CNS Peroxiredoxins and Their Regulation in Health and Disease

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

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Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

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S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

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Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

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S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

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High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

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Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

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Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

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Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

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NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

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Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

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The Nrf2–ARE Pathway

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Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

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Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert -Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

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Nrf2, a multi‐organ protector?

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The complexity of neurobiological processes in acute ischemic stroke

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

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Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

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A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia<i>In Vivo</i>

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The High Reactivity of Peroxiredoxin 2 with H2O2 Is Not Reflected in Its Reaction with Other Oxidants and Thiol Reagents

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Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

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Hyperglycemia Promotes Oxidative Stress through Inhibition of Thioredoxin Function by Thioredoxin-interacting Protein

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Regulation of Neuronal Glutathione Synthesis

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Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers

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Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

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Antioxidant Activities of Bile Pigments

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Hemin-induced Activation of the Thioredoxin Gene by Nrf2

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Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

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NF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons

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Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

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Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders

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Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

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Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons

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Nuclear Ca2+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

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Coupling of the NMDA receptor to neuroprotective and neurodestructive events

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S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease

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Nrf2-mediated protection against 6-hydroxydopamine

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Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease

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Thioredoxin, a Singlet Oxygen Quencher and Hydroxyl Radical Scavenger: Redox Independent Functions

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Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus

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Activation of the Nrf2–ARE signaling pathway: a promising strategy in cancer prevention

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Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death.

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Cell death: protein misfolding and neurodegenerative diseases

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Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

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Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H2O2-induced c-Jun NH2-terminal Kinase Activation and Apoptosis

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Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance

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In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

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Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

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Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1,2‐dithiole‐3‐thione

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Transcriptional Regulation of the AP-1 and Nrf2 Target Gene Sulfiredoxin

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Survival Signaling Pathways Activated by NMDA Receptors

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JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span

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Existing and emerging mechanisms for transport of iron and manganese to the brain

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Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

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Mitochondrial peroxiredoxin‐3 protects hippocampal neurons from excitotoxic injury in vivo

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Postsynaptic mechanisms of excitotoxicity: Involvement of postsynaptic density proteins, radicals, and oxidant molecules

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Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

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Characterization of neural cell types expressing peroxiredoxins in mouse brain

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Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers

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Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila

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Emerging roles of thioredoxin cycle enzymes in the central nervous system

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Pro-survival signalling from the NMDA receptor

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Activation of Nrf2–ARE pathway in brain after traumatic brain injury

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Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

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Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum

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The Involvement of Thioredoxin and Thioredoxin Binding Protein‐2 on Cellular Proliferation and Aging Process

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Role of sestrin2 in peroxide signaling in macrophages

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Interaction of amyloid binding alcohol dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer’s disease patients and a transgenic Alzheimer’s disease mouse model

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Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

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Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

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Pronounced Cell Death in the Absence of NMDA Receptors in the Developing Somatosensory Thalamus

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Typical 2‐Cys peroxiredoxins – modulation by covalent transformations and noncovalent interactions

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