Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2

AMPA Receptor Trafficking and Synaptic Plasticity

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AMPA receptor trafficking at excitatory synapses

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PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

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Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

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Adaptable adaptors for coated vesicles.

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Postsynaptic signaling and plasticity mechanisms

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Recycling Endosomes Supply AMPA Receptors for LTP

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Clathrin-mediated endocytosis in AP-2–depleted cells

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Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

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Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

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Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes.

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Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

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Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD

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Homeostatic plasticity and NMDA receptor trafficking

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Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD

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Ubiquitin and AP180 Regulate the Abundance of GLR-1 Glutamate Receptors at Postsynaptic Elements in C. elegans

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Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons

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Potentiation of NMDA receptor currents by dopamine D 1 receptors in prefrontal cortex

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Lateral organization of endocytic machinery in dendritic spines

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Evolving nature of the AP2 α‐appendage hub during clathrin‐coated vesicle endocytosis

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Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA A receptors regulates the efficacy of inhibitory synaptic transmission

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Stonin 2 Is an AP-2-Dependent Endocytic Sorting Adaptor for Synaptotagmin Internalization and Recycling

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Dual interaction of synaptotagmin with μ2‐ and α‐adaptin facilitates clathrin‐coated pit nucleation

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Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

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Molecular constituents of neuronal AMPA receptors

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Recognition of a Basic AP-2 Binding Motif within the C2B Domain of Synaptotagmin Is Dependent on Multimerization

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Regulation of AP-2-Synaptotagmin Interaction by Inositol High Polyphosphates

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Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

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The AMPA Receptor Code of Synaptic Plasticity

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The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

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Regulation of AMPA receptor trafficking and synaptic plasticity

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Glutamate receptor dynamics in dendritic microdomains.

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Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

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Adaptor protein complexes and intracellular transport

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Survey of the year 2007 commercial optical biosensor literature

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Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord

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AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression

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Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

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Corticosterone Alters AMPAR Mobility and Facilitates Bidirectional Synaptic Plasticity

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Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABA A receptor γ2 subunit

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Clathrin‐Mediated Endocytosis at Synapses

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Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

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Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease

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Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury

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AMPAR trafficking in synapse maturation and plasticity

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Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression

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Neuronal functions of adaptor complexes involved in protein sorting

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Regulation of postsynaptic AMPA responses by synaptojanin 1

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AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis

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Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2

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AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases

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PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin

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The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions

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Endocytosis and recycling of AMPA receptors lacking GluR2/3

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Stabilization of GABAAReceptors at Endocytic Zones Is Mediated by an AP2 Binding Motif within the GABAAReceptor β3 Subunit

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New insights in endosomal dynamics and AMPA receptor trafficking

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AP1S1 defect causing MEDNIK syndrome: a new adaptinopathy associated with defective copper metabolism

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The GLUR2 subunit of AMPA receptors: Synaptic role

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Synaptic Plasticity 101: The Story of the AMPA Receptor for the Brain Stimulation Practitioner

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Regulation of GABAA receptor membrane trafficking and synaptic localization

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HNK-1 Glyco-epitope Regulates the Stability of the Glutamate Receptor Subunit GluR2 on the Neuronal Cell Surface

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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

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Endosomal trafficking of AMPA-type glutamate receptors

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Calpain Hydrolysis of α- and β2-Adaptins Decreases Clathrin-dependent Endocytosis and May Promote Neurodegeneration

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Synaptotagmin 1 Is Necessary for the Ca2+Dependence of Clathrin-Mediated Endocytosis

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The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

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Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain: Clues for synaptic pathology

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PICK1 is implicated in organelle motility in an Arp2/3 complex–independent manner

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Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity

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Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System

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The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A

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Calcyon is necessary for activity‐dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus

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Brain‐specific functions of the endocytic machinery

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Complementary roles of the neuron‐enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking

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Endocytic Adaptor Epidermal Growth Factor Receptor Substrate 15 (Eps15) Is Involved in the Trafficking of Ubiquitinated α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

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Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway

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Biophysical mechanisms regulating AMPA receptor accumulation at synapses

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BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3

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Identification and Investigation of Drosophila Postsynaptic Density Homologs

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Involvement of PRMT1 in hnRNPQ activation and internalization of insulin receptor

Iwasaki, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.051 · Cited by 15 · see citing works

Endocytic proteins: An expanding repertoire of presynaptic functions

Tehran, D. A., & Maritzen, T. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.01.004 · Cited by 13 · see citing works

The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord ofCaenorhabditis elegans

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Transcriptomic expression of AMPA receptor subunits and their auxiliary proteins in the human brain

Shen, K., & Limón, A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135938 · Cited by 11 · see citing works

ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility

Wei, M., Yang, L., Su, F., Liu, Y., Zhao, X., Luo, L., Sun, X., Liu, S., Dong, Z., Zhang, Y., et al. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102559 · Cited by 10 · see citing works

Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification

Chen, K. H., Yang, J., Liu, B., Jiang, C., Koylass, N., Zhang, Z., Sun, S., Huganir, R. L., & Qiu, Z. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115302 · Cited by 9 · see citing works

Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca2+ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch

Selvakumar, D., Drescher, M. J., Deckard, N. A., Ramakrishnan, N. A., Morley, B. J., & Drescher, D. G. (2016) · Biochemical Journal · doi:10.1042/bcj20160690 · Cited by 9 · see citing works

Hormonal regulation of AMPA receptor trafficking and memory formation

Krugers, H. J. (2009) · Frontiers in Synaptic Neuroscience · doi:10.3389/neuro.19.002.2009 · Cited by 8 · see citing works

The lemur tail kinase family in neuronal function and disfunction in neurodegenerative diseases

Larose, A., Miller, C. C. J., & Mórotz, G. M. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05480-0 · Cited by 7 · see citing works

Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons

Matsuda, S., & Yuzaki, M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100949 · Cited by 6 · see citing works

Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus

Lertpeerapan, P., Kanlayaprasit, S., Thongkorn, S., Kasitipradit, K., Panjabud, P., Songsritaya, K., Jantheang, T., Morita, M., Akaike, T., Hu, V. W., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00744-1 · Cited by 5 · see citing works

Adaptor Proteins in Neuronal Development and Neurological Disorders: A Comprehensive Review of Their Roles and Importance

Zhang, J., Cheng, Y., & Xing, Q. (2023) · Journal of Bio-X Research · doi:10.34133/jbioxresearch.0003 · Cited by 4 · see citing works

Identification of differentially expressed genes in the brain of Sebastiscus marmoratus in response to tributyltin exposure

Li, B., Wang, C., Yu, A., Chen, Y., & Zuo, Z. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.05.002 · Cited by 4 · see citing works

Neuronal functions of clathrin-associated endocytic sorting adaptors – from molecules to disease

Kononenko, N. L., & Haucke, V. (2020) · e-Neuroforum · doi:10.1515/nf-2020-0023 · Cited by 2 · see citing works

Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats

Banerjee, B., MEDDA, B. K., Zhang, J., Tuchscherer, V. J., Babygirija, R., Kannampalli, P., Sengupta, J. N., & Shaker, R. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12834 · Cited by 1 · see citing works

Dendritic Organelles for Postsynaptic Trafficking

Hanus, C., & Ehlers, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_8 · Cited by 1 · see citing works

Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity

Smith, G. B. (2010) · DSpace@MIT (Massachusetts Institute of Technology)

Signalbindung und Membraninteraktion von heterotetrameren Adaptorprotein-Komplexen

Späte, K. (2007) · doi:10.53846/goediss-230

A post-synaptic forgetting mechanism controlled by synaptotagmin 3

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Papel de los adaptadores de clatrina GGA y Ent3, y de la SNARE Fsv1 en el tráfico entre la red trans del Golgi, el endosoma prevacuolar y la vacuola

Samaniego, F. Y. (2019) · doi:10.14201/gredos.140570

Faculty Opinions recommendation of AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis.

Taraska, J. W., & Sochacki, K. A. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718010602.793476802

Spatiotemporal expression of AP-2/myosin Ⅵ in mouse cochlear IHCs and correlation with auditory function

Gu, X., & Lin, L. (2024) · Acta Oto-Laryngologica · doi:10.1080/00016489.2024.2341126

AMPA receptors: molecular mechanisms of synaptic plasticity and the potential of Ampasse in addressing cognitive impairment

Киселев, А. В., Titova, N., Arseenkova, O. Y., Vedenkin, A. S., & Хохлов, А. Л. (2026) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202612606159

Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2

Kastning, K. (2005) · doi:10.53846/goediss-648

Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD

Lee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441 · see citing works

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 554 · see citing works

Phosphorylation of the AMPA receptor subunit GluA1 regulates clathrin-mediated receptor internalization

Sathler, M. F., Khatri, L., Roberts, J. P., Schmidt, I. G., Zaytseva, A., Kubrusly, R. C. C., Ziff, E. B., & Kim, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.257972 · Cited by 35 · see citing works

Contribution of cytoskeleton to the internalization of AMPA receptors

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