Immune aging and autoimmunity

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States

Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673 · see citing works

Accelerated telomere shortening in response to life stress

Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works

Switching and Signaling at the Telomere

Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893 · see citing works

Untitled work

Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works

Association between telomere length in blood and mortality in people aged 60 years or older

Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761 · see citing works

Telomeres and human disease: ageing, cancer and beyond

Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works

Telomere reduction in human colorectal carcinoma and with ageing

Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works

Homeostasis of Naive and Memory T Cells

Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works

A telomerase component is defective in the human disease dyskeratosis congenita

Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works

Antibody response to influenza vaccination in the elderly: A quantitative review

GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works

X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., & Dokal, I. (1998) · Nature Genetics · doi:10.1038/ng0598-32 · Cited by 976 · see citing works

The Influence of Age on T Cell Generation and TCR Diversity

Naylor, K., Li, G., Vallejo, A. N., Lee, W.-W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C. M., & Goronzy, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7446 · Cited by 802 · see citing works

Medium- and Large-Vessel Vasculitis

Weyand, C. M., & Goronzy, J. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022694 · Cited by 786 · see citing works

Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis

Müller, M. C. M., Wandel, S., Colebunders, R., Attia, S. L., Furrer, H., & Egger, M. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70026-8 · Cited by 749 · see citing works

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

King, C., Ilic, A., Koelsch, K., & Sarvetnick, N. (2004) · Cell · doi:10.1016/s0092-8674(04)00335-6 · Cited by 747 · see citing works

Genetic determination of telomere size in humans: a twin study of three age groups.

Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works

Telomerase maintains telomere structure in normal human cells

Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738 · see citing works

Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia

Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works

TELOMERES AND THEIR CONTROL

McEachern, M. J., Krauskopf, A., & Blackburn, E. H. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.331 · Cited by 716 · see citing works

Vaccines for preventing influenza in the elderly

Demicheli, V., Jefferson, T., Pietrantonj, C. D., Ferroni, E., Thorning, S., Thomas, R. E., & Rivetti, A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004876.pub4 · Cited by 706 · see citing works

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

Goldrath, A. W., Bogatzki, L. Y., & Bevan, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.557 · Cited by 637 · see citing works

Telomere length and replicative aging in human vascular tissues.

Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works

CD28− T cells: their role in the age-associated decline of immune function

Weng, N., Akbar, A. N., & Goronzy, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 630 · see citing works

Extensive allelic variation and ultrashort telomeres in senescent human cells

Baird, D. M., Rowson, J., Wynford-Thomas, D., & Kipling, D. (2003) · Nature Genetics · doi:10.1038/ng1084 · Cited by 570 · see citing works

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · see citing works

Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes.

Liuzzo, G., Goronzy, J. J., Yang, H., Kopecky, S. L., Holmes, D. R., Frye, R. L., & Weyand, C. M. (2000) · Circulation · doi:10.1161/01.cir.101.25.2883 · Cited by 552 · see citing works

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

Cho, B. K., Rao, V. P., Ge, Q., Eisen, H. N., & Chen, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.549 · Cited by 509 · see citing works

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482 · see citing works

T cell subset-specific susceptibility to aging

Czesnikiewicz-Guzik, M., Lee, W.-W., Cui, D., Hiruma, Y., Lamar, D. L., Yang, Z.-Z., Ouslander, J. G., Weyand, C. M., & Goronzy, J. J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.12.002 · Cited by 478 · see citing works

Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?

Weng, N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.001 · Cited by 476 · see citing works

T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis

Hirota, K., Hashimoto, M., Yoshitomi, H., Tanaka, S., Nomura, T., Yamaguchi, T., Iwakura, Y., Sakaguchi, N., & Sakaguchi, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062259 · Cited by 475 · see citing works

Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty‐year period

Doran, M. F., Pond, G. R., Crowson, C. S., O’Fallon, W. M., & Gabriel, S. E. (2002) · Arthritis & Rheumatism · doi:10.1002/art.509 · Cited by 468 · see citing works

T cell homeostasis in patients with rheumatoid arthritis

Koetz, K., Bryl, E., Spickschen, K., O’Fallon, W. M., Goronzy, J. J., & Weyand, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9203 · Cited by 467 · see citing works

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · see citing works

Multistep Pathogenesis of Autoimmune Disease

Goodnow, C. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.033 · Cited by 427 · see citing works

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11091 · Cited by 418 · see citing works

Regulated expression of telomerase activity in human T lymphocyte development and activation.

Weng, N., Levine, B. L., June, C. H., & Hodes, R. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2471 · Cited by 403 · see citing works

Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire

Robins, H. S., Srivastava, S. K., Campregher, P. V., Turtle, C. J., Andriesen, J. G., Riddell, S. R., Carlson, C. S., & Warren, E. H. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001442 · Cited by 383 · see citing works

Promiscuity and the single receptor: NKG2D

Eagle, R. A., & Trowsdale, J. (2007) · Nature Reviews Immunology · doi:10.1038/nri2144 · Cited by 374 · see citing works

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

McKinney, E. F., Lyons, P., Carr, E. J., Hollis, J., Jayne, D. R. W., Willcocks, L. C., Koukoulaki, M., Brāzma, A., Jovanović, V., Kemeny, D. M., et al. (2010) · Nature Medicine · doi:10.1038/nm.2130 · Cited by 371 · see citing works

Age-dependent incidence, time course, and consequences of thymic renewal in adults

Hakim, F. T., Memon, S. A., Cepeda, R., Jones, E. C., Chow, C. K., Kasten-Sportès, C., Odom, J., Vance, B. A., Christensen, B. L., Mackall, C. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522492 · Cited by 358 · see citing works

T-cell-mediated lysis of endothelial cells in acute coronary syndromes

Nakajima, T., Schulte, S., Warrington, K. J., Kopecky, S. L., Frye, R. L., Goronzy, J. J., & Weyand, C. M. (2002) · Circulation · doi:10.1161/hc0502.103348 · Cited by 356 · see citing works

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypesPreprint

Warren, R. M., Freeman, J., Zeng, T., Choe, G. H., Munro, S., Moore, R., Webb, J. R., & Holt, R. A. (2011) · Genome Research · doi:10.1101/gr.115428.110 · Cited by 351 · see citing works

T cell immune reconstitution following lymphodepletion

Williams, K. M., Hakim, F. T., & Gress, R. E. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.004 · Cited by 340 · see citing works

The role of CD8⁺ T‐cell replicative senescence in human aging

Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

Allsopp, R. C., Morin, G. B., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Blood · doi:10.1182/blood-2002-07-2334 · Cited by 324 · see citing works

Expansion of unusual CD4+ T cells in severe rheumatoid arthritis

Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290 · see citing works

Perturbation of the T cell repertoire in rheumatoid arthritis

Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14447 · Cited by 278 · see citing works

T cell development and receptor diversity during aging

Goronzy, J. J., & Weyand, C. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.020 · Cited by 278 · see citing works

Association between aplastic anaemia and mutations in telomerase RNA

Vulliamy, T., Marrone, A., Dokal, I. S., & Mason, P. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09087-6 · Cited by 276 · see citing works

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis

Kieper, W. C., Burghardt, J. T., & Surh, C. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.40 · Cited by 246 · see citing works

How Much TCR Does a T Cell Need?

Labrecque, N., Whitfield, S., Obst, R., Waltzinger, C., Benoist, C. O., & Mathis, D. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00170-4 · Cited by 231 · see citing works

Memory T cell homeostasis and senescence during aging

Akbar, A. N., & Fletcher, J. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.019 · Cited by 225 · see citing works

T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection

Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.002 · Cited by 223 · see citing works

Shortened telomere length in white blood cells of patients with IDDM.

Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217 · see citing works

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages

Schönland, S. O., Lopez, C., Widmann, T., Zimmer, J., Bryl, E., Goronzy, J. J., & Weyand, C. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233561100 · Cited by 216 · see citing works

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis

Namekawa, T., Snyder, M. R., Yen, J., Goehring, B. E., Leibson, P. J., Weyand, C. M., & Goronzy, J. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.1138 · Cited by 210 · see citing works

Peripheral Blood and Granuloma CD4+CD28− T Cells Are a Major Source of Interferon-γ and Tumor Necrosis Factor-α in Wegener’s Granulomatosis

Komócsi, A., Lamprecht, P., Csernok, E., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61118-2 · Cited by 206 · see citing works

Stem cells and the aging hematopoietic system

Beerman, I., Maloney, W. J., Weissman, I. L., & Rossi, D. J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.007 · Cited by 206 · see citing works

Vaccines for preventing influenza in the elderly

Rivetti, D., Jefferson, T., Thomas, R. E., Rudin, M., Rivetti, A., Pietrantonj, C. D., & Demicheli, V. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004876.pub2 · Cited by 206 · see citing works

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

Weng, N., Palmer, L. D., Levine, B. L., Lane, H. C., June, C. H., & Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01026.x · Cited by 203 · see citing works

Toll-like receptor driven B cell activation in the induction of systemic autoimmunity

Green, N., & Marshak-Rothstein, A. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.01.016 · Cited by 202 · see citing works

Functional properties of CD4+CD28− T cells in the aging immune system

Weyand, C. M., Brandes, J. C., Schmidt, D., Fulbright, J. W., & Goronzy, J. J. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00161-9 · Cited by 201 · see citing works

Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation.

Goronzy, J. J., & Weyand, C. M. (2003) · Arthritis Research · doi:10.1186/ar974 · Cited by 199 · see citing works

Resistance to apoptosis and elevated expression of Bcl-2 in clonally expanded CD4+CD28− T cells from rheumatoid arthritis patients

Schirmer, M., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.1018 · Cited by 191 · see citing works

Transfer of the human telomerase reverse transcriptase(TERT) gene into T lymphocytes results in extension of replicative potential

Rufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180 · see citing works

Humoral and Cellular Immunity to Varicella‐Zoster Virus: An Overview

Arvin, A. M. (2008) · The Journal of Infectious Diseases · doi:10.1086/522123 · Cited by 178 · see citing works

Do Tricyclic Antidepressants Work?

Coppen, A. J., & Ghose, K. (1976) · The Lancet · doi:10.1016/s0140-6736(76)99012-7 · Cited by 176 · see citing works

TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque

Sato, K., Niessner, A., Kopecky, S. L., Frye, R. L., Goronzy, J. J., & Weyand, C. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051062 · Cited by 175 · see citing works

Rheumatoid arthritis

Goronzy, J. J., & Weyand, C. M. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00245.x · Cited by 175 · see citing works

Telomerase insufficiency in rheumatoid arthritis

Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., & Weyand, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811332106 · Cited by 172 · see citing works

The molecular program induced in T cells undergoing homeostatic proliferation

Goldrath, A. W., Luckey, C. J., Park, R., Benoist, C. O., & Mathis, D. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407417101 · Cited by 172 · see citing works

Prognostic markers of radiographic progression in early rheumatoid arthritis

Goronzy, J. J., Matteson, E. L., Fulbright, J. W., Warrington, K. J., Chang‐Miller, A., Hunder, G. G., Mason, T. G., Nelson, A. M., Valente, R. M., Crowson, C. S., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11445 · Cited by 170 · see citing works

T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool

Kong, F.-K., Chen, C.-L. H., Six, A., Hockett, R. D., & Cooper, M. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1536 · Cited by 169 · see citing works

Thymic output: a bad TREC record

Hazenberg, M. D., Borghans, J. A. M., de Boer, R. J., & Miedema, F. F. (2003) · Nature Immunology · doi:10.1038/ni0203-97 · Cited by 164 · see citing works

Analyses of immunosenescent markers in patients with autoimmune disease

Thewissen, M. M., Somers, V. A., Venken, K., Linsen, L., van Paassen, P., Geusens, P., Damoiseaux, J. G. M. C., & Stinissen, P. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.01.005 · Cited by 160 · see citing works

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.

Shao, L., Fujii, H., Colmegna, I., Oishi, H., Goronzy, J. J., & Weyand, C. M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082251 · Cited by 159 · see citing works

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

Kassiotis, G., Zamoyska, R., & Stockinger, B. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021812 · Cited by 159 · see citing works

Heat-Shock Protein 60-Reactive CD4 + CD28 null T Cells in Patients With Acute Coronary Syndromes

Zal, B., Kaski, J. C., Arno, G., Akiyu, J. P., Xu, Q., Cole, D., Whelan, M., Russell, N., Madrigal, J. A., Dodi, I. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000118476.29352.2a · Cited by 155 · see citing works

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

Seddon, B. P., & Zamoyska, R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3752 · Cited by 150 · see citing works

How αβ T cells deal with induced TCRα ablation

Polić, B., Kunkel, D., Scheffold, A., & Rajewsky, K. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.141218898 · Cited by 142 · see citing works

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

Goronzy, J. J., & Weyand, C. M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01841-x · Cited by 137 · see citing works

Will telomere erosion lead to a loss of T-cell memory?

Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135 · see citing works

Activating systemic autoimmunity: B's, T's, and tolls

Shlomchik, M. J. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.08.005 · Cited by 130 · see citing works

Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

Čičin-Šain, L., Messaoudi, I., Park, B., Currier, N., Planer, S., Fischer, M., Tackitt, S., Nikolich-Žugich, D., Legasse, A., Axthelm, M. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705905104 · Cited by 129 · see citing works

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity

Calzascia, T., Pellegrini, M., Lin, A., Garza, K. M., Elford, A. R., Shahinian, A., Ohashi, P. S., & Mak, T. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712135105 · Cited by 127 · see citing works

Direct measurement of T cell subset kinetics in vivo in elderly men and women

Wallace, D. L., Zhang, Y., Ghattas, H., Worth, A., Irvine, A., Bennett, A. R., Griffin, G. E., Beverley, P. C. L., Tough, D. F., & Macallan, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1787 · Cited by 115 · see citing works

A molecular switch underlies a human telomerase disease

Comolli, L. R., Smirnov, I. V., Xu, L., Blackburn, E. H., & James, T. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262663599 · Cited by 114 · see citing works

Virus-Induced CD8+ T Cell Clonal Expansion Is Associated with Telomerase Up-Regulation and Telomere Length Preservation: A Mechanism for Rescue from Replicative Senescence

Maini, M. K., Soares, M. V. D., Zilch, C. F., Akbar, A. N., & Beverley, P. C. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4521 · Cited by 110 · see citing works

Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis.

Colmegna, I., Diaz‐Borjon, A., Fujii, H., Schaefer, L., Goronzy, J. J., & Weyand, C. M. (2008) · Arthritis &amp; Rheumatism · doi:10.1002/art.23287 · Cited by 108 · see citing works

Formation of the Killer Ig-Like Receptor Repertoire on CD4+CD28null T Cells

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Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28− T cells

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