin, P. J., Hayes, J. D., et al. (2014) · Antioxidants & Redox Signaling

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 66

Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

Perkins, E. M., Burr, K., Banerjee, P., Mehta, A. R., Dando, O., Selvaraj, B. T., Suminaite, D., Nanda, J., Henstridge, C. M., Gillingwater, T. H., et al. (2021) · Molecular Neurodegeneration

Amyotrophic Lateral Sclerosis ResearchNeuroscience and Neuropharmacology Research

Cited by 54

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

McKay, S., Ryan, T. J., McQueen, J., Indersmitten, T., Marwick, K. F. M., Hasel, P., Kopanitsa, M. V., Baxter, P. S., Martel, M.-A., Kind, P. C., et al. (2018) · Cell Reports

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 42

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

Deighton, R. F., Márkus, N. M., Al-Mubarak, B., Bell, K. F. S., Papadia, S., Meakin, P. J., Chowdhry, S., Hayes, J. D., & Hardingham, G. E. (2014) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressNuclear Receptors and Signaling

Cited by 30