van der Flier, Wiesje M.

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease

Chételat, G., Ossenkoppele, R., Villemagne, V. L., Perrotin, A., Landeau, B., Mézenge, F., Jagust, W. J., Dore, V., Miller, B. L., Egret, S., et al. (2016) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease

Tesi, N., van der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., van Schoor, N. M., Scheltens, P., van der Flier, W. M., Huisman, M., Reinders, M. J. T., et al. (2020) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

Tesi, N., van der Lee, S. J., Hulsman, M., Jansen, I. E., Stringa, N., van Schoor, N., Meijers-Heijboer, H., Huisman, M., Scheltens, P., Reinders, M. J. T., et al. (2019) · European Journal of Human Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Amyloid PET and cognitive decline in cognitively normal individuals: the SCIENCe project

Timmers, T., Ossenkoppele, R., Verfaillie, S. C. J., van der Weijden, C. W. J., Slot, R. E. R., Wesselman, L. M. P., Windhorst, A. D., Wolters, E. E., Yaqub, M., Prins, N. D., et al. (2019) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 63

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

(ADNI), A. D. N. I., Kleineidam, L., Chouraki, V., Próchnicki, T., van der Lee, S. J., Madrid-Márquez, L., Wagner-Thelen, H., Karaca, I., Weinhold, L., Wolfsgruber, S., et al. (2020) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 62

A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease

Skillbäck, T., Mattsson, N., Hansson, K., Mirgorodskaya, E., Dahlén, R., van der Flier, W., Scheltens, P., Duits, F., Hansson, O., Teunissen, C., et al. (2017) · Scientific Reports

Advanced Proteomics Techniques and ApplicationsAlzheimer's disease research and treatments

Cited by 61

Gray matter network disruptions and amyloid beta in cognitively normal adults

Tijms, B. M., Kate, M. T., Wink, A. M., Visser, P. J., Ecay, M., Clerigue, M., Estanga, A., Garcia Sebastian, M., Izagirre, A., Villanua, J., et al. (2016) · Neurobiology of Aging

Functional Brain Connectivity StudiesDementia and Cognitive Impairment Research

Cited by 59

Cognitively healthy centenarians are genetically protected against Alzheimer's disease

Tesi, N., van der Lee, S., Hulsman, M., van Schoor, N. M., Huisman, M., Pijnenburg, Y., van der Flier, W. M., Reinders, M., & Holstege, H. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

Single subject classification of Alzheimer’s disease and behavioral variant frontotemporal dementia using anatomical, diffusion tensor, and resting-state functional magnetic resonance imaging.

Bouts, M. J. R. J., Möller, C., Hafkemeijer, A., van Swieten, J. C., Dopper, E., van der Flier, W. M., Vrenken, H., Wink, A. M., Pijnenburg, Y. A. L., Scheltens, P., et al. (2018) · Journal of Alzheimer’s Disease

Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

Cited by 47

The added value of 18-fluorodeoxyglucose-positron emission tomography in the diagnosis of the behavioral variant of frontotemporal dementia

Kerklaan, B. J., van Berckel, B. N. M., Herholz, K., Dols, A., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L. (2014) · American Journal of Alzheimer's Disease & Other Dementias®

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 46

Differential Expression of microRNA in Cerebrospinal Fluid as a Potential Novel Biomarker for Alzheimer’s Disease

van Harten, A. C., Mulders, J., Scheltens, P., van der Flier, W. M., & Oudejans, C. B. M. (2015) · Journal of Alzheimer's Disease

MicroRNA in disease regulationDementia and Cognitive Impairment Research

Cited by 41

Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease

van Es, A. C. G. M., van der Flier, W. M., Admiraal-Behloul, F., Olofsen, H., Bollen, E. L. E. M., Middelkoop, H. A. M., Weverling-Rijnsburger, A. W. E., Westendorp, R. G. J., & van Buchem, M. A. (2006) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAdvanced MRI Techniques and Applications

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CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

Ahmad, S., Milan, M. D. C., Hansson, O., Demirkan, A., Agustin, R., Sáez, M. E., Giagtzoglou, N., Cabrera-Socorro, A., Bakker, M. H. M., Ramirez, A., et al. (2020) · Scientific Reports

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scores

de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., et al. (2019) · medRxiv

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score

Ebenau, J. L., van der Lee, S. J., Hulsman, M., Tesi, N., Jansen, I. E., Verberk, I. M. W., van Leeuwenstijn, M., Teunissen, C. E., Barkhof, F., Prins, N. D., et al. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 26

Nature and implications of sex differences in AD pathology

Babapour Mofrad, R., & van der Flier, W. M. (2019) · Nature Reviews Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 24

Impact of imaging and cerebrospinal fluid biomarkers on behavioral variant frontotemporal dementia diagnosis within a late-onset frontal lobe syndrome cohort

Krudop, W. A., Dols, A., Kerssens, C. J., Prins, N. D., Möller, C., Schouws, S., Barkhof, F., van Berckel, B. N. M., Teunissen, C. E., van der Flier, W. M., et al. (2016) · Dementia and Geriatric Cognitive Disorders

Dementia and Cognitive Impairment ResearchHistorical and Modern Theater Studies

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TREM2 risk variants and associated endophenotypes in alzheimer’s disease

Dijkstra, J. I. R., Vermunt, L., Venkatraghavan, V., Ozhegov, G., Coomans, E. M., Ossenkoppele, R., van de Giessen, E., Hulsman, M., de Geus, C. M., van der Flier, W. M., et al. (2025) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Large-scale cerebrospinal fluid proteomic analysis in Alzheimer’s disease patients reveals five molecular subtypes with distinct genetic risk profiles

Tijms, B. M., Vromen, E. M., Mjaavatten, O., Holstege, H., Reus, L. M., van der Lee, S., Wesenhagen, K. E., Lorenzini, L., Vermunt, L., Venkatraghavan, V., et al. (2023) · medRxiv

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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