Nestler, Eric J.

Epigenetic Mechanisms of Depression and Antidepressant Action

Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology

Epigenetics and DNA MethylationStress Responses and Cortisol

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Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models

Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience

Treatment of Major DepressionStress Responses and Cortisol

Cited by 262

Establishment of a repeated social defeat stress model in female mice

Takahashi, A., Chung, J.-R., Zhang, S., Zhang, H., Grossman, Y., Aleyasin, H., Flanigan, M. E., Pfau, M. L., Menard, C., Dumitriu, D., et al. (2017) · Scientific Reports

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

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ΔFosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 245

β-catenin mediates stress resilience through Dicer1/microRNA regulation

Dias, C., Feng, J., Sun, H., Shao, N. Y., Mazei-Robison, M. S., Damez-Werno, D., Scobie, K., Bagot, R., LaBonté, B., Ribeiro, E., et al. (2014) · Nature

Resilience and Mental HealthStress Responses and Cortisol

Cited by 240

Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction

Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience

Sleep and Wakefulness ResearchRegulation of Appetite and Obesity

Cited by 234

Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain

Nestler, E. J., Terwilliger, R. Z., Walker, J. R., Sevarino, K. A., & Duman, R. S. (1990) · Journal of Neurochemistry

Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Cited by 232

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors

Wook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 231

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

Heller, E. A., Cates, H. M., Peña, C. J., Sun, H., Shao, N., Feng, J., Golden, S. A., Herman, J. P., Walsh, J. J., Mazei-Robison, M., et al. (2014) · Nature Neuroscience

Neurotransmitter Receptor Influence on BehaviorEpigenetics and DNA Methylation

Cited by 227

Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice

Warren, B. L., Vialou, V. F., Iñiguez, S. D., Alcantara, L. F., Wright, K. N., Feng, J., Kennedy, P. J., LaPlant, Q., Shen, L., Nestler, E. J., et al. (2013) · Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 222

∆FosB: A transcriptional regulator of stress and antidepressant responses

Nestler, E. J. (2015) · European Journal of Pharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 220

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Peña, C. J., Smith, M., Ramakrishnan, A., Cates, H. M., Bagot, R. C., Kronman, H. G., Patel, B., Chang, A. B., Purushothaman, I., Dudley, J., et al. (2019) · Nature Communications

Stress Responses and CortisolChild Abuse and Trauma

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Epigenetic mechanisms of depression

Nestler, E. J. (2014) · JAMA Psychiatry

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 217

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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Early Stress Evokes Age-Dependent Biphasic Changes in Hippocampal Neurogenesis, Bdnf Expression, and Cognition

Suri, D., Veenit, V., Sarkar, A., Thiagarajan, D., Kumar, A., Nestler, E. J., Galande, S., & Vaidya, V. A. (2013) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

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MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications

Treatment of Major DepressionMicroRNA in disease regulation

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Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens

Feng, J., Wilkinson, M., Liu, X., Purushothaman, I., Ferguson, D., Vialou, V., Maze, I., Shao, N., Kennedy, P., Koo, J., et al. (2014) · Genome Biology

Genomics and Chromatin DynamicsNeurotransmitter Receptor Influence on Behavior

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FosB differentially modulates nucleus accumbens direct and indirect pathway function

Grueter, B. A., Robison, A. J., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2013) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., et al. (2013) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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BDNF is a negative modulator of morphine action

Koo, J. W., Mazei-Robison, M. S., Chaudhury, D., Juarez, B., LaPlant, Q., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D., et al. (2012) · Science

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility

Russo, S., Cathomas, F., Lin, H.-Y., Chan, K., Li, L., Durand-de Cuttoli, R., Parise, L., Aubry, A., Muhareb, S., Desland, F., et al. (2023) · Nature

Tryptophan and brain disordersStress Responses and Cortisol

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Circulating myeloid-derived MMP8 in stress susceptibility and depression

Cathomas, F., Lin, H.-Y., Chan, K. L., Li, L., Parise, L. F., Alvarez, J., Durand-de Cuttoli, R., Aubry, A. V., Muhareb, S., Desland, F., et al. (2024) · Nature

Tryptophan and brain disordersStress Responses and Cortisol

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Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability

Hultman, R., Ulrich, K., Sachs, B. D., Blount, C., Carlson, D. E., Ndubuizu, N., Bagot, R. C., Parise, E. M., Vu, M.-A. T., Gallagher, N. M., et al. (2018) · Cell

Neural dynamics and brain functionTreatment of Major Depression

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ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment

Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M. (2005) · European Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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