Obesity in mice with adipocyte-specific deletion of clock component Arntl
Open accessAbstract
Adipocytes store excess energy in the form of triglycerides and signal the levels of stored energy to the brain. Here we show that adipocyte-specific deletion of Arntl (also known as Bmal1), a gene encoding a core molecular clock component, results in obesity in mice with a shift in the diurnal rhythm of food intake, a result that is not seen when the gene is disrupted in hepatocytes or pancreatic islets. Changes in the expression of hypothalamic neuropeptides that regulate appetite are consistent with feedback from the adipocyte to the central nervous system to time feeding behavior. Ablation of the adipocyte clock is associated with a reduced number of polyunsaturated fatty acids in adipocyte triglycerides. This difference between mutant and wild-type mice is reflected in the circulating concentrations of polyunsaturated fatty acids and nonesterified polyunsaturated fatty acids in hypothalamic neurons that regulate food intake. Thus, this study reveals a role for the adipocyte clock in the temporal organization of energy regulation, highlights timing as a modulator of the adipocyte-hypothalamic axis and shows the impact of timing of food intake on body weight.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CLOCK:BMAL1 transcription targets many genes in different cellular contexts across tissues.
“Because CLOCK:BMAL1-mediated transcription targets a variety of genes in different cellular contexts across tissues (Janich et al., 2011; Marcheva et al., 2010; Paschos et al., 2012; Yu et al., 2013)”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Paschos et al., 2012
The adipose clock regulates lipid storage and mobilization.
“For example, the hepatic clock regulates fasting glycemic control and glucose clearance (8), the pancreatic clock regulates insulin secretion and its response to glucose (9-11), the adipose clock regulates lipid storage and mobilization (12,13), and the skeletal muscle clock regulates glucose uptake and metabolism (14).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ropelle, E. R., Flores, M. B. S., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000465 · Cited by 326 · see citing works
RetractedSummaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,906 · see citing works
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,143 · see citing works
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
Self-citationDisruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Self-citationKondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Self-citationPhysiological significance of a peripheral tissue circadian clock
Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works
He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works
Circadian timing of food intake contributes to weight gain
Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works
Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924 · see citing works
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Light at night increases body mass by shifting the time of food intake
Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works
System-level identification of transcriptional circuits underlying mammalian circadian clocks
Ueda, H. R., Hayashi, S., Chen, W., Sano, M., Machida, M., Shigeyoshi, Y., Iino, M., & Hashimoto, S. (2005) · Nature Genetics · doi:10.1038/ng1504 · Cited by 786 · see citing works
Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works
Self-citationRhythmic histone acetylation underlies transcription in the mammalian circadian clock
Etchegaray, J.-P., Lee, C., Wade, P. A., & Reppert, S. M. (2003) · Nature · doi:10.1038/nature01314 · Cited by 679 · see citing works
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation
Miller, B. H., McDearmon, E. L., Panda, S., Hayes, K. R., Zhang, J., Andrews, J. L., Antoch, M. P., Walker, J. R., Esser, K. A., Hogenesch, J. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611724104 · Cited by 509 · see citing works
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works
A clock shock: mouse CLOCK is not required for circadian oscillator function
DeBruyne, J. P., Noton, E., Lambert, C. M., Maywood, E. S., Weaver, D. R., & Reppert, S. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.041 · Cited by 430 · see citing works
Mizuno, T. M., & Mobbs, C. V. (1999) · Endocrinology · doi:10.1210/endo.140.2.6491 · Cited by 387 · see citing works
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
Cintra, D. E., Ropelle, E. R., Moraes, J. C., Pauli, J. R., Morari, J., de Souza, C. T., Grimaldi, R., Stahl, M., Carvalheira, J. B., Saad, M. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030571 · Cited by 381 · see citing works
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works
Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag
Kießling, S., Gregor Eichele, C., & Oster, H. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41192 · Cited by 273 · see citing works
Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans
Pietiläinen, K. H., Róg, T., Seppänen‐Laakso, T., Virtue, S., Gopalacharyulu, P. V., Tang, J. P., Rodríguez‐Cuenca, S., Maciejewski, A., Naukkarinen, J., Ruskeepää, A., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000623 · Cited by 238 · see citing works
Binge-eating disorder and the night-eating syndrome
Stunkard, A. J. (1995) · Appetite · doi:10.1016/s0195-6663(95)80090-5 · Cited by 216 · see citing works
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211 · see citing works
Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207 · see citing works
Self-citationInvolvement of Hypothalamic Histamine H1 Receptor in the Regulation of Feeding Rhythm and Obesity
Masaki, T., Chiba, S., Yasuda, T., Noguchi, H., Kakuma, T., Watanabe, T., Sakata, T., & Yoshimatsu, H. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2250 · Cited by 203 · see citing works
Wei, E., Ali, Y. B., Lyon, J. G., Wang, H., Nelson, R. C., Dolinsky, V. W., Dyck, J. R. B., Mitchell, G. A., Korbutt, G. S., & Lehner, R. S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.005 · Cited by 177 · see citing works
Disrupted fat absorption attenuates obesity induced by a high‐fat diet in <i>Clock</i> mutant mice
Oishi, K., Atsumi, G.-I., Sugiyama, S., Kodomari, I., Kasamatsu, M., Machida, K., & Ishida, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.11.063 · Cited by 166 · see citing works
Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo
Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.739227 · Cited by 155 · see citing works
Self-citationReyes, T. M., Walker, J. R., DeCino, C., Hogenesch, J. B., & Sawchenko, P. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05607.2003 · Cited by 149 · see citing works
Self-citationCharacterization of the Core Mammalian Clock Component, NPAS2, as a REV-ERBα/RORα Target Gene
Crumbley, C., Wang, Y., Kojetin, D. J., & Burris, T. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129288 · Cited by 136 · see citing works
Grant, G. R., Liu, J., & Stoeckert, C. J. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti407 · Cited by 96 · see citing works
Self-citationStudy of shift work and risk of coronary events
Ellingsen, T., Bener, A., & Gehani, A. A. (2007) · The Journal of the Royal Society for the Promotion of Health · doi:10.1177/1466424007083702 · Cited by 76 · see citing works
Roberts, L. D., Hassall, D. G., Winegar, D. A., Haselden, J. N., Nicholls, A. W., & Griffin, J. L. (2009) · Genome Medicine · doi:10.1186/gm115 · Cited by 38 · see citing works
Self-citationStucchi, P., Gil‐Ortega, M., Merino, B., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1023 · Cited by 38 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works
Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598 · see citing works
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works
Self-citationCircadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524 · see citing works
Self-citationSpaeth, A. M., Dinges, D. F., & Goel, N. (2013) · Sleep · doi:10.5665/sleep.2792 · Cited by 457 · see citing works
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock
Dyar, K. A., Ciciliot, S., Wright, L. E., Biensø, R. S., Tagliazucchi, G. M., Patel, V. R., Forcato, M., Paz, M. I. P., Gudiksen, A., Solagna, F., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.005 · Cited by 454 · see citing works
“The various responses of clock genes and clock-associated genes to Bmal1 inactivation were in agreement with previous reports for global and tissue-speci fi c Bmal1 knockouts [16].”
BackgroundResultCircadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works
Health Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291 · see citing works
Daily eating patterns and their impact on health and disease
Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263 · see citing works
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260 · see citing works
Circadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258 · see citing works
Circadian timing of metabolism in animal models and humans
Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198 · see citing works
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198 · see citing works
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
The circadian coordination of cell biology
Chaix, A., Zarrinpar, A., & Panda, S. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201603076 · Cited by 159 · see citing works
Circadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147 · see citing works
Physiological responses to food intake throughout the day
Johnston, J. D. (2014) · Nutrition Research Reviews · doi:10.1017/s0954422414000055 · Cited by 158 · see citing works
Intrinsic muscle clock is necessary for musculoskeletal health
Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145 · see citing works
Circadian disruption in the pathogenesis of metabolic syndrome
Maury, E., Hong, H. K., & Bass, J. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.12.005 · Cited by 132 · see citing works
Fonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125 · see citing works
Mammalian circadian systems: Organization and modern life challenges
Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117 · see citing works
Clock Genes Control Cortical Critical Period Timing
Kobayashi, Y., Ye, Z., & Hensch, T. K. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.036 · Cited by 99 · see citing works
Foundations of circadian medicine
Kramer, A., Lange, T., Spies, C., Finger, A.-M., Berg, D., & Oster, H. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001567 · Cited by 99 · see citing works
“Bmal1 knockout in various tissues leads to phenotypes such as hypoglycemia and dyslipidemia (in the liver) [22], metabolic inefficiency and impaired triglyceride biosynthesis (in the muscle) [23], obesity (in adipose tissue) [24], or increased inflammation and insulin resistance (in myeloid cells) [25].”
BackgroundTime restricted eating: A dietary strategy to prevent and treat metabolic disturbances
Schuppelius, B., Peters, B., Ottawa, A., & Pivovarova-Ramich, O. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683140 · Cited by 93 · see citing works
Meal timing, aging, and metabolic health
Kessler, K., & Pivovarova-Ramich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081911 · Cited by 95 · see citing works
Chrono-biology, Chrono-pharmacology and Chrono-nutrition
Tahara, Y., & Shibata, S. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r06cr · Cited by 94 · see citing works
Minutes, days and years: molecular interactions among different scales of biological timing
Golombek, D. A., Bussi, I. L., & Agostino, P. V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0465 · Cited by 80 · see citing works
Chronobiology and obesity: Interactions between circadian rhythms and energy regulation
Summa, K. C., & Turek, F. W. (2014) · Advances in Nutrition · doi:10.3945/an.113.005132 · Cited by 82 · see citing works
Meal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72 · see citing works
Physiological links between circadian rhythms, metabolism and nutrition
Johnston, J. D. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.078295 · Cited by 59 · see citing works
Circadian transcription from beta cell function to diabetes pathophysiology
Perelis, M., Ramsey, K. M., Marcheva, B., & Bass, J. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416656949 · Cited by 57 · see citing works
Heritability of the timing of food intake
Lopez-Minguez, J., Dashti, H. S., Madrid-Valero, J. J., Madrid, J. A., Saxena, R., Scheer, F. A. J. L., Ordoñana, J. R., & Garaulet, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.03.002 · Cited by 45 · see citing works
Mashaqi, S., & Gozal, D. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.03.020 · Cited by 40 · see citing works
A metabolomic study of adipose tissue in mice with a disruption of the circadian system
Castro, C., Briggs, W., Paschos, G. K., FitzGerald, G. A., & Griffin, J. L. (2015) · Molecular BioSystems · doi:10.1039/c5mb00032g · Cited by 33 · see citing works
Self-citationThe circadian clock control of adipose tissue physiology and metabolism
Lekkas, D., & Paschos, G. K. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.05.001 · Cited by 26 · see citing works
Self-citationPeters, B., Koppold-Liebscher, D. A., Schuppelius, B., Steckhan, N., Pfeiffer, A. F. H., Kramer, A., Michalsen, A., & Pivovarova-Ramich, O. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.765543 · Cited by 20 · see citing works
Metabolism as an integral cog in the mammalian circadian clockwork
Gamble, K. L., & Young, M. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.786672 · Cited by 18 · see citing works
Fitzgerald, G. A., Yang, G., Paschos, G. K., Liang, X., & Skarke, C. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12526 · Cited by 15 · see citing works
Self-citation
- Authors
- Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., Griffin, J. L., Wang, F., Lawson, J. A., & FitzGerald, G. A.
- Affiliations
- University of Pennsylvania (US)
- University of Wisconsin–Madison (US)
- Georgia State University (US)
- MRC Elsie Widdowson Laboratory (GB)
- Corresponding author
- FitzGerald, Garret A
- ORCID
- Venue
- Nature Medicine
- Published
- 2012-11-11
- Volume
- 18
- Issue
- 12
- Pages
- 1768-1777
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3782286
- OpenAlex
- W2025018502
- Cited by
- 465
- References
- 50
- Citations by year
- 2026: 23 · 2025: 36 · 2024: 24 · 2023: 30 · 2022: 40 · 2021: 42 · 2020: 37 · 2019: 35 · 2018: 23 · 2017: 41 · 2016: 33 · 2015: 34 · 2014: 37 · 2013: 29 · 2012: 1
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pennsylvania
- National Institutes of Health
- Medical Research Council (MC_EX_G0800783)
- Biotechnology and Biological Sciences Research Council (BB/H013539/2, BB/H013539/1)
- National Heart, Lung, and Blood Institute (R01HL097800)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK045586, P30DK019525)
- National Institute of Environmental Health Sciences (R01ES005703)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, Bmal1, circadian clock, adipocytes, hypothalamic neuropeptides, polyunsaturated fatty acids, triglycerides, feeding behavior, circadian timing, night shift workers, metabolic disorders
- MeSH terms
- Animals, Appetite Regulation, Calorimetry, Chromatography, Liquid, Circadian Rhythm, Energy Metabolism, Fatty Acids, Unsaturated, Histological Techniques, Hypothalamus, Neuropeptides, Obesity, Mass Spectrometry, Blotting, Western, Absorptiometry, Photon, Discriminant Analysis, Gene Deletion, Adipocytes, DNA Primers, Statistics, Nonparametric, Protein Array Analysis, Chromatin Immunoprecipitation, Mice, ARNTL Transcription Factors, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
