ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment
Abstract
The transcription factor deltaFosB is induced in the nucleus accumbens and dorsal striatum by chronic exposure to several drugs of abuse, and increasing evidence supports the possibility that this induction is involved in the addiction process. However, to date there has been no report of deltaFosB induction by drugs of abuse in the ventral tegmental area (VTA), which is also a critical brain reward region. In the present study, we used immunohistochemistry to demonstrate that chronic forced administration of cocaine induces deltaFosB in the rat VTA. This induction occurs selectively in a gamma-aminobutyric acid (GABA) cell population within the posterior tail of the VTA. A similar effect is seen after chronic cocaine self-administration. Induction of deltaFosB in the VTA occurs after psychostimulant treatment only: it is seen with both chronic cocaine and amphetamine, but not with chronic opiates or stress. The expression of deltaFosB appears to be mediated by dopamine systems, as repeated administration of a dopamine uptake inhibitor induced deltaFosB in the VTA, while administration of serotonin or norepinephrine uptake inhibitors failed to produce this effect. Time course analysis showed that, following 14 days of cocaine administration, deltaFosB persists in the VTA for almost 2 weeks after cocaine withdrawal. This accumulation and persistence may account for some of the long-lasting changes in the brain associated with chronic drug use. These results provide the first evidence of deltaFosB induction in a discrete population of GABA cells in the VTA, which may regulate the functioning of the brain's reward mechanisms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Electrical stimulation of the LHb inhibits most DA neurons indirectly via the RMTg.
“Furthermore, electrical stimulation of the LHb inhibits the vast majority of DA neurons [69, 71, 72]. Such inhibition is not direct, but rather occurs through the stimulation of neurons in the rostromedial tegmental nucleus (RMTg) [73].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [73]
Cites
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
Pan, L., Gurevich, E. V., & Gurevich, V. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209532200 · Cited by 1,758 · see citing works
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072 · see citing works
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
Graybiel, A. M., Moratalla, R., & Robertson, H. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6912 · Cited by 963 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641 · see citing works
ΔFosB: A sustained molecular switch for addiction
Nestler, E. J., Barrot, M., & Self, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191352698 · Cited by 640 · cited 2× · see citing works
“…DFosB in nucleus accumbens and dorsal striatum is seen with chronic administration of virtually any drug of abuse, as well as with chronic stress (Nestler et al., 2001; Perrotti et al., 2004a, b), it was of interest to determine whether DFosB induction in the posterior VTA is similarly…”
BackgroundRegulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00007.2003 · Cited by 583 · see citing works
The neurobiology of craving: Implications for the understanding and treatment of addiction.
Wise, R. A. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.118 · Cited by 564 · see citing works
Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., & Nestler, E. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90061-2 · Cited by 563 · see citing works
Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors.
Young, S., Porrino, L. J., & Iadarola, M. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1291 · Cited by 497 · see citing works
Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Tzschentke, T. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00033-2 · Cited by 481 · see citing works
Hope, B. T., Kosofsky, B. E., Hyman, S. E., & Nestler, E. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5764 · Cited by 474 · see citing works
Fitzgerald, L., Ortiz, J., Hamedani, A., & Nestler, E. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00274.1996 · Cited by 450 · see citing works
Molecular Neurobiology of Addiction
Nestler, E. J. (2001) · American Journal on Addictions · doi:10.1080/105504901750532094 · Cited by 412 · see citing works
Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area
Steffensen, S. C., Svingos, A. L., Pickel, V. M., & Henriksen, S. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08003.1998 · Cited by 388 · see citing works
Harris, S. (1990) · Medical Entomology and Zoology · Cited by 354 · see citing works
Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine
Pich, E. M., Pagliusi, S. R., Tessari, M., Talabot‐Ayer, D., van Huijsduijnen, R. H., & Chiamulera, C. (1997) · Science · doi:10.1126/science.275.5296.83 · Cited by 347 · see citing works
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress
Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L. M., Duman, R. S., & Nestler, E. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2542-04.2004 · Cited by 330 · see citing works
Chronic Fos-Related Antigens: Stable Variants of ΔFosB Induced in Brain by Chronic Treatments
Chen, J., Kelz, M. B., Hope, B. T., Nakabeppu, Y., & Nestler, E. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-04933.1997 · Cited by 327 · see citing works
Bonci, A., & Malenka, R. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03723.1999 · Cited by 318 · see citing works
White, F. J., Hu, X. T., Zhang, X., & Wolf, M. E. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09601-6 · Cited by 291 · see citing works
Borgland, S. L., Malenka, R. C., & Bonci, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-04.2004 · Cited by 291 · see citing works
Hiroi, N., Brown, J. R., Haile, C. N., Ye, H., Greenberg, M. E., & Nestler, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10397 · Cited by 285 · see citing works
Moratalla, R., Elibol, B., Vallejo, M., & Graybiel, A. M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80288-3 · Cited by 276 · see citing works
Delta FosB regulates wheel running.
Werme, M., Messer, C. J., Olson, L., Gilden, L., Thorén, P., Nestler, E. J., & Brené, S. (2002) · PubMed Central · doi:10.1523/jneurosci.22-18-08133.2002 · Cited by 224 · see citing works
Striatal Cell Type-Specific Overexpression of ΔFosB Enhances Incentive for Cocaine
Colby, C. R., Whisler, K., Steffen, C., Nestler, E. J., & Self, D. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02488.2003 · Cited by 217 · see citing works
Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.
Nye, H. E., & Nestler, E. J. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08777-2 · Cited by 212 · see citing works
Nye, H. E., Hope, B. T., Kelz, M. B., Iadarola, M. J., & Nestler, E. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12232-5 · Cited by 207 · see citing works
Kalivas, P. W. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)01063-q · Cited by 192 · see citing works
Doucet, J. ‐., Nakabeppu, Y., Bédard, P. J., Hope, B. T., Nestler, E. J., Jasmin, B. J., Chen, J. ‐., ladarola, M. J., St-Jean, M., Wigle, N., et al. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01220.x · Cited by 185 · see citing works
Hope, B. T., Kelz, M. B., Duman, R. S., & Nestler, E. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04318.1994 · Cited by 165 · see citing works
Hiroi, N., Marek, G. J., Brown, J. R., Ye, H., Saudou, F., Vaidya, V. A., Duman, R. S., Greenberg, M. E., & Nestler, E. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06952.1998 · Cited by 139 · see citing works
Synaptic plasticity in the mesolimbic dopamine system
Thomas, M. J., & Malenka, R. C. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1236 · Cited by 137 · see citing works
Winston, S. M., Hayward, M. D., Nestler, E. J., & Duman, R. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04892.x · Cited by 119 · see citing works
Brain transcription factor expression: effects of acute and chronic amphetamine and injection stress
Persico, A. M., Schindler, C. W., O’Hara, B. F., Brannock, M. T., & Uhl, G. R. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90113-4 · Cited by 109 · see citing works
Nimchinsky, E. A., Hof, P. R., Young, W. G., & Morrison, J. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961007)374:1 · Cited by 105 · see citing works
Peakman, M., Colby, C. R., Perrotti, L. I., Tekumalla, P. K., Carle, T. L., Ulery, P. G., Chao, J. R., Duman, C. H., Steffen, C., Monteggia, L. M., et al. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02230-3 · Cited by 103 · see citing works
Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Marinelli, M., Cooper, D., Baker, L. K., & White, F. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1491-1 · Cited by 100 · see citing works
Factors That Determine a Propensity for Cocaine-Seeking Behavior during Abstinence in Rats
Sutton, M. A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00160-8 · Cited by 97 · see citing works
Andersson, M., Westin, J. E., & Cenci, M. A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02469.x · Cited by 84 · see citing works
Barrot, M., Marinelli, M., Abrous, D. N., Rougé‐Pont, F., Moal, M. L., & Piazza, P. V. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00525.x · Cited by 82 · see citing works
Functional Diversity of Ventral Midbrain Dopamine and GABAergic Neurons
Korotkova, T. M., Ponomarenko, A. A., Brown, R. E., & Haas, H. L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:243 · Cited by 79 · see citing works
Antipsychotic drug treatment induces differential gene expression in the rat cortex
Kontkanen, O., Törönen, P., Lakso, M., Wong, G., & Ċastrén, E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01213.x · Cited by 77 · see citing works
Chou, Y.-H., Halldin, C., & Farde, L. (2000) · Synapse · doi:10.1002/1098-2396(200011)38:2 · Cited by 57 · see citing works
Cornish, J. L. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00239-x · Cited by 46 · see citing works
Vahid-Ansari, F., Nakabeppu, Y., & Robertson, G. S. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01579.x · Cited by 41 · see citing works
Minabe, Y., Matsuno, K., & Ashby, C. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199908)33:2 · Cited by 40 · see citing works
Koeltzow, T. E., & White, F. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.860 · Cited by 32 · see citing works
Nakahara, D., Ishida, Y., Nakamura, M., Kuwahara, I., Todaka, K., & Nishimori, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00510-7 · Cited by 31 · see citing works
Rodrı́guez, J. J., García, D., Nakabeppu, Y., & Pickel, V. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7612 · Cited by 12 · see citing works
Jones, K. L., & Barr, G. A. (2000) · Synapse · doi:10.1002/1098-2396(200102)39:2 · Cited by 11 · see citing works
Miyamoto, A., Yamamoto, T., Ohno, M., & Watanabe, S. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00500-3 · Cited by 7 · see citing works
Flagged first, then by citations
2 of the 61 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696 · see citing works
Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance
Stamatakis, A. M., & Stuber, G. D. (2012) · Nature Neuroscience · doi:10.1038/nn.3145 · Cited by 564 · see citing works
Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21891 · Cited by 503 · see citing works
Hong, S., Jhou, T. C., Smith, M., Saleem, K. S., & Hikosaka, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1384-11.2011 · Cited by 390 · see citing works
Transcriptional mechanisms of addiction: role of ΔFosB
Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 392 · see citing works
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366 · see citing works
“Although investigators originally postulated that the DA released from the VTA mediates only the hedonic or pleasurable effects of natural reinforcers and drugs in the NAc, evidence indicates that DA can signal events of opposite hedonic valence based on novelty or salience.”
BackgroundInfluentialLee, K.-W., Kim, Y. D., Kim, A. M., Helmin, K. A., Nairn, A. C., & Greengard, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511244103 · Cited by 354 · see citing works
Afferents to the GABAergic tail of the ventral tegmental area in the rat
Kaufling, J., Veinante, P., Pawlowski, S. A., Freund‐Mercier, M., & Barrot, M. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21983 · Cited by 347 · see citing works
Self-citationOne Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351 · see citing works
Sex differences in the neurobiology of drug addiction
Bobzean, S. A. M., Nobrega, A. K. D., & Perrotti, L. I. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.022 · Cited by 261 · see citing works
Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area
Omelchenko, N., Bell, R., & Sesack, S. R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06924.x · Cited by 253 · see citing works
Balcita‐Pedicino, J. J., Omelchenko, N., Bell, R., & Sesack, S. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22561 · Cited by 236 · see citing works
VTA GABA Neurons at the Interface of Stress and Reward
Bouarab, C., Thompson, B. V., & Polter, A. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00078 · Cited by 224 · see citing works
Braking Dopamine Systems: A New GABA Master Structure for Mesolimbic and Nigrostriatal Functions
Barrot, M., Sesack, S. R., Georges, F. E., Pistis, M., Hong, S., & Jhou, T. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3370-12.2012 · Cited by 215 · see citing works
Distinct patterns of ΔFosB induction in brain by drugs of abuse
Perrotti, L. I., Weaver, R. R., Robison, B., Renthal, W. R., Maze, I. S., Yazdani, S., Elmore, R. G., Knapp, D. J., Selley, D. E., Martin, B. R., et al. (2008) · Synapse · doi:10.1002/syn.20500 · Cited by 213 · see citing works
A new control center for dopaminergic systems: pulling the VTA by the tail
Bourdy, R., & Barrot, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.007 · Cited by 208 · see citing works
Jhou, T. C., Good, C. H., Rowley, C. S., Xu, S., Wang, H., Burnham, N. W., Hoffman, A. F., Lupica, C. R., & Ikemoto, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-12.2013 · Cited by 198 · see citing works
Matsui, A., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4570-11.2011 · Cited by 191 · see citing works
Lecca, S., Melis, M., Luchicchi, A., Muntoni, A. L., & Pistis, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.302 · Cited by 185 · see citing works
An update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 172 · see citing works
Efferent Pathways of the Mouse Lateral Habenula
Quina, L. A., Tempest, L., Ng, L., Harris, J. A., Ferguson, S. M., Jhou, T. C., & Turner, E. E. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23662 · Cited by 165 · see citing works
Topographical organization of GABAergic neurons within the ventral tegmental area of the rat
Olson, V. G., & Nestler, E. J. (2006) · Synapse · doi:10.1002/syn.20345 · Cited by 170 · see citing works
The Influence of ΔFosB in the Nucleus Accumbens on Natural Reward-Related Behavior
Wallace, D. L., Vialou, V., Rios, L., Carle-Florence, T. L., Chakravarty, S., Kumar, A., Graham, D. L., Green, T. A., Kirk, A., Iñiguez, S. D., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1531-08.2008 · Cited by 166 · see citing works
Deurwaerdère, P. D., & Giovanni, G. D. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.004 · Cited by 164 · see citing works
Lecca, S., Melis, M., Luchicchi, A., Ennas, M. G., Castelli, M. P., Muntoni, A. L., & Pistis, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.190 · Cited by 158 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
The Lateral Habenula:No Longer Neglected
Geisler, S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016710 · Cited by 149 · see citing works
Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context
Hara, E., Kubíková, Ľ., Hessler, N. A., & Jarvis, E. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05600.x · Cited by 142 · see citing works
Gonçalves, L., Sego, C., & Metzger, M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22787 · Cited by 134 · see citing works
Induction of ΔFosB in the Periaqueductal Gray by Stress Promotes Active Coping Responses
Berton, O., Covington, H. E., Ebner, K., Tsankova, N. M., Carle, T. L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G. M., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.033 · Cited by 129 · see citing works
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
Nieh, E. H., Kim, S., Namburi, P., & Tye, K. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.001 · Cited by 129 · see citing works
Kokane, S. S., & Perrotti, L. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00074 · Cited by 123 · see citing works
Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 126 · see citing works
Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens
Kim, Y. D., Teylan, M., Baron, M. L., Sands, A., Nairn, A. C., & Greengard, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813179106 · Cited by 120 · see citing works
Pistillo, F., Clementi, F., Zoli, M., & Gotti, C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.002 · Cited by 113 · see citing works
Bourdy, R., Sánchez-Catalán, M. J., Kaufling, J., Balcita‐Pedicino, J. J., Freund‐Mercier, M. J., Veinante, P., Sesack, S. R., Georges, F. E., & Barrot, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.129 · Cited by 113 · see citing works
Zhao-Shea, R., Liu, L., Soll, L. G., Improgo, M. R., Meyers, E. E., McIntosh, J. M., Grady, S. R., Marks, M. J., Gardner, P. D., & Tapper, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.240 · Cited by 113 · see citing works
The antero-posterior heterogeneity of the ventral tegmental area
Sánchez-Catalán, M. J., Kaufling, J., Georges, F. E., Veinante, P., & Barrot, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.025 · Cited by 112 · see citing works
The "Ups and Downs" of Signaling Cascades in Addiction
Dorit Ron, A., & Jurd, R. (2005) · Science s STKE · doi:10.1126/stke.3092005re14 · Cited by 106 · see citing works
Yetnikoff, L., Cheng, A. Y., Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23797 · Cited by 101 · see citing works
Ferreira, J. G. P., Del-Fava, F., Hasue, R. H., & Shammah‐Lagnado, S. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.003 · Cited by 101 · see citing works
Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving
Zahm, D. S., & Root, D. H. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.004 · Cited by 91 · see citing works
Molecular neurobiology of addiction: what’s all the (Δ)FosB about?
Ruffle, J. K. (2014) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2014.933840 · Cited by 87 · see citing works
ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward
Pitchers, K. K., Frohmader, K. S., Vialou, V., Mouzon, E., Nestler, E. J., Lehman, M. N., & Coolen, L. M. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00621.x · Cited by 87 · see citing works
Endogenous opiates and behavior: 2005
Bodnar, R. J., & Klein, G. E. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.011 · Cited by 85 · see citing works
Functional neuroanatomical review of the ventral tegmental area
Trutti, A. C., Mulder, M., Hommel, B., & Forstmann, B. U. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.062 · Cited by 90 · see citing works
The lateral habenula and the serotonergic system
Metzger, M., Bueno, D., & Lima, L. B. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.007 · Cited by 81 · see citing works
Hub and switches: endocannabinoid signalling in midbrain dopamine neurons
Melis, M., & Pistis, M. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0383 · Cited by 79 · see citing works
Drug-Induced Epigenetic Changes Produce Drug Tolerance
Wang, Y., Krishnan, H. R., Ghezzi, A., Yin, J. C. P., & Atkinson, N. S. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050265 · Cited by 77 · see citing works
Metzger, M., Souza, R., Lima, L. B., Bueno, D., Gonçalves, L., Sego, C., Donato, J., & Shammah‐Lagnado, S. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14647 · Cited by 77 · see citing works
Kaufling, J., Veinante, P., Pawlowski, S. A., Freund‐Mercier, M. J., & Barrot, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.001 · Cited by 73 · see citing works
Steidl, S., Wasserman, D., Blaha, C. D., & Yeomans, J. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.022 · Cited by 72 · see citing works
GABAB Receptor-Positive Modulation Decreases Selective Molecular and Behavioral Effects of Cocaine
Lhuillier, L., Mombereau, C., Cryan, J. F., & Kaupmann, K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301102 · Cited by 67 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Efferent projections of Vglut2 , Foxp2 , and Pdyn parabrachial neurons in mice
Huang, D., Grady, F. S., Peltekian, L., & Geerling, J. C. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24975 · Cited by 65 · see citing works
Kaufling, J., Waltisperger, E., Bourdy, R., Valera, A. M., Veinante, P., Freund‐Mercier, M. J., & Barrot, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00984.x · Cited by 66 · see citing works
Ventral Tegmental Area Afferents and Drug-Dependent Behaviors
Oliva, I., & Wanat, M. J. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00030 · Cited by 62 · see citing works
Camarini, R., & Pautassi, R. M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.006 · Cited by 60 · see citing works
Smith, R. J., Vento, P. J., Chao, Y. S., Good, C. H., & Jhou, T. C. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1761-7 · Cited by 58 · see citing works
Efferent connections of the rostral linear nucleus of the ventral tegmental area in the rat
Del-Fava, F., Hasue, R. H., Ferreira, J. G. P., & Shammah-Lagnado, S. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.039 · Cited by 56 · see citing works
Cornish, J. L., Hunt, G. E., Robins, L., & McGregor, I. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.004 · Cited by 57 · see citing works
The mesopontine rostromedial tegmental nucleus: An integrative modulator of the reward system
Lavezzi, H. N., & Zahm, D. S. (2011) · Basal Ganglia · doi:10.1016/j.baga.2011.08.003 · Cited by 56 · see citing works
Neural mechanisms of freezing and passive aversive behaviors
Jhou, T. (2005) · The Journal of comparative neurology · doi:10.1002/cne.20734 · Cited by 51 · see citing works
Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0368-z · Cited by 54 · see citing works
Brain regional differences in CB1 receptor adaptation and regulation of transcription
Lazenka, M. F., Selley, D. E., & Sim‐Selley, L. J. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.023 · Cited by 55 · see citing works
Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli
Sánchez-Catalán, M. J., Faivre, F., Yalçın, İ., Muller, M., Massotte, D., Majchrzak, M. J., & Barrot, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.139 · Cited by 55 · see citing works
Parker, J. G., Wanat, M. J., Soden, M. E., Ahmad, K. T., Zweifel, L. S., Bamford, N. S., & Palmiter, R. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1715-11.2011 · Cited by 53 · see citing works
Lahti, L., Haugas, M., Tikker, L., Airavaara, M., Voutilainen, M. H., Anttila, J., Kumar, S., Inkinen, C., Salminen, M., & Partanen, J. (2015) · Development · doi:10.1242/dev.129957 · Cited by 62 · see citing works
Bobzean, S. A. M., Kokane, S. S., Butler, B. D., & Perrotti, L. I. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.057 · Cited by 50 · see citing works
The lateral habenula: A hub for value-guided behavior
Groos, D., & Helmchen, F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113968 · Cited by 43 · see citing works
Edwards, A., & Abizaid, A. B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.032 · Cited by 50 · see citing works
Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement
Morel, C., Montgomery, S. E., & Han, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14160 · Cited by 45 · see citing works
Kaplan, G. B., Leite‐Morris, K. A., Fan, W., Young, A. J., & Guy, M. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023574 · Cited by 44 · see citing works
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test
Addy, N. A., Nunes, E. J., & Wickham, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.002 · Cited by 42 · see citing works
Vento, P. J., Burnham, N. W., Rowley, C. S., & Jhou, T. C. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.018 · Cited by 41 · see citing works
Jhou, T. C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108763 · Cited by 40 · see citing works
Zhu, H., Lee, M.-S., Agatsuma, S., & Hiroi, N. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm027 · Cited by 39 · see citing works
Wille‐Bille, A., de Olmos, S., Marengo, L. G., Chiner, F., & Pautassi, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.11.008 · Cited by 38 · see citing works
Rotllant, D., Márquez, C., Nadal, R. A., & Armario, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.020 · Cited by 37 · see citing works
The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia
Taylor, N. E., Long, H., Pei, J., Kukutla, P., Phero, A., Hadaegh, F., Abdelnabi, A., Solt, K., & Brenner, G. J. (2019) · Pain · doi:10.1097/j.pain.0000000000001647 · Cited by 38 · see citing works
Quina, L. A., Walker, A. W., Morton, G., Han, V. Z., & Turner, E. E. (2020) · eNeuro · doi:10.1523/eneuro.0527-19.2020 · Cited by 38 · see citing works
McGinty, V. B., Hayden, B. Y., Heilbronner, S. R., Dumont, E. C., Graves, S. M., Mirrione, M. M., du Hoffmann, J., Sartor, G. C., España, R. A., Millan, E. Z., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.036 · Cited by 36 · see citing works
Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine
Cardona-Acosta, A. M., & Bolaños‐Guzmán, C. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109374 · Cited by 36 · see citing works
Molecular regulation of GABA ergic neuron differentiation and diversity in the developing midbrain
Lahti, L., Achim, K., & Partanen, J. M. (2013) · Acta Physiologica · doi:10.1111/apha.12062 · Cited by 36 · see citing works
Fu, R., Chen, X., Zuo, W., Li, J., Kang, S., Zhou, L.-H., Siegel, A., Bekker, A., & Ye, J.-H. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.027 · Cited by 35 · see citing works
Mesolimbic Dopamine and Habenulo-Interpeduncular Pathways in Nicotine Withdrawal
Dani, J. A., & De Biasi, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012138 · Cited by 34 · see citing works
Psychiatric research: psychoproteomics, degradomics and systems biology
Kobeissy, F. H., Sadasivan, S., Liu, J., Gold, M. S., & Wang, K. (2008) · Expert Review of Proteomics · doi:10.1586/14789450.5.2.293 · Cited by 34 · see citing works
Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion
Gordon-Fennell, A., & Stuber, G. D. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108725 · Cited by 37 · see citing works
Modulation of Locomotor Activation by the Rostromedial Tegmental Nucleus
Lavezzi, H. N., Parsley, K. P., & Zahm, D. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.223 · Cited by 33 · see citing works
Morello, F., & Partanen, J. M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.10.001 · Cited by 34 · see citing works
Fu, R., Zuo, W., Gregor, D. M., Li, J., Grech, D., & Ye, J.-H. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12974 · Cited by 33 · see citing works
Substantia Nigra, Ventral Tegmental Area, and Retrorubral Fields
Halliday, G. M., Reyes, S., & Double, K. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10013-6 · Cited by 33 · see citing works
The transcription factor ΔFosB is recruited by inflammatory pain
Luis‐Delgado, O. E., Barrot, M., Rodeau, J., Ulery, P. G., Freund‐Mercier, M. J., & Lasbennes, F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03970.x · Cited by 32 · see citing works
Huff, M. L., & LaLumiere, R. T. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.260 · Cited by 32 · see citing works
Conrad, W. S., Oriol, L., Kollman, G. J., Faget, L. C., & Hnasko, T. S. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100183 · Cited by 33 · see citing works
Petzel, A., Bernard, R., Poller, W. C., & Veh, R. W. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24200 · Cited by 31 · see citing works
Chocyk, A., Czyrak, A., & Wędzony, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.045 · Cited by 31 · see citing works
Assessment of genome and proteome profiles in cocaine abuse
Hemby, S. E. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58009-4 · Cited by 31 · see citing works
- Authors
- Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Florida State University (US)
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2005-05
- Volume
- 21
- Issue
- 10
- Pages
- 2817-2824
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1967616722
- Cited by
- 178
- References
- 61
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 17 · 2015: 9 · 2014: 14 · 2013: 9 · 2012: 14
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ΔFosB, ventral tegmental area, GABAergic neurons, cocaine, amphetamine, psychostimulants, drug addiction, dopamine, brain reward, cocaine self-administration, cocaine withdrawal, chronic drug exposure, transcription factor induction
- MeSH terms
- Animals, Cocaine, gamma-Aminobutyric Acid, Kinetics, Male, Morphine, Self Administration, Transcription Factors, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Ventral Tegmental Area, Cocaine-Related Disorders, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
