Kaplitt, Michael G.

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet

Deep Brain Stimulation and Movement DisordersVirus-based gene therapy research

Cited by 1,067

AAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery controlled, randomised trial

LeWitt, P. A., Rezai, A. R., Leehey, M. A., Ojemann, S. G., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., Thomas, K., Sarkar, A., Siddiqui, M. S., et al. (2011) · The Lancet Neurology

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 681

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

Schweitzer, J. S., Song, B., Herrington, T. M., Park, T.-Y., Lee, N., Ko, S., Jeon, J., Cha, Y., Kim, K., Li, Q., et al. (2020) · New England Journal of Medicine

Pluripotent Stem Cells ResearchParkinson's Disease Mechanisms and Treatments

Cited by 542

The nucleus accumbens: a comprehensive review

Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery

Deep Brain Stimulation and Movement DisordersNeurotransmitter Receptor Influence on Behavior

Cited by 489

Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA

Worgall, S., Sondhi, D., Hackett, N. R., Kosofsky, B., Kekatpure, M. V., Neyzi, N., Dyke, J. P., Ballon, D., Heier, L., Greenwald, B. M., et al. (2008) · Human Gene Therapy

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 402

Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.

Rezai, A. R., Ranjan, M., D’Haese, P.-F., Haut, M. W., Carpenter, J., Najib, U., Mehta, R. I., Chazen, J. L., Zibly, Z., Yates, J. R., et al. (2020) · Proceedings of the National Academy of Sciences

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 365

Subthalamic GAD Gene Therapy in a Parkinson's Disease Rat Model

Luo, J., Kaplitt, M. G., Fitzsimons, H. L., Zuzga, D. S., Liu, Y., Oshinsky, M. L., & During, M. J. (2002) · Science

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 325

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease

Plotkin, J. L., Day, M., Peterson, J. D., Xie, Z., Kress, G. J., Rafalovich, I., Kondapalli, J., Gertler, T. S., Flajolet, M., Greengard, P., et al. (2014) · Neuron

Genetic Neurodegenerative DiseasesNerve injury and regeneration

Cited by 187

Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

Feigin, A., Kaplitt, M. G., Tang, C., Lin, T., Mattis, P., Dhawan, V., During, M. J., & Eidelberg, D. (2007) · Proceedings of the National Academy of Sciences

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 181

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Rosenberg, J. B., Kaplitt, M. G., De, B. P., Chen, A., Flagiello, T., Salami, C., Pey, E., Zhao, L., Ricart Arbona, R. J., Monette, S., et al. (2018) · Human Gene Therapy Clinical Development

Virus-based gene therapy researchAlzheimer's disease research and treatments

Cited by 176

Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior

Warner-Schmidt, J. L., Schmidt, E. F., Marshall, J. J., Rubin, A. J., Arango-Lievano, M., Kaplitt, M. G., Ibañez-Tallon, I., Heintz, N., & Greengard, P. (2012) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 163

Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

Alexander, B., Warner-Schmidt, J., Eriksson, T. M., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., et al. (2010) · Science Translational Medicine

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 140

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson’s disease

Niethammer, M., Tang, C. C., LeWitt, P. A., Rezai, A. R., Leehey, M. A., Ojemann, S. G., Flaherty, A. W., Eskandar, E. N., Kostyk, S. K., Sarkar, A., et al. (2017) · JCI Insight

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 124

Focused ultrasound–mediated blood-brain barrier opening in Alzheimer’s disease: long-term safety, imaging, and cognitive outcomes

Rezai, A. R., Ranjan, M., Haut, M. W., Carpenter, J., D’Haese, P.-F., Mehta, R. I., Najib, U., Wang, P., Claassen, D. O., Chazen, J. L., et al. (2023) · Journal of Neurosurgery

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 111

β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

D’Haese, P.-F., Ranjan, M., Song, A., Haut, M. W., Carpenter, J., Dieb, G., Najib, U., Wang, P., Mehta, R. I., Chazen, J. L., et al. (2020) · Frontiers in Human Neuroscience

Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatments

Cited by 94

Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound

Stavarache, M. A., Petersen, N., Jurgens, E. M., Milstein, E. R., Rosenfeld, Z. B., Ballon, D. J., & Kaplitt, M. G. (2019) · Journal of Neurosurgery

Ultrasound and Hyperthermia ApplicationsVirus-based gene therapy research

Cited by 76

Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2

Sondhi, D., Kaminsky, S. M., Hackett, N. R., Pagovich, O. E., Rosenberg, J. B., De, B. P., Chen, A., Van de Graaf, B., Mezey, J. G., Mammen, G. W., et al. (2020) · Science Translational Medicine

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 72

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

Eriksson, T. M., Alvarsson, A., Stan, T. L., Zhang, X., Hascup, K. N., Hascup, E. R., Kehr, J., Gerhardt, G. A., Warner-Schmidt, J., Arango-Lievano, M., et al. (2013) · Molecular Psychiatry

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 45

Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits

Kokotos, A. C., Antoniazzi, A. M., Unda, S. R., Ko, M. S., Park, D., Eliezer, D., Kaplitt, M. G., De Camilli, P., & Ryan, T. A. (2024) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 42

Framework for advancing rigorous research

Koroshetz, W. J., Behrman, S., Brame, C. J., Branchaw, J. L., Brown, E. N., Clark, E. A., Dockterman, D., Elm, J. J., Gay, P. L., Green, K. M., et al. (2020) · eLife

Academic Publishing and Open AccessResearch, Science, and Academia

Cited by 28

Apolipoprotein E, Aβ‐Amyloid, and the Molecular Pathology of Alzheimer's Disease Therapeutic Implicationsa

KAPLITT, M., GOURAS, G. K., MAKIMURA, H., JOVANOVIC, J., SWEENEY, D., GREENGARD, P., RELKIN, N. R., & GANDY, S. (1996) · Annals of the New York Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 12