Sheng, Morgan

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease

Zeng, H., Huang, J., Zhou, H., Meilandt, W. J., Dejanovic, B., Zhou, Y., Bohlen, C. J., Lee, S.-H., Ren, J., Liu, A., et al. (2023) · Nature Neuroscience

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 233

Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior

Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 220

Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

Foster, K. A., McLaughlin, N., Edbauer, D., Phillips, M., Bolton, A., Constantine-Paton, M., & Sheng, M. (2010) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 219

Sociability and motor functions in Shank1 mutant mice

Silverman, J. L., Turner, S. M., Barkan, C. L., Tolu, S. S., Saxena, R., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · Brain Research

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 218

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 212

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Meilandt, W. J., Ngu, H., Gogineni, A., Lalehzadeh, G., Lee, S.-H., Srinivasan, K., Imperio, J., Wu, T., Weber, M., Kruse, A. J., et al. (2020) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 210

Functional anatomy of neural circuits regulating fear and extinction

Knapska, E., Macias, M., Mikosz, M., Nowak, A., Owczarek, D., Wawrzyniak, M., Pieprzyk, M., Cymerman, I. A., Werka, T., Sheng, M., et al. (2012) · Proceedings of the National Academy of Sciences

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 187

The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42

Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 175

Differential Regional Expression and Ultrastructural Localization of α-Actinin-2, a Putative NMDA Receptor-Anchoring Protein, in Rat Brain

Wyszynski, M., Kharazia, V., Shanghvi, R., Rao, A., Beggs, A. H., Craig, A. M., Weinberg, R., & Sheng, M. (1998) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 168

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

Zhou, J., Wade, S. D., Graykowski, D., Xiao, M.-F., Zhao, B., Giannini, L. A. A., Hanson, J. E., van Swieten, J. C., Sheng, M., Worley, P. F., et al. (2023) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 152

Sharpin, a Novel Postsynaptic Density Protein That Directly Interacts with the Shank Family of Proteins

Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., & Kim, E. (2001) · Molecular and Cellular Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 151

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

Chang, M. C., Srinivasan, K., Friedman, B. A., Suto, E., Modrusan, Z., Lee, W. P., Kaminker, J. S., Hansen, D. V., & Sheng, M. (2017) · Journal of Experimental Medicine

Amyotrophic Lateral Sclerosis ResearchAutophagy in Disease and Therapy

Cited by 141

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

Shen, K., Reichelt, M., Kyauk, R. V., Ngu, H., Shen, Y.-A. A., Foreman, O., Modrusan, Z., Friedman, B. A., Sheng, M., & Yuen, T. J. (2021) · Cell Reports

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 138

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

Shin, S. M., Zhang, N., Hansen, J., Gerges, N. Z., Pak, D. T. S., Sheng, M., & Lee, S. H. (2012) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 126

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons

Hung, A. Y., Sung, C. C., Brito, I. L., & Sheng, M. (2010) · PLoS ONE

Neuroscience and Neuropharmacology ResearchUbiquitin and proteasome pathways

Cited by 106

Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2

Kastning, K., Kukhtina, V., Kittler, J. T., Chen, G., Pechstein, A., Enders, S., Lee, S. H., Sheng, M., Yan, Z., & Haucke, V. (2007) · Proceedings of the National Academy of Sciences

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 88

Glutamate receptors put in their place

Sheng, M. (1997) · Nature

Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Cited by 81

Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD

Han, K., Kim, M.-H., Seeburg, D., Seo, J., Verpelli, C., Han, S., Chung, H. S., Ko, J., Lee, H. W., Kim, K., et al. (2009) · PLoS Biology

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 71

AMPA receptor trafficking and synaptic plasticity: major unanswered questions.

Sheng, M., & Hyoung Lee, S. (2003) · Neuroscience Research

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 71

Proline-Rich Tyrosine Kinase 2 Regulates Hippocampal Long-Term Depression

Hsin, H., Kim, M. J., Wang, C.-F., & Sheng, M. (2010) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 55

Strength in numbers

Sheng, M., Malinow, R., & Huganir, R. (2013) · Nature

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 9

Multimodal synaptomics reveals coordinated synaptic activity, protein synthesis and reorganization in NMDAR regulation

Falkovich, R., Aryal, S., Sheng, M., & Bathe, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 2