Pawelec, Graham

Immunosenescence and cancer

Pawelec, G. (2017) · Biogerontology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 140

Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study

Di Benedetto, S., Derhovanessian, E., Steinhagen-Thiessen, E., Goldeck, D., Müller, L., & Pawelec, G. (2015) · Biogerontology

T-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research

Cited by 131

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

Derhovanessian, E., Theeten, H., Hähnel, K., Van Damme, P., Cools, N., & Pawelec, G. (2013) · Vaccine

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 121

Impact of age on T cell signaling: A general defect or specific alterations?

Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J.-Y., & Fulop, T. (2011) · Ageing Research Reviews

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 108

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

Wistuba-Hamprecht, K., Martens, A., Heubach, F., Romano, E., Geukes Foppen, M., Yuan, J., Postow, M., Wong, P., Mallardo, D., Schilling, B., et al. (2017) · European Journal of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 108

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

Derhovanessian, E., Maier, A. B., Hähnel, K., Zelba, H., de Craen, A. J. M., Roelofs, H., Slagboom, E. P., Westendorp, R. G. J., & Pawelec, G. (2013) · AGE

T-cell and B-cell ImmunologyCytomegalovirus and herpesvirus research

Cited by 102

Oxidative stress modulation and T cell activation

Larbi, A., Kempf, J., & Pawelec, G. (2007) · Experimental Gerontology

Redox biology and oxidative stressExercise and Physiological Responses

Cited by 102

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly

Derhovanessian, E., Maier, A. B., Hähnel, K., McElhaney, J. E., Slagboom, E. P., & Pawelec, G. (2014) · The Journal of Immunology

Influenza Virus Research StudiesCytomegalovirus and herpesvirus research

Cited by 93

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

Turner, J. E., Campbell, J. P., Edwards, K. M., Howarth, L. J., Pawelec, G., Aldred, S., Moss, P., Drayson, M. T., Burns, V. E., & Bosch, J. A. (2014) · AGE

Cytomegalovirus and herpesvirus researchT-cell and B-cell Immunology

Cited by 87

The SENIEUR protocol after 16 years

Pawelec, G., Ferguson, F. G., & Wikby, A. (2001) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 83

Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection

Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology

Influenza Virus Research StudiesCytomegalovirus and herpesvirus research

Cited by 74

Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human cd4+ tcr2+ cultured T cell clones

Pawelec, G., Sansom, D., Rehbein, A., Adibzadeh, M., & Beckman, I. (1996) · Experimental Gerontology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 68

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit

Aiello, A. E., Dowd, J. B., Jayabalasingham, B., Feinstein, L., Uddin, M., Simanek, A. M., Cheng, C. K., Galea, S., Wildman, D. E., Koenen, K., et al. (2016) · Psychoneuroendocrinology

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 66

Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

Adibzadeh, M., Pohla, H., Rehbein, A., & Pawelec, G. (1995) · Mechanisms of Ageing and Development

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 64

Induction of HIF-1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells

Larbi, A., Zelba, H., Goldeck, D., & Pawelec, G. (2009) · Journal of Leukocyte Biology

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 58

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus

Wistuba-Hamprecht, K., Frasca, D., Blomberg, B., Pawelec, G., & Derhovanessian, E. (2013) · Immunity & Ageing

Cytomegalovirus and herpesvirus researchT-cell and B-cell Immunology

Cited by 52

Vaccination in the elderly

Derhovanessian, E., & Pawelec, G. (2012) · Microbial Biotechnology

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 51

Are skin senescence and immunosenescence linked within individuals?

Waaijer, M. E. C., Goldeck, D., Gunn, D. A., van Heemst, D., Westendorp, R. G. J., Pawelec, G., & Maier, A. B. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 48

Does the human immune system ever really become “senescent”?

Pawelec, G. (2017) · F1000Research

Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

Cited by 45

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

Goldeck, D., Pawelec, G., Norman, K., Steinhagen-Thiessen, E., Oettinger, L., Haehnel, K., & Demuth, I. (2016) · Biogerontology

Nutrition and Health in AgingFrailty in Older Adults

Cited by 30

Immunoageing—the cause or effect of morbidity

Pawelec, G., & Solana, R. (2001) · Trends in Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 29

IL2- and IL4-dependent proliferation of T-cell clones derived early after allogeneic bone marrow transplantation: Studies of patients with chronic myelogenous leukaemia

Bruserud, Ø., Hamann, W., Patel, S., Ehninger, G., & Pawelec, G. (1992) · European Journal Of Haematology

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

Cited by 21

An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells

Marthandan, S., Hyland, P., Pawelec, G., & Barnett, Y. (2013) · Immunity & Ageing

Antioxidant Activity and Oxidative StressRedox biology and oxidative stress

Cited by 16

SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures

Marthandan, S., Freeburn, R., Steinbrecht, S., Pawelec, G., & Barnett, Y. (2014) · Immunity & Ageing

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 5