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Therapeutic targeting of senescent cells in the CNS

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Single-cell multiplex chromatin and RNA interactions in ageing human brain

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Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease

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PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

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Deep learning-based cell-specific gene regulatory networks inferred from single-cell multiome data

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The night’s watch: Exploring how sleep protects against neurodegeneration

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Gene networks and systems biology in Alzheimer's disease: Insights from multi‐omics approaches

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scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links

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Human brain vascular multi-omics elucidates disease-risk associations

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Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms

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Therapeutic Options in Alzheimer’s Disease: From Classic Acetylcholinesterase Inhibitors to Multi-Target Drugs with Pleiotropic Activity

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Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities

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Integrating amyloid and tau imaging with proteomics and genomics in Alzheimer’s disease

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Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer’s disease continuum

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Single‐Cell Patch‐Clamp/Proteomics of Human Alzheimer's Disease iPSC‐Derived Excitatory Neurons Versus Isogenic Wild‐Type Controls Suggests Novel Causation and Therapeutic Targets

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Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1

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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease

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Microglia networks within the tapestry of alzheimer’s disease through spatial transcriptomics

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Collation of fullerenes and carbon nanotubes with genistein for synergistic anti-Alzheimer's activity by amyloid-β deaggregation

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Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways

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Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulationPreprint

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Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

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Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review)

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Epigenetics in Neurodegenerative Diseases

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Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability

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A wearable spatiotemporal controllable ultrasonic device with amyloid-β disaggregation for continuous Alzheimer’s disease therapy

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Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders

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Multi-omics and high-spatial-resolution omics: deciphering complexity in neurological disorders

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Decoding Alzheimer’s Disease: Single-Cell Sequencing Uncovers Brain Cell Heterogeneity and Pathogenesis

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AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer–regulated axis

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The broken Alzheimer’s disease genome

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The AD odyssey 2023: Tales of single cell

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Cognitive resilience to Alzheimer's disease characterized by cell‐type abundance

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Single cell variant to enhancer to gene map for coronary artery diseasePreprint

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HIF-1α-induced microglia-mediated neuroinflammation is involved in Alzheimer's disease: Evidence from single-cell transcriptomic analysis

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Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s disease

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Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer’s Disease

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Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens

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Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer’s DiseasePreprint

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The SPI1/SMAD5 cascade in the promoting effect of icariin on osteogenic differentiation of MC3T3-E1 cells: a mechanism study

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Mettl3 regulates the pathogenesis of Alzheimer’s disease via fine-tuning Lingo2

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Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis

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A bibliometric and visual analysis of epigenetic research publications for Alzheimer’s disease (2013–2023)

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Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities

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Chromatin accessibility provides a window into the genetic etiology of human brain disease

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scMultiMap: Cell-type-specific mapping of enhancers and target genes from single-cell multimodal data

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Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability

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Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease

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Alzheimer's disease: from molecular pathways to therapies

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Revolutionizing Alzheimer’s Detection: Immune-Related Gene Biomarkers as Non-Invasive Predictors

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Cognitive rejuvenation through partial reprogramming of engram cells

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Simultaneous isolation of intact brain cells and cell-specific extracellular vesicles from cryopreserved Alzheimer’s disease cortex

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GWAS highlights the neuronal contribution to multiple sclerosis susceptibilityPreprint

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Functional insight into East Asian–specific genetic risk loci for Alzheimer's disease

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SPI1 affects Aβ1–42-induced microglia-mediated neuroinflammation by transcriptionally regulating FOSL2 expression

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Single Cell Sequencing Technology and Its Application in Alzheimer’s Disease

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GoFCards: an integrated database and analytic platform for gain of function variants in humans

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Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types

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Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer's disease

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Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time

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fSuSiE enables fine-mapping of QTLs from genome-scale molecular profilesPreprint

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Redox-sensitive high mobility group box 1 (HMGB1) protein is a multipotent regulator in the pathogenesis of Alzheimer's disease

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Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

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The role of astrocytes in Alzheimer’s disease: a bibliometric analysis

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The China Brain Multi-omics Atlas Project (CBMAP)

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Single-cell sequencing: accurate disease detection

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Single‐cell digital twins identify drug targets and repurposable medicine in Alzheimer’s disease

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ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

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Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder

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Impacts of host genetics on gut microbiome composition in Alzheimer’s disease

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Dysfunction of the neurovascular unit as a temporal driver in Alzheimer’s pathogenesis

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Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

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